Monoclonal Gammopathy of Undetermined Significance (MGUS) [Hot Topic]

Monoclonal gammopathy of undetermined significance (MGUS) is laboratory finding. This diagnosis is very common in older patients, but can cause significant concern about which patients require close monitoring and which do not. In this presentation, Dr. Willrich provides an overview of the testing involved in both the diagnosis and monitoring of patients with MGUS.
A presentation by Maria Willrich, PhD.

[@younessbagachoul5896]

This video really helped me understand the difference between MGUS and other monoclonal gammopathies. Thanks!

[@notredox2]

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[@patriziavalenti8124]

I'm just hoping for the best

[@leelabrock4266]

god bless you all!

[@susanyoung8104]

Thank you. Excellent slides. Questions: how many of these patients had MOTHERS who were Rh negative? How many of these patients (if any) are Rh negative themselves? How many have (probably undiagnosed) a red blood cell parasite , such as Babesia? Babesiosis is similar to Malaria. causes macrocytic anemia, and at “chronic” levels is VERY hard for lab tests to find. How many patients have (again, undiagnosed, but very destructive over time) helminth infections? (Fish tapeworms, pork tapeworms.) And eosinophilia doesn’t occur! -Or hookworms? They can take a liter of blood daily from a human. Possible co-morbid factors worth further investigation.

[@MariaReyes-jp4lb]

My mother had MGUS unspecified, Rh-, she got very sick the last 3 years of her life and passed at the age of 62😢, I am 52, RH-, lots of bone issues, surgeries, and lots of joint pain and other issues, not diagnosed or tested yet. My brother has lost the use of kidneys and on dialysis. He was recently diagnosed with lupus due to his dr doing a biopsy of kidney at 53. I am so scared of also dying young without a proper diagnosis. Mom had her marrow tested yearly.

[@joannzappoli3667]

If a patient has 2.7 spike with no symptoms, no fractures of the bones would this be considered mgus? CT scan and bone marrow has not been performed at this time but will be next week.

[@leelabrock4266]

I have the same

[@leelabrock4266]

I hope it all goes well m spike 2.70 just got Diagnosed with precancerous

[@stephenrichards5386]

What are the units of the 2.70 ? Is it g/ltr or mg/dltr or g/dl ?

[@rumplestiltskin1682]

This is very helpful, just stop saying “muggus”... it’s M.G.U.S.

[@stephenrichards5386]

It's called MUGUS throughout the world of medicine. I think you may have to adapt

[@rumplestiltskin1682]

stephen richards Get over it, it was said kind tongue in cheek.

[@stephenrichards5386]

@@rumplestiltskin1682 I'm not under it, thanks. You should remember why emojis were invented when you write a comment "tongue in cheek "

[@rumplestiltskin1682]

Just read the comments and move on, how old are you? Have the last word...

[@stephenrichards5386]

@@rumplestiltskin1682 with age comes wisdom. With youth comes pedance and stupidity