CAR T Cells: Beating Cancer with the Immune System

Doug Olson's terminal cancer was miraculously cured through genetic modification of his own immune cells. While this sounds like it's straight out of a science fiction novel, many cancer patients are currently receiving this revolutionary new cancer treatment: CAR T cell therapy. Learn about the mechanism, side effects, and the exciting future of CAR T cells in this episode of Medicurio.
Please go to my website for the video transcript, references, and extra info about the video:
• Doug Olson’s Story
• What’s the Fuss About Co-Stimulation?
• The Natural Cancer-Killing Ability of the Immune System
• New Ideas for CAR T Cells
• Hypogammaglobulinemia, CRS, and ICANS
• Thank You, Alpacas, For Your Nanobodies
Website: medicurio.ca/2023/09/04/car-t...
Timestamps
00:00 Introduction
01:30 T cell signaling mechanisms
03:32 How T cells destroy infected cells
04:46 Chimeric antigen receptor structure
07:03 CAR T cell manufacturing
07:53 Approved CAR T cell therapies and clinical trials
09:28 CAR T cell therapy side effects
10:37 The future of CAR T cell therapy
12:56 Outro

[@albrigo]

As an experienced health professional, I'm impressed to see how a graduate student explains in a simple and educational yet scientific way such difficult pharmacological concepts. I encourage you to continue like that, and I am pleased to follow your videos!

[@JAB6322]

Man its been 3 years since you uploaded this. Your presentation animation and style are simple, straight to the point and eye catching. 😍

[@SupLuiKir]

We don't necessarily need a universal CAR T cell. The process is expensive because right now it's artisanal. You need teams of qualified technicians to perform every step of the process. Once you can slot in the bag of blood received from the hospital into a machine and reliably receive the modified CAR T cells with minimal oversight, a massive portion of the costs will be eliminated. From there, the machine can simply be produced in enough quantities that the economy of scale phenomenon takes hold.

[@garygenerous8982]

So glad to see you back and what an amazing video. That was so interesting and informative. Can’t wait for more.

[@sarveshanand2008]

Wow after 3 years medicurio is active back. By the way thank you medicurio for uploading on cart cell therapy. It's really helpful

[@ChaseTrent]

Woah, I actually forgot about this channel. Super glad I got a notification!

[@MrCythos]

You're back! Excited to watch!

[@saraisantiago5154]

You're so great at explaining difficult Pharmacology concepts and medications! You should do more videos on Meds like antidepressants and anxiolytics. The videos you have though are definitely getting me through PA school. Big thank you for that!

[@mussabm2981]

Amazing channel pls don’t stop your narrative is so soo unique and grabs attention. I really watch so many medical, science-related channels but yours are currently the best i have watched. Your graphics. Your details and information are things you don’t see in other channels

[@nazgu1]

Yay, he's back!

[@ikeoluwaonasanya7105]

BMT nurse here! This was so helpful! Thank you!

[@iRemmi]

welcome back!

[@waelfadlallah8939]

You're making history right now 😅

[@harryli5979]

Brooo you are back. Love your vids. I was just watching one yesterday

[@Alex-mq8jb]

this was just great

[@livnorium4207]

The king is back 💪

[@justafellab7677]

Great to have you back

[@waelfadlallah8939]

What made you come back after all that long time 😄

[@antitorpiliko]

💯

[@Negarnorz]

this video and the information you collected are really amazing and useful. thank you for this brief explanation based on really good papers that you had chosen .

[@akk6783]

Nice graphics and clear explanations.

[@90klh]

So CAR T cells are like really trigger happy guards given a license to kill (no secondary message needed to activate)

[@amirhosseinrahbar9368]

So accurate. Thank you

[@Miruoart]

Omg welcome back!! 🎉🎉🎉

[@PedroOjeda]

My lab works on CAR NK cells. Same killing ability of T cells, no cytokine storm since NK cells do not release as many cytokines

[@benjaminoh]

So goood

[@BasicallySteve23]

Yooooooo welcome back!

[@debismita09]

Omygod thankyou soo muchh😭🖐🏻

[@markotien2203]

Woah cool!

[@dariomics8520]

Never clicked on a video so fast

[@TheUnXplainer]

Long time 😊