Novel Agents Targeting Diffuse Astrocytoma

This video Presentation was recorded at the Brain Tumour National Conference in Toronto, Ontario on Saturday, October 20th, 2018 with Sabra Salim and Nikoo Aghaei (McMaster University) for part of The Pam and Rolando Del Maestro Family Undergraduate Student Research Competition.
Hypothesis:
We hypothesize that cells harboring IDH1-mt status have increased tumorigenic, proliferative, self renewal and malignant transformation capacity. When used in combination with current treatment options, IDH1 inhibitors may provide a novel therapeutic modality and drive preventative treatment options for high-grade glioma transition for patients with diffuse astrocytoma. Furthermore, we hypothesize that induction of a high-grade phenotype may elucidate novel cell signalling pathways and subsequent targeting of markers in malignant transformation.
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