Respiratory | External Respiration: Ventilation Perfusion Coupling

Correction @27:50 , the ventilation INCREASES as we go down from the Apex to the Base, but the perfusion increases SIGNIFICANTLY more. Since Perfusion increases more than Ventilation as we move to the base of the lung, the V/Q ration decreases at the base
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In this lecture Professor Zach Murphy will be teaching you about external respiration, simply known as breathing. During this lecture we will be discussing ventilation perfusion coupling. We hope you enjoy this lecture and be sure to support us below!
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[@flynn8936]

27:15 !Ventilation is higher at the base of the lungs (in an upright position) due to gravity pulling on lung tissue which increases pleural pressure!

[@samoei3780]

Wow! this is exremely wonderful. Thanks alot, you made this things very easy. Point of correction- The lower zones of the lung ventilate better than the upper zones and the middle zones have intermediate ventilation.

[@samoei3780]

In addition ventilation perfusion ratio increases three times in the apex than in the base

[@SunShine-vq9sz]

But in that won't the v/q ratio be disturbed?Could u explain why u think ur point is right?

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I feel like you should have emphasized that the smooth muscle in the arterioles contracts and relaxes because capillaries dont have smooth muscle and so the illustration can be misleading.

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[@BlaackAnchor]

At time 27:30, you said that ventilation decreases from apex to base, but actually it increases from apex to base of the lung. Perfusion also increases from apex to base, but much more significantly that we have a lower V/Q at the base.

[@caidenlu]

but shouldnt air goes against the direction of the gravity?

[@BlaackAnchor]

@@caidenlu we are talking about ventilation here, not just air. Thanks for your input....

[@caidenlu]

@@BlaackAnchorbut isn't ventilation the movement of air? but i get youre right, just still got confused here about why

[@caidenlu]

@@BlaackAnchor is it because at the end of expiration, the FRC at the apex area is more than the bottom, so the ventilation at the apex is considered lower?

[@omarnakhleh6600]

@@caidenlu The ventilation is low because the cross sectional area (surface area) is low in the apex of the lungs

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[@miladdulloo1997]

There is an error: ventilation is higher at the base than at the apex because of increasing compliance. The V/Q ratio is biggest at the apex because at the apex: Q higher is relatively to V. V/Q ratio is lowest at the base because V is higher comparatively to Q.

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Hello u said that ventilation is better in the top(apex ) of the lung ,but actually it should be decreased bec all books said that lower zones of the lung ventilated better thant upper ,i wish u explain!! + ur the best in explaining physiology

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[@abhishekgholap1300]

28:00 . Isn’t Ventilation more at the base of the lung? Ref: Ganong’s

[@akshitverma3328]

The ventilation being talked abt is in the alveoli and not outside the alveoli..the ventilation will be more at the base but that phenomenon is applicable to the outside of the alveoli

[@rachellugtu2776]

Ventilation and perfusion is higher at the base and lower at the apex of the lungs. However, V/Q ratio is higher at the apex and lower at the base.

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Yes due to gravity

[@shayandin9709]

this doesnt make sense to me either

[@shayandin9709]

@@rachellugtu2776 if the perfusion is lowest at the apex then whould the apex of the lung not try and match the ventilation therefore at the top of the lung would have a high ventilation?

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[@BlackHole257]

Correction : ventilation and perfusion both is less in the apex of the lung

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[@reezis1619]

Correction: Type 1 Alveolar cells make up 40% of the alveolar cells in number and Type 2 make up 60% of the cells in number, however the type 1 alveolar cells take up approx. 95% of the space and type 2 approx 5% of the space Correction 2: Nitric Oxide causes smooth muscle relaxation by activating guanylyl cyclase, increasing cGMP concentrations in the smooth muscle cell, activating cGMP dependent protein kinase which in the end phosphorylates and activates Myosin Light Chain phosphatase which leads to smooth muscle relaxation. It is not dependent on K+ efflux.

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Ventilation increases from apex to the base. Please correct it ! Other than that ! A big fan ! Great job zack !

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