Multiple sclerosis | Understanding the roles of B cells

Multiple sclerosis (MS) is a leading cause of neurological disability affecting 2.3 million people worldwide. Recent clinical evidence suggests that B cells contribute to both the inflammatory and neurodegenerative aspects of the disease. Learn about the role B cells are believed to play in the origination and development of MS.
Once inside the central nervous system, B cells have the capacity to impact the underlying pathophysiology of MS through a number of functions, including antigen presentation, cytokine production, autoantibody production and ectopic lymphoid follicle-like aggregates.
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Roche has been committed to improving lives since the company was founded in 1896 in Basel, Switzerland. Today, Roche creates innovative medicines and diagnostic tests that help millions of patients globally.
Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and neuroscience.
For more information and insights visit: www.roche.com/

[@R-skl]

We need more of this content.Everything is clear here

[@sbarrmed]

One of the finest medical animations I have ever seen. Bravo!

[@meganjuergensen5596]

sbarrmed just wish all the cartoons were also in English

[@beequinn5204]

My only living sister has MS I’m going to share this podcast as it explains her condition. Many thanks

[@Paul9735]

I have relapses every 3-5 weeks with enhancing lesions. Should be starting Ocrevus in 2 days and I’m very excited to see what it’ll do.

[@jazz_octavian]

This is great guys. This is the type of branded content I like to be served - so educational, interesting and valuable to watch. Watched the whole thing :)

[@hydrogeddonn]

Educational, beautiful, and very professional. Amazing in all sense of the word. Good job.

[@lorrainejohnson829]

Ive had MS for 25 yrs and this finally helps me understand the disease! thank you so much-WOW!!!

[@robertatozer5250]

Amazing and very informative, helps understand how important research really is. Well done Roche you helped me understand MS a little better.

[@limerence8365]

This is a great video. I don't know if I have MS but I do get fatigue, depression sometimes my legs go numb and tired (usually one at a time) and get tired as if I've been working them all day and stay that way even after rest. I've been concerned about it and these videos have been very helpful.

[@roche]

Hi Limerence, Thank you for getting in touch with us. If you have questions regarding a treatment or medication, please consult your healthcare provider first or get in touch with one of our offices in your country. You can find a detailed list of Roche offices: www.roche.com/about/business/roche_worldwide.htm. It’s not that we don’t want to help, but social media is not the right place to discuss private health information. Wishing you all the very best. Your Roche KZbin team

[@SelfReflective]

Limerence: Have you been diagnosed?

[@TrueWealths]

The animation on this was incredible!

[@BridgetMermikides]

Incredible video thank you - I have just received my first Ocrevus infusion so it's great to this explained so clearly.

[@PATRICIANEWITT]

Excellent explanation

[@margueriteondoa3152]

great video, very educational. Makes it easy to understand.

[@chickenman7032]

I hope all them people who make desisions on ssi cases the judges the dr's and the lawyers get m.s. and has to live with this horrible illness for telling people they do not need ssi its not that bad! they suck and dont know how bad this is to live with.

[@viviannemerr5084]

😓

[@kelticach4999]

The problem with this concept is that in most MS patients np autoantigen can be identified (anti-MOG or AQP4 identify rare subgroups of MS-like diseases). An interesting phenomenon to be discussed is also the MRZ reaction.

[@Nodif]

SOOOOOOOOOOOOOOOOOOOOOOOO COOL I AM SOOOOOO AMAZED

[@L丁]

Amazing video - only missing out the very important plasma cells in the meningeal lymphoid follicles.

[@ajwangabrendah1592]

very informative

[@ameer2016-r6w]

المقطع جميل جداً شكراً ❤️👏🏻

[@acoooodvdoooo]

amazing video!

[@thunderning8321]

Beautiful animation

[@huynhanh3586]

Nice illustration! This video also reminds me of the important function of astrocytes in the human brain.

[@francescomarcelli5278]

aggiornato, chiaro. bellissimo lavoro

[@Orthodox.777]

So those cells destroy myelin? Sorry i don't understand English language that good

[@sergeyslepov]

Are we getting any closer to finding a cure for MS? Any expectations on this?

[@mohamedorayith4626]

probably not... There doesn't seem to be any true treatment for nearly all brain disorders

[@huraizulhalkap9464]

The main function of the Blood Brain Barrier is to protect the brain and keep it isolated from harmful toxins that are potentially in the blood stream. The Blood Brain Barrier has certain requirements because of the function that it serves. The barrier only allows substances that weigh less than 500 amu (atomic mass units), are relatively compact in shape and size, and are lipid soluble to pass through into the brain. Properties of Essential Oils Being aromatic, essential oils can easily circulate in the air so that they can enter our noses and be detected as a smell. Essential oils are all less than 500 amu (most are under 300 amu). Essential oils are compact in shape - almost always containing ring structures. Other fatty molecules, even though they weigh less than 500 amu, consist of long chains rather than rings and thus their shape prohibits them from going through the “filter”. Reference source: The Chemistry of Essential Oils Made Simple by Dr David Stewart. Essential oils are also fat soluble. This makes them easy to enter into the blood tissue of the brain, thus affecting brain function and delivering its therapeutic benefits. Other molecules do not have all of these characteristics. Even water. Although its atomic mass unit (weight) is only 18, it is not fat soluble - which is a good thing as too many water molecules in the brain can be dangerous. There are substances besides essential oils that can cross the blood brain barrier. Many of these are toxic and they are chemicals we come in contact with every day - gasoline, cleaning solutions, pesticides, herbicides, and pollutants in the air, among others.

[@paulsauter7123]

Why are toxic substances able to pass through the barrier? Or is that the reason why we die when we consume these kinds of substances?

[@saanvafi6476]

I was celiac for 15 yrs.whenever I ingested gluten, I had pian in gut , rashes, diarrhea .... With no problem in brain. After hep B vaccination ..... I developed confusion &. Extreme stuttering . I learnt hep b vaccine induces B cells ... I hope someone can come up with solution to undo what hepb vaccine did

[@santiagoserranorodriguez8396]

Its surprising how we nknow the disesase and slow found solution for the diseases

[@rauldominguez1438]

soy paciente con Esclerosis múltiple. Favor suministren información en Spanish

[@roche]

Hi Raúl, Thank you for reaching out. We kindly want to refer you to our Spanish website: www.rochepacientes.es/ If you are still in need of further information kindly contact our colleagues: spain.pacientes(a)roche.com

[@youcefbenchouk5030]

L'enquête officielle entre l'entrevue et le spectateur

[@jorgechristiamestupinanflo3812]

traduccion al Castellano

[@suvikhyasiingh]

auto reactive b cell is an imposter

[@obviouslytwo4u]

Hope my b cells are not leaning this bad habit lol Go vegan