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"Medicine" is the second single from rapper Plies fourth studio album, Goon Affiliated. The track features singer-songwriter Keri Hilson. There are two versions, one with a more radio friendly, slow beat and one with a more club beat. The original version of the song was by Three 6 Mafia ft. Gucci Mane & Keri Hilson under the same title. The tempo is somewhat slower in that version.
The song use a sample of Ex fan des sixties by Jane Birkin and composed by french singer and songwriter Serge Gainsbourg.
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