Non-linear pharmacokinetics

As you increase the dose the pharmacokinetic parameters (ADME) also increases linearly, therefore known as linear pharmacokinetic. Whereas by increasing the dose of drug the pharmacokinetic parameter either increases or decreases or remain constant, therefore known as non linear pharmacokinetic.

[@shariarvorosha7734]

I am A.S.M Sahariar Rahman from Bangladesh a Mpharm student I would like to thank you from the bottom of my heart , live long and spread your knowledge.

[@FirdousAnsari]

Thank you so much 😊🙏

[@tabassumqureshi2436]

Fabulous 🥹 please make such videos more

[@FirdousAnsari]

Thank you 😊

[@anshishemeemank6107]

Very helpful... lecture thanku mam❤❤

[@adebimpeebunoluwa5504]

Thank you so much

[@FirdousAnsari]

Welcome

[@anshishemeemank6107]

Thankyou maam❤....

[@FirdousAnsari]

Welcome 😊

[@vijaypatel-us1ij]

Thank you so much mam 🙂👌👍please mam make more videos

[@FirdousAnsari]

Welcome 😊✌

[@Ashishsharma-xs5us]

Awesome Outstanding explanation 👌👌 Carry on

[@FirdousAnsari]

Thank you 😊

[@jithukrish4491]

Derivations are superb

[@FirdousAnsari]

Thanks for the comment 😊 it means alot.

[@sandhyasandy8977]

Great explanation tq

[@FirdousAnsari]

Welcome 😊

[@chalavadiguruswamy7662]

Good explanation madam 👍

[@FirdousAnsari]

Thank you 😊

[@12guruprasath.t.n16]

Lovely concept mam

[@FirdousAnsari]

😊

[@preethichinni6216]

Tq so much mam❤

[@FirdousAnsari]

Welcome 😊

[@mazherazhar9263]

Nice explanation mam 👍👍👍

[@FirdousAnsari]

Thank you 😊

[@ruchitamath9298]

Mam u are always awesome.......keep it up mam ......lots of support and love🥰🥰🤩😍

[@FirdousAnsari]

Thanks dear 😊

[@Cricholic_GPATian]

For this excellent lecture

[@NaveenKumar-wb6sq]

Romba thanks ma. Excellent lecture. Keep rock

[@FirdousAnsari]

Romba welcome 😀😀😀🙏🙏🙏

[@NaveenKumar-wb6sq]

@@FirdousAnsari 😊😊😍

[@karthikb3261]

Nice lecture mam....

[@FirdousAnsari]

Thank you 😊

[@Padmashrinaren]

This was amazingggg ❤❤❤❤❤❤❤

[@FirdousAnsari]

Thank you 😊

[@anishalamichhnae5262]

I dont understand how absorption decreases on adding dose .... I think 750mg amoxicillin should show concentration as much as 375mg ...not less why it shows less coz transporters are in same number

[@FirdousAnsari]

The transporter got saturated as you increase the dose of drug. It is an example to explain that factor.

[@FirdousAnsari]

Not arbitrary value, reference book is leon shargel.

[@anishalamichhnae5262]

@@FirdousAnsari does everytime concentration decreases with increse in dose or its something u suppose?

[@poshalabindhu1805]

Tq so much

[@FirdousAnsari]

Welcome 😊

[@Cricholic_GPATian]

Thank you ma'am

[@FirdousAnsari]

Welcome 😊

[@vijaypatel-us1ij]

Mam ek confusion tha ye jo nonlinear kinetics he usme ADME dose independent he na?and pharmacokinetics parameter dose dependent am I right mam?

[@FirdousAnsari]

First of all, dose dependent means adme increases with increase in dose and decrease with decrease in dose in a linear fashion, hence known as linear pharmacokinetics. Whereas dose independent means adme may increase or decrease or remain same with fluctuating dose, therefore non linear pharmacokinetics. Second part of your question: unless and until you don't give any dose of drug, there won't be any pharmacokinetic or pharmacodynamic or any thing 😁😁😁 Hope u understood ☺✌✌✌

[@vijaypatel-us1ij]

@@FirdousAnsari yes mam now I understood thank you so much mam😊😊😇

[@poojar6673]

Nice madam👍

[@FirdousAnsari]

Thnx for the comment, it means a lot 😊

[@poojar6673]

@@FirdousAnsari ❤️

[@muhammadadilmalik6417]

Madam💖