Mixed (crossed) aldol condensation | Alpha Carbon Chemistry | Organic chemistry | Khan Academy

How to find the product of a mixed (crossed) aldol condensation. Created by Jay.
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Organic Chemistry on Khan Academy: Carbon can form covalent bonds with itself and other elements to create a mind-boggling array of structures. In organic chemistry, we will learn about the reactions chemists use to synthesize crazy carbon based structures, as well as the analytical methods to characterize them. We will also think about how those reactions are occurring on a molecular level with reaction mechanisms. Simply put, organic chemistry is like building with molecular Legos. Let's make some beautiful organic molecules!
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[@hlp4060]

You are seriously, seriously AMAZING!

[@samuelkorger3567]

Extremely helpful.

[@grettlowski]

Thank you for working it out

[@salmamohamed1186]

This is really helpful,thank you.

[@cjckw9323]

Thank you very much...

[@hanna5408]

7:20 - how do we know that cyclohexanone acts as the electrophile? The other compund has 2 partially positive carbons too, hasn’t it?

[@pewnit]

WHERE IS SAL??? jk. All of you are amazing. Thanks for another amazing lesson.

[@danielemarotta8583]

how can the OH-, a srong base, behaves as an leaving group?

[@adndscndlcnd]

I might be wrong but in acidic conditions it does act like a leaving group

[@emuwhee]

I believe it's because you add heat, which allows that to happen cause of condensation

[@ab5249]

The leaving group is H2O: After protonation oxygen acquired positive charge in molecule and served as a good leaving group

[@LiLi-zd4mi]

@Daniele_Marotta You are right but the driving force of the leaving of HO- is the great stability of the alpha-beta unsaturated systems

[@grettlowski]

This is the kind of problem ACS will throw at you

[@cwevans5873]

my dude, i thought OH- was a horrible leaving group

[@Freshyest]

He says multiple times that he's not concerned about the exact mechanisms, and is more focused on showing us the intermediates and product of each step. The video would be double the length if he made sure to mention every single technicality, including the protonation of each OH group prior to leaving.

[@thebluebeyond2329]

This is old.