Regulation of the Cell Biology of Antigen Presentation in Dendritic Cells by Dr. Julie Blander

[@hraqhraq]

7:48 " if you look at this peptide T-cells can not tell where it came from self or microbe" Actually it can tell by the type of MHC it attach to, so if Naive CD4+ T-cells encounter the MHCII presentation then it knows exactly that it is foreign antigen sequence because dendritic cells put these 7-9 peptide sequences on MHCII; but if the presentation of the Antigen was through MHCI then Naive CD8+ cell will recognize it and know it is DAMP of self. Then DC-T cell need 2nd and 3rd signals for activation. 2nd signal will be CD40 CD80/86 costimulatory proteins and the third signal is the most important because it will determine Naive T cell TYPE fate and is determined by the Cytokines DCs produce. So DCs are extremely important and is the key for activation of Adaptive immune cells. There are also similar cells to DCs like Macrophages, Monocytes, Kuppfer cells, Langerhans cells,... which do the same like DCs.

[@JDeffenb]

Not correct. Viral peptides (which are non-self) are presented on MHC-I. Exogenous peptide loaded onto MHC-II can also be derived from self.

[@hraqhraq]

@@JDeffenb Where is the evidence or proof?

[@JDeffenb]

@@hraqhraq For viral antigen on MHC-I: www.ncbi.nlm.nih.gov/pmc/articles/PMC4005948/ For self-peptide on MHC-II: www.ncbi.nlm.nih.gov/pmc/articles/PMC3267721/