Michaelis-Menten Equation & Enzyme Kinetics - Biochemistry Series

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

You are so welcome! I hope you enjoy the rest of this Biochemistry Playlist!

[@franzcalipusan3367]

not only a high yield video but also an entertaining one..indeed it makes perfect sense..

[@MedicosisPerfectionalis]

Thank you!

[@waelfadlallah8939]

Great Michaelis-Menten graph explanation also a good reminder of enzymology. Good to know in the upcoming one we'll be talking about the 3 types of enzyme inhibition which also drives students nuts 😅 but of course no more, thanks to your comprehensive lectures.

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Thank you 🙏

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[@MedicosisPerfectionalis]

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[@Mr_Jester980]

Thank you. THANK YOU for posting this video in the first place. Once, I was absolutely fucking confused with the whole Michaelis-Menten Equation thingy that only a few of my peers got it. But now, after watching this video, I'm now enlightened. Thank you!

[@MedicosisPerfectionalis]

Thank you so much for watching!

[@BAShireSATAX]

Thank you so much, I have never enjoyed a learning video this much.

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[@MedicosisPerfectionalis]

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[@SE-sh4il]

ok, this is the first time I understand the equation, thank you.

[@MedicosisPerfectionalis]

Happy to help!

[@shakibaaagshjwkw]

That "why do you call it Km why not FU" cracked me up 😂😂😂😂

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Crystal clear concept thanks

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almost fall asleep after the mid term exam, but jerk up by " why it is Km constant not a fu? " hahhaha woke me up!

[@MedicosisPerfectionalis]

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I like medicosis like enzyme love thier substrates

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[@MedicosisPerfectionalis]

Indeed :)

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[@Dshinshi1]

Hey, Thank you so much for the video! I have a question about the affinity. Leninger 8th edition (page 785) says "The term (Km) used (often inappropriately) as an indicator of the affinity of an enzyme for its substrate. The actual meaning of Km depends on specific aspects of the reaction mechanism, such as the number and relative rates of the individual steps. When k2 is rate-limiting, k2 ≪ k−1, and Km reduces to k−1/k1, which is defined as the dissociation constant, Kd, of the ES complex. Where these conditions hold, Km does represent a measure of the affinity of the enzyme for its substrate in the ES complex. However, this scenario does not apply for most enzymes" As I understand it, Km represents affinity only when k2 is wery low, and Km=Kd. I just can't understand why is it so. Also, I googled it and mostly everyone says that Km is an indicator of affinity. I hope you'll have a look at this, maybe you will be able to put it in simple words, as you do. Thanks again for your amazing content!

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[@MedicosisPerfectionalis]

My pleasure!

[@nadinesalnikova1042]

So basically if there is a lot of Km meaning a lot of substrate the enzymes will have lower (less affinity) because there are too many substrates and enzymes are very specific?

[@mduduzinsibande37]

No!!! Km measures enzyme affinity for a substrate, remember Km is half Vmax. Meaning if an enzyme has high Km, it means an enzyme requires high concretration of a substrate to reach Vmax. The increase in substrate has no effect on Vmax, as the Vmax remains the same

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Please make a video on the 10 step proof for the Michaelis-Mentin Equation.

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[@nermeenahmed1708]

hi medicosis thank you so match could you please explain why km have inverse relation with affinity ?

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[@MedicosisPerfectionalis]

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[@jnx0a216]

Thank you, But i lowkey didn’t get the affinity point what does it mean?

[@foooi5suki723]

Hii thank you so much, l wanted to ask if rate of enzyme reaction is the same as rate/velocity of reaction

[@Drikkerbadevand]

ok but I don't understand why knowing the 1/2 Vmax/Km is relevant. What can you use it for?

[@garyho3981]

Got a question: I saw Kcat on my text book, what is Kcat?

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Ty

[@MedicosisPerfectionalis]

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4:29 why not _b

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[@MedicosisPerfectionalis]

Examples of what?

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[@saiteja6742]

Why do enzymes or protein get saturated? Saturation: What Does That Mean? Does that imply fatigue? Is it comparable to a man who works extremely hard all day being exhausted (saturated) and losing all energy? please shed some light on this comment

[@MedicosisPerfectionalis]

Saturation means that all the available receptors are busy, and therefore can’t bind more substrate (think of it as a call center where all the customer service representative are busy with other clients, i.e. saturated).

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[@dubscheckum8246]

Most of the time, the substrate concentration is well below Km

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[@MedicosisPerfectionalis]

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Why Km and not Fu😂😂😂😂

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* Why do you call it Km , Why not FU * LMAO , he did it on purpose

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Km why not Fu😅😅😅😅

[@MedicosisPerfectionalis]

:)

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[@MedicosisPerfectionalis]

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Stop unnecessary talk and come to the point straight

[@withmanmann]

I didn't understand Km 🥹

[@MedicosisPerfectionalis]

Please watch my biochemistry videos in order in my Biochemistry playlist!