Pro-clotting Mechanisms - Thromboxane A2, Endothelin - Coagulation - Hematology

[@MedicosisPerfectionalis]

What are you waiting for?!!... My 50 hematology *cases* (vignettes) are waiting for you...board-style questions...www.patreon.com/medicosis/

[@adrianpop4427]

Hi, love your vids, especially those in the coagulation playlist, but I would like to add a couple of things. First von Wilebrand factor is also produced in the megakaryocytes, that's why you find it in platelets as well ( makes things clearer for people who wonder how does it get in the platelet in the first place ). Secondly after many hours of searching in articles and books I couldn't find any mention that factor VIII cannot be activated without the vWF. High clearance of factor VIII is responsible for its lower activity in vWD. Also only in type 3 vWD there is a complete lack of vWF ( which are less than 5% percent of cases ), so it would be more accurate to say " lower levels or modified activity of vWF" rather than " you don't have the vWF". Hope that you can tell me where you read about factor VIII not being able to be activated without vWF, that would make all that searching worth while. Cheeers!!

[@MedicosisPerfectionalis]

Adrian Pop I think I should look it up

[@eugeniebreida]

@@MedicosisPerfectionalis Did you look this up yet, my very fav online Prof??

[@KFSBonder]

​@@MedicosisPerfectionaliswaiting for the answer, my Prof. Please. Thanks 😊

[@kckckrc]

Great video with great information!

[@MedicosisPerfectionalis]

Thanks 😎

[@shumailairshad8775]

You are simply amazing 😍

[@MedicosisPerfectionalis]

Thank you so much!

[@randomps3gamerx]

Isn't VWF also made in megakaryocytes?

[@deepikayadav2363]

Why effect of aspirin last for 48 hrs if it inhibits platelets irreversibly and life of plt is 8 to 12 days?

[@MedicosisPerfectionalis]

Because the bone marrow doesn’t wait for 8 to 12 days until all platelets die and then decide to produce new ones...It’s a 24/7 process...After 48 hours, you have a sufficient number of new platelets that are capable of primary hemostasis...Excellent question by the way!

[@deepikayadav2363]

@@MedicosisPerfectionalis thanks a lot...u are awesome...but I m still confused...why do we stop aspirin 5 to 7 days before any surgery if 48 hrs is all it takes to wear off it's effect...

[@MedicosisPerfectionalis]

Because you will have more platelets if you wait more, which makes the surgery safer. Please watch my video on thrombocytopenia where I discuss the difference between a platelet count of 150,000 , 90,0000, 50,000 , 20,000, etc...It will start to make more sense then.

[@deepikayadav2363]

@@MedicosisPerfectionalis ok thanks a lot...please make more rheumatology videos...sincere request🙏

[@MedicosisPerfectionalis]

I will...Thank you, dear!

[@paulhetherington3854]

PRO-- Powered memories, of optics? Swedish--- THROM- Thrice recon, this is! movements of! Royal islanders. "Don't have a, Thrombone!" Austin Powers

[@M.e.d.c.i.n.e]

I LOOOOOOOVE IT❤