Mixed (crossed) aldol condensation | Alpha Carbon Chemistry | Organic chemistry | Khan Academy

[@hlp4060]

You are seriously, seriously AMAZING!

[@samuelkorger3567]

Extremely helpful.

[@grettlowski]

Thank you for working it out

[@cjckw9323]

Thank you very much...

[@salmamohamed1186]

This is really helpful,thank you.

[@pewnit]

WHERE IS SAL??? jk. All of you are amazing. Thanks for another amazing lesson.

[@danielemarotta8583]

how can the OH-, a srong base, behaves as an leaving group?

[@adndscndlcnd]

I might be wrong but in acidic conditions it does act like a leaving group

[@emuwhee]

I believe it's because you add heat, which allows that to happen cause of condensation

[@ab5249]

The leaving group is H2O: After protonation oxygen acquired positive charge in molecule and served as a good leaving group

[@LiLi-zd4mi]

@Daniele_Marotta You are right but the driving force of the leaving of HO- is the great stability of the alpha-beta unsaturated systems

[@grettlowski]

This is the kind of problem ACS will throw at you

[@hanna5408]

7:20 - how do we know that cyclohexanone acts as the electrophile? The other compund has 2 partially positive carbons too, hasn’t it?

[@cwevans5873]

my dude, i thought OH- was a horrible leaving group

[@Freshyest]

He says multiple times that he's not concerned about the exact mechanisms, and is more focused on showing us the intermediates and product of each step. The video would be double the length if he made sure to mention every single technicality, including the protonation of each OH group prior to leaving.

[@thebluebeyond2329]

This is old.