Metabolism | The Krebs Cycle

[@YK-fr5lg]

Someone give this man an award please. Best teacher I've ever seen.

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Why wait? Award him💃💯

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He desreves more than that ♥️

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he deserves an award for real#nobel prize teacher -of those 37 ppl (30 of them were his classmates and he topped there score, and 7 just cant learn)

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Its me who I'm gonna make it!!!!! Leh me finish did high school first$!!!!

[@KhushbooSingh-mw8wg]

In 5 years of medical school, i never understood this and you just lad this out so easily in merely 30 minutes. You're a blessing!

[@g-mannG]

Which Med School?

[@graceremo5724]

HAHAHAHAHA! EXACTLY!

[@KidVll]

this is why I don't visit doctors...

[@lachyt5247]

@@KidVll You don't visit doctors because they studied medicine instead of biochemistry?

[@KidVll]

@@lachyt5247 OP didn't say they weren't taught this in medical school, they said they didn't understand it. And yes it's troubling someone can get through medical school without understanding the very basics of cell metabolism.

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The mnemonic "Citrate Is Krebs Starting Substrate For Making OAA" just BLEW MY MIND. Trying so hard to memorize it and this made it sooo much easier!! Thank you Lord for you and your team! Keep it up!!

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One I found online was “Can I keep selling s*x for money, Officer?”🤣

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He literally takes a chapter and condenses it into a 32 min video with more simplifications and better understanding than any professor I have had. Goodness gracious I only need him as a teacher for everything. He gets straight to the point without the fluff.

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32:15 minutes and no mistaken terms, no mistakes at all! So fluent, quick enough and revising the necessary parts. I don't know how much work you put in this video (I think a lot in order to be so professional) but it's amazing👏

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University lectures are an hour and a half, yours are thirty minutes! Insane.

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I know!! Mine are two hours, this guy is amazing!

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Ours is 3 hours straight 😅

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Ameen

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ameen

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Ameeen

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@CALLIE-CO 2 this didnt age well

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aamiiin

[@yanyansanchez4540]

Your videos greatly helped me understanding biochemistry in med school! As a visual learner and as a person who loves taking down notes, I now know the bigger picture of these metabolic pathways and their clinical significance! Continue doing videos like these! :)

[@corporatetochiro5986]

I cannot thank you enough for your videos. I have watched probably 15-20 of them so far (some multiple times) which represents a significant amount of my study time because you explain these processes so clearly, you repeat the names of steps or enzymes and recap often, you draw pictures to help us remember, you give clinical applications to relate these concepts to real-world issues, and you are organized and methodical in your explanations making it easy to follow along. PLEASE keep up the good work and keep producing these incredible videos! Many, many thanks!

[@jjcoolman59]

This guy is the absolute GOAT!!!! He makes it so easy to understand such a “complex” process🤙🏾

[@RogeyBaby]

25:18 - “Look at this freak...(points at enzyme)” cracked me up! As an artist crossing over into science I’ve learned so much from your methods and use of imagery. Thank you for making these lessons available.

[@NinjaNerdOfficial]

You’re so welcome! Glad to help!

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You're Bob Ross!

[@junaidahmed2382]

That freak looks like Picasso's genius work.

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@@NinjaNerdOfficial Literally Sir, thanks for your lectures make my work far easier. Looking for more interesting topics ahead.

[@iamvsimon]

That part cracked me up, too! 😂

[@alilotfalian8954]

Dude I’ve never seen someone teach kerbs cycle like this 😳👌 pretty simple

[@arslanshahid4026]

The mnemonic bro.....it won my heart❤️

[@kapendachinyama3505]

As a medical student,I really find your videos very helpful. you have so much information and your explanations are great ! I love your channel

[@AnkitSingh-ri5gh]

i have studied metabolism for one whole semester and understood nothing tomorrow is my exam and watching his 30 min video has made me understand every topic so clearly that im not afraid of metabolism now. thankyou sir!!!!!

[@NessaUrombo]

I love how you added the inhibition in this video as it made it much more informative, and the visual enzymes make the process easy to remember :)

[@RafaelTorres_Ashes]

RIP Betty White, replenishing the levels of isocitrate in heaven.

[@medizzy6723]

the drawings are so beautiful and easy to understand. the teaching style is too and the slow pace and frequent repetition of the facts make the information easier to remember. glad i found this channel, thank you for the work you do Ninja Nerd Science !

[@b.tann__]

During my six years of university education (masters included), the concepts always seemed elusive to me. With just a week left until my MCAT, you managed to explain the Krebs cycle to me in just 30 minutes, and I'm incredibly grateful!

[@Bcrios13]

Omigosh I love you. When I get my Microbiology and Chemistry degrees I'm going to shout out Ninja Nerd Science

[@johnb3222]

Love your videos, however I'd like to point out an error for other people who may be watching. Mutations in Isocitrate Dehydrogenase, NOT alpha-ketoglutarate DH (as you mentioned in the video) lead to accumulation of 2-hydroxyglutarate and ultimately cancer. If anybody is familiar with cancer literature, you'll often read about "IDH mutations" which are very common in certain cancers (gliomas and acute myeloid leukemia especially). "IDH" is just a fancy abbreviation for "isocitrate dehydrogenase." IDH normally converts isocitrate to alpha-ketoglutarate; however when it is mutated, it also converts alpha-ketoglurate to 2-hydroxyglutarate which causes the problems mentioned in the video. More specifically and for those people who may be interested, there are three human IDH isoforms: IDH1, IDH2, and IDH3. IDH3 is what was discussed in the video and functions in the mitochondria to convert isocitrate to alpha-ketoglutarate while reducing NAD to NADH. The other two isoforms, IDH1 and IDH2 are the isoforms that are mutated in cancers and reduce NADP to NADPH (rather than NAD to NADH). IDH1 functions in the cytosol whereas IDH2 functions in the mitochondria. IDH3 is not normally mutated in cancers. Otherwise great video Here are some links if you want to learn more: www.ncbi.nlm.nih.gov/pmc/articles/PMC4109985/ advances.sciencemag.org/content/advances/5/5/eaaw4543/F1.large.jpg

[@gabifoxlow1053]

Omg this is actually the best learning video I have ever seen !! In my second year of uni and watched a lot of different teaching and this is another level I loved it

[@erinsahm]

"We have another enzyme. Look at this, look at this freak!"

[@TourniquetTwin]

You just helped me memorize this whole cycle, having spent a week circling in panic with only acetyl coa and oaa in my head. A stable genius you are, Zach.

[@kipkipcryptos104]

I was blank after lecture,,, but when I got this am full.Best teacher ever I will over nothing bigger than thanks giving.

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You are so freaking amazing. God bless you. You helped me so much!

[@NinjaNerdOfficial]

+Casey McConnell We are so happy we could help Casey! Good luck to you!

[@sumagangjean2439]

@@NinjaNerdOfficial sir what will happen to those substances (like for example alpha-ketogluterate) if their next step is being stopped (succinyl COA binds to alpha-KG D.H. to inhibit conversion of alpha-ketogluterate to succinyl COA)? will those substances just stay in place?

[@Elena-ex6bn]

Professor Zach Murphy is the truly gifted teacher!

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Can't thank you guys enough for your hard work! This is beyond amazing🔥👑

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most understood able teacher ive ever seen in my life

[@manonwittorski2669]

It's amazing! It has been 4 years trying to learn this, I never understood. Now it's done so easily :)

[@AK-bv4tb]

This is by far the best krebs explanation I have seen on youtube. Thank you.

[@jacabuswalford4201]

The mnemonic was very helpful.

[@yisihakiabraham2679]

Everywhere ever time when I talk about Biochemistry,I never forget you

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love this guy thank you for saving my biochem grade

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I know you get comments like this all the time but brother you're still helping uni students to this day. Really appreciate you!!

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Thanks a lot Mr Zach . I have biochemistry test tmmrw but this helped me a lot . Hopefully I pass and get good grades ❤

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Wow! To be honest this great man deserves a reward, concept driven home in the best way possible.

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[@gracielesantos7191]

MY GOOOOOOOOOOOOD, MAN, U'RE A GENIUS. I'M NOT KIDDING. CANT BELIEVA THAT I FINALLY UNDESRTAND THE KREBS PATHWAYS

[@areebakashif3651]

krebs cycle was a NIGHTMARE to me until I watched this FANTASTIC video! I'm subscribing rn!!!

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what an absolute unit of a lad

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Thank you teacher, please don't run when you explain, Thank you will never and ever be enough 👍👍📖🧠

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idk what I'd do without you

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Me too

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This guy deserves a Nobel peace prize. Thank u so much for being such an excellent teacher!

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God bless you brother. You deserve Millions of Subscribers

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"look at this freak" smh bigotry is everywhere

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Mr Zack! I wish you best of health! Many children and a lot of wealth! May Allah shower you with his blessings and may you live FOREVER!!!

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my goodness i've never seen such a funny and beneficial way at the same time, you make things so simple !

[@Joshua_Gobindah]

Awesome. Now I fully understand the Kreb Cycle.

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THANK YOU THANK YOU for making something so confusing easy to understand😮‍💨😌😌

[@ayushtripathi9575]

The best mnemonic I have seen here Just wanna thank you❤

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i hated biochemistry so badly even failed a med school biochemistry exam BUT I UNDERSTAND IT NOW THANKS TO YOU I LOVE BIOCHEMISTRY I LOVE YOU MAY YOU BE REWARDED

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Best teacher in the world.

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I will never forget crebs from now on!!! you are amazing please keep doing your amazing teaching.

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You are indeed a blessing Sir.

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Ninja Nerd is a lot better than my professor in my university, my friend once asked one of the Biochem professor about the carbohydrates topic, that professor just simply said ‘I don’t know, this is not my topic, I don’t know’, we were just like ????. Wtf? U r the head of Biochem department and yet u didn’t know???? Like I feel like I can be a professor too cuz most of the professors in my university apparently don’t know anything when we ask them something 🤷🏻‍♀️ what do I even pay the tuition fee for? To pay for the answers of ‘I don’t know?’ I would love to pay my tuition fee for this channel other than my university, which thank god the most helpful channel where I can get some clear and understandable knowledge!!!!

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Hello, you are the best person to explain this topic to us in a way that makes it look beautiful and understandable, but we need to translate the video into Arabic so that all students from all over the world, whether they are Arabs or foreigners, can benefit from your wonderful explanation. Thank you.

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May God give u reward for such a marvelous effort

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Amazing video. Easy to follow yet a thorough and detailed explanation of the process. Thank you!

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Awesome....thats all i can say about your videos. Wish i had these 20 years ago in grad school.

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Best explanation of krebs cycle 🙌🙌

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this gave me an exact picture of what's actually going on in mt and all i can say is a big THANKS

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watching this during the COVID19 Pandemic You shall be my professor!