How much caffeine in coffee?

[@guard13007]

Loved the part about the coffee room not being allowed to close if there are people talking in there.

[@unlink1649]

I would like to upvote you but you have 420 upvotes and I can't ruin this

[@Braeden123698745]

"When people are relaxed some of the best ideas come into their heads" That hit me like a ton of bricks because of course thats why our best ideas happen in the shower.

[@alienweirdo8337]

Braeden Hamson So they should install group showers in Cambridge, and apply the same rule of keeping it open in case people are getting ideas in there

[@Mdxfiend]

Braeden Hamson They make dry erase boards for showers too I think

[@Braeden123698745]

Jason Yingling​ If you have a plastic or glass shower it already is shower. But water splashing.

[@Mdxfiend]

Wut? 0_o

[@Braeden123698745]

Jason Yingling the water would wash the marker away, and dry erase works on any smooth non abosorbant surface

[@svenp6504]

I was hoping he was going to snort it off the spoon at the end.

[@JeoshuaCollins]

I'm willing to bet they didn't let that caffeine go to waste. But just... not on camera, man.

[@frostedlambs]

@@BillAnt maybe something a bit easier to make like 3-meo-pcp

[@gianmariadri8515]

I've personally done it a few times, but you really need to have more quantity in order to actually feel something. I suggest minimum 1g.

[@gabeloftus9773]

@@BillAnt I love Pinky pink 😎

[@aaronlandry3934]

Gianmnaut What’s it like to snort Caffeine?

[@DavidWorley94]

To anyone questioning the practical methods - this was only a quick demo. The guy knows what he's doing, honestly!

[@LimaHotel807]

I'm glad someone here has some sense.

[@JayMark2049]

Jemima Puddleduck --- He could have used a proper solvent like DCM. It doesn't take any more time.

[@persekarva6444]

Industrially, caffeine extraction is done using supercritical carbon dioxide as a solvent.

[@yellowjello2143]

Lol literally using these extraction/purification techniques in organic chemistry lab rn.

[@pietrotettamanti7239]

I'd be okay with it being a quick demo if the objective was just to show that you can extract caffeine from coffee, but it clearly was to determine how much caffeine is in coffee. So it's reasonable to expect them to at least try to make a quantitative extraction (and maybe measure the volume they're working with).

[@ObadiahtheSlim]

At 80 cups of coffee, the water will probably be more toxic than the caffeine

[@oscargr_]

Nonsense

[@apexmike849]

@@oscargr_ I think that he was attempting humour. Illogical, but very human.

[@Ultiminati]

It can be true by the way. But it depends on the time that it is being taken.

[@أمادو-ذ6ف]

Actually .. I did the math and I was horrified .. some days I stay fo almost 24 hour or even more because I had work to do and the boiler is next to me .. every time my cup empties I get a new one .. thats about a cup every 15 to 25 mins .. add a ciggarette every time I have a cup .. I can see now I nearly killed myself a few times .

[@vincentrobinette1507]

You might be right: imagine guzzling 5 gallons of any liquid in a day. It would take me some effort to drink more than 1 gallon in a day (assuming 8 Oz cups) That's 16 cups per gallon.

[@julionica]

that ummhu at the end sounded so disappointing

[@jaykhan8089]

hsahaha

[@markgritzan2841]

Thought the same :D

[@marcosmota1094]

He put the work in and explained the process. He didn't need to be excited about doing 10th grade chemistry...did you read the part where he has a doctorate?

[@atav-q3c]

I'm deeply saddened that they did not recrystalize. :(

[@PsychedelicFern]

Ik totally skews the yield! What about the contaminates that were soluble in the ethyl acetate!!!

[@nfactorial4074]

kenneth avanzino hahahahahahahaha

[@gspecial3778]

5 years later I'm also deeply saddened they didnt recrystalize

[@NN-DMT]

Me too

[@aaronlandry3934]

I’m sad they didn’t do anything with the Caffeine. Adding it to some decaf or snorting it would have been how I used it

[@5688gamble]

Caffeine is THE drug, every country has their favorite pick up. It is quite addictive too as like other drugs you develop a tolerance, caffeine blocks a major neurotransmitter, adenosine, which builds up naturally over the course of the day and makes you feel tired. Caffeine fits the same place as adenosine but does not possess the same depressant effect, this reduces the space for adenosine and blocks it's. In response your body develops a sensitivity to adenosine producing tolerance and resulting in a withdrawal syndrome if stopped abruptly. The vast majority of the worlds population consume caffeine in some form on a daily basis and most would feel a noticeable loss in energy without it. The vast majority of the population or earth therefore are at least mildly dependant on the drug. Great news for plants that produce caffeine, they have us hooked so we'll make sure they survive and reproduce. A clear symbiosis where two unrelated species provide a service for each other. It would appear that tea and coffee have lured us in like bees to nectar.

[@SuperFalcoFalco]

can you explain the step: "In response your body develops a sensitivity to adenosine producing tolerance and resulting in a withdrawal syndrome if stopped abruptly." maby a bit more in deep? Does that mean that if you dirnk a lot of coffee (or other caffeine) the body builds more receptors where the adenosine or caffeine can bind to ? Or how does this adaption occur ?

[@5688gamble]

www.ncbi.nlm.nih.gov/pubmed/1865359 www.ncbi.nlm.nih.gov/pubmed/8246157 www.ncbi.nlm.nih.gov/pubmed/1846425

[@manictiger]

SuperFalcoFalco I don't know what causes tolerance to develop, but I know the withdrawal is not caused by chemistry, but by basic vascular physics. Coffee dilates the blood vessels in your brain and in response, your brain compensates by constricting them. When the coffee wears off and the dilation ends, your body is still constricting them. This is what causes the "caffeine crash". If I over-do the coffee (usually in excess of 28 ounces of Arabica), it causes a more immediate crash. Robusta is what most people drink and it is much higher in caffeine content.

[@5688gamble]

manictiger The vascular effects do cause a headache as blood vessels that were being constricted dilate but I'm sure that tolerance and dependence develop to it's stimulant effects as it increases the levels of cortisone and adrenaline being released, as well as blocking adenosine which makes you feel tired, the body adjusts to any change in chemistry and when the caffeine is removed the adaptations remain leaving your body chemistry imbalanced again, while you adapt again you will have non-vascular withdrawal symptoms like fatigue in addition to vascular headaches.

[@abberss]

That symbiosis is rather strange in itself as the plants with caffeine in them probably developed it as a toxic defense system against being eaten. It's just that humans are large enough to handle the toxicity of it while also being aware enough to appreciate its effects on the mind.

[@boredbun9546]

_"80 cups a day is lethal. do not approach that al all"_ *Me looking at my 20th cup of coffee* : Well, I am safe.

[@mousey451]

I’m the same with drinking coffee 😂

[@mapelaanjakoodaansuomeksi3432]

Didn't Fry from Futurama drink a hundred cups one day?

[@robertwilloughby8050]

Don't know about Fry, but Honre De Balzac drank 50 cups of strong coffee a day (and ruined his stomach in the process!) I think he died in his early fifties pretty much directly from his coffee consumption.

[@arddermoutcramer5695]

​@@robertwilloughby8050 50 cups? what a motorhead

[@notmenotme614]

“80 cups a day is lethal” Sounds like a challenge.

[@Lellistair]

I drank coffee every day in college and it did nothing for me except give me the super-shits

[@Wyattttt710]

+Stephen MacLellan And yet you kept drinking. That's dedication.

[@quicksilver5253]

I laughed with tears for 10 mins straight...

[@becnal]

As you get older, that becomes a major reason to keep drinking coffee. Helps facilitate the process. :)

[@tahdahloo4884]

Oumaumau Kinda, It helps you go boo boo

[@insolentish4529]

You're in a logical fallacy. Whatever you perceived to be a non-increase in energy may have been you at increased energy. Without the copy you may have been a wandering buffoon.

[@loveja1234]

Whenever i spill something: "Scattering atoms everywhere"

[@mozkitolife5437]

10:52 "Thank you very much."... "Hmm, mmm.... I'm off to do some rails.".

[@Weisior]

You would never want to sniff caffeine. Trust me XD

[@mozkitolife5437]

Now you tell me... 7 months later. I can't smell anymore.

[@Weisior]

Jason Axford Like I mean, 2c-p is so painfull, and taking a big line of clephedrone intra nasal is a "masochist trip" or like Jezus's "Cross way on Golgota" xD

[@Weisior]

Hopefully with a BIG reward after few minutes :D

[@sporknife123]

you not supposed to snort phenethylamines :p

[@punishedexistence]

I remember doing this exact extraction in college, then when done, I had about 250 mg of pure caffeine, so what do you think I did with it? Like any young college student, I railed it up and snorted it much to the amusement of my lab-mates. Of course I regretted this action about 5 seconds later, my nose felt like it was on fire, and about 15 minutes later I thought I was gonna have a heart attack. But don't ask me what I did with the eugenol I extracted out of cloves... haha!

[@MyLonewolf25]

What did you do with the eugenol?

[@rottingsun]

Dude what DID you do with the eugenol?

[@zombiesandguns1]

Tell us!

[@harrickvharrick3957]

Yea forget about caffeine, what DID you do with Eugenol???

[@iceni6409]

punishedexistence what

[@HerbertLandei]

I would really like to see Capsaicin extraction.

[@Hackanhacker]

Nurd Rage did it

[@justsomecommentchannel8602]

so did nilered

[@Lordosvk]

Or pure thc.

[@lombremic4840]

Here's my mixtape

[@kokorosenshi]

this video makes me want to be a chemist, not because caffeine was involved but how they removed the caffeine from coffee was really cool

[@mindtreat]

Did you become a chemist btw?

[@lindy6572]

MindTreat he became a drug dealer

[@TheRudian2011]

depending the drugs you can combine those 2

[@alphonsokurukuchu]

@@lindy6572 must be in prison rn

[@mattwelshman590]

7:09 "hah, kek.." 7:14 "oh.."

[@Sinberg]

+Matt Welshman KEK

[@Typisktmattan]

+Matt Welshman I guess was TOP KEK

[@BaalFridge]

+Matt Welshman rest in kek

[@bobbyb9258]

Kek died. Me too I've noticed we're not allowed to laugh at a lot of things anymore since 2011.

[@ralphdeguzman770]

it's keck

[@hikaru-live]

It is so cute seeing Sam gushing over that little necklace.

[@trycensorthis3676]

He's describing a very interesting body reaction, creating the antidote for caffeine. This effect takes place with all drugs consumed and it is not only linked to time but also to the place that you are used to take drugs. Drugs used in unknown areas will have a way stronger effect, because the body does not start the counter reactions to the drugs.

[@dielaughing73]

And it seems like that's exactly what addiction is

[@learnmyname123]

That was the most genuine and endearing change of hearts I've ever seen on youtube.

[@koshi6505]

That's some weak coffee.

[@kevindifranco3494]

Yeah I think Tim Horton's said their large Coffee had 80 mg.

[@geometricart7851]

yeah usually I drink 600 mg of coffee a day that would be like 36 cups of their coffee. I'd be peeing every 5 minutes

[@redbloodedamerican2743]

My preworkout has 400mg of caffeine per scoop

[@b.c.2281]

@@kevindifranco3494 Tim Hortons coffee isn't really all that strong. A large drip coffee from starbucks has 300-330mg of caffeine, which is kind of ridiculous when you consider that's roughly equivalent to a 4 pack of original red bull cans.

[@sanderkinney2758]

@@geometricart7851 600mg of coffee or did you mean caffeine?

[@NophexHD]

I'm only 13 but in the last few weeks I've been watching PeriodicVideos, I've learned more information on a decent portion of the periodic table than all the information I have learned in school in the last year. I've been interested in learning more about chemistry for a while and this channel has kept it very simple and very interesting as well. Thanks!

[@ryann7760]

now that you're 22, did you study chemistry in university?

[@JAzzWoods-ik4vv]

@@ryann7760 Not OP, but I started watching PV back in middle school, and I'm currently studying pharmaceutical chemistry

[@1337fraggzb00N]

Curly hair professor rocks :)

[@bobtheservant2647]

its rick harrison if you didnt know and its his pawn shop

[@1337fraggzb00N]

bob jim k

[@95ern]

He reminds me of a older Dr.Strangleove.

[@1337fraggzb00N]

Er n k

[@xxxax31xxx]

SIR curly hair professor :P

[@CellRus]

Ahhh, I remember doing the extraction and recrystallisation in my 1st year chem at uni! So nostalgic!

[@TheEddzifyz0r]

After drinking coffee for awhile, it doesn't make me hyper. It makes me rather relaxed but still a bit more 'awake'.

[@Supermanohman]

Eddzify CSGO that's what ADHD meds do too. It makes you "stimulated" but without the need to be hyper.

[@chickenmonger123]

Vic Vinegar That is exactly right. Although, I have done many times the recommended dose, 400 mg and that will leave me buzzed and fidgety, talking a mile a minute.

[@The_Gallowglass]

chickenmonger123 So in other words you're drinking 30 cups of coffee? :P

[@The_Gallowglass]

chickenmonger123 I'll go for 8 with cream plz.

[@randomvideosn0where]

+Ó Slatraigh The coffee in this experiment is weak. Typical 8oz cup of coffee has 100-200mg of caffeine in it. People complain about kids drinking energy drinks and the terrible amount of caffeine but usually energy drinks have less caffeine by volume than coffee.

[@lemaplestory]

3:15 Sodium hydroxide shouldn't deprotonate caffeine Sodium hydroxide deprotpnate tannin and extract tannin to water-layer

[@ColonelFlickage]

lemaple shut up no one cares

[@0xbaadf00d]

+Xavier Brenneman you shut up no one cares about you not caring

[@billtsirtsis7060]

Einstein once called coffee the beverage of geniuses (Jerry Einstein from Peoria).

[@imthescatguy]

i only drink cola also, fry drank 100 cups but didn't die

[@jl7986]

9:02 looks kinda like saturn lol, without the rings

[@aldionsylkaj9654]

jl7986 Not if you imagine!

[@jl7986]

***** nichilas cage ET kinda turns me on

[@aldionsylkaj9654]

jl7986 Flying elephants turn me on!

[@nehpetsaaa]

***** ur mum turns me on LEL

[@nikkitamayo9929]

It kind of look like Jupiter, for me because of the shades of orange..

[@duytdl]

Wow. 8 year old videos of this channel still blowing my mind. I liked the 3-story interlaced narrative as well.

[@magellanicraincloud]

I immensely enjoyed this video not only because I love this channel, but I am also (if I do say so myself) a rather highly trained barista. One of the things you learn early on as a speciality barista is the different parts of an espresso shot. The fourth and final part (we divide into four. some do three) is dry distillates and caffeine. All the flavour you want comes out early. Caffeine is something good baristas want to limit, since it tastes awful.

[@JohnVKaravitis]

100 mg from SIX cups of coffee? These Brits must drink EXTREMELY WATERED-DOWN coffee! Mayo Clinic website says 95 mg to 200 mg from a typical 8 oz. cup of coffee!

[@PeregrineHawthorn]

Or the methods they used had a very low percent yield. In any sort of chemical process like this, you expect to loose a small amount of the product you're looking for. It's entirely possible that they only managed to pull a very small amount of the caffeine out of the original six cups of coffee.

[@christine1902]

A better way to analyze it is via HPLC, this extraction yields too little.

[@RobertSeviour1]

lose

[@JeoshuaCollins]

How much solvent did they use? How long did they let it sit? Did they stir it or just let it sit for an hour or so? Basically, they didn't extract all the caffeine in the pot. I bet they didn't even get a fifth of it. And what they did get wasn't 100% pure, as you can tell from the coffee color in the end product (pure caffeine powder is white)

[@perasturiaadastra]

And if you believe the video he just added Ethylacetate once, normally you do it at least 3-4 times

[@Palifiox]

Strong coffee reduces the pain of jellyhead, once suffered by those who handled explosives containing nitroglycerin.

[@Eric.Morrison]

"Thank you very much" "Mm hmm. That'll be £600"

[@matts9371]

He isnt lying when he said some of your most brilliant ideas come to you in a relaxed state. I'm working on one of mine right now. I cant wait till its finished.

[@fernandomescalito5307]

Cannabis is waaaaay better for thinking and introspection.

[@chrisr9766]

This an old video but one of the more relatable to many. I'm a metallurgical technician so have never had much to do with organics other than as sample mounting materials, coatings and reagents for my assorted etching compounds. I love this channel.

[@crcaccounts]

He said 30mg of caffeine for 6 cups of coffee? That's not right. Should be closer to 600mg.

[@basmca1]

for normal coffee its 25-58 mg per 100ml.

[@crcaccounts]

Fallingout EMS I was wrong, he said 6 cups yielded 100mg, but according to your math, 6 cups is 1419ml which yields 354mg to 819mg. That's either some really weak coffee, or he lost a good chunk of the overall caffeine during the process.

[@SecularMentat]

crcaccounts I'm guessing there was some loss in the process. It didn't show what preperation they did for the ethyl acetate extraction aside from the sodium hydroxide. Seems like if they had shaken it at that point it might have pulled more to the organic solvent layer. Then again there might not have been enough of a basic shift to force that to happen as well.

[@lachlanallen341]

crcaccounts I've done a similar process to extract the caffeine for a chemistry subject, and we only got about 1/3rd of the original caffeine. I think probably the same happened here, and there was a huge loss during the process.

[@JosephCatrambone]

Variations in temperature, grind, and brewing time will also impart varying amounts of caffeine into the coffee.

[@LuiKang043]

Lol! I love how Dr. Tang changed her mind after seeing the necklace!

[@way000]

I feel like I'm listening to drug addicts explain why their drug isn't that bad.

[@sauercrowder]

That is literally what's happening, so

[@rogeradam7391]

So what

[@FishPit]

I have the molecule tattooed on my calf. Used to work nights so was and still is a huge part of my life.

[@vycanon7057]

Its not so much the coffee in discussions but the fact that people across a department are communicating in a casual setting which increases efficiency. There was an Australian study into it but i cant remember it unfortunately to cite it.

[@chasegilley1906]

the only thing I could focus on was that screen saver moving from screen to screen.

[@Noodleude]

+Chase Gilley same

[@engineerisdead1303]

What your body does is, the brain has special receptors that process a chemical that makes you tired. When the tiredness chemical enters the receptor you begin to feel tired. What caffeine does is, it's molecular structure resembles the tiredness chemical (I can't think of the name off the top of my head). So the caffeine begins going into these receptors, using them up so the tiredness chemical cannot get it. therefor reducing tiredness. But over time the body adapts and makes more of these receptors which over time makes the coffee useless. also if you stop drinking coffee after you drank coffee a lot, since you have more tiredness receptors then the tiredness chemical will have more places to go. This makes you go into a withdraw of sorts, being more tired that usual for a while until the body removes these extra receptors.

[@emilychb6621]

Adenosine is the chemical you can't remember.

[@engineerisdead1303]

@@emilychb6621 oh jeez this is an old comment

[@JuraIbis]

I would like to know more about this "caffeine-blocking product" the body creates and how it works.

[@yichern4351]

Im not entirely sure, but if I recall correctly, the brain releases a certain type of hormones that makes one tired and these hormones will attach themselves to corresponding receptors in the brain. Caffeine is able to act as a substitude for these hormones as they can attach themselves to said receptors too, blocking out the "tired" hormones. So thats why you feel more alert when you take caffiene. Eventually the body catches on to this though, so before your scheduled "coffee time", it will boost the production of these "tired" hormones, causing the body to feel very tired and craving the caffiene. Does that amswer your question?

[@mitchelljacky1617]

Do you mean adenosine?

[@nessunodorme3888]

I think it might just be extra adenosine.

[@nickjohn2051]

@@yichern4351 I thought it is related to upregulation of receptors site. I.e the brain create more receptors for caffeine to bind to. Thus minimizing the caffeine effect as the adenosine now can also bind to the receptors as the receptors number grew.

[@anaml3879]

Oh, love his hair. Currently my style while doing a chemistry class. It paint a big smile on my face. Thanks

[@edexnorth123]

*It's not the coffee helping the scientists to win a Nobel prize but the aura created by brilliant people in that room while relaxing by drinking something to stimulate you, this does not necessarily have to be a cup of coffee.*

[@michaelbeary]

8:01 Dr. Rob Stockman demonstrates his "cold finger"

[@drstrangelove09]

Wish that the caffeine powder had been collected and placed on a sheet of paper for viewing. Overall very interesting, indeed, though! Thank you!

[@GamesFromSpace]

You can buy pouches of it on ebay very cheaply. It looks like any other very fine white powder, maybe a bit heavier than icing sugar.

[@nehpetsaaa]

Joshua Pearce so it's a very fine white powder that gives the user energy and can make the consumer hyper.. so it's crack?

[@TheAnon90]

lol Crack is a hard substance that is smoked, cocaine is what you are probably referring to.

[@GamesFromSpace]

Great, now I have to do some chemistry and see if I can figure out how to make caffeine rocks.

[@Hackanhacker]

@@nehpetsaaa yeah kind of .... its a drug !!!

[@realitea.avanova]

"You usually see it on people's coffee cups..." And I was thinking our office was particularly nerdy :D

[@Thumbsupurbum]

Caffeine was developed by nature as an pesticide. Everytime you drink something with caffeine, you're drinking pesticide. ;P

[@qwerty687687]

And water is a common solvent in industrial processes. Every time you drink water, you're drinking industrial solvent.

[@nephdrummond3168]

My chemistry teacher has a trinitrotoluene molecule tattoo, because he’s the bomb, and he was talking about getting a caffeine tattoo too. Since you mentioned how you see it everywhere.

[@Bourinos02]

Caffeine is the only compound in coffee that is soluble in ethyl acetate?

[@AguaFluorida]

The yellow colour of the solvent suggests not - caffeine is a white powder. (A bit late, I know.)

[@elexs8754]

better late than never!

[@MelindaGreen]

Could someone make something like a litmus test to easily tell how much caffeine is in a drink? I'd buy that.

[@jesper10201]

Oh wow, the Kek clip just REEEEd pretty quietly after he mentioned it.

[@psycotria]

If you were watching, NaOH is needed to deprotonate the caffeine, thereby making it more soluble in organic solvents. Making dry ice is easy. CO2 is simply sprayed into a bag, or a special block forming apparatus. All of the energy required has already been expended compressing the CO2 into the tank.

[@pruttelpot1]

Who knows if it is pure? Maybe there is something else in the end product. Why not use use Nuclear Magnetic Resonance to determine the purity of the product? And was the solution shaken when the product was seperated using the separatory funnel? Sorry, I am a scientist myself, and wonder what exact steps were taken :P

[@geyza0711]

I would have snorted it to determine its purity! :D

[@666Zwerg666]

Róbert Németh ah yeah! TIGHT TIGHT TIGHT!

[@OeNoesRAWR]

Well he said he would of recrystallised it after his final step, this would of removed some impurities I believe. And based on the difference in colours from when he added the solvent to when he removed the bottom layer he had decanted properly off-screen.

[@TheEnrisoto]

Determining the melting point is quicker than NMR if you want to know if its pure or not ;)

[@kevinbyrne4538]

9:29 -- LOL !!! Well, gentlemen, now you know how to win a girl's heart (at least if she's a chemist).

[@abaundwal]

Necklaces !!

[@sicktoaster]

Outsmart your body, change the time when you take your coffee.

[@calebwieszczyk8247]

At 7:45 he meant to say raising the boiling point. Lowering the preasure makes solvents more volatile

[@vincentrobinette1507]

You're right, but he said it right. Lowering the absolute pressure lowers the boiling temperature. (boiling point) because, like you said, it makes the solvents more volatile.

[@strizlivejmetlos]

This channel is the one of the best chemistry channel's I've ever seen (besides Cooking with Walter White)

[@cougarhunter33]

Didn't even get enough caffeine to chop up a decent line.

[@NahkoWahko]

100 mg from 6 cups of coffee and im sitting here with a rockstar energy drink that contains 240mg caffeine

[@MrDannyArcher]

I drink mountain dew, pepsi, coffee and tea everyday. I drink them quite alot really. One time I stopped drinking. On day 3 I went close to insanity. Anxiety, tiredness, nausea and general not feeling good. Caffeine withdrawal sure is scary. If you want to stop, do it slowly. Sudden withdrawal is bad.

[@SoulDelSol]

MrDannyArcher prob related to your sugar intake as well

[@sidritmeaj2157]

That is such a wonderful video! In fact,every video of "Periodic table of videos" is wonderful! As a great chemistry lover I am really fascianated! Greatest respects from Albania🇦🇱

[@salvagebar]

RIP Dr. Keck - your name will live on forever

[@user-kz8zr4si3i]

" if youve never had coffee, no doubt you will feel some effects from it" Ive been drinking coffee for 10+ years and every morning ITS LIFTOFF TIME BABYYYYY

[@xXturbo86Xx]

Coffee has the opposite effect on me, i get tired and sleepy. It's chocolate that gives me a big boost.

[@bobtheservant2647]

then your buying coffie from a drug dealer no offence

[@apexmike849]

Like my mum.

[@executiveorder7146]

Chocolate has caffeine in it and most dont know that some tea or soda has lots of caffeine in it

[@Deverlaid]

KEK clips by Dr.KEK kek

[@aeriumsoft]

+Deverlaid topkek is the best topkek. u wit me m8?

[@carlthecanadianjew4606]

In the words of Jess Pinkman, Mr. Stockman, you're a goddamn artist!

[@confuded]

Thanks to Destin at SmarterEveryDay, I've subscribed to this channel. This was totally worth it...

[@TheTweakerTechnique]

Coffee makes me have to poo.

[@Jerz4lunch]

+Jesus Christ, it only happens to me when I drink old coffee though.

[@tohopes]

+Jesus Christ Maybe eating poo would make you defecate caffeine. You should do a test and upload video.

[@MrCheezeNip]

+Jesus Christ Coffee is a laxative

[@Lambda_Ovine]

+Jesus Christ It makes me pee and my pee smells terribly similar to coffee.

[@turbotortiose]

+Jesus Christ The reason why: Its a bean! Lots of people forget that.

[@ideadlift20kg83]

That's a really weak coffee if it's 17mg per cup.

[@shunkaiy]

this video makes me miss organic chemistry labs :)

[@abhinavdas3089]

"Drinking it, rather than inking it"...that was poetic

[@tundras4ever552]

I quit drinking coffee 6 years ago and have felt so much better! No more head aches and feeling tired

[@tfos993]

The fact that there was a doctor kek

[@pirobot668beta]

Couldn't you have acidified the caffeine, crystallized out of solvent, then accounted for the ion? Sulfate?

[@VICARI0S]

Greg Gallacci Okay, Armchair-Chemist.

[@pirobot668beta]

No arms on this chair!

[@subh1]

Nathan Yeung how do you know he is an armchair chemist and not a chemist by profession?

[@menkio]

Nathan Yeung look at your more recent posts... im going to assume your a poser.

[@pirobot668beta]

I thought the issue was acidifying the base to drive it out of the organic solvent, then filtering solids out, rather than the tedious evaporation of solvent, and gunk stuck in your flask. Yes, you gotta account for the acid when you weigh the final result, but you still have solvent left, quicker results and less equipment costs. Chemistry has the same pressures over cost containment as any other profession. How much cost in one way over the other? That was the conversation I was trying to have.

[@ThijsHagens]

This video gave me a craving for some good hot coffee, brb.

[@Hackanhacker]

im making one right now

[@HeavyProfessor]

During my period of heaviest caffeine use, I was taking upwards of 2500 mg per day of reagent-grade caffeine powder. Definitely one of my favorite chemicals.

[@sureshm-ir5ev]

hailing from india and seeing amazing person and learning chemistry as it is my fav subject and currently pursuing it feels lucky.

[@GueVonez]

Google says a cup of coffee has 95mg.....but you guys only got 100mg out of 6 cups!

[@wupme]

+Broseff G a cup of coffee has around 10-40mg caffeine, some up to 60mg. But not 100mg.

[@curtiswaters7415]

+Broseff G A large cup of coffee from Tim Hortons (a Canadian coffee chain) has 170mg per cup. 10-40 is not realistic.

[@Rabidum]

+Curtis Waters The rather big difference might stem from the fact that in europe the measurement of cups usually refers to teacups up to normal mugs which are around 200ml while the "cup" you refer to is around 700ml

[@MrTwisted003]

+Eure Dudheit But the cup markings on the coffee pot are international. So, my [mug] doesn't hold [2 cups] of coffee, it holds 2 [cups of coffee]. And still, 95 mg is not correct either, would be more like 10-50 mg...has a big dependence on what beans from where, that are blended to make your brand you drink. That's why coke and Mtn Dew have more than coffee. =D In-b4 my coffee shop has....espresso is different.

[@TooShortPlancks]

It's really dependent on the strength of coffee you make (i.e. more grounds, more caffeine can dissolve into the water) plus he was sort of off-handedly stating how much they had extracted. Towards the beginning, he did point out that caffeine is far, far more soluble in water than in an organic solvent, so there would be quite a lot remaining in the coffee, plus they were being quite rough and imprecise with the extraction, which can drastically effect your efficiency (easily halving or quartering the amount). That said, I would double check exactly which measurement size you got through Google - an average 'cup of coffee' is not the same as 'a cup of average coffee'.

[@bingola45]

"How much caffeine in coffee?" How much salt is in stew?

[@Spocklee]

This could go on forever

[@bingola45]

Well that was wasted. A year later, and no-one saw the joke.

[@zapfanzapfan]

Well, that put me in the mood for some coffee :-)

[@efdbjon2114]

same lol its 3 am but time for coffee now

[@CaseNumber00]

I remember watching this program that said caffeine enlightened thinkers in the 1700 and 1800s. These were the times were great amounts of tea and coffee started to being imported to Europe. Also, scholars sometimes liked to meet together to discuss their ideas and coffee cafes were great place to meet.

[@bink9113]

I think its so cool that these elements that we see play a part in everything that is. When they link up a certain way it makes such and such. But what tells them to link up in that fashion. There has to be a creator or a code atleast that tells these things to do this.

[@CLaw-tb5gg]

17mg? That's some weak coffee. A Starbucks cappuccino has about 150mg.

[@erinmayo5170]

For real. I'm an amateur chemist and I did this but with anhydrous ethanol and I recrystallized, which causes lower yields and I got ~430 mg from 5 cups.

[@TechMage299]

the editing in these videos is so perfectly times

[@yishaqdavid2029]

6 cups of coffee is like 400mg? All they got was 30mg?

[@yishaqdavid2029]

***** I dunno how I got 30mg, but they still said 100mgs at the end.

[@Ildarioon]

Yiṣḥāq David All coffees aren't the same?

[@alexeysaranchev6118]

Yiṣḥāq David "a cup" is not an actual measurement, they should've told, for example the mass of the dry coffee used, or at least the amount of teaspoons. Also the coffeine amount is probably varying depending on type of coffee, place of growth and many other conditions.

[@yishaqdavid2029]

Alexey Saranchev True, but where I live in Canada a cup is measurement. Not in a lab, but in the kitchen. I got mixed up. Anyway a cup is 250mls in Canada. That being said I am still wrong. When they said a cup of coffee I was thinking like whatever a large "star bucks coffee is". Anyway a large here has around 100mg of caffeine, but its much larger then 250ml. I Dont drink coffee so I cant tell you the exact size. You are totally right. I see my error. Now they are probably talking about those small white foam cups. Accounting for some loss of caffeine during the process and the very small foam cups, 30mgs does sound right. Thanks for making me rethink this. Nothing wrong with learning.

[@damianp7313]

+Yiṣḥāq David coffee maker beaker is 2L 8 X250ml

[@Shanman91]

If you imagine you're actually watching The Office, it makes this video 1000x's more enjoyable.

[@xgengx7530]

Ritalin is better than coffee. It doesn't have nasty withdrawals like coffee. It also provides better focus and concentrarion.

[@patriciahansenwithan]

thank goodness tequila is caffeine free.

[@vincentrobinette1507]

2 out of 3 ain't bad. The 3 most addicting drugs there are: Caffeine, alcohol, and nicotine. They're legal, because everyone in congress is addicted to one or more of them. People don't even realize they're addicted to caffeine.

[@jacobjochem]

can you smoke it?

[@astone_ua]

+Jacob Jochem nothing special happens, I tried it)

[@dilksjoel]

Why?

[@shoulders-of-giants]

smoking anything destroys the organ you breathe with so why would you if you have alternatives

[@Robostate]

Dr. Tang produces an exothermic reaction. ;)

[@aileenbos5115]

Bitter molecule (alkaloid C8H10N4O2) 4m53s 6:02 6:49 9:29 10:13 chemica S. Tang

[@proventure307]

6:55min great work, the double bond drawing in the middle of the molecule is wrong. It should not touch the ring.

[@looseele]

Caffeine: The most widely tolerated and accepted addiction in the world.

[@vincentrobinette1507]

Agreed. the three most addictive drugs in the world: Caffeine, alcohol, and nicotine. They're so addicting, they CAN'T be outlawed. Everyone in congress, is addicted to at least one or more of these drugs.

[@vincentrobinette1507]

@moo While caffeine is among the least dangerous, it's still among the most addicting. Denying someone of their "morning cup of joe" would be absolute torture. fortunately, the withdrawal symptoms are not life threatening, and caffeine takes about 2~3 weeks to clear their systems. It's a psychological, rather than physical addiction. I don't know how long it would take for a lifetime coffee drinker to loose the need. Caffeine is pointless anyway. At first, it really works, then, you continue drinking it, just to avoid the lull you experience from withdrawal. After a few months, the caffeine is just maintaining the energy levels you would have, had you never touched the stuff. Save your liver, and just avoid it all together. All the studies on the benefits of coffee are based on anti-oxidants, and NOT the caffeine. The only studies showing ANY benefit to coffee or even alcohol, are sponsored by the purveyors of the vices, not independent studies.

[@skarpengland]

Wow, this is so molecool!

[@beat461]

+lasse skarpengland HISSSSSS

[@TheArabsolga]

Get out.

[@skarpengland]

dude no

[@TheArabsolga]

***** I said get out. I can't believe you just said that. D:

[@skarpengland]

and i say, fekk off. i write whatever dry joke i want here on youtube. why are you so ...negative?

[@prwexler]

How much caffeine in coffee? NOT ENOUGH!!!

[@shoulders-of-giants]

10:54 Thank you very much Mhm (>Òvó)>

[@mikecawood]

That caffeine necklace is great.

[@gordonweiss7558]

Actually quite nice watching videos after more than 5 years.. the old youtube site at the picture where matt was holding a coffee makes me miss the old version of youtube.

[@alanfalleur6550]

I can't sleep without coffee.

[@thunderbolt997]

+Alan Falleur its usally the other way aroud haha :D

[@Olordrin]

+Alan Falleur Denotes a caffeine dependency, your body can't function correctly without it

[@alanfalleur6550]

I need help!!! ( ˘▽˘)っ♨

[@Olordrin]

Best answer: Lessen your caffeine intake severely or cut it off completely. The withdrawal symptoms are kinda awful, but don't usually last more than a day or two in my experience.

[@alanfalleur6550]

Just say no!!! (￣^￣)／ ♨