Pharmacology 4th semester important questions। With solution Notes। Shahruddin khan।

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Unit-1
General Pharmacology
Introduction to Pharmacology- Definition, historical landmarks and scope of
pharmacology, nature and source of drugs, essential drugs concept and routes of drug
administration, Agonists, antagonists (competitive and noncompetitive), spare receptors,
addiction, tolerance, dependence, tachyphylaxis, idiosyncrasy, allergy.
Pharmacokinetics- Membrane transport, absorption, distribution, metabolism and
excretion of drugs. Enzyme induction, enzyme inhibition, kinetics of elimination.
Unit-2
General Pharmacology
Pharmacodynamics- Principles and mechanisms of drug action. Receptor theories and
classification of receptors, regulation of receptors. drug receptors interactions signal
transduction mechanisms, G-protein-coupled receptors, ion channel receptor,
transmembrane enzyme linked receptors, transmembrane JAK-STAT binding receptor
and receptors that regulate transcription factors, dose response relationship, therapeutic
index, combined effects of drugs and factors modifying drug action.
Adverse drug reactions.
Drug interactions (pharmacokinetic and pharmacodynamic).
Drug discovery and clinical evaluation of new drugs -Drug discovery phase, preclinical
evaluation phase, clinical trial phase, phases of clinical trials and pharmacovigilance.
Unit-3
Pharmacology of drugs acting on peripheral nervous system
Organization and function of ANS.
Neurohumoral transmission, co-transmission and classification of neurotransmitters.
Parasympathomometic, Parasympatholytic, Sympathomimetics, sympatholytic.
Neuromuscular blocking agents and skeletal muscle relaxants (peripheral).
Local anesthetic agents.
Drugs used in myasthenia gravis and glaucoma.

[@durgendershishodia1996]

U-1 2:52 Pharmacology, Pharmokinetics, Phamacodynamics 6:30 Essential drug concept 9:33 route of administration 18:12 agonist & antagonist 19:50 term addiction,..... 25:00 mechanism and factor effecting of drug absorption 40:46 Biotransformation (51:20 phase 2) U-2 54:28 classify receptor & transduction mechanism 1:05:26 JAK-STAT 1:09:36 factor modifying drug action 1:15:24 ADR 1:18:13 Pharmacovigilance U-3 1:30:16 classify neurotransmitter 1:32:04 Parasympathomimetic drug & pharmacology of acetylcholine 1:40:11 Co-transmission 1:42:35 sympatholytic, classify & pharmacology of propranolol 1:46:45 skeletal muscle relaxants & pharmacology of tubocuraine 1:53:05 classify local anesthetic & MOA

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Sir acetylcholine to sympathetic nervous system pe work karti he But aapne parasympathetic N.S. pe bataya he me confused hu please sir reply me

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1:32:37

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Transduction Mechanism (1:01:08) Activate G - Protien by Converting GTP to GDP👉 Is wrong,,, Correct 👉 Activate G - Protien By converting GDP to GTP.

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The actual amount of drug that reaches the blood circulation.....called bioavailability

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