Popular Classic (Sp13)- Medullary conc. gradient

This video has been RE-RECORDED (and I think the new version is MUCH better). However, this seems to be a popular video, so I'm not going to delete it. I do suggest you check out the entire updated playlist at • Physio 17- Filtrate Re...

[@ruqayagabier5431]

THANK YOU SO MUCH FOR THIS, I'M WRITING ON FRIDAY AND I LITERALLY JUST CRIED FOR AN HOUR BECAUSE I DIDN'T UNDERSTAND THIS AND NOW I DO, THANK YOU SO MUCH, I WISH YOU ALL THE HAPPINESS AND JOY -YOU ARE THE BEST EVER AND SO ENTHUSIASTIC, JUST THE BEST EVER THANK YOU

[@kinleyhm7326]

You are my favorite youtuber ever. EXCELLENT at explaining things. Truly one of the only people I can understand. I love how passionate you are about your subject.

[@lorafalamic]

Woman, I love you so much, nowhere in our textbook is a picture that shows these two processes at the same time! I've been jumping up and down out of pure happiness when I saw this! luv u!!!

[@701elie]

omg, your drawing is so clear, i literally never understood which way the blood was flowing in the vasa recta, i thought it was in the same direction as the urine

[@mkshn111]

one other thing though, as pointed out in some text books, is that during the ascending portion of the VESA RECTA counter exchange (with itself), it UNLOADS majority of those solutes back to the descending portion of the vesa recta. so therefore apparently there are two kinds of countercurrents going on here. 1. between vesa recta and the tububle, and 2. between the up and down portion of the vesa recta itself. this is interesting because as you said that some of the solutes need to go back to the systemic circulation, if it continues to happen eventually it will dilute out the medullary ISF. so bottom line, the LOH, and medulla, and the sourrnding vesa recta are all there to servce once purpose: keep a very high medullary ISF osmolarity, so when antidiareusis is required, ADH can properly do its job and take back water from the collecting duct. this video kinda explains my point: Vasa Recta Counter Current Exchange

[@mkshn111]

so pretty much the reason vesa recta contributes to maintaining the osmolarity of the Medullary ISF is because it is able to suck up those water reabsorbed in the descending loop. other wise, the osmolarity of the medullary ISF would be watered down. and in order to do that, it picks up some of the solutes reabsorbed in the ascending loop. thanks for making me understand!

[@lukeverbaten6428]

Legend thanks heaps for the simple explanation. said it simpler then my Uni Lecturer who took 30mins to try and explain this.

[@markulinos]

best explanation! dont even hear what they say!you saved me hours of reading!!! thank you

[@Helikopter654]

You're awesome! Keep going. Your lectures are much better than the dry written textbooks. Unfortunately, we can't do without books. C'est la vie! Best wishes! :))

[@ananyamalaviya1297]

Thank you so much ma'am. You made it a lot easier to understand for me. Keep making such videos. :)

[@fluorescentmug8333]

Clear and concise explanation, thank you.

[@rachael4775]

I’m am medial student and this literally helped me so much after struggling w renal for weeks 😭😭😭 you made it so simple

[@aniruddhasphotography]

thanks for the video... it helps me a lot...keep making such videos!!!

[@abigailb55]

Thank you so much - this is a life savior!!!

[@altbeb]

l would like to know that if the Interstitial fluid is at a higher osmolarity than the tubule, why is the water flowing from the IF into the vasta recta, that seems to have the same OsM das the IF, for water to diffuse, it will attempt to dilute the more concentrate fluid, which in this case is the IF..

[@AVW_Dr.Dr.]

I taught this the other day, and your explanation is clearer than mine. I'll be sure to revamp my lecture to make it this clear. Thanks! Most (all) textbooks fail to explain this clearly. Oh I almost forgot, many sources also list urea as a contributor to the medullary tonicity, coming from the collecting tubule. How do you feel about that?

[@wendy-riggs]

Hey Adam! Thank you for the compliment. Kidneys are tough! As for urea, I have (for several years now) wanted to clarify how it contributes to the medullary concentration gradient...and just haven't taken the time. One of the bummers about the flipped video lectures is the exhausting desire to update the videos...and the unfortunate lack of time to do so.

[@AVW_Dr.Dr.]

Do you have a clear understanding of that urea component? I always mention it but I don't know how strong its contribution is to total tonicity.

[@chanchalchauhan2265]

Mam medullary osmolarity remain same before birth??? means is it remain same BEFORE first time urination in newly born baby...

[@MyKrishanu]

How does it concentrate the urine?? when urine enters into the Dlh, osmolarity was 300, when it leaves the Alh, osmolarity is 100......Although the urine lost its water and solute, it is hypoosmolar when it leaves the Alh......

[@meteorgarden89]

makes so much more sense than school lecture!

[@emptyuserprofile1422]

Hi Wendy! What program are you using to do this? Ive been looking for something that looks exactly like this to communicate with my students online. Thanks!

[@wendy-riggs]

+Alex Payne Hey Alex-- I use Adobe Captivate. It is sort of a hack...I"m sure there are better things out there. But I recorded a video of how I record the videos...it is sort of odd, but might help? I've also messed with Screencastomatic (free)- that works too. kzbin.info/aero/PL5GRRRmaGVqWr87PN7l6MVD1TZAHuPmsd

[@oumaimabenbouzid5993]

THANK YOU SOOOOOOOOOOOOOOOOOOOO MUCH

[@chanchalchauhan2265]

Plzzz reply mam of my question

[@seniordoctor5478]

i got it thanks

[@classicjohnson1]

Try recording at a better time, 1am? lol. Sounds like you need a break.

[@Xtremelylawl]

You could do so much better without all the useless drama, very annoying

[@jessicalorenzana4867]

+Xtremelylawl Not true, kept me captivated! And it's not like the "drama" is cluttered with tangental talking. It's a pretty efficient lecture!

[@Xtremelylawl]

Well, I am speaking for my preference. What she does cannot appeal to everyone and in this case, it's me. If you enjoyed it, go ahead and support it, I'm just giving my personal feedback.

[@jol666]

Jesus...finally someone who knows how to explain this concept!!! THANK YOU

[@stuartk4426]

This is the best explanation I've found after a day of trying to work this out for my renal block exams. Thank you so much, you are an amazing teacher. I think I'm in love, I want to steal your brain.

[@ismailklnc5287]

Water is absorbed from the descending limb of Henle and water is given to the surrounding interstitium, and solute is sucked from the ascending limb and solute is given to the surrounding interstitium. In this case, is the osmolarity of the interstitium around the descending and ascending arm different? Or will their osmolarity equalize because they are so close to each other?

[@火鳥-c1t]

What a unique explanation! I’ve never understood it this way! Can you please send me the playlist of this Video? I want to reach videos that are listed in this one. Thank you❤

[@ismailklnc5287]

The descending limb of the vasa recta loses water as it moves deeper into the medulla, but gains solute when exposed to a hypertonic environment. On the contrary, as it rises again in the medulla, it changes from hypertonic to hypotonic, and the ascending limb of the vasa recta absorbs water and loses solute. In this case, if the vasa recta is giving back what it has absorbed while descending, how can it absorb the water and solutes that pass from the tubules to the interstitium?

[@oxford_phd]

Ah you make this so unbelievably easy! People you need to watch her new video on this it's even better!!

[@malihakhan1861]

thnx for the video, best video i found on youtube.

[@ottilieswinyard2761]

omg this literally cracked me up!

[@rohanghosh7820]

this was an amazing explanation, thank you!

[@MehediHasan-gy8uz]

U r really brilliant, love from Bangladesh 💕

[@beauvos04]

GOAT

[@orangecaprinun]

MY MEDICAL ADMISSIONS TEST IS IN 6 DAYS I'M DYINGGGGGG BUT THANK YOU SO MUCH FOR THESE VIDEOS!!!

[@wendy-riggs]

You can DO THIS!!! Good luck in 6 days. You've worked so hard!

[@dnined5963]

i study medicine in french but this helped alot , thank u ....and cant believe its 10 years since this video was uplaoded i was in primary school haha

[@wendy-riggs]

Wow! This is such an old video! I'm glad it helped!

[@kristiemcarthy]

I love you Wendy! I have been struggling to understand this concept, my text/lecture slides say (I'm kinda rewording a bit) "the vasa recta absorbs more water on way out than the way in, and thus it carries away water reabsorbed from the collecting duct and nephron loop" but I couldn't get my head around why, the wolf foot analogy followed by your next lecture gave me the most amazing OMG experience!

[@mcatbs9]

THANK YOU SO MUCH

[@rkdogz]

great one, you just helped me understood this concept in 10 minutes whilst i was reading the book for an hour couldn't figure out what's going where thanks!

[@victorialiere8071]

I am a current medical school student. I use your videos to supplement our classes! Thank you so much! You are amazing at explaining concepts

[@madchen.roentgen]

YOU SAVED MY LIFE !!! I LOVE YOU !!! I'VE BEEN WATCHING A LOT OF VIDEOS, BUT YOURS...

[@nomcebobiyela4609]

Thanks, Wendy! The countercurrent system ACTUALLY makes sense :-p peace! haha :) blessings!

[@enemorgan4124]

OMG this is AMAZING!!! And you're really enthusiastic about it too! Thank you.

[@nadhirahputeh884]

thank you from a med student in Malaysia! :) you're awesome and your face expression is funny! haha *peace*!

[@MsAnnalea20]

Thank you so much. My professor made this so hard. This was so easy to understand!

[@thegoodguy2054]

hi very well done. can u plz tell me what do u use to make these videos. thabk u

[@Doc_McStuffins]

beautiful explanation. thank you!

[@AngusLBuf]

Good explanation :) Are you a teacher?

[@enigmaticfool]

you're hilarious and awesome.

[@ssmielectropathy7717]

This is the best explanation I have ever seen

[@yakoubhamdi3239]

legendary explanation thank u

[@evilbadguystrikes]

where's the next video to this??

[@sameemtak]

thanks for the explanation

[@mkshn111]

serve * one* purpose*

[@gauritiwari4459]

😍✌️✌️👍👍👍👍👌

[@michigan1085]

Thanks for not deleting this lol... I come back to it once in a while. You're the best btw... you keep my adhd brain focused 💕

[@wendy-riggs]

This makes me sooooo happy! I love this. Teamwork!

[@tanhung8027]

YOU RE AWESOME

[@thesixthcourier]

Literally the best video I have seen on this topic. I read books, watched a 45 min video and you nailed it. Thank you!

[@wendy-riggs]

Wow, thank you! I'm sooooo glad!

[@mahuubao]

well done go on