Turning aspirin into a insane weight loss drug

[@inferior2884]

we presenting to the emergency room with this one

[@LBODryPowder]

@chubbyemu video coming when?

[@ashkan_1339]

JC presenting to the er with abdominal pain

[@mortezashafei-ss1lk]

‏‪0:53‬‏

[@Calliber50]

Explosive you say? Do I hear a 4th of July special coming up??? Tchaikovsky 1812 Overture starts playing!

[@MadScientist267]

The real reason for posting with the new TOS requirements in mind? 🤣

[@maui3947]

You like classical music too?

[@LostInAutism]

Are you and Chemdelic trying to see which one gets a visit from the government first?

[@thezikaz]

Damn my generation cant even get ephedrine in crystal light anymore... The 30s must have been wild walking around as your own geo-thermal reactor.

[@aryanprivilege9651]

Practically showing you…

[@EddieTheH]

Hypromellose is hydroxypropyl methylcellulose, so yeah, just a binder.

[@thezikaz]

I looked up HPMC, does being "inert" mean that it couldnt possibly react with whatever medication its in?

[@EddieTheH]

@@thezikaz Yeah, pretty much.

[@HomemadePyroQuebec]

your FBI and DEA agents are having a zoom call right now

[@Wavy_Gravy]

They hate each other. Feds are like hot chicks, they just don't get along.

[@FirstLast-qp9on]

Hey, mom? Can we go sweat at the beach? No, Kyle. We have beach-level sweating at home.

[@johnathancorgan3994]

Typically nitration of phenol results in a mixture of 2- and 4-nitrophenol and your target 2,4-dinitrophenol, the exact proportions depending on the reaction temperature and nitration mixture. This is a good opportunity to characterize your product not only by melting point but with some form of spectroscopy.

[@johangrundlingh3729]

You're right, direct nitration of phenol will result in a mixture of 2,4 and 2,6-dinitrophenol. If you're after the 2,4 isomer it's probably better to first make 4-nitrosophenol and then go from there.

[@NinjaChemistChannel]

Base - acid purification + recristallization. Should be pretty pure. 5 years ago I made pure dinitrophenol (95% by NMR) by nitration of phenol in dioxane by 65 % HNO3 very clean and simple reaction. Purification is not required.

[@johnathancorgan3994]

@@johangrundlingh3729 Even better is to nitrate chlorobenzene (which is much cleaner) then convert the chloro group to the alcohol. Coincidentally this is the path that Chemdelic just published a few hours after this one. Of course this isn't starting from aspirin tablets, the point of this video.

[@johangrundlingh3729]

@@NinjaChemistChannel now that nitration in dioxane sounds very interesting! Can you tell me more?

[@NinjaChemistChannel]

@@johangrundlingh3729 i found this article in Reaxys, I dont have an access to this search engine now but i can raise my old lab notes, wait 1-2 days. As far as i remember there was nothing special, just add dropwise HNO3 and heat it for few hours. Pour reaction mix in water and filter the product. I'll write more details when i found my notes.

[@andan2293]

Maybe you should also mention it's hepatotoxic (damaging liver), that's why it was banned in the first place AFAIK. If not for this, it would be safe to use, with right precautions.

[@rjwaters3]

also vision loss (cataracts), hearing loss, cancer, birth defects, issues with white blood cell counts, and bone marrow, and a bunch of other things

[@kelseycochrane3103]

I remember reading a horror story on blue light about some poor idiot that nearly died taking this as a weight loss supp. Fully knew the risks and everything. Wish I could find it again…

[@ve2vfd]

25 years ago I was a roided up powerlifter gym rat and a few of my fellow rats on the bodybuilding side used DNP during their cutting cycles. They would melt away fat fast, but would overheat SO badly it was crazy dangerous. We're talking being constantly soaked in sweat, waking up to a soaked mattress, just insanity. I never touched the stuff, I was happy with my Fred Flintstone shape. :)

[@Steevo69]

No roids but some ephedra and hydroxycut with so much coffee. My piss smelled like coffee and fresh cut grass and ammonia. Cut all carbs and stair climber at the gym and elliptical at home at max level 180-200BPM for 45 minutes a round…

[@monad_tcp]

2:59 everything has corn, maybe that's why people need weight loss drug, even the weight loss drug might have corn

[@MrAnthonyx2]

Some pointers: -Why evaporate the original solution of IPA and not just crystallise the aspirin from it (I understand it was 91% IPA but a little extra degradation would have been worth the risk). -Could have easily also purified the salicylic acid by doing a solvent extraction (leaving water soluble impurities in the Aq layer) than easily re extracting into a basic water solution (removing organic impurities) and re precipitating via acidification of the aq solution. - As a safety tip you should have quenched the nitrating mixture with base before distilling off the ethanol (the base was eventually still added for purification)

[@AK47_718]

I know absolutely nothing about chemistry. I could tell you know what you’re talking about. I have a Cashapp or Zelle payment for you if you can teach me how to make my own 2 4 Dinitrophenol. Step by step.

[@AK47_718]

I really didn’t learn much from this video. I don’t even know what the glass items he used are called or where I can get them lol

[@nasonguy]

Oh yeah? Well I can turn a common decongestant into a REEEAALLLYYY good weight loss drug. No side effects I promise.

[@guerrillaradio9953]

You mean I won't try to cut an acre of grass with scissors and a ruler to make sure it's all exactly the same length??!?! 😳

[@jakebaldwin1308]

​@@guerrillaradio9953 don't fret, if they were really good they'd know how to pull the calcium off of the cold packs used (which they can't use any longer) and even more they'd be able to use ephedra nevadenisis to bypass the need for raising alarm bells with the cough meds.... But what do I know right?! It isn't that difficult to purchase lithium in quantity from the interweb but they just love giving energizer their money for some reason. #SUPPORTCHEMISTRY

[@MrBen-sn8ys]

You deserve more, i love your chem videos :)

[@beck4218]

I've got a doc in biochem from UTA. DNP is brutal but you can inhibit the uncoupling in an OD with oral ubiquinol or -one.

[@Pootycat8359]

No need to remove glycols---they nitrate very nicely. Nitric esters of polyyhydric alcohols never fail to please! 😄

[@takeohtyme]

This guy is every highschool Advanced Chemistry teachers dream student, but the only dreams they have are nightmares.

[@heathwilliams1489]

wintertime survival drug, cant freeze if your burning up

[@Sauce787]

It causes hypothermia, you would just expedite the process of freezing to death

[@Kyle-gw6qp]

​@@Sauce787 No, it causes hypERthermia

[@levansegnaro4637]

​@@Sauce787it causes hyperthermia not hypothermia. There are still a few mountain rescue places that will give dnp to people suffering from hypothermia to warm them up faster. Do some research before commenting bud.

[@SMGA14]

The Russians actually used it in ww2 to not freeze believe it or not

[@roobs4245]

@@Sauce787 As someone who actually used the stuff: Assuming enough calories can be freed up, you'd definitely NOT go hypothermic. DNP, even at a modest 400 mg/d dose, means sleeping naked with the windows open in winter. Even just walking around in a t shirt in freezing weather will cause one to overheat even more. Crazy stuff, crazy effective, crazy terrible side effects.

[@herrbrahms]

Unpopular opinion: leaded paint shouldn't have been banned for indoor use, just regulated. The pigments would never fade as the compounds were simple and stable. Paint chips are only a serious problem in locations where the paint is subject to wear and tear from weather, sunlight, etc. -- places like wooden windows. Elsewhere it is much stabler than what replaced it.

[@bcubed72]

It should have been banned for indoor use, but okay for outdoor.

[@MrDrDeaGood]

I have to say I totally appreciate your honesty with how time consuming chemistry can unexpectedly be throughout this process 😅

[@rylanpeepee]

3:55 every pharmacist worst nightmare

[@Francois_Dupont]

what?

[@aryanprivilege9651]

Yeah, counting mistakes

[@mexoc]

So nice to see someone having so much trouble with basic stuff and not get frustrated by it

[@atashgallagher5139]

This is what they mean when they say a pre-workout has explosive fat burning power.

[@h7qvi]

Just think of the poor dishwasher 😅

[@sugarcan1110]

Carefull now mr chemist

[@panjobasbaraparimo9256]

It is also used as a dye and its absolutely horrible to get off any surface. Effects were discoverd by accident during ww1 when factory workers were exposed to the compounds during munition manufacturing.

[@Pootycat8359]

9:21 Use "boiling stones"! If you don't want to buy them, crushed glass works just as well,

[@herrbrahms]

Honestly, it doesn't sound like a bad idea to take a little of this and head out for a relaxing day of ice fishing in Minnesota. Hyperthermia? Hold my beer.....literally.

[@RomanBekker2022]

very nice video and cool multi-step synth with all the failures and mishaps being openly discussed RESPECT!

[@jakobpfeil4243]

Hypromellose is a binder found also in vegetarian meat and paste for sticking materials like paper. It can cause chronic digestive diseases.

[@juliusbernotas]

Reminds me of that beefcake south park episode. Disclaimer: causes irreversible damage to your kidneys and liver

[@EddieTheH]

One day you'll get the hang of filtrate vs filter! Lol!

[@metaprotium]

you should make metal salicylates (copper, cobalt, iron, etc.). if the ferric salicylate was that beautiful purple color, maybe other metals would make for nice colors

[@panjobasbaraparimo9256]

Bodybuilders use it, its commonly found in samples taken from sewage water during contests as it is a very good cutting agent. Unfortunately it will boil you alive. Maybe good in extreme cold conditions to prevent hypothermia.

[@charleschidsey2831]

Its weight loss properties were discovered during WWI when workers in plants producing explosives for the war effort were found to be losing weight despite eating normally. This anomaly was eventually traced back to 2,4 DNP. As you and other commenters have noted, its numerous toxicities precluded its use as a weight loss drug. Now, 100+ years later we have the GLP-1 inhibitors.

[@Paksusuoli95]

If you use too much solvent for the recrystallisation, you can just let it evaporate over night. Slow evaporation of solvent is also a popular technique to grow crystals (source: currently doing a doctoral degree in chemistry).

[@foxyfoxington2651]

Seems like this might cause spontaneous human combustion…

[@ClarkPotter]

My favorite episode is his MDMA one. It's easier than you think!

[@maddmarkk1]

As a bodybuilder with an interest in chemistry, thank you

[@Nonya704]

NO

[@spiderdude2099]

Did you miss the part where it’s BAD for you?

[@soulreaper359]

This way u produce harmful side products there’s more to it :D

[@catboy_official]

Please be careful 😢

[@TheFiremanEd]

interest? This gentleman has obviously had some college/university and a lot of lab time. No, to the power of infinity?

[@youtubeaccount931]

you could exercise but why not just eat explosives lmao

[@atashgallagher5139]

This is what they mean when they say a pre-workout has explosive fat burning power.

[@MyName-yx7rh]

So people in bomb factories were exposed to DNP and lossed weight. How where they exposed to it? Contact with hands or breathing it?

[@e3498-v7l]

Skin contact is enough, there are documented cases of workers ODing through skin contact.

[@KA54the]

so many fuckin benzene based molecules. too many fuckin benzene base molecules.

[@alex-mzlzl]

DNP could be reacted with oxalyl chloride to make dinitrophenol oxalate (DNPO) which is a replacement for TCPO chemiluminescent chemical if you don't want to make 2,4,6-trichlorophenol

[@seananon4893]

Ah, yes! Dinitrophenol oxalate is indeed a viable alternative to 2,4,6-trichlorophenol in chemiluminescent reactions. The reaction with oxalyl chloride is quite straightforward. Here's a quick outline of the process: Begin by carefully preparing a solution of Dinitrophenol (DNP) in an appropriate solvent, such as ethanol or acetone. Make sure you're wearing protective gear, as DNP can be quite reactive and potentially hazardous. Slowly add the oxalyl chloride to the DNP solution while stirring continuously. The reaction may be exothermic, so it's important to keep an eye on the temperature. As the reaction progresses, you'll notice the formation of a white precipitate. This is the dinitrophenol oxalate, or DNPO. Once the reaction is complete, filter the mixture to separate the DNPO from any unreacted materials. Wash the DNPO with cold solvent to remove any residual reagents, and then allow it to dry completely.

[@Correct_Opinion]

​@@seananon4893they're not even trying to make the bots not obvious

[@ChemicalEuphoria]

@@Correct_Opinion chat GPT ahh comment

[@madmax2069]

​@@Correct_Opinion who are you calling a bot, and what makes you think they are?

[@Correct_Opinion]

@@madmax2069 you're a bot if you can't tell who and why

[@kellyshea92]

I remember hearing body builders talking about and using this chem. They said it would literally make them sweat through their mattress while they slept.

[@jiritichy6855]

@7:10 Isn't aspirin made of Salicilic acid. it is normally sold as a liquid in various concentrations. Of course if it evaporates, what is left is pure white crusty material. So I a wondering, if it would not be easier to buy the Salicilic acid rather then waste time with manufacturing it from Aspirin.

[@ClarkPotter]

Bro, you're awesome.

[@applejuice_box8544]

4:00 euphoria asmr

[@eliaskerlin5465]

Man where'd you get nitric acid?

[@uoli7770]

I think it might be possible to skip the decarboxylation. I've made some picric acid (2,4,6 trinitrophenol) and I just sulfonated the salicylic acid and then nitrated it. It might be possible to just nitrate the sulfosalicylic acid at lower temps for the 2,4 DNP, I'm not sure tho.

[@MadScientist267]

It would seem in the end it took itself... it would appear to work very well indeed.

[@hansharz8321]

Probably some mono nitrates in that product. They are also yellow. There is a Russian paper which mentions nitration of pehnol in alcoholic medium. "New highly selective method is suggested for synthesis of 2,4-dinitrophenol by nitration of phenol with nitric acid in an aqueous-alcoholic medium at the boiling point of the reaction mixture. The yield of 2,4-dinitrophenol is as high as 80%." EDIT: you used C2H5OH as medium.

[@-r-495]

people with skin conditions can get straight pharmEur salicylic acid for preparing a washing lotion. well done, I enjoy watching your vids.

[@technoman9000]

This is literally a poison

[@mwilson14]

I have a ton of Aspirin saved for some chemistry some day. I was gonna make phenol with it and most likely still will eventually. I just have to be careful because I am allergic to Aspirin along with many other medications and just about all pollen. FML.

[@rey3472]

DNP was used as a herbicide.

[@themonkeyspaw7359]

Asmr sounds were very satisfying

[@henrikg7661]

Can you make ephedrine hcl?

[@NotSure416]

4:00 "I just want to eat them" me too buddy. me too.

[@MyName-yx7rh]

When you did the research for this video what was the minimal dosage to see any effect from DNP?

[@TrentonTompkins]

Awesome video!

[@bugabateinc971]

Your synthesis seem to go similar to mine. Always unexpected issues . Practice makes you better. Lucky your 24/40 stopper didn't break. I think its better to hydrate your NaOH on clean up

[@alish5417]

Thats aspiring

[@meatharbor]

13:07 ✨ *TAR* ✨

[@joeldichter1320]

17:00 love the story

[@Wavy_Gravy]

That's rhabdo piss, lol. 17:04 It won't kill you, so long as you don't exert yourself on it. So, don't take a shit, or you'll end up like Elvis.

[@fireworkstarter]

next time you could use the same solvent you are already filtering to warm up the filter. just heat up a seperate beaker of ipa

[@DonnyHooterHoot]

You created the piss of a dehydrated 13 year old?! Congratulations!! Cool viddy!

[@Francois_Dupont]

wtf, pedophile detected.

[@atashgallagher5139]

What I dont get is why not just dose this at like half or a quarter of normal, or take it only every other day. It would make it a lot safer rather than only ever dosing it at like 90% of a fatal dose so that one slipup or one slightly more heavily dosed capsule is fatal.

[@snoowbrigade]

You and Chemdelic made the same compound!

[@SuLokify]

Metabolic toxins are the worst.

[@kouros0]

I thought DNP was banned, I had heard horror story in the past, someone took too the highest dose and mf got heart palputations while in the bathroom and thought he was going to died, also I think you can make this compound to be explosive, someone on youtube has done it I'm sure

[@justinbanks2380]

4:03 I mean... Technically you can eat them. They are even designed to be. Just not that many, lol

[@larry_ellison]

And if it was outlawed in the 30s.... You know its good

[@anthonyplayground1402]

They ban things is they work too well too ... especially if its cheap

[@MyName-yx7rh]

What was the dosage for humans before they banned DNP?

[@joenemeth9606]

For science.....

[@RiehlScience]

5:40 Wow, who could have possibly forseen that happening?

[@nico3534]

does bro live next to an airstrip

[@atashgallagher5139]

No fat rats around to test very very very small quantities on?

[@DruggiePlays]

I love the purple stuff💜

[@republikas]

do an ozempic synthesis in home lab

[@alish5417]

Adinosene tri phosphate atp if any one dosnt know what atp is

[@namonef]

4:03 no you can't, you'll bleed easily. Excessive aspirin causes blood thinning effect.

[@TecraTube]

do the chickens have large talons? im learning a lot from your history lessons

[@JCrow-kz4nw]

Interesting.

[@jonathondavidson3018]

"just consume less calories" oh shutup give me the tube

[@jiritichy6855]

I do not know, what is Ozempic, but I know what is Ozembouch! Do they have something in common?

[@ClarkPotter]

Seems like there could be a dose sweet spot that won't risk overheating you but still effects dramatic weight loss.

[@WielkiKaleson]

And just normal toxicity, right?

[@Mrtomatopeels]

8:31 I have that exact same scale

[@Dlab_s]

Am i triping or this is a difrent work space.

[@HackingClan]

Would be cool to see you do mitragynine extracted from M. speciosa into 7-hydroxymitragynine using oxone.

[@ashe1.070]

There’s at least 40 different alkaloids present in that plant, so any extract isn’t going to contain a lot of (-)-mitragynine. For example, accelerated solvent extraction (ASE) with ethanol gives a dry (-)-mitragynine content of varying from 2% to 7% according to one paper. Isolating it from all of the other alkaloids would also be very difficult.

[@HackingClan]

@@ashe1.070 You could start from an already available pure extract I suppose. A crude extract using MeOH and a Soxhlet Extractor would be sufficient, you're just going to be oxidizing the other alkaloids as well.

[@HackingClan]

​@@ashe1.070 Check out The Malaysian Journal of Analytical Sciences, Vol 15 No 1 They use a methanolic picric acid solution to crash out the MIT.

[@morallycorruptmaleficentti1194]

ngl I researched this stuff when i was in college and i was working towards a pro card in bodybuilding and I took this stuff for about a week. It worked but I was sweating like a mf. I made sure to always be in AC environments and basically keep cool. I wouldnt recommend bc its toxic af obviously. It can cause neuropathy (peripheral neuritis) which basically affects your hands and feet.

[@Sauce787]

Hopefully it's carcinogenic effects don't impact you in the long-term

[@T8ersalad]

Are you near the ocean????? Why is there so much rust?????

[@hantrio4327]

Labs look like that. It's the corrosive gases etc.

[@joenemeth9606]

He lives near hydrochloric acid

[@HachiHugada-ve8ex]

I have used this and lost a lot of weight. You do need to he really careful.

[@nooneisback]

If you follow the prescription correctly, yeah. Even if you accidentally take 2 capsules, it'll just cause a fever for the rest of the day. But more than that and good luck surviving in an ice cold bathtub.

[@joenemeth9606]

STORY! STORY! STORY! So tell us

[@vernaracey1174]

Ordered mine from China. It came in capsule form. I took just one at first and day two took two. After about a week I had dropped 32 pounds of belly fat.

[@joenemeth9606]

@@vernaracey1174 😳😳😳😳😳😳

[@maynardjohnson3313]

Yeah, don't take it but why not test to see if it gets all splody and shit.

[@midwestchem368]

So picric acid could be even more effective?! Lol jk jk Man great video the weight loss drugs over time have been absurd. Just look at fen-phen for example. Too much 5ht2b agonism lead to damage of the heart valves. The effective otc weight loss drugs seem to just be dangerous.

[@TheOpticalFreak]

Burning fat so fast you explode!! 😂

[@RCM442]

To quote That Chemist with the stopper...PHOOMP

[@ericlondon5731]

Weight loss by poison or explosion ......

[@tntomega]

Explosive?