Bilirubin Metabolism & Jaundice - Gastrointestinal (GI) Physiology & Pathology- Physiology Series

[@MedicosisPerfectionalis]

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[@aasemahsan]

13:52 Jaundice 18:47 Pre-Hepatic & Post-Hepatic Jaundice comparison 21:44 Comparison among Pre-hepatic, Hepatocellular & Post-hepatic jaundice 23:41 Congenital Pathologies

[@jasminels]

*literally me every time i watch a medicosis video:* "this is my new favorite video"

[@MedicosisPerfectionalis]

I am so delighted! Thank you!

[@kitsunefire92]

Not sure if your intended audience includes Medical Lab Tech students but I appreciate these videos none the less.

[@MirandaLovesPathology]

Lab tech here!!! I binge watched so many Medicosis videos during school…I still do sometimes for a refresher ❤️🫡

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@@MirandaLovesPathology they're so good! and they help me so much!

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Hi , I'm a lab technologist and working on my channel to help others out, do visit my lab house if you want! 😃⭐

[@antonyshigin4977]

My favourite physiology channel: Medicosis perfectionalis

[@MedicosisPerfectionalis]

Thank you so much, Anthony!

[@Dr_strange_2652]

My best online teacher I am lucky enough to get ur classes in online....❤❤❤❤❤❤❤​@@MedicosisPerfectionalis

[@waelfadlallah8939]

If the stool is not brown we need to talk, if it floats we need an appointment and if it's pencil-shaped we need surgery!😅 Great explanation encompassing all bilirubin related pathologies 👍

[@MedicosisPerfectionalis]

Thank you 😊

[@samaafaiz6523]

How talent you are at interpretation staffs in scientific way.

[@MedicosisPerfectionalis]

Thank you!

[@imeann...]

I cannot express how much this helped me. Really really grateful

[@nooralhoda8529]

It's been a week since I've searched for your jaundice video 😅, I'm happy that you've posted it today 😍

[@MedicosisPerfectionalis]

Hope you enjoyed it!

[@Dr_strange_2652]

Hey medicosis Please make a live session with us As we can see you directly.. don't know why i feel great connection with u medicosis. I never have so passionate and caring teacher like u ever in my life😢😢. I don't know if i get the opportunity to meet u or not! But its my belief that i will get the opportunity to meet u somewhere inshaAllah.. please sir if possible please have a visit to Bangladesh..... Take care and keep sharing your wisdom Sir

[@raphaellaballa6884]

Honestly you are a rare gem ❤

[@MedicosisPerfectionalis]

Thank you so much!

[@alanwaterman1328]

Yes it all makes perfect sense with your words of wisdom.

[@MedicosisPerfectionalis]

:)

[@shafiqkassim_]

never imagined myself laughing and learning medicine. BIG UP MEDICOSIS

[@MedicosisPerfectionalis]

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[@احمدصادق-ك8غ]

Thank you so much medicosis, follow your videos from egypt

[@MedicosisPerfectionalis]

Thank you 🙏

[@kdhani9196]

So far the fav channel ❤

[@MedicosisPerfectionalis]

Thank you so much! I appreciate you! Can you please help me by sharing my videos with others?

[@sanahameed4205]

U r my real life hero....thank you for existing ❤

[@pashenw5519]

congratulation for 1 million 😁

[@MedicosisPerfectionalis]

Thank you so much!

[@0xApollo]

You make me call pathology a babyyy Thanks so much 🙏🏻 💓

[@MedicosisPerfectionalis]

My pleasure!

[@nehakurmi538]

Great explanation

[@MedicosisPerfectionalis]

Thank you 🙏

[@lanaalfares8350]

Thank you so much I appreciate your effort to make this masterpiece (mastervedio) جزاك الله خيرا

[@MedicosisPerfectionalis]

I appreciate you!

[@mahimapearlin7432]

Talented sir❤❤❤❤❤

[@ubaidullah1611]

Awesome lecture

[@gironkid8303]

❤❤❤❤❤❤ saving my grade ❤❤❤❤❤❤

[@MedicosisPerfectionalis]

I am honored!

[@tinghuanhsu3469]

it's awesome !thank you

[@MedicosisPerfectionalis]

My pleasure!

[@saumyalandge7349]

Thank you so much

[@MedicosisPerfectionalis]

You're most welcome!

[@Dr_strange_2652]

Another boss level explanation ❤❤ Greetings from Bangladesh

[@MedicosisPerfectionalis]

Glad you liked it!

[@Dr_strange_2652]

@@MedicosisPerfectionalis always liked boss

[@Wandererp_19]

Bestest video❤️ Thanks🙏

[@jacenite8517]

Sir please I’ll like you to go a bit deep into creatinine, lft and rft with practical applications so I can prepare before exams

[@randomthingstovlog]

please don't skip ads..

[@gironkid8303]

I LOVE YOU MEDICOSIS

[@MedicosisPerfectionalis]

:)

[@yomnahabashy3254]

‏‪ ‏‪10:39‬‏ Famous Egyptian professor.. Dr Nagi ❤❤❤

[@tmsff9893]

1- the urobilin and Urochrom are the same? 2-In hepatic and post hepatic what does make the urine dark if there is no urobilinogen?

[@alexsheremett3097]

Fantastic thank you!

[@MichelleDespres]

Wondering if you could discuss this process with no gall bladder and also extremely low iron... I'm having infusions.

[@tiss]

Very informative video... Thank you

[@MedicosisPerfectionalis]

My pleasure!

[@rispaadoma5734]

Love this ❤

[@-Emune]

Not joking i opened the PDF given to us by the professeor and it is legit this video in slides 🤣🤣

[@MedicosisPerfectionalis]

Wow! I appreciate you so much! Side note: Your wonderful professor never asked for permission or even said thanks!

[@lolo-dv4yi]

19:10 How obstructive jaundice can be intrahepatic? doesn't it confuse with hepatocellular jaundice?? Thanks for this greatness really❤️❤️👏

[@shams-100p]

Brilliant 🤩

[@MedicosisPerfectionalis]

Thank you, Shams! Would you please help me by sharing?

[@shams-100p]

@@MedicosisPerfectionalis sure 🫡🤍

[@MedicosisPerfectionalis]

Thanks!

[@moinn230]

Please make video about hepatitis ❤

[@asifshahriar9685]

Thank you❤

[@anastasia1431]

I literally manifested this video 😂 God bless you

[@MedicosisPerfectionalis]

God bless you too!

[@reh303]

As someone with autoimmune hemolytic anemia, this was very informative. Thank you.

[@MedicosisPerfectionalis]

Thank you! I wish you the best!

[@grahamsmith5768]

I had jaundice, and it was a wake up call to look after my liver.

[@naaengmann2117]

really helpful!

[@MedicosisPerfectionalis]

Thank you so much!

[@ABC-fv7ow]

Superb🎉

[@MedicosisPerfectionalis]

Thanks 🤗

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Itss Just Awsumm. Toooo Goood.

[@MedicosisPerfectionalis]

Thank you!

[@LeahRebecca]

ty

[@MedicosisPerfectionalis]

My pleasure!

[@idea4022]

10:41 Prof naji ❤

[@MedicosisPerfectionalis]

Indeed!

[@SomaDler-cy4we]

Thank you.

[@danielsima882]

Is there a chance that, direct bilirubine can regurgitate back in the liver (in cholestasis) and affect the conjugation process in healthy hepatocytes and therefore the indirect bilirubin gets to raise too a little bit?

[@ivymatimati]

Weldone this is short ñ simple

[@MedicosisPerfectionalis]

Thank you so much! Would you please help me by sharing?

[@shashishekhar----]

Good video

[@MedicosisPerfectionalis]

Thank you 🙏

[@aureliavruzhaj3191]

beautiful

[@jaguararts2296]

Sir! Please add chapters in this video. So we can easily seek

[@Dr_joona]

Thankyouu so much👍👍👍👍👍👍

[@qamar997]

awesoom❤🎉

[@MedicosisPerfectionalis]

Thank you 🙏

[@hamzaalghurbani]

I love that famous Egyptian prof 😂🤍🤍 Two hearts one for him and the other ... 😂

[@kira01982]

Guys, I have a question ❓ I have jaundice from time to time with lower dried lips and feel sleepy most of the times. I did CBC test and all was normal except my bilirubin was way higher than peak ,the liver enzymes were OK as well POINT : I FAST ALL DAY ONLY TO EAT AT DINNER , is this common or related to liver damage?

[@AAtkinson]

Sounds like Gilbert’s Syndrome. It’s a common genetic condition which leads to elevated bilirubin due to an enzyme deficiency of UTG1A1. Affects about 10% of Caucasians. When the body is under stress the liver produces less of this enzyme. Lack of sleep, excess exercise, dehydration, emotional stress. Fasting is a type of stress. I bet if you stopped fasting and drank more water the jaundice and bilirubin would normalize, or the bilirubin would be only slightly elevated.

[@shubhamparande6002]

Hey even I am dealing with same. My cbc test all was normal but sgpt was 125 . Can anyone help me out pls

[@Z.almagdi]

It sounds like Gilbert’s syndrome, a genetic hereditary disorder where slightly higher than normal levels of bilirubin build up in the blood, causing jaundice., everything in CBC will be normal and okay except for bilirubin obviously. No treatment is needed but several factors, including FASTING for long periods of time like this , illness, and dehydration etc , may trigger symptoms! So don’t worry but be carful

[@ibrahimgalal9136]

10:40 د/ ناجي اسكندر

[@MedicosisPerfectionalis]

Yes!

[@mohsenahmed1270]

Amazing 🤩

[@lolo-dv4yi]

How is stercobilin produced in hemolytic jaundice? It is preheat defect so, it can't reach intestine so, urobilinogen isn't produced and it is produced from oxidation of urobilinogen?? I wish I didn't misunderstand😢😢.

[@meloukabelalia]

thank you but how conjugated bilirubin will increase in the blood in hepatocellular when the liver can not conjugate bilirubin !

[@thehigherevolutionary]

Thanks!

[@MedicosisPerfectionalis]

Thank you for your support!

[@okk2101]

Great!

[@MedicosisPerfectionalis]

Thank you 🙏

[@shinn-tyanwu4155]

Great 😊

[@MedicosisPerfectionalis]

Thank you so much!

[@jacenite8517]

25:16 Sir please I’ll like you to go a bit deep into creatinine, lft and rft with practical applications so I can prepare before exams

[@MedicosisPerfectionalis]

Check out my “labs” playlist.

[@shahadaljouf8638]

My question is the bilirubin greenish color cuz our doctor said it’s colorless but once it differentiates in the intestine it gets the color and in urine it will be colorless

[@Ahdbfbfbeh]

How many liters of bile do we make per day or expect to drain into a tube?

[@moinn230]

Thx bro❤

[@medmindmap4931]

why does conjugated bilirubin rise in rotor's syndrome since it is a defect in OATP that take unconjugated bilirubin into the hepatocyte?

[@ThinleyMbbs]

Sir doesn’t Alp increase in hepatocellular jaundice??

[@drdurdana3668]

Why stools are dark in hemolytic anemia plz clear it reason behind it??

[@kzthluv5598]

Because of increase in the total amount of urobilinogen

[@kjasalewjathan]

Is jaundice the same as scleral icterus

[@MedicosisPerfectionalis]

Scleral icterus is a symptom of jaundice.

[@Abdullah10466]

Who is the famous Egyptian professor ?

[@fatimamaryam3168]

Hi I have a question, if due to obstruction bacterias are not able to form urobilinogen and stools are pale then how the urine colour is dark, as urobilinogen has to be converted to urobilin and excrete in urine?

[@MedicosisPerfectionalis]

The urine is dark because of conjugated bilirubin.

[@mahmoudhassan6934]

You are slightly affected by dr Nagi 1973 Chole conjugate Ca contrac And many things Watching you after him Best wishes from Egypt

[@mahmoudhassan6934]

I comment before this 11.6 Feeling proud 😊 Their is Egyptian teaches medicine concepts very well with brilliant accent even for American students.

[@abdelrahmantarek7713]

هو مصري

[@abdelrahmantarek7713]

شوف اكتر فيديو مشاهدة عنده

[@mahmoudhassan6934]

@@abdelrahmantarek7713 مصري ايوا كان بيخمي تجربته علي الفيس أنه بدأ يشرح كدا من ايام كان بيذاكر رمد في مصر وكان في ريل هنا لما كان بيتكلم عن thalathemia قال إنه مصري

[@darrenj.griffiths9507]

As always, bloody amazing 👏 (excuse the pun). Thank you!

[@mariama.sgodhelpme2264]

The Egyptian professor is he Dr Nagy Iskandar ? 😅 I think i heard him saying the same way from many years

[@MedicosisPerfectionalis]

Yes!

[@ValentinaKajcinovska]

Should urine always be yellow, mine is non colour at times. I call yellow bilirubin..

[@yanbingzhu2550]

Hi Medicosis, if the patient have hemolytic disease of RBC, doesn't their hemoglobin ends up in the urine and cause hematuria? Therefore, the urine will be red, full of hemoglobin? Why did you say the urine will be normal color?Thank you, medicosis.

[@MedicosisPerfectionalis]

There are 2 different types of hemolytic anemia (intravascular and extravascular). I was referring to extravascular hemolysis. You referred to intravascular hemolysis. Moreover, the video is concerned with the effect of bilirubin and its metabolites on the color of the urine, and not the effects of other factors.

[@yanbingzhu2550]

@@MedicosisPerfectionalis I see. Acute hemolytic transfusion reaction must belong to the intravascular hemolytic anemia. RBC got killed and bursted by IgM antibodies in the blood vessel. The spleen macrophages probably did not eat those RBCs. Is Rh incompatible hemolytic disease of new born intravascular or extravascular? Do you have a video talking about the differences between intravascular and extravascular hemolytic anemia? Thank you so much.

[@hello-un8gh]

In hemolytic jaundace shouldn't be the urobilinogen in the urine increased? Both CB and urobilinogen in the urine give coca cola like appearance?

[@عمادزيتاوي-و1ف]

Big like 🌹

[@MedicosisPerfectionalis]

Thank you!

[@drsidhant11]

could jaundice be more simplified, no! ❤

[@Dr_strange_2652]

Hey perfectionalis Please make something easier payment system like DR.Nazeeb. as we from Bangladesh can't enroll in ur courses due to lack of credit cards. You can make a deal with some Bangladeshi online payment pages who help in payment... Please medicosis, help us in this wayyy❤❤❤

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I love you

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❤❤❤

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:)

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Hi how are you love from jess x

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🎉🎉

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:)

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Just go the site and buy it from there

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In love with you ❤

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😅first

[@MedicosisPerfectionalis]

Thank you 🙏

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Are you Egyptian?😅😅😅

[@hishamabu1170]

❤❤❤❤❤