Professional antigen presenting cells (APC) and MHC II complexes | NCLEX-RN | Khan Academy

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are you a pharmacist now?!?

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Story of my life

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i wish all the videos were numbered its so annoying when i miss a part .

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They do have a website and they are in order. www.khanacademy.org/science/health-and-medicine/human-anatomy-and-physiology/introduction-to-immunology/v/professional-antigen-presenting-cells-apc-and-mhc-ii-complexes

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Jason Newport hey tankx a lot ;) its million times easier now

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Thank you very much indeed. I have tried many video presentations all with no exception are too long, too detailed and so confusing. Yours are pleasant, full of good humor and give a sound background for further deepening in one subject or another. These beautiful video are no less than true masterpiece!

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After watching your video you made the reading in my text more clear. Thank you.

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Absolutely outstanding. This should be a must for every medical student, resident, fellow and faculty.

[@fleshcookie]

Sal slays me. "Professional, so this is what they do for a living!" lol

[@krmanjahmad659]

یەکێک لە هەرە باشترین ڤیدیۆ ڕونکراوەکانی بایۆلۆجی بەڕاستی لە وانە وتنەوەکەت تێئەگەم one of the best explanation vedios of biology i really get understood of your lecturing

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it is been 7 years i'm watching your videos and now i'm in Pharmacy school and still watching your videos . thank you so much you help me a lot.

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Dude.. You just taught me a whole semester in One day.. Much obliged

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Sal you're the greatest, you know this already. Your videos got me thru chemistry, A&P, and microbiology. (:

[@ryanasgalbraith7824]

My exam is tomorrow, and thanks to this video I finally fucking understand MHCs. Why couldn't I have discovered this channel sooner?!

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Your biology videos make me understand much more than my textbook. Thank you.

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Khan academy's lessons R perfect for students all ages

[@TheNeverborn]

@pyromanizak The short answer is yes. Each B cell gets a unique antibody during it's growth, but you have so many B cells that eventually the viruses run into one with antibodies that work. That B cell begins dividing, but its daughter cells have a high rate of mutation for the antibody tips. Since they're all in competition with each other for antigen, the ones that bind better keep reproducing, and the ones that bind worse die. So eventually you get a very good antibody for the antigen.

[@海草猫]

"Hey, you're a bacteria, I don't know what kind you are, I'm just gonna eat you up, you look shady, I don't know what type you are or if I've seen you before."

[@EckosamaGhostTsushima]

I know, I was like, man I wish he did other stuff (that I learn for my major) besides chemistry. Then I saw this, and I was like, goodie!, I'm taking immunology right now.

[@paaojipop]

thank you so much !!! you made me more understand about MHCs. i will watch others video of yours. :)

[@youtubec8563]

Up to 4:15, it's review from previous video the nonspecific response.

[@youtubec8563]

Up to 7:35 it's a review from the B cell video

[@youtubec8563]

Watch up to 0:05 review of B cell, but more importantly compare the similarity of B cell and MHCs (they both present pathogen's on the membrane)

[@tenzinlhakyi6610]

always saves me. Thanx for this wonderful tutorial.

[@TheCakeWizardGuy]

Downloading Knowledge - download complete. Thanks for these videos, makes everything a lot more clearer than any book could try to do! :)

[@sabrinagunawan6170]

So basically both phagocytes (macrophages, etc) and most of the B-cells don't know whether the antigen is the enemy - they just combine, cut up and present the antigen, with the difference between them being that phagocytes can engulf any cells while B-cells can only engulf one specific type of cell? And then that's where the T-cells come in, so that they can recognize and then stimulate? I'm sorry, Biology's not really my forte, so I'd be grateful if anyone can clarify on this :)

[@jamesrichard1140]

Does this mean a Bcell is phagocyte if it actually engulfs the antigen and presents it on its surface?

[@sabrinagunawan6170]

james fancourt No, a B-cell is not a phagocyte even if it engulfs the antigen and presents it. The habit of presenting the antigen is just something that the two of them have in common. Their reactions are different: phagocytes will do the 'destroying' of the foreign pathogens, while B-cells will develop and produce a lot of antibodies which will guide the phagocytes and let them know which cell is the enemy, so that the phagocytes can engulf them. The part where they present the antigen is only a common thing, and that is basically to stimulate the T-cells. (T-cells, as the guy in the video said, will decide whether it's dangerous or not, and will then 'sound the alarm'. It is, basically, the immune system's alarm) :)

[@jamesrichard1140]

constellations of books wow thanks a lot! Really helped

[@sabrinagunawan6170]

james fancourt oh hey, thats awesome, you're welcome :D

[@jeffjohn3870]

thank you

[@elkozako12]

I am in nursing school. God Bless you for these videos. My book is like foreign language. Finals in 2 days.

[@solianalovesfrogs8357]

you are amazing! thanks for the great, fun and easy to understand explanation

[@chamich24]

Thank you so much for all of your videos. The illustrations really help!

[@Grimething]

You look shady :,D gets me everytime

[@ohyeabananas]

This is so much more exciting and entertaining than my AP Bio class... thanks, its good review!

[@markfalina9160]

Sal, don't you think it's kind of important to go into a little bit of how the macrophage knows the item it "eats" is unwanted? Maybe a macrophage bumps into a red blood cell. How does it know not to "eat" it?

[@elysegarrison]

thank you so much for your videos. They have been a god-send

[@Destroyer9623]

Macrophages have invariable receptors and cannot recognize all pathogens, they can only recognize a small subset of similar pathogens.

[@theWellSeasonedWoman]

are there amateur antigen presenting cells? sorry, couldn't resist...

[@Reglage]

theWellSeasonedWoman T cells can present, when activated, antigens on their cell surface (has been shown in literature). These T cells however are not as able to stimulate other T cells and to process antigens in the efficient manner as the 'professional' APCs can and do. This is also the case for for example fibroblasts and endocytes. When these types of cell gets activated by cytokines (mainly IFNg), they acquire the ability to present ligands.

[@theWellSeasonedWoman]

CubicRegje you may be accurate, but no fun at all!

[@KinesioNeuroHealth]

thanks for helping me study for neuro/chem/immunology

[@Nicker000]

thanks, good reference brush-up in time of need.

[@meeker1021]

thank you so much for your help. my teacher could not get through to me...why? thick accent...yours: perfect!

[@OxAxS]

Beautiful clear explanation. Will use the info I get from this for our group PBL tomorrow.

[@nazlimcfian]

i feel so lucky to find this video ! who would have known! a video shared 9 years ago would save immunology grades of a dental student >.< ahaha thank you so much sir.

[@HollowZee]

I love this stuff! And YOU, my intelligent one, are AMAZING. Thanks for all your hard work and please continue.

[@thegreatMSG]

Thank you so much!

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Thanku sir. U r great

[@manalabushadi8050]

Thank you so much ✨

[@cristianerazovilla5770]

You need to keep doing more videos please! you're awesome !!!

[@marianoh44]

awesome video, clears up pretty much all my questions, now on to the next video

[@fang2111]

Hi! Could u do a video on priming of T and B cells, or cross-presentation by Dendritic cells?

[@ichigo9919]

So Dendritics, macrophages ect. are like the Dexter of the cell world

[@mahadshakil5356]

I understood that reference :3

[@margotgabrielefalcone6106]

really clear indeed! u are my idol!

[@aspirezakura]

So, soooo good. Thanks for helping my fellow slacker medics and I.

[@AussieStormbuddy]

Yay for APC's!

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Thank you thank you so much sir .. you are the BEST

[@sharedivinelove]

Thanks again. U r awesome. God bless U!

[@therealmunkyhaus]

BRILLIANT ! thank you

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Thank you for this video! It's beneficial!

[@rachrachel1]

can you teach my teacher for immunobiology how to explain so good these stuff?? thank you so much great help!

[@cwaddle]

Amazing video. Having 0 Dislike is a testament to your video

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This is what they do for a living :D awesome man,,,..... i am still smiling :)

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u r the reason why i'll be meeting the president for getting the highest marks in my Baccalaureat exam:)

[@sadafshefa2285]

What I don’t like about khanacademy videos is that they simplify the concept way too much that it gets confusing. I’d really appreciate it if they used more scientific words or would not talk too much around the topic.

[@pajeshjp9087]

Very clear

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You are brilliant. Thankyou for helpin us

[@taiyesamuel5618]

Thank u khan academy

[@shreygarg3755]

thank u

[@emynoack7344]

Wonderful explanation. Thank you.

[@ivancharm]

OMG....you are the GOD man !

[@mikecastro4403]

Wow 8 years ago

[@kamstergtohello]

Very very helpful!!!!

[@luv4pupies]

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[@tranle92]

best explanation!!!!!

[@zigzagline1]

Thank you for posting this video.. Excellent

[@abdisalamelmi5075]

Thanks much more.

[@imegatrone]

Nice Video That You Share , So Very Nice Thanks You How professional antigen presenting cells present parts of engulfed pathogens on MHC II complexes

[@pinoycharms5077]

Why is it in slow motion?..please fix it..it really helps me a lot

[@geepeeone]

@akored23 The antigen-immunoglobulin complex has to be endocytosed first then presented along with the MHCII complex has to happen first so that the T-helper cells with the same immunogenic specificity are able to bind with the said B-cells, which results in B-cells' activation, then monoclonal proliferation with some turning into Plasma cells, while others into Memory cells,.

[@brittanyjacobson5199]

very nice, thanks so much

[@sofiaarias13]

thank you!! NICE

[@hostagelai]

AWESOME!!

[@BikRunGirl81]

wait, does b stand for bursa? lol... love your videos they are a lifesaver!

[@Mightymumble]

You are amazing!

[@rukado]

You really can make this stop looking like chinese to me. I dont know how you can draw so well with your mouse. Thank you very much!

[@sesamesprite986]

+rukado i think he uses a drawing pad

[@NoName-qt4tt]

When APC presents antigen on MHC CLASS 2 then after production of antibodies what will happen with antigens on MHC?

[@taiyesamuel5618]

Still here in 2022 🙏🏻🙏🏻❤

[@ThiaguKannan]

You know what's funny. I am 10 years old and i am watching this while most of ya'll are watching this for their medical things and all y'all are mature adults.

[@hadiloo1]

I LuuuV youuuu !!! thankssssssssssssss

[@Beautylicionista]

Hey it's actually "TI", major histocompatibility complexes!!!

[@rachelj59]

I thought it was only macrophages and neutrophils that were phagocytic. Does this mean that dendritic cells and B cells are phagocytic too? Thanks :)

[@slaydrian3024]

+Rachel J macrophages, neutrophils, and dendritic cells (all phagocytes) perform phagocytosis, B cells are immune cells that pretty much identifies them for the phagocytes to engulf!

[@kanchanshinde6887]

your voice is like mr.bean in hindi series !

[@migwke1]

Im a little confused as to what happens after the macrophage presents the polypeptide on the MHC II complex. Who is it presenting it to?

[@rico1660]

so APC's and MHC II are both still apart of the innate nonspecific response?

[@yerinpark1610]

yes

[@2rki1]

Is dendritic and macrophages consider professional APC’s then??

[@LovelyMetalAmanda]

@vrwhitlockable the B cells were non specific.

[@nima4719]

Little bit of original pathogen on APC??

[@fredd298]

are these DNA shufflings random? Meaning if a few people happened to have a immunity to a new virus it is a stroke of luck that their b-cells happened to have made the correct antibody?

[@ossmbc]

is the adaptive immune system in human body only ?? or in mammals and animal kingdom as well ?

[@NK32202]

Does he explain NK cells in any of the videos?

[@Mai-rammah97]

so wait, both the phagocytes and the B-cells are considered professional antigen presenting cells?

[@kpdg027]

Yes. Also macrophages

[@zero1610]

But the macrophages are not "professional" they're only "antigen presenting cells", the description "professional" only applies to dendritic cells.

[@dhevannrajramalingam4163]

Will the plasma and the memory cells have the MHC type 2 as well ?

[@moemad001]

Dhevannraj Ramalingam No. All nucleated cells and Platelets have MHC class 1. Only APCs have MHC class 2

[@banannarama27]

Ha! 293 likes and no dislikes. That's fantastic.

[@bushrax9]

i was wondering what program was used in this explanation ?

[@delyankyupribashiev6381]

you are life

[@hooiyuanteng]

I like your videos... ^^

[@arendmes]

MHC = HLA in human