Nobel Prize in Chemistry 2021 Part 1, Asymmetric Organocatalysis, Enantioselective Organic Chemistry

[@harishsuryadevara3736]

Incredibly interesting- this is one of the clearer explanations I’ve seen of enantioselective rxns. Could you touch on alternate transition states aside from the 6-membered ring in the future?

[@CasualChemistry]

🙂 Thanks. It's certainly on my list to do in the future. I'm planning to expand my playlist of models in organic chemistry, which will definitely be including different transition state models in non-cyclic systems.

[@copycat2508]

Dear Casual Chemistry, thanks so much for these videos! I keep on finding myself rewatching the same vids of yours to help with my orgo knowledge. We are currently learning this in Professor Jacobsen's class so this is a nice refresher! Hope you are doing well！

[@CasualChemistry]

😀 Brilliant! Thank you so much for this feedback. It’s exactly what I hoped to achieve by starting this channel that students and beyond will have it there when it’s useful, even if not obvious on a first watch. This type of hopefully evergreen type of video takes a quite a bit of thought on how to pitch the level. I have a few other asymmetric catalysis stuff on my planning board 😎

[@alexkarr7592]

These videos are pretty clear and concise. I now have more videos to binge.

[@CasualChemistry]

Many thanks for the feedback 😀 More videos on the way including a follow-up one on organocatalysis - I just need to find some time to do the editing.

[@nihalkhatiwoda6961]

You explained it in one of the best ways possible! It was really great!

[@CasualChemistry]

😀 Thanks for the feedback. Glad you found the video useful.

[@patsa5876]

Thank you so much for the clip, i was confused for long time.

[@CasualChemistry]

😀 Glad it was helpful. I'll be planning on making further videos on related topics in the future.

[@patsa5876]

@@CasualChemistry Awesome

[@YoAddicts]

Good. Relatively easy to understand and a highly under-rated video.

[@CasualChemistry]

🙂 thanks for the feedback - very much appreciated! Please feel free to share my channel to your Chemistry friends

[@copycat2508]

At 10:20, how do you know whether to place the aryl groups equatorial or axial?

[@CasualChemistry]

You have to have determined the double bond geometry in the enamine and electrophile first and then fit them in according to any constraints - if you have a genuine choice, the transition state is best if you can choose to put it equatorial. In this example, the imine is trans-configured but the N lone pair must be inside the ring core of the transition state so it can hydrogen bond. The other groups on the imine are then both forced axial.

[@bhawnajoshi1335]

It's super awesome explanation

[@CasualChemistry]

Thank you 🙂 Glad you found the video helpful!

[@rohanbatra6317]

Thank You so much ! it really helped me :)

[@CasualChemistry]

No worries - glad it was helpful :)

[@ephemeral2552]

What resources did you read to get into assymetric synthesis? I still have a hard time wrapping my head around it so would be nice with a book!

[@CasualChemistry]

It’s a tricky field for sure because of a lack of good textbooks on these topics - probably partly due to the history of the research taking lots of separate looking paths. A good resource to start with getting to know some of the earlier work (which modern methods build on) are the Evans lecture notes (Harvard), which are usually findable in PDF form on the internet. Though to be honest most of my learning of this area came from research papers and taking lab projects in those areas - and I definitely felt in at the deep-end to begin with

[@ephemeral2552]

@@CasualChemistry tysm ily. I'll have a look at some of them asap:)

[@CasualChemistry]

Also very useful are these Myers ones: faculty.chemistry.harvard.edu/myers/pages/chem-115-handouts

[@user-mp4bc9qp2x]

nobel prize material here.

[@CasualChemistry]

Indeed there is (!) I swear I didn’t know about the Nobel Prize when I made the video. Did my first PostDoc in asymmetric catalysis so perhaps I should make some more content in this area

[@ChemNews]

Thanks! I actually also made a video about the Nobel prize in chemistry. Would you like in we advertise each other's channel in the next video to share audience?

[@CasualChemistry]

Hi. I'm not sure how overlapped we are in terms of content. Most of my videos will be taking a teaching perspective rather than tracking news in the field. Though if you have any ideas how we might collaborate let me know.

[@ChemNews]

@@CasualChemistry Well, it is good that we are not overlapping in content. We can simply mention each other's channels in the next video. Something like "if you guys like chemistry, you may like also the ABC channel - see the link in the description".