A Mitochondrial Cocktail to Restore Your Cellular Health | Dr Mark Tarnopolsky Interview

[@ModernHealthspan]

BiOptimizers Magnesium Breakthrough 10% with code Modern10 bioptimizers.com/modern. This video brought to you by BiOptimizers. If you would like to support our channel please consider joining our patreon patreon.com/ModernHealthspan Stemregen 15% discount Code MODERN tinyurl.com/45z968yr (Only available in the US) DoNotAge 10% discount code MHS Creatine tinyurl.com/m6jc9auf CoQ10 tinyurl.com/4tpjxw7r Renue By Science 10% discount code MHS: tinyurl.com/37ahmr7d Wellness Extract 10% discount Code MODERNWE Geranylgeraniol Essential wellnessextract.com/RICHARDWE Delta Gold Vit E Pure Clean Performance 15% code MODERNHEALTH15 Pyre Clean Beets tinyurl.com/bdfhfanw NOVOS Core $5 discount CODE 5OFFMHS24 novos.sjv.io/daqJ0Q n1o1 Nitric Oxide 10% discount with code Modern tinyurl.com/3esakm4s n1o1 Nitric Oxide Lozenges tinyurl.com/yh4rrtht OmegaQuant 5% discount Code MODERN omegaquant.com/shop/ Bulletproof 15% off code: HEALTHSPAN15: tinyurl.com/4npjk5vp Omega-3 Krill Oil bulletproof.fdf2.net/xkdxmy Pendulum Akkermansia pendulumtherapeutics.sjv.io/baoQVg Metabolic Daily pendulumtherapeutics.sjv.io/NkqE0q Nuchido Time+ 20% discount of first purchase with code MODERN20 nuchido.com/MODERN OneSkin 15% Discount: Code MODERN tinyurl.com/3t6tevj8 OS-01 Face Topical Supplement tinyurl.com/29c8wrr2 ☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan

[@KenOtwell]

Would it be possible to get a list of the nutraceuticals discussed and suggested dosage?

[@ModernHealthspan]

Hi Ken, thanks for the question. I think that simplest way is to use the dosing from Dr Tarnopolsky's website. The Trim 7 and Muscle 5 supplements contain all of the nutraceuticals that he talked about and you can see the dosages. His site does not have a product with just the four that he used for mitochondria but these are CoQ10, Creatine, Alpha lipoic acid and Vit E (as alpha tocopherol)

[@higherresolution4490]

At approximately Minute 30:00, the professor talks about redox coupling, which is to say, a combination of two or more antioxidants, that after doing their job and becoming pro-oxidants, can regenerate each other. The matrix (inside the inner membrane) of the mitochondria is where all the activity is taking place, including the Krebs Cycle. The primary 5 antioxidants found in the matrix are glutathione, CoQ10, alpha lipoic acid, vitamin C, and vitamin E with all 4 tocopherols and the 4 tocotrienols. Glutathione is by far the most important antioxidant of them all. Not only can it regenerate itself, but can regenerate the other antioxidants. Most importantly, it is endogenous. Just eat enough sulfur containing vegetables like cruciferous vegetables, onions, and garlic. By the way, melatonin is the most potent of all antioxidants, and it is also endogenous. It's interesting to note that the body's cells can live longer without oxygen than they can without glutathione due to its powerful reduction properties.

[@smileman9174]

I watch and have listened to thousands of KZbin health videos over the last 3 years. I stumbled on this channel. This was an outstanding interview filled with great information and knowledge from a doctor who's not trying to sell anything! Very hard to find such interviews. I thank both of you very much and I'm going to search for more videos from both of you and subscribe.

[@ModernHealthspan]

Hi thank you! It is so encouraging to get comments like this!

[@betzib8021]

So true...EVERYBODY is trying to sell something but this guy just seems to want to share info.

[@oldflute]

At 38:00, you mention alpha lipoic acid. I am retired now in my 80s, but I taught and practiced Endocrinology 40 years. During the last 12 years I was in private practice, I had all my diabetic patients on daily oral alpha-lipoic acid (only 50-200 mg), CoQ10 if on a statin, and a mix of alpha and gamma tocopherol (vitamins E). NONE showed any new development of or progression of neuropathy or retinopathy, and one patient over a period of 6 years regained touch and vibration sensation in her feet, which had developed the Charcot deformity from previously dense neuropathy. Two conclusions: 1. The official ADA guidelines say ALA "may be helpful" in neuropathy. I say it is an essential nutrient for every patient with diabetes. 2. Even severe diabetic peripheral neuropathy is potentially reversible.

[@ModernHealthspan]

Hi, thank you for sharing your experience. Super interesting to know about the effectiveness of ALA.

[@binathere2574]

What about Thiamine? Thiamine successfully addresses peripheral neuropathy.

[@keithmarshalldds511]

Thank you for sharing this. I will look further into this.

[@natalie8518]

​@@binathere2574I l9ve thiamine for everything....have you read derek lonsdale book re dysautonomia etc? Brilliant

[@Freckles303]

Some say that the R-form of alpha-lipoic acid is the best form to take because the body uses it best. R-lipoic acid is also said to be better absorbed and more stable in the plasma than the solid form. Some studies suggest that S-lipoic acid may not be effective and may interfere with R-lipoic acid function. Don’t bother with the S form, which is what most supplements offer. Find the R form!

[@oreoandoz7723]

Excellent, as always. Truly what KZbin SHOULD be - education on issues that matter. Thank you!

[@ModernHealthspan]

Hi thank you!

[@Schu2505]

I love Life Extension's Mitochondrial Energy Optimizer with PQQ. I just take one (4 is a serving) to get through the last hour of my shift and arrive home ready to go.

[@ModernHealthspan]

Hi thanks for sharing!

[@USAtoElsewhere]

No wonder! Life Extension is owned by a very smart and motivated immortalist, Bill Faloon. I'd rather buy from an immortalist than someone who believes our death from aging is inevitable, everything else being equal.

[@Freckles303]

Life Extension sells the R-form of Alpha-lipoic-acid, which is the only form that works. Seems like a very good company just based on that!

[@oldflute]

Sun exposure is a two way street. The UV portion of the solar spectrum damages DNA and mitochondria in the skin. The near infrared portion of the solar spectrum is beneficial to mitochondria, both in the skin and the tissues below, because the longer wavelength infrared light (not visible) penetrates a few inches. Infrared exposure is known to increase free radical scavengers in mitochondria: cytochrome C oxidase, glutathione, and melatonin (a more recent discovery). You can increase the ratio of infrared to UV that reaches the skin in two ways: 1. Wear light clothing that will block UV but not infrared, or 2. Get the exposure near dawn or sunset when the atmosphere filters out much of the UV, but little infrared. You can also get lamps that generate red and infrared, but no UV.

[@ModernHealthspan]

Hi thanks for the detailed explanation. This does make sense but I assume that blocking the UV will mean that limited Vit D is created. I am always conflicted on whether enough sun to make sufficient Vit D is good or not!

[@keithmarshalldds511]

This strategy will also increase the collagen in the skin and give further protection from mid day summer sun. Other seasons at higher latitudes won’t be giving any appreciable amounts to do any harm even mid-day.

[@higherresolution4490]

Dr Mark Tornopolsky explains his scientific focus on mitochondria very clearly. He has an unusual ability to make a complex subject understandable. In this respect, he's a lot like Professor Douglas Wallace of mitochondrial fame, with whom I had the opportunity to spend much time in his UCI lab. By the way, apoptosis is a Greek word, hence the second "p" is silent.

[@ModernHealthspan]

Hi thanks. I did not the second p was silent.

[@ScottChristensenabc]

Excellent interview…both interviewee and interviewer! Thanks, Richard

[@ModernHealthspan]

Hi Scott, thanks!

[@markusantonious8192]

A shout out here to Prof. Emeritus C. D. Rollo, also of McMaster U.....whose work antedates the good Prof here by two decades or so, and whose work on multiple nutritional supplement stacks demonstrated dramatic amelioration of aging in animal studies....including total *abolishment* of cognitive decline, resistance to radiation, extension of maximal lifespan, very significant lowering of mitochondrial oxidative stress etc.

[@ModernHealthspan]

Hi Mark, thanks for sharing.

[@ccamire]

Richard, always good and professional content

[@ModernHealthspan]

Thanks!

[@KathyPianoHarp]

Brilliant discussion! So many keys to optimal aging. Thank you. I shall listen to this a second time & take notes of all the practical things I can do to affect my life trajectory.

[@ModernHealthspan]

Hi Kathy, thanks for your kind words.

[@peterz53]

Excellent episode. Appreciate guests who actually do and study the science they talk about. Being a 70 yo old male, moderate daily exercise for over 10 years, I would like to know if there might be an optimum time to take some of these supplements with respect to time of most vigorous exercise. Would waiting an hour or so after to let the signaling effect of the exercise induced ROS burst clear be better than taking supplement just before or just after enhance the effects? Will be checking out details in his papers.

[@ModernHealthspan]

Hi Peter, thanks. That is an excellent question, I have explored the importance of protein intake before but not other supplements particularly related to mitochondria. I will also have a look in the papers and when they used it there.

[@Daissweetest]

B1 deficiency is a big one, I have more energy with b1 hcl.

[@ModernHealthspan]

Hi thanks for sharing!

[@higherresolution4490]

If vitamin B1 seems to be deficient, then it's best to supplement with both the methylated coenzyme form of B1 and Benfotiamine. The result is quite noticeable if you do strenuous exercise.

[@binathere2574]

​@@higherresolution4490HCL works for me

[@billtrudell1636]

Now i take alpha-lipoic acid and coenzyme q10 and acetyl-l-carnitine. I also do keto but these have helped get rid of many nerve issues my feet have full feeling returned and my brain fog is gone. Plus many other improvements in skin and with keto blood sugar completely under control and lost 70lbs and off my blood pressure,medicine. But those 3 supplements made a huge difference and the acetyl-l-carnitine helps with energy and passes through blood brain barrier.

[@ModernHealthspan]

Hi Bill, thanks for sharing your experience. It is great to hear protocols that work! Sounds great. I should give acetyl-l-carnitine a try.

[@reggie5]

​@@ModernHealthspan yes. when I tried Bryan Johnson's suite, it wasn't until I reintroduced Alpha lipoic acid and acetyl l carnitine back alongside it (they were missing from his concoctions) that I started feeling well again. they seem to go well together. I have a local manufacturer in Germany that sell them both in one supplement, referencing Bruce Ames in their product development

[@Elizabeth-l6n]

@@ModernHealthspan

[@redlightglassesonthischannel]

amazing chat, thank you, both. Got 2/3 way through, will come back to finish. 👍👍

[@ModernHealthspan]

Thanks! I hope that you enjoy the rest of the interview!

[@redlightglassesonthischannel]

@@ModernHealthspan thanks Richard, get a pair of these glasses, will slow the ageing of your eyes and can improve color vision

[@redlightglassesonthischannel]

@@ModernHealthspan hi, yes, went back to finish, awesome chat, like Prof Tarnopolsky, he seems right on the case, had a look at his website, good products, unfortunately as yet they do not ship to the UK, will try and keep up with them to see when they will, thanks Richard

[@volkstouareg5620]

Great interview!

[@ModernHealthspan]

Thanks!

[@higherresolution4490]

The subject of CoQ10 is quite interesting. If you use it to help re-establish the efficacy of the electron transport chain, that is to say, electron transport from complex 1 and Complex 2 to Complex 3, use the oxidized form called ubiquinone. If you're using CoQ10 as an antioxidant, particularly for the matrix of the mitochondria, use ubiquinol, the reduced form. Ubiquinone is much cheaper. So, if you're using it for enhanced energy production, don't waste your money on ubiquinol. To be used for this purpose, it will have to be oxidized from the expensive reduced form.

[@griffinharvey3910]

FWIW - FTI - Just today I had an ND tell me about ubiquinone & ubiquinol. He said just the opposite; that ubiquinol is the one to take. While he doesn't typically suggest some retailers over others, he said in this case that the price at Costco is about 1/2 what you'll find in health food shops.

[@ModernHealthspan]

Hi thanks for the explanation. I admit I don't fully understand this. In the ETC CoQ10 is constantly converted from oxidised to reduced form. It just seems strange that the original form that it is taken in should matter that much.

[@higherresolution4490]

For young people, taking ubiquinone is perfect for use as both an antioxidant and tuning agent for the electron transport chain. When we are young, the body has no problem taking the oxidized form and reducing it so that it becomes a powerful antioxidant. However, the conversion rate decreases over time, especially significant for those over 50. Therefore, paying more money and using ubiquinol makes sense. But if you're using CoQ10 to tune up the electron transport chain, then it would be better to use ubiquinone, regardless of age. No conversion is necessary. Whether you supplement with one or the other depends upon what you're using it for.

[@higherresolution4490]

Just as a note, CoQ10 is a fat-soluble nutraceutical. Never buy it in dry form. So when you purchase CoQ10 in a gel caplet, be sure to test the Integrity of the carrier oil when you first open the bottle, and from time to time thereafter. You do this by biting open the gel caplet onto your tongue. If it is rancid, it will sting, and tastes horrible. The rancidity of the carrier oil is very common. Beware of this. I worked in nutraceutical manufacturing and formulation for 10 years. Costco is the worst example of cheap production. I'd never buy a vitamin from costco.

[@higherresolution4490]

​@griffinharvey3910 I think you misread what I said. There are 2 distinct uses for supplementation with CoQ10. If you're using CoQ10 for tuning up the electron transport chain, then you waste money buying ubiquinol. The ETC uses ubiqinone for reduction in complex III. You can use ubiquinol, but it's quite an expensive way to get the proper form of CoQ10 for that purpose.

[@chrisf6421]

So..the mitochondria cocktail is simply creatine, Vitamin E, ALA, COQ10?

[@ModernHealthspan]

Hi Chris, thanks. Yes. Which to me is good news. It is a simple set of OTC supplements and Dr Tarnopolsky has shown their effectiveness in an RTC. Would you prefer something more complicated?

[@chrisf6421]

@@ModernHealthspanno! It’s a great combo I will try. Just wanted to make sure I wasn’t missing something!

[@GodfreyMann]

Richard, you’re a busy bi - you kip miting so many interesting scientists who highlight the nids for educating us on meetochondria…kip up the great work!

[@ModernHealthspan]

Hi Godfrey, thanks! Sorry for my pronunciation!

[@ifeelfine72]

Super interesting conversation! Hopefully you will continue to have him back on. Towards the end of the conversation, he talked about a specific product which contained both whey and casein. I missed what that was.

[@jaym9846]

Muscle 5.

[@ModernHealthspan]

Hi thanks! Yes, that was one of his products. Muscle 5 as Jay mentioned. I looked for other protein supplements which contain both whey and casein in the right ratio but could not find any. So I guess I will have to make my own!

[@barbaralopez265]

Thamk you for sharing this wealth of information I wixh we had this caliber of doctor in the US. Wow I really appreciate this interview

[@ModernHealthspan]

Hi Barbara, thanks! I am glad you liked the interview.

[@theancientsancients1769]

Nice video , create a shorter version please with a summary and what to take at what dosages

[@bonnieschmidt5882]

Maybe just listen to it while doing something else and just listen for the “big ideas”? I, myself, prefer the details.

[@ModernHealthspan]

Thanks for the suggestion. A couple of thoughts on this. Having summaries for the right kind of interviews is a good idea. Hopefully I can find an AI system to do much of the work for me. I do also post clips from the interviews in which I aim to include some of the key messages. In general biology is complex and I think that the background is important.

[@theancientsancients1769]

@@bonnieschmidt5882 I love to listen to everything on many important subjects, unfortunately people are exposed to so many health videos daily by different people so longer videos make it a bit of a challenge which is why many big channels like Dr Beth have switched to shorter videos. I was a subscriber to this channel since it started and love it .

[@lucybecker8]

For those of us with adhd this would make it much easier. No way can most adhd ers focus that long, unless the topic is a personal passion, which can get the dopamine going. In the meantime we have to pass, or, hope there is someone who makes a summary in the comments.

[@chrispompano]

What you say? That's my ADHD talking to your ADHD!🤔

[@shiftyparadigm7049]

I would prefer to measure lactate in the interstitial fluid than the blood. Haem iron 2+ (useful) is more important the ferritin 3+ (storage). No discussion of warburg metabolism, however, lactate was mentioned. No discussion of deuterium. No discussion of emfs. Small mention of pH but redox not discussed. No discussion of glutamine fermentation. I thought aerobic glycolysis uses oxygen through nad without oxidative phosphorylation, therefore, not all oxygen consumption is at the electron transport chain. Even if all these issues are irrelevant i would like to hear the rebuttals.

[@rejeanorscott1555]

I listened to the interview twice and read both the transcript and the info in your first pinned comments. I can not decipher which of the supplements were mentioned by Dr. Tarnopolosky. Can you identify them for your listeners? Also do you have links to the research?

[@marinevetalexander]

I'm waiting for the reply too.

[@kare5252]

Isn’t it the one pinned above 👆

[@shiftyparadigm7049]

Alpha Lipoic acid, co q 10, vitamins e, creatine. I question this advice, but have no evidence. Personally I like the low deuterium high fat carnivore diet with only low amounts of endurance exercise and increased resistance exercise. So weight training and walking without the jogging. Perhaps a little medium intensity exercise for a warm up.

[@tabularasa3269]

​@shiftyparadigm7049 I question it also. I like crisps and donuts and to walk slowly and eat high quantities of salt.

[@shiftyparadigm7049]

@@tabularasa3269 check out dr Sean o'mara and his work on visceral fat and bone marrow. Seems pretty conclusive about high intensity exercise to me. Crisps have carbohydrates and unless you make your own in tallow they also have seed oils, both of these will increase your deuterium levels. As for salt this can be dangerous if you have high insulin levels, but if you are carnivore, your insulin will not be high and sodium retention will not be an issue. Some salt has added aluminium (anticaking agent 554) which I would avoid. Carnivores can salt to taste, but many find they prefer the flavour without the salt.

[@Daissweetest]

I thought calcium was not good to supplement without k2?

[@ModernHealthspan]

Hi thanks that is a good point and I should have asked about that. It is also required for proper operation of of Vit D. So if you are building your own version it would do no harm to add K2.

[@binathere2574]

​@@ModernHealthspancoq10 will do the same as VitK.

[@MixtrisUFOimages]

great interview, learned a few valuable things. Richard if you can ask Professor Mark Tarnopolsky what's his view on nicotinamide and its supposed effects inhibiting sirtuins. ubiquinone is cheap but i find better effects with the more expensive ubiquinol, so dont know what to make of that

[@DavidBreneisen]

On the exercise benefit blunting effects of antioxidants, my guess is that the antioxidant groups could make up for it by simply being able to handle more exercise and having a more active lifestyle, but because the studies control for exercise volume that isn't taken into account. But this is also why I take antioxidants before bed so they can help improve recovery without blunting the hormetic stress during the day.

[@ModernHealthspan]

Hi David, thanks for sharing. That makes sense to me.

[@jaym9846]

Does Cytochrome-C oxidize cardiolipins in the mito membrane?

[@John-kd1bf]

It feels like if you were to interview 100 health researchers, 50 would say Urolithin A was not beneficial and 50 would say it’s the eighth wonder of the world.

[@ModernHealthspan]

Hi John, thanks. I find this is true about many things in health. Fats and carbs, NAD precursors, antioxidants, rapamycin......

[@thomaswipf7986]

Novos has 8-10 ingredients. I don't know about taking vitamin e outside food(almonds)

[@ModernHealthspan]

Hi Thomas, thanks. Yes, NOVOS has 12 ingredients. I see it as a less focused supplement cocktail, as it is aiming for multiple hallmarks of aging, while Dr Tarnopolsky is targeting only mitochondria.

[@jontpt]

Nice interview, but the supplements are super expensive and seem to contain just bog-standard ingredients which can be purchased much cheaper elsewhere. Also, there seems to be a complete lack of clinical evidence on the website, so just more blah, blah, blah, claim, claim, claim...

[@ModernHealthspan]

Hi Jon, thanks for the comment. As Dr Tarnopolsky said, you can indeed get them separately if you want. I have not looked at his website in detail, but he has completed and published multiple clinical trials. I have linked to some of them in the description. But in any case, the video was not about selling his supplements.

[@leadfoot8045]

Silly , Embarrassing , Childish Comments “jontpt” !!

[@billbbobby2889]

​@leadfoot8045 Ya, that dude is most likely a 100 lbs. overweight karen couch potato. Complain, complain, complain.

[@expotube1]

Thanks for review! You saved me an hour of time

[@matsinilsson9578]

If you pay attention to your health and performance, you should pay attention to dosing and labeling, such as NPN number and reliable third party certification (especially if you are an athlete). This is a quality guarantee and means improved safety, purity and obviously also benefits. The alternative is that you can (maybe) buy cheaper, risk your well being and getting caught in a drug test, and support the Chinese supplement market? Furthermore, multi-ingredient supplements are also convenient and you don’t have to buy them separately. Quality, purity and convenience all matter and this is why StayAbove Nutrition is still on the market. Beyond that, I would checking the pricing again and compare by gram of protein, for example.

[@betzib8021]

Thank you for this informative video. However...activating mtor w casein would also activate cancers. Casein is carcinogenic in adulthood. So is muscle growth worth that? At least this is stated by t colin campbell in " the china study". So im confused about what really benefits longevity. Could you interview t colin campbell too?

[@ModernHealthspan]

Hi thanks for the comment. Re: cancer. Interesting, I see papers which say that casein does cause proliferation of prostate cancer, but also that it is protective against cancer (specifically I saw breast cancer.). Thanks for the suggestion of Dr Campbell, I will look at that.

[@AdAstra870]

Interesting that NMN in the study didn't show much help with aging in general. I take it with caffeine to simultaneously boost NADH and have found it to be a game changer for me. Much better than any other supplements such as ALA I've tried for my neuropathy. I have CMT type 2 though, so the benefit might be related to my specific gene mutation.

[@ModernHealthspan]

Hi thanks. It is always interesting to hear positive anecdotal results from NMN when the trials seem less clear cut.

[@reggie5]

very interesting. as a long COVID sufferer of 2.5 years, I have also found alpha lipoic acid one of the goto products I return to. also, recently I used Dr Childs fat loss product which also contains forskolin and, by accodent, I also found I had an energy boost during that period. maybe there's a connection, as suggested. (I also had noticeable boosts with creatine, clean whey protein powders helped, and have justed started trying Urolithin A in the last 2 weeks). however, exercise can still be problematic, and people have reported having bad set backs being put through VO2 max testing during rehab processes in terms of testing mitochondrial health.

[@ModernHealthspan]

Hi Reggie, thanks for sharing.

[@chrisunherded2374]

If you're dealing with cancer, will thiis help or hinder?

[@shiftyparadigm7049]

I would check out profs thomas Seyfried, Laszlo boros and gabor somlyai. Their research focuses on mitochondria and cancer directly. Focus on deuterium depletion and consider glutamine fermentation inhibitors as well.

[@chrisunherded2374]

@shiftyparadigm7049 Thank-you for taking the time to answer. I will check all that out.

[@shiftyparadigm7049]

@@chrisunherded2374 Seyfried has research on 6-diazo-5-oxo-L-norleucine (DON). Somlyai works with deuterium depleted water. Boros works with somlyai but also discusses metabolic water that is created in the mitochondria through respiration. I hope that is a good launching off platform, afaik they all work with oncologists and use their concepts as adjuncts to improve outcomes.

[@ModernHealthspan]

Hi Chris, thanks for the question but I don't know the answer. I hope that @shiftyparadigm7049 s answer is helpful!

[@lucybecker8]

Also, highly recommend looking at How To Starve Cancer and Kill It With Ferroptosis by Jane McLelland. Dr. Seyfried wrote an endorsement for the book. Also, if you are near a Chinatown with experienced TCM doctors working out of the back room you could go-getter an assessment do end boilup the herbs they give you. Traditional Chines Medicine has herbs that shrink tumors and strengthen your immune system and chi.

[@tim1878]

i have chronic kidney disease and creatine is not on the menu. Is there a way around this?

[@ModernHealthspan]

Hi Tim, thanks for your question. I cannot comment directly but I do not see much data showing that creatine hurts kidneys.

[@tim1878]

@@ModernHealthspan Thanks for responding. I think the problem is that creatine increases the level of creatinine, which throws off the blood test. I'll see if I can get a different test.

[@John-kd1bf]

This video confuses me. I went to the presenter’s web site to look for a mitochondria booster, but only found weight loss & protein. What product does this speaker offer for boosting mitochondria without the weight loss?

[@ModernHealthspan]

Hi John, thanks for the comment. I did not look at the web site before talking to Dr Tarnopolsky so was also surprised to see that he does not have a specific product with only the mitochondria components. He did however mention the ones that he used, CoQ10, creatine, Vit E and ALA. You can find each of these in the other products (Trim 7 has CoQ10, Vit E and ALA, Muscle 5 has creatine) so you could get them from other sources and use the doses from his supplements.

[@slowmopoke]

Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults

[@ChrisGroggyCreaser]

Hopefully I'll have time to watch this video- in the future!!... :)

[@ModernHealthspan]

Hi Chris, thanks. Hm, we used to release interviews in chunks but also got requests for the whole video. We now release the complete interview and select clips.

[@dianetonacia2122]

Excellent

[@ModernHealthspan]

Hi Diane, thanks!

[@tomprovan50]

hi just some thoughts. You need leucine to trigger mtor for muscle growth and this would one would think tend to be better than whey. Then use BCAA for muscle growth and glutimine for recovery? Along with weight training. And yes creatine calcium for contraction omega 3 for cell lipid bi-layer and vit. D

[@ModernHealthspan]

Hi Tom, thanks for your thoughts. My understanding is that, although it is leucine which turns on mTor, we would want all the amino acids to be able to build the muscle, certainly all the essential amino acids. And whey gives them in roughly the correct ratio (though I am planning to add casein in now per Dr Tarnopolsky's suggestion).

[@tomprovan50]

@@ModernHealthspan I use leucine /creatine prelockout. BCAA during or after, larger amino acids profile. Whey 2 hrs after that its cheap gives you protein not as specific but allows for the necessary amount of protein for muscle growth. Glutamine for recovery, 30 minutes or sooner before supper. Lucien with super. Glutamine before bed. Just some thoughts.

[@Earwaxfire909]

Really great interview! Would like to know more about this approach! And - Did you accidentally misspell his name in the title? Tarnopolsky

[@ModernHealthspan]

Hi thanks! Yes I did. Thanks for pointing that out. Fixed!

[@tammiecheramie837]

What is your or his take on raw cows milk??

[@richardprice9730]

Its not meti condrial its mito after mitosis, crazy good to listen to an expert

[@ModernHealthspan]

Hi Richard, thanks. I hope you enjoyed the interview. Did I say "meti condrial"!?

[@richardprice9730]

@@ModernHealthspan yep the Biochemistry of electron transfer and Mitochondria is very complex in fact, IT is an important factor we have general ageing , metabolic waste , RNS -DNA mapping dysregulation as per D Sinclair and probably a whole host oof other factors influencing Mitochondrial function , why I think PEMF , RED Light and other similar protocols are worth considering , it may be over the last few millennia we have evolved slowly to age at a particular rate ie telomere length etc may have lots of reasons psycho social even spiritual Ageing may be built in now whether we can unravel why this is or modify enough factors the yaminka exp seems to suggest it is possible to turn back cells too stem cell stage, but even this may not be enough , perhaps slowing it down considerably is achievable while we alos upregulate heaaling mech to deal with diseases opr injuries or other problems FUNCTIONALITY remains key in my opinion live healthy and be very functional to an advanced age , all this idea of escape velocity is utter nonsense . we are pprobably another 50-100 years away from any treatment protocol that can actually reverse age predictably without side effcets ie cancer BUT its worthe trying multiple approaches simultaneously to see what happens biologically ageing clocks in o9ne part of the body will pull other parts along with them, so far we haven't even figured this syncronistic event out .Quality of Life IS everything and being able to help others

[@keithmarshalldds511]

Near the end egg white protein was touted as a top one or two on the list of quality food. Is he suggesting leaving out the yolk? I hope not.

[@ModernHealthspan]

Hi Keith, thanks for the question. I don't think so. We were specifically discussing protein rather than diets in general. He was saying that the protein in egg white is the optimal for growth as it is what nature has developed as the best for the chick.

[@grasucat1720]

"long term endurance exercise" "30 minutes 3 times a week" - that sounds like "regular" exercise

[@ModernHealthspan]

Hi thanks for the comment. I think that Dr Tarnopolsky meant "long term" as in continued over many years.

[@slowmopoke]

Mitochondrial DNA shifting in older adults following resistance exercise training

[@healtheverymoment]

How about Spirolina?

[@ModernHealthspan]

Hi Daisy, thanks for the question. Dr Tarnopolsky would need to answer his thoughts on spirulina but having a quick look it seems to have many ingredients and so would be harder to know exactly what dose of each part the person was getting.

[@ijohnny.]

Too long didn't watch. After all the the song&dance, what is the "cocktail"? Thanks.

[@peacekeepermoe]

Creatine Monohydrate Vitamin E Alpha Lipoic Acid Coenzyme Q10 (Ubiquinone)

[@ModernHealthspan]

Hi Johnny, thanks for the question. I think it is always better to understand the background. But the ingredients specific to mitochondria were creatine, CoQ10, Alpha lipoic acid and Vit E. To find the doses, you can go to Dr Tarnopolsky's website Stay Above Nutrition. He has specific products but the ingredients are all listed and available elsewhere.

[@Paul-dorsetuk]

Interesting body chemistry. However regarding supplements I'd far rather be eating the right food and doing enjoyable exercise in the outdoors than taking tablets.

[@ModernHealthspan]

Hi thanks. I am with you in principal. But I have a couple of thoughts on this. Our food, even organic, is not the same as it was and vital nutrients could be missing, getting enough protein can be a challenge and humans were 'designed' to live to 40 so it is not clear that in our 60's and later even the right food can provide all the ingredients we need.

[@Paul-dorsetuk]

@@ModernHealthspan yup good point hadn't thought of that. I suppose a whole battery of tests would be needed..

[@slowmopoke]

A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly

[@ModernHealthspan]

Hi thanks. The paper is linked to in the description as well.

[@John-kd1bf]

2000 units a day of vitamin D seems super low. Anyone else agree?

[@ModernHealthspan]

Hi John, thanks for the question. Hopefully other people will jump in, but my thought is that it does appear to be in the middle of the range. According to the mainstream sites (in this case Healthline) required is about 600IU, upper limit is 4,000 IU.

[@binathere2574]

​@@ModernHealthspanthere recent studies saying taking high does of VitD may cause heart palpitations.

[@peace-c2r]

That's a most egregious shocker that Ozemprick's drug causes as much or more muscle & bone loss as fat loss? If true, that should put it to a quick end!

[@ModernHealthspan]

Hi thanks for the comment. My (limited) understanding of how Ozempic works is that it is an appetite suppressant. Which means that you will just eat less. That is a great way to loose weight but unless it is combined with exercise and sufficient protein it makes sense that it would mean loss of lean tissue as well as fat.

[@peace-c2r]

@@ModernHealthspan Oh, okay, so it's not that they put something in it to cause muscle & bone loss -- that is just the effect of an appetite suppressant? How then would bone loss, or muscle loss be a result of a mere appetite suppressant? Unless eating less we're assuming doing less and less weight bearing?

[@binathere2574]

​@@peace-c2reating less, no desire to eat. So snacking is probably what people are doing, not nourishing themselves.

[@franzberger8420]

BUT GLYCINE TOO IT HELPS TO SLEEP BETTER ..

[@ModernHealthspan]

Hi Franz, thanks for sharing.

[@martinworkens6130]

Cancer is mitochondrial dysfunction .

[@ModernHealthspan]

Hi Martin, thanks for sharing.

[@PFCNordic1]

Yes, most likely because the cell(S) are forced into an anaerobic metabolism whic is 36x less effecive than «the normal» aerobic/oxygene cell metabolism. Most frequent reason sees to be to much sigar/ high residualninsuline.

[@charlesfuchs]

Beetroot has tons of OXALATES!

[@marynamarousa9729]

eat carnivore diet, will be grate without any supplements

[@cocoweepah]

What is “Cellular HEATH” ? Proof ! … of no Proof Reading on the title page. 😂

[@ModernHealthspan]

Hi thanks for you comment. It is a title. If you find the information in the video helpful then that is good.

[@f-authority6926]

An infomercial masquerading as an interview.

[@ModernHealthspan]

Sorry that you think that. The supplements that he talks about (and others that I link to) are common OTC supplements. You can get them from other sources if you want. Whether you think the information about mitochondria is helpful is up to you.

[@aluckyman]

I found it incredibly annoying that while talking to an expert about mitochondrial health you kept pronouncing the word "Meet O Chondria' rather than 'Mighto Chondria" as almost everyone in the world does. This conflicting use of the word maybe 100 times during the podcast was incredibly annoying. It seemed to me that you were pushing your guest time and time again to your 'version' of the word. I found it so distracting that I may have missed some of the important information contained within.

[@ModernHealthspan]

Hi thanks for the feedback. Apologies, I never noticed that I pronounced mitochondria that way. Certainly not trying to change Dr Tarnopolsky's pronunciation! I will fix it in future.

[@aluckyman]

Sorry it just stuck out like (as we say in australia) dog’s balls ;)

[@aluckyman]

Appreciate your content and the hard work getting the information out there.

[@higherresolution4490]

From my experience, the Brits pronounce "mitochondria" the same way that the interviewer does. I'm surprised that other commonwealth countries like Australia don't have the same pronunciation.

[@leadfoot8045]

Stupid and childlike comments . Go get your psych meds changed !

[@vincentfoster6811]

He needs to get some muscle on him.

[@ModernHealthspan]

Hi Vincent, thanks. He does talk about that and how he has taken up resistance training.

[@vincentfoster6811]

Why do you, the interviewer, pronounce things differently that the expert you are talking to? It sounds ridiculous.

[@ModernHealthspan]

Hi Vincent, thanks for the feedback. What did I pronounce incorrectly?

[@_FMK]

​​@@ModernHealthspan The word Mitochondria .. You repeatedly mispronounced it "meatochondria". Many viewers found the mispronounciation annoying to listen to, myself included 😅 You still have an interesting channel though! Thanks for bringing interesting guests

[@shellyaus]

you lost me at taking vit D instead of sunshine

[@ModernHealthspan]

Hi Michelle, thanks for your comment. I always prefer natural ways to get sufficient nutrients but Vit D can be difficult. I don't think that either way is right or wrong. Sunshine is damaging to the skin and in the northern countries (like Canada) it must be difficult to get sufficient sunlight especially in winter.

[@shellyaus]

@@ModernHealthspan Sunshine is not damaging, it is essential especially to the mitochondria, it helps prevent cancer, people with cancer have a Vit D deficiency, even a UK dermatologist says so, artificial light is damaging, we were designed or evolved to be outside naked.

[@roblovegreen]

@@shellyausI don’t go outside in the sun naked ever. Do you? I do try to get sunlight daily but sometimes it’s harder especially in the winter. That’s when I usually start taking vitamin D 3 just to keep my levels up. Are you against taking vitamin D as a supplement and if so why?

​@@roblovegreen Producing vitamin D is an 8 step process with the sun and cholesterol (It lowers cholesterol) whereas taking it orally bypasses that process and it can disrupt the natural cycle. It is quantized meaning your body has to acclimate to UV radiation before producing it locally in your tissue. I don't think taking it orally distributes it to your tissue anywhere close to the same ability producing it does. I haven't tested for this yet, take this with a grain of salt, but that's the way I see it.

@@ModernHealthspan Infrared light from the morning sun produces enough energy for your mitochondria to absorp the uv in the afternoon. I would recommend that first and for someone that doesn't have the skin for strong UV exposure only 10-30 minutes in the afternoon is enough to start with and they can increase once they have been through a few cycles.