Acetylcholine (A.Ch) vs Nor-Epinephrine (Nor-Epi) - PANS vs SANS - Physiology and Pharmacology

[@MedicosisPerfectionalis]

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[@dr.elaineluther6562]

FYI, the prefix "nor" (short for normal) in chemistry means a molecule has had a methyl removed from it. Nor-epinephrine is epinephrine less a methyl. Therefore, converting nor-epinephrine to epinephrine is a matter of adding a methyl. That's the only structural difference. There are many "nor" combos in chemistry, eg testosterone/nortestosterone, opianic acid/nor-opianic acid, etc. In most cases, the molecules will have identical functions. The additional methyl influences the potency of the molecule in unpredictable ways. That is, sometimes the methyl enhances function, and sometimes the methyl interferes with functions. Nevertheless, you can expect the molecules to have the same function, but at different operating levels of effectiveness.

[@erfananvari370]

Is that why methyl-amphetamine is more potent than amphetamine?

[@kevinjohansyah7321]

Clear and concise with appropriate dose of humor to keep us engaged 😂, keep up the good work !!

[@MedicosisPerfectionalis]

Thank you so much, Sir!

[@none128]

i love your videos and the descartes joke made me pause it so i could share it with friends :D thank you for your hard work !!!!!

[@MedicosisPerfectionalis]

My pleasure 😇

[@cathoderaytube1613]

Your video notifications always make my day! Been watching your videos since I was a student and even now they help me better manage my Covid patients. P.S. im stealing your Renée Descartes joke

[@MedicosisPerfectionalis]

Haha 😂 Thank you so much 😊 The joke is not mine. It’s one of the classic jokes that they tell in philosophy classes :)

[@admortem8901]

This is brilliant, you are brilliant brother.

[@MedicosisPerfectionalis]

Thank you 🙏

[@MedicosisPerfectionalis]

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[@aishah00807]

You Egyptians are the kings of humor and apparently medicine too 😂

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@risha7936]

i was sleepy because of online classes but your video notifications makes me excited again!! i'm a high schooler incase you forgot but hey i could understand what you were talking, at least 70% which i thought was one of the greatest things about your channel : it really is where medicine makes perfect sense even for high-schoolers with 0 knowledge about medicine xD i've watched till 11:41 but classes are gonna start again soon so bye for now😭❤️

[@MedicosisPerfectionalis]

Bye bye 👋, dear :) Take care! Thank you so much for watching!

[@FarzanasLaw]

FANTASTIC VIDEO!!!

[@MedicosisPerfectionalis]

Thank you!

[@loubnadr7407]

machaalha your the best i highly recommended you to every medical student

[@MedicosisPerfectionalis]

Thank you 🙏

[@ABC-fv7ow]

Its always good to hear you.God bless

[@MedicosisPerfectionalis]

God bless you too!

[@HolyStreetSmoke]

Funfact: I am a medical cannabis user, and I want to point this out. Too much acetylcholine can cause new blood vessels to form and form tumors that can grow into cancer. The thing I love about cannabinoids and I've been smoking and injesting cannabis for about over a year now and it saved me from nicotine addiction withdrawals and 💊 like stimulants and depressants anti pyschotics etc which I am now proudly off of. One last thing I want to say is THC/CBD Inhibit my Cholergenic system so basically there is proof is slows down acetylcholine and slowing down cancer and tumor formation. 🍃

[@HolyStreetSmoke]

Life is so wonderfully interesting to the point where we must study our earth's plants more and see what they do to the human body.

[@soundsofmercyinternational4902]

Please do a video series on catatonia, schizophrenia, neurotransmitter metabolism disorders, auto immunity conditions causing psychosis catatonia such as anti nmda, and other auto immunity or metabolism dosorders that cause psychosis and catatonia.

[@eliasali9383]

That "I think not" joke was amazing 😂😂😂😂

[@MedicosisPerfectionalis]

Haha 😂

[@muhammadaliaslam4023]

Sir U have Written Anticholine Esterase as both Nicotinic agonist and Muscarinic Agonist. ???? Sir as u say we use Dopamine against CHF by Acting on Beta 1 receptor but we also use Beta Blockers against CHF. Isn't it Opposite?

[@mowyatt6487]

So funny!! Love your humor!

[@MedicosisPerfectionalis]

Thank you so much! Would you please help me by sharing?

[@medico_fudger7534]

"Something your professor never tells you" yeah they never do ha ha bro awesome

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@LILO2003SHAHAS]

why nicotine in a high dose will inhibit the nicotinic receptor ?

[@ራያራዩማ-ፈ8ዠ]

You are unique

[@MedicosisPerfectionalis]

Thank you ☺️

[@هلالالحميري-د5ض]

Reappearing is bad sir, cut to the chase plz....thank so much, u are the best ever..

[@MedicosisPerfectionalis]

What do you mean by reappearing?

[@هلالالحميري-د5ض]

@@MedicosisPerfectionalis sorry,I meant,repeating

[@docdiary9672]

Medicine is all about revising. The repetition makes us recall and retain things better. That's one of the things I absolutely love about medicosis. You can skip those parts if it's inconvenient for you. :)

[@musebibs]

😅i love your videos!!! U are funny and educative 😅💕💕✨

[@MedicosisPerfectionalis]

Thank you 😊

[@alphagonist4748]

Actions of anticholinergics and adrenergics same?

[@MedicosisPerfectionalis]

What do you mean?

[@dr.Daniyalmustansar]

brother plz tell. me. the treatment of hsp. pupura upper respiratory streptococcus a... it again come back 2nd time after 2 year😓😓😓

[@MedicosisPerfectionalis]

I don’t know. Please talk to your doctor! No one can treat you online.

[@stephensmith4339]

How can one naturally reduce acetylcholine levels?

[@MedicosisPerfectionalis]

What would you want to reduce it?

[@stephensmith4339]

@@MedicosisPerfectionalis I suffer from all those you listed if acetylcholine goes into the blood. I would call myself parasympathetic dominant.

[@stephensmith4339]

@@MedicosisPerfectionalis my 4 point urine neurotransmitter results show very low norepinephrine, however it’s not an issue that I can’t produce it, because I can. I can work out with high intensity so lack of norepinephrine is actually not the issue, but I think something is blocking it or suppressing it, particularly at rest. And I think that acetylcholine is blocking my sympathetic system. Would that sound correct? Thanks!

[@MedicosisPerfectionalis]

I appreciate your comment, Stephen. Many ideas may sound great in theory, but clinically they don’t. Example, a patient has swallowed an acidic solution, and then realizing that this is a problem, he decided to ingested a basic solution to neutralize the former. Theoretically, it makes sense, but in the real world, it is harmful. Did you know that low Acetylcholine is associated with dementia (memory loss)? Neurotransmitters are not like chess pieces that we can move and manipulate at ease. The body is insanely complex that it can confound a computer. If I were you, I would first seek to get an accurate diagnosis (not just a blood level) from an excellent physician with experience. Then, I will start looking at treatment options. Good luck to you, Stephen!

[@stephensmith4339]

@@MedicosisPerfectionalis totally understand. Very complex. I’ve had a lot of different tests and they all seem to point to acetylcholine. Maybe the enzyme Acetylcholinesterase is not working correctly. One more question if I may, can BCAA supplementation increase Acetylcholinesterase? Appreciate your responses either way 🙏

[@Mouthdieter]

what is the difference between piconomic and medicos. I am so confused.

[@MedicosisPerfectionalis]

Two different companies. I am Medicois...Picmonic is my great sponsor.

[@zakirzak1494]

At somatic fiber also Ach is secreted ? (On the marriage slide )

[@MedicosisPerfectionalis]

Yes. That’s right. Somatic fibers secrete ACh at thr NMJ to stimulate skeletal muscles.

[@zakirzak1494]

@@MedicosisPerfectionalis that is parasympathetic anyway right ... so it is not cheating by using ACH.

[@MedicosisPerfectionalis]

Somatic fibers are somatic, they are not autonomic (i.e. not parasympathetic).

[@zakirzak1494]

@@MedicosisPerfectionalis oh yeah ... just realised , thx

[@jeremiahbaker6396]

lool you are so great

[@sarahfellows3074]

Haha i love that ...is it the main hormone secreted by the adrenal medulla. Shut up! The main hormone is epinephrine :'‐D

[@rlybruh765]

I swear for some reason I just knew you're Egyptian 😂

[@MedicosisPerfectionalis]

😊😊😊

[@RameshRam-tr4zn]

I hate this video. the word adrenal or adrenaline is a anxiety trigger