Potential role of cardiolipin nanoparticles in improving upper motor neuron health in ALS.

Mukesh Guatam, PhD, is a research assistant professor in the Northwestern University Feinberg School of Medicine Department of Neurology. He received his MS from Barkatullah University in Bhopal, India in Bioscience with specialization in Biotechnology; and his PhD from University of Delhi, India, Department of Zoology. Dr. Gautam's research is focused on understanding underlying mechanisms that contribute to vulnerability of motor neurons in the context ALS. He is particularly interested in exosomes-mediated cellular communication, epigenetic regulation of gene expression, and identification of targets for therapy development. Dr. Gautam uses in vivo and in vitro model systems, immuno-coupled electron microscopy (iEM), correlative light electron microscopy (CLEM), extracellular vesicles, and next-generation sequencing approaches to answer his research questions.
Talk Description: Dr. Guatam will discuss nanoparticle mediated improvement of mitochondria structure as a potential treatment strategy for ALS.