Rat/Mouse Brain Hybrid Created: New CRISPR Method for Cross-Species Chimeras

[@Spookspek]

1980: I bet there'll be flying cars in the future 2014: new rat just dropped

[@zealotoffire3833]

you are a decade behind, it is currently 2024 not 2014

[@SmokeFactory]

“flying cars” are planes and they had those in the 80s…

[@puntloosPD]

@@SmokeFactory wrong

[@MabusTiefsee]

You can already buy them, regulations are high and the wings are often in the way

[@SmokeFactory]

@@puntloosPD wow amazing reply

[@maxpowers802]

damn that's crazy. instead of thinking about cheese it was probably thinking about cheese

[@Littleprinceleon]

Cheddar instead of camembert: the devil lies in the details 😊

[@Flesh_Wizard]

It was cheesed to meet me

[@miikalewandowski7765]

Ratatouille more likely 😊

[@vinniepeterss]

😂

[@noreply5461]

Dude, that's so creepy. Just imagine being a mouse thinking about cheese and minding your own business and then just one day, boom, everything changes and you can't stop thinking about cheese. Horrible I tell you, horrible!

[@edmclaughlin4923]

You have a knack for dumbing down information without insulting anyone. This was a great and exciting video.

[@bloodaid]

Well, if information must be dumbed down, it's because it's targetted towards a dumb audience. Surely a smart person wouldn't need a dumbed down version of a smarted up piece of information. Getting offended by dumbed down information just porves that one is dumb. It's not his fault that someone is dumb. However it is the dumb persons responsibility to get smarter.

[@edmclaughlin4923]

@@bloodaid There was no insult intended. It is extremely complicated material he is relaying to us. I was able to enjoy it and learn a few things. If he were to assume we all had advanced biology degrees, I am sure we would have seen a different video.

[@CoperliteConsumer]

Me: "ya can we have affordable housing" The world: "best incan do is rat mouse chimera!"

[@neo-filthyfrank1347]

Cool science projects are more important than marginally improving the quality of life of poor people.

[@iammichaeldavis]

@@neo-filthyfrank1347 if all those poor people had a secure life maybe they could all be working on cool science

[@neo-filthyfrank1347]

@@iammichaeldavis That's not how it works buddy

[@Mavrik9000]

@@neo-filthyfrank1347 Only because some rich people say so.

[@neo-filthyfrank1347]

@@Mavrik9000 Nah it's just a lame thing to care about any way you slice it.

[@tigrerojo9685]

"So basically we genetically engineered a rat with body dysmorphia" '...why?' "it sounded cool"

[@whatthefunction9140]

Science bro

[@auriel8300]

My first tought was : "God if the Furies find this, we're in big trouble"

[@andrewjohnson4021]

👏🏼🤣

[@SAM-LISBETH]

already Q3Q

[@mridlon1634]

We would’ve never reached this point if that Austrian painter actually won…

[@andrewjohnson4021]

@@mridlon1634 is it possible to go back and see them winning and if people could believe that it would change the course energetically. Kind of like dragon timeline hopping? Essentially what I'm saying is if we could have our mind believe since we believe everything else. If we believe that they won then they did. In fact they did win even if it wasn't televised correctly.

[@rr.studios]

​@@mridlon1634False. Under that certain painter, we probably would've reached here much earlier, though you'd probably not like how wrle'd reach it. Have you heard of the experiments they did on the Je ws? Yep. Under Mr. Austrian Painter, the experiments would've probably continued and we probably would've done these silly little genetic experiments much earlier...maybe even on humans.

[@DaenaMichelle]

Cat girls are coming, guys

[@durschfalltv7505]

Oh hell naaw

[@jacobobos]

​@@durschfalltv7505it's an old meme

[@jimmyturner5438]

Well if Cat Girls are coming on guys, it’s only fair that Cat Guys get to come on Girls…

[@LouiesLog]

You're an old meme.

[@Antleredangelbun]

15 year old cat BOYS!!! :D!!!!!

[@barzinlotfabadi]

The pinky, the pinky and the brain brain brain brain..

[@acheyawachtel9409]

Narf

[@MabusTiefsee]

Plot twist, pinky got the human brain parts

[@mridlon1634]

😂

[@EveloGrave]

Another step closer to Humans being capable of photosynthesis.

[@FoamBanana]

Out of anything anyone has said would be the best in changing human dna THIS is the best. It would literally solve 80% of the problems with humans

[@MabusTiefsee]

You would need a lot of skin flaps and sit all day in the sun, like a plant

[@fungushoney9958]

Now THATS what I keep saying!

[@mycelia_ow]

+200% energy +3000% melanoma risk

[@WeirdInfoTV]

This is mind blowing

[@bromine_35]

"hey guys, i guess that's it"

[@Mavrik9000]

Literally... for the mice/rats.

[@Variety_Pack]

Is this a mat or a rouse?

[@CoperliteConsumer]

Rouse.

[@renzojeripalomino4885]

Even thought I don't fully understand most of your videos I can't avoid finding them really interesting. Keep up the great work!

[@jooch_exe]

Damn, Jurassic Park for real.

[@TimelessInsanity]

Ah yes, human horrors beyond our comprehension.

[@Hector-bj3ls]

Humans are the true monsters. Why are we building all the tools for Scorn universe to actually exist.

[@keith3761]

I missed does this require immunocopromised?

[@ihmcurious]

It wasn't mentioned in the paper. The cells are added at such an early stage that there is no immune system to reject them. As it develops, the immune system should adapt to the presence of the donor cells and learn to recognize them as "self" and not a threat.

[@thecoolguy3498]

@@ihmcuriouswoah. Would that translate to humans too? If you introduce foreign DNA early enough on in life, does the immune system usually recognize that tissue a self? Thanks!

[@watsonwrote]

​@@thecoolguy3498 Yes, genetic chimeras exist. XX people already have a degree of chimerism, but some people fully integrate with a non-identical twin in-utero and thus have a mosaic of different genetic identities across their body, and they have no self-immune issues. There's even a case of a woman who was thought not to be the genetic the parent of the children she birthed because she was a chimera and her ovaries had a different genetic profile than the tissue that was sampled for genetic testing. This presented a legal issue that was resolved when they discovered her chimerism. My understanding is that we've even been able to have a human child born without a working thymus to accept a donor heart without immunosuppressents at a very young age because the surgeons also transferred the thymus. This trained their body's immune system to accept both host and donor tissue. If this can happen post-utero it can happen before then.

[@napalmholocaust9093]

Interesting this can overcome the innate genetic library of acceptable proteins/cells. I figured it was early since blastocyst implantation is essentially the work of a retrovirus and genetic compatability outside of a someone gestating it's own clone is not a thing.

[@MabusTiefsee]

​@@thecoolguy3498 I know a woman who got a calf organ transplant during WW2 who swears she got it. And she is still alive. However the documentations of that operations are lost, since it was WW2 Germany....

[@ms04041]

test which one is more dominant by seeing if it'll snitch

[@Wildcard242]

Interesting. I wonder what cause the conversation of the donor cells back to mouse cells. Chemical signals, environment, the body's immune system? So fascinating.

[@TheRABIDdude]

Assuming you meant "conversion" rather than "conversation". The rat cells didn't convert back to mouse cells. Rather, new mouse cells were moving into the forebrain so the ratio of rat cells in that area decreased over time. Potentially also some of the rat cells were dying, which makes sense since they weren't designed to be in that environment.

[@RichterScale-oz5pp]

Is this a similar concept to how Killer Bees didn't used to be part killer?

[@MabusTiefsee]

Chimeras reproduce only one of the pure species, since the cells don't exchange DNA

[@CheapSushi]

Gattaca incoming

[@Shotzeethegamer]

Wonderful. Man made horrors beyond imagination.

[@mookfaru835]

Wow that’s interesting. You make it easy to understand these things.

[@popkinbobkin]

hey you got a big sponsor keep it up!

[@ihmcurious]

Thanks, Farty!

[@napalmholocaust9093]

Knock-out the kidney absorber. In early development, many mammals have several pairs. I think we have 6 pairs at one point. That's why many of us have a third.

[@Stevie-J]

Can CRISPR make me fit and attractive though? 🤔

[@MavetSomnus]

It's science, not magic ☺️

[@Stevie-J]

@@MavetSomnus Good point, thank you for the clarification. My search continues..

[@tezcanaslan2877]

When you respawn ask your doctors

[@swayback7375]

@@tezcanaslan2877underrated answer! Nope it can’t make you better, but it could have if your parents used it… but you can be a parent yourself, just get these nerds to squirt of that extra forebrain juice in there, then have your kids watch this, they can understand and explain toy you why crispr can help them but it just won’t help you.

[@SciFiMangaGamesAnime]

Eventually.

[@PhysicsViolator]

Cool mate , I want a talking t-Rex in my backyard.

[@MabusTiefsee]

Reminds me on a case here, germany. An old woman got an implant of calf tissue as transplanted organ. Because the choice was that or death and documentation was tight, since it was during WW2 She survived her son (saddly) and no doctor believes her I assume bodys can tolerate way more new cells than we know. Specially females, since their immune system is already optimised to survive pregnancy. And a lot becone mirco chimeras during that time.

[@KelvinNishikawa]

Mrs Frisby’s husband definitely had human brain cells.

[@Fastlan3]

A mammalian and avian brain hybrid would be very interesting.

[@Bug_Bait]

People on the streets running into windows and flapping their arms

[@ctlo4403]

They made frog/ axolotl embryos and made eyes by the butts and they grew back to the correct order at Michael Levin’s lab.

[@DWSP101]

Looks like Space Marines ain’t too far off! War hammer

[@tatianatub]

Technological horrors within my comprehension

[@phulbig]

This was great Thanks!

[@serventofallah1426]

So we will have a chimera arc in real life too😂

[@Austin-mane]

For me the conjured images seem grey but I can feel color if I think about it ¿ But if im imagining an object I know of or a memory i see the color like a translucent feeling of a picture

[@emmanuelokodogbe1037]

Breakdown and rebuild my DNA like Mindcraft,.. make me like Logan & Deadpool to regenerate,..lol😅

[@LinkEX]

*MOTHER 3 Chimera Research Theme intensifies*

[@pirateradioFPV]

2024: Cat girl jokes 2094: Genetically manufactured soldiers 2194: Completely genetically engineered social classes

[@pokemonmahoney796]

Lol, Huxley rolling in his Alpha Plus grave.

[@thegrey8643]

Humans seem to be unique as we seem to have a certain amount of tamper protection built into our code from what I can tell.

[@MabusTiefsee]

Yeah it is mostly ethics stoping us from doing this official. Just look at the poor guy who got into trouble because he admitted that he created the Chinese crisper twins...

[@SlavTiger]

just more complicated expressions probably. mice are a lot simpler genetically which make them great for study subjects

[@acheyawachtel9409]

Reminds me of a very nice doctor and his son and dog

[@elihusolano5993]

“The real point is this: We don't know where to go because we don't know what we are. Do you want to go back to living in a sewer-pipe? And eating other people's garbage? Because that's what rats do. But the fact is, we aren't rats anymore. We are something Dr. Schultz has made. Something new.” ― Robert C. O'Brien, Mrs. Frisby and the Rats of NIMH

[@tylermacdonald8924]

But how did they behave with other mice? Or rats?

[@Zomfoo]

New Cool-Aid and Hawaiian Punch mix invented! Big whoop. 😒 Cross a platypus and a turkey vulture and I’ll be excited.

[@android01978]

I think I’ve seen this movie before… next they replace some ape brain with human, the apes developed human intelligence then there’s a war between humans and apes. Spoiler: Doesn’t end well for us!

[@SlavTiger]

i wonder if this can be done to grow human organs

[@brentwilbur]

This is some _Secret of Nimh_ type shit going on.

[@eduardschreder1623]

does someone have a pdf link to the paper? i only find the "long" 36 page version.

[@alanESV2]

Hey I like crow brains. They’re clearly small and crazy smart. Maybe even more, pound per pound of gray matter, than humans

[@mycelia_ow]

We've cross-species chimeras before GTAVI....

[@NgKimSan黃金山]

Egypt had different animal heads like human are created from history, we are a bit slow now than recover

[@Iowa599]

Did the hybrid rat-mice have multiple personality disorders?

[@ROFLance]

We really got chimeras before GTA 6.

[@joalsoal1645]

Question! At 3:12 (best view) I noticed in the forebrains they had a dark circle area within the forebrain. I have no idea of mouse neuroanatomy so I was wondering if anyone knew what anatomical part or feature was? Thanks for any help!

[@ihmcurious]

That will become an eye

[@blkauxpro]

This how you get Pinky and the Brain.

[@nanzymyap]

Grow human fore brain in chimps

[@NeoKailthas]

This is fantastic!

[@pokemonmahoney796]

Man made horrors beyond my comprehension. Neat!

[@elyakimlev]

What if you injected human stem cells instead? Would the mouse grow human brain cells? Would it get smarter?

[@IhmHomeFarm]

They’re so cute❤️

[@ricasiogaming7873]

If mice ever become super intelligent we are cooked asf

[@apocalypsator6]

They should get to work on a Kaiju for the new religion.

[@illogicmath]

If we make a cat with the brain of a mouse and a mouse with the brain of a cat, will the mouse chase after the cat and the cat try to get away?

[@taylorhall2591]

Not so Secret of NIMH

[@theredstormer8078]

so when we getting the cow with a whole human brain

[@edmclaughlin4923]

You see human embryonic stem cells to grow a mouse cortex. Talking mice?

[@AraAshmayne]

They would have human intelligence but to speak you would need to modify the vocal chords to make those sounds.

[@edmclaughlin4923]

@@AraAshmayne Excellent point! Thank you. You are correct. It would still be cool to see if the intelligence moves on the scale.

[@Antleredangelbun]

Yea it isnt intelligence that stops other animals from replicating our speech. Its physiology. See videos of dogs doing multiplication, playing minecraft, or speaking. Huskies and malamutes have the most videos of them talking

[@Antleredangelbun]

​@@edmclaughlin4923Humans are not by default more intelligent than other animals; Intelligence isn't about how much information you can hold, that's memory; Intelligence is about how much you can do with the least amount of information

[@AraAshmayne]

@@Antleredangelbun I agree with you. My wording was not great.

[@MabusTiefsee]

We need to place a human uterus in a cow/pig/horse and we get a chimeric artifical womb.

[@secretsanny]

Get away ethicists Making scientific progress here

[@CM-mo7mv]

OK now octopus mouse

[@burrdid]

i can't tell if i watched your video if you make a red outline

[@tabcaps5819]

Oh shit

[@noreply5461]

This is just so wrong, this is exactly why G-d had to send the flood.

[@rip4real437]

we got a new rat before GTA 6

[@BADGIZM0]

i know its unethical but man would it be cool to see the data on a monkey and human.......

[@BADGIZM0]

@@peaceful5172 wtf really? or you messing with me? if its real thats insane.

[@luisgregori3817]

can you make a monkey with human brain pls ? and make a video

[@asemic]

braaaaaaaains

[@andrewjohnson4021]

And they use people like you to explain it to everybody to try and act like it's something cool that they're working on that they're not going to use against all of you like they've done with other stuff.

[@ihmcurious]

Who's they?

[@andrewjohnson4021]

@@ihmcurious all your kind.

[@andrewjohnson4021]

@@ihmcurious go ahead give it a shot see if you can feed on me. I dare you.

[@andrewjohnson4021]

@@ihmcurious you're definitely are they because you have to hide behind a fake persona. So be curious about who they might be George. As you play dumb. Ok 👌🏼

[@grndzro777]

This is how Tribbles are created....God help us all.

[@manman7985]

Nothing new under the sun. Only Noah had pure genes. One step closer to the next deluge, this time by fire.

[@AKU666]

This video feels a bit quiet.

[@kenisi_thedevilonhigh]

Useful stuff to learn but...

[@ZionistWorldOrder]

its a full circle for the evil rich and powerful who believe this is how we were made, sumerien tablets..

[@nyaruko-do2ok]

This is some evil mad scientist shit

[@maxaltenkirch1022]

someone tell andy dwyer they made a real mouserat

[@jesuslovesyoujohn314-21]

Talk about confused animals.

[@christopherleubner6633]

Furries will finally get their wish. 😮

[@napalmholocaust9093]

Put people into dolphins 🐬 and eagles.

[@theredhead42]

Eduuu warrrdd?

[@xentaurro]

furries are going to rejoice

[@DonaldDucksRevenge]

Squeeeakk

[@dragon67849]

Yo can we stop playing god like this?

[@creepystory2490]

No😂

[@xeno._yt]

Who’s playing God? We are just utilizing the laws of nature and physics as they exist in our universe. Nothing godly about that.

[@KameroonEmperor]

Rat

[@BryanKirch]

This is so wrong

[@Antleredangelbun]

15 yr old bunny boyfriend real 2026

[@E.Pierro.Artist]

Unethical. Deplorable.

[@Joshua-eo5hr]

Let's not do this...

[@Second_Library_of_Alexandria]

Disgusting.

[@chashmal10]

Evil

[@aby110]

Stuart Little with a New York brain