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This 16-minute Presentation gives an overview on High Dose Thiamine (B1) therapy in Parkinson's Disease and explains why this therapy holds a high potential as an intervention to modify the course of Parkinson’s Disease. It goes through Dr Costantini’s research work, ending with the plan to confirm his preliminary findings through a Randomized, Double-Blind, Placebo Control Trial (RCT). Donations to support the study can be made through GoFundMe at www.gofundme.com/f/high-dose-thiamine-protocol . Disclaimer - This presentation is provided for information and education purposes only. You should consult your physician for advice on treatment, including supplements. Supplements may interact with other supplements, medicines and other health conditions, so check with your doctor first. The findings presented are only preliminary findings and need still to be confirmed. Any actions taken based on what is provided and mentioned in this Presentation is your sole responsibility. I disclaim any liability, loss or risk, personal or otherwise, including death, that is incurred as a consequence, directly or indirectly, from the use, misuse and application of any suggestions or information contained in the Presentation.