Parkinsonism (Part 01) = Basic Introduction of Parkinson's Disease | Parkinson's Disease Etiology

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Parkinson's disease is a progressive nervous system disorder that affects movement. Symptoms start gradually, sometimes starting with a barely noticeable tremor in just one hand. Tremors are common, but the disorder also commonly causes stiffness or slowing of movement.
In the early stages of Parkinson's disease, your face may show little or no expression. Your arms may not swing when you walk. Your speech may become soft or slurred. Parkinson's disease symptoms worsen as your condition progresses over time.
Parkinson's signs and symptoms may include:
(1) Tremor. A tremor, or shaking, usually begins in a limb, often your hand or fingers. You may rub your thumb and forefinger back and forth, known as a pill-rolling tremor.
(2)Slowed movement (bradykinesia). Over time, Parkinson's disease may slow your movement, making simple tasks difficult and time-consuming.
(3) Rigid muscles. Muscle stiffness may occur in any part of your body. The stiff muscles can be painful and limit your range of motion.
(4) Impaired posture and balance. Your posture may become stooped, or you may have balance problems as a result of Parkinson's disease.
(5) Loss of automatic movements. You may have a decreased ability to perform unconscious movements, including blinking, smiling or swinging your arms when you walk.
(6) Speech changes. You may speak softly, quickly, slur or hesitate before talking.
(7) Writing changes. It may become hard to write, and your writing may appear small.
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[@vaishnavivanshakrithmath4540]

Sir i didn't understood what is the function of the inhibitory gaba neurons. like u said sir dopamine decreases Ach . What is the function of gaba ? , Sir like I just referred in sembulingam- gaba plays a very imp role in Parkinson and they mentioned some lewisbodies , but i didn't get that sir?

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Sir acetylcholine muscle contraction karne ki bagese muscle ka motility hotahe.lekin Excesive Acetylcholine kese impaired motility kartahe ,pls reply..

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Sir in K.D Tripathi its written inhibitory - acetylcholine and exhitatory - dopamine . Thankyou so much sir for your lecture!

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Sir you said that , the neuron is inhibitory neuron of dopamine , then blockage of inhinibitory neuron should have to incrise realease of dopamine , I dont understand that concept please clear it.

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