Peptic Ulcer (Part-04) Proton Pump Inhibitors Mechanism of Action | PPI Drugs | Peptic Ulcer

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Peptic ulcer disease (PUD) is a break in the inner lining of the stomach, the first part of the small intestine, or sometimes the lower oesophagus. An ulcer in the stomach is called a gastric ulcer, while one in the first part of the intestines is a duodenal ulcer. The most common symptoms of a duodenal ulcer are waking at night with upper abdominal pain and upper abdominal pain that improves with eating. Other symptoms include belching, vomiting, weight loss, or poor appetite. About a third of older people have no symptoms. Complications may include bleeding, perforation, and blockage of the stomach. Bleeding occurs in as many as 15% of cases.
Common causes include the bacteria Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs). Other, less common causes include tobacco smoking, stress due to serious illness, Behcet disease, Zollinger-Ellison syndrome, Crohn's disease, and liver cirrhosis. Older people are more sensitive to the ulcer-causing effects of NSAIDs
A dull or burning pain in your stomach is the most common symptom of a peptic ulcer. You may feel the pain anywhere between your belly button and breastbone. The pain most often
1. happens when your stomach is empty-such as between meals or during the night
2. stops briefly if you eat or if you take antacids
3. lasts for minutes to hours
4. comes and goes for several days, weeks, or months
Less common symptoms may include
1. bloating
2. burping
3. feeling sick to your stomach
4. poor appetite
5. vomiting
6. weight loss
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Sir very nice video..pp ke sath antacid use na Karna aaur restrict to prolong use ye do BAAT mujhe aaj pata Chala...bahut Accha description tha Aapka..Thanks a lot Sir.❤️

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[@preetsaggal788]

Sir agar ppi ke prolong use 1 month use se acid supression hogea to kese thik kare stomch pain bi hota hy?

[@spanda909]

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[@titikshakumarsagar568]

Sir, it inhibits the microsomal enzyme and decreases metabolism of diazepam, warfarin but according to KDT "Omeprazole inhibits oxidation of certain drugs: diazepam, phenytoin and warfarin levels may be increased." ?

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[@SUMANTKUMAR-qh5ps]

Sir longest acting ppi kon se ha plzz sir tell us

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Sir pharmacology lipponcot mn yh drugs Kis class sy related hn?

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But sir, pantoprazole is in more and has got effective use nowadays,,, since there are more usage of Pan-40, or Pan-L, Pan-D, than Omesec.

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[@solutionpharmacy]

Yes

[@himalayanhawks9137]

Sir can we made these drugs for Sublingual route or is it necessary to give these drugs by Oral Route

[@solutionpharmacy]

That's depends on drug' nature and need. Currently it's given by oral

[@suntuzuki5753]

Sir AAP ne kaha ki omaprazole acid medium ki jarurut Hoti hai per ye drug to small intestine me absorption hota hai to kese (according Thakur publication

[@solutionpharmacy]

Absorb bhale hi intestine me ho raha hi but activation ke liye jo medium chaiye wo stomach me milegea

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[@mdmizanurrahaman4921]

Why should we use Antacid, when we can block or inhibit acid formation and secretion by using H2 Anti- histamine and PPI?

[@solutionpharmacy]

Blocking may affect many other function

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[@abdulrehmanimran5480]

Sir, ppi required acidic medium to get activated so it's mean we can't prescribed omeprazol with antacid and h2 blockers.??

[@solutionpharmacy]

Yes but if time regimen is different then it may be

[@solutionpharmacy]

Yes that should not use but it will not deactivate but effect may reduce

[@garimachaturvedi1828]

Proton pump ko aur explain chahiye sir

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Sir you said long term so how long it will take for osteoporosis occur in months Or years??

[@solutionpharmacy]

Its depends on individual but years ate common

[@28aartikuril19]

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[@Priyanka95911]

Sir which one is better H2 antagonists or PPIs. Plz answer

[@solutionpharmacy]

Depends on patient condition and other drug used by patient. Basically PPI are prefered as you have stated eralier

[@biochem.digambar1720]

Sir enteric coated is responsible for to protect the drug from acidity then how Omeprazole will activate in acidic?

[@solutionpharmacy]

That means it will act on acidic ph after absorption

[@biochem.digambar1720]

@@solutionpharmacy means after absorption it will activate

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[@arshikalsi5941]

Sir one doubt Omeprazole is enteric coated, bt enteric coated Tablets show action in intestine, and as per the drug it activates in the acidic pH bt intestine pH is alkaline, so can't understand how does it justify

[@solutionpharmacy]

I have seen omeprazol capsule in the form of granules. Ranitidine comes in enteric coating. Correct me if i am wrong

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[@SayedaRaihan]

Sir I have question please tell me why we should use ppi drugs before food?

[@solutionpharmacy]

To make it better absorb

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[@solutionpharmacy]

Our pharmacology lectures in English (Started From 01/12/2020). Link- Complete Pharmacology Topics (English) kzbin.info/aero/PLOsge3l7t_CTpZW0qDKEHoYyYBTYPozex Channel list - kzbin.info

[@kavya6032]

@@solutionpharmacy okay sir tq

[@anitapahadiya5983]

Sir i have a dout regarding this topic..apne kaha ppi category drugs ko before food lete h..to ky antihistamines ko bhi before food lena chahiye??..why??..please explain bcz ye line apne antihistamines topic me nh btai h🤔

[@solutionpharmacy]

Every drug has some specific phenomena regarding to the pH in gastric so that’s depends on drug

[@anitapahadiya5983]

Solution- Pharmacy Thank you sir but my question is ..can antihistamines are taken before food or not?

[@solutionpharmacy]

ANITA PAHADIYA There are many classes of antihistaminic drugs they may take in before me but they cause sedation so as per safety reason most of them are taken after meal

[@FarhanKhan-ri6wh]

Sir normal Bolte hai gas k liye bhi ppI use krte hai

[@solutionpharmacy]

Ha

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Khush rahiye

[@rabinbera5944]

Sir it may be GERD(Gastroesophageal reflux disease)

[@solutionpharmacy]

Rabin Bera Yes. Please check i have made correction

[@rabinbera5944]

Ok sir.

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Sanandia Rohit ye uska salt form hai jo uske solubility ke liye hai

[@sanandiar]

Ok thank you

[@Priyanka95911]

Which NSAID can cause ulcer

[@solutionpharmacy]

Non selective cox inhibitor

[@solutionpharmacy]

Non selective cox inhibitor

[@Priyanka95911]

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[@pankajsahu7705]

सर आजकल कोई भी मेडिसिंस लेने पर omeprazole जरूर दिया जाता है,क्या ये हमारे लिए नुकसानदेह हो सकता है?

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Upto some extent

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Sir are u a doctor

[@solutionpharmacy]

No

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