Primary myelofibrosis

[@stanleykim1924]

At 22:40, I wrongly described that grape juice is a strong CYP3A4 inhibitor. It is grapefruit juice, not grape juice.

[@jtdemers75]

This is so helpful -- thank you!

[@stanleykim1924]

So glad!

[@JohnMcSmith-b9t]

Should I even worry about Intermediate PMF if I have stage IIIa CRLM?🤔

[@stanleykim1924]

New drug approval: Momelotinib On September 15, 2023, the FDA approved momelotinib for the treatment of patients with intermediate- or high-risk myelofibrosis, including primary or secondary myelofibrosis, and disease-related anemia.Findings from the phase 3 MOMENTUM trial (NCT04173494), as well as data from a subpopulation of adult patients with anemia from the phase 3 SIMPLIFY-1 trial (NCT01969838), supported the regulatory decision. Twenty-five percent of patients with symptomatic and anemic myelofibrosis who were previously exposed to a JAK inhibitor experienced at least a 50% reduction in tumor symptom score (TSS) with momelotinib vs 9% of patients treated with danazol, which translated to a treatment difference of 16% (95% CI, 6%-26%; P < .01). Additionally, 30% of patients in the momelotinib arm achieved transfusion independence (TI) vs 20% of those in the danazol arm, which translated to a noninferiority treatment difference of 14% (95% CI, 2%-25%; P = .023). Spleen volume reduction and a decrease in anemia-related symptoms were also observed with momelotinib.

[@leessssa]

What is the probability that anisocytosis, poikilocytosis and teardrop cells in the blood is myelofibrosis

[@stanleykim1924]

Frequent

[@stanleykim1924]

New 5th edition of WHO classification was published. No major changes in PMF. www.nature.com/articles/s41375-022-01613-1#Tab8