Resveratrol, Fasting, & Rapamycin | Matt Kaeberlein

Professor Matt Kaeberlein discusses aspects of aging and proposed interventions to improve health. He gives an in-depth review on sirtuins, resveratrol, fasting, NAD precursors, and rapamycin.
Timestamps
0:00 Intro
0:25 Discovery of Sirtuins
7:30 Resveratrol & Health
11:05 Calorie Restriction & Fasting
17:07 What Is A Healthy Diet?
21:46 NAD+ Precursors
29:07 Rapamycin & Lifespan
32:50 Rapamycin & Dog Aging Project
38:45 Intermittent Fasting In Dogs
40:45 Rapamycin Human Clinical Studies
50:30 DNA Methylation Clocks
54:15 What Areas Are Exciting For Healthspan Extension?
56:25 Yamanaka Factors
59:55 How Do We Avoid Hype Over Substance?
1:06:50 Senolytics
1:17:36 What Supplements Does Professor Kaeberlein Take?
💊 My full supplement stack: drstanfield.com/pages/my-supp...
💊 MicroVitamin (multivitamin & mineral): drstanfield.com/products/micr...
💊 Supplements I use from Amazon: amzn.to/44oEGZz
✨15% Discount Code: BRAD ✨
• ProHealth: www.prohealth.com/collections...
✨10% Discount Code: BRAD ✨
• DoNotAge.org: donotage.org/products/
• Renue By Science: renuebyscience.com/?rfsn=5206...
Donate towards my Rapamycin & Exercise clinical study: bit.ly/3QwugRx
✔️ Roadmap - Look Young & Feel Strong: drstanfield.com/pages/roadmap
✔️ Twitter: / bradstanfieldmd
✔️ Patreon: / bradstanfieldmd
Here are the links to the research papers referenced in the video:
pubmed.ncbi.nlm.nih.gov/15684...
pubmed.ncbi.nlm.nih.gov/31303...
If you like this video please smash the thumbs up button, it really helps with the KZbin algorithm :-)
#Resveratrol #Rapamycin #Health
The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

[@ats89117]

Outstanding interview! It's really refreshing to hear from a top researcher who is not shilling anything. Thanks!

[@helpholocaustsurvivors3480]

A true and honest scientist

[@mayahobsbawm415]

I have been following you since day one and have been amazed at the continuous improvement of your content and the width of information. Matt Kaeberlein is an outstanding scientist, whom I have been admiring for years. Congratulations for having him on and for the immensely informative discussion!👍

[@DrBradStanfield]

Thanks for your support

[@williamperkowski9025]

My anecdotal story: I'm a 60 year old male in Palm Springs, CA. I started taking NR(NAD precursor) about 6 months ago. I dropped from 240 pounds to 190 pounds and have kept the weight down, but bounce up and down with about an 5 pound variation. I believe the benefit of NR was to stimulate my exercise program which is basically 1 hr walk in the morning, 1 hr walk in the evening, plus intermittent gym based light weight lifting on machines. I have also tried variants of fasting, but have found that a 5 day water fast consuming only water and green tea works extremely well from a psychology point of view. Once I get past the first 24 hr fast, then the next 4 days are much easier because my appetite is suppressed. I'm taking NR during the fast. Also, started watching Dr. Stanfield about the same time I started the NR regimen(began with 300 mg per day, but now take 600 mg per day). The youtube support from Brad and others is invaluable. Thank you for helping everyone.

[@DrBradStanfield]

You’re a legend, great job

[@fastingfeastingbeasting]

You are a rockstar William ! Great to read ur message ! On On !!

[@bluellamaslearnbeyondthele2456]

Not sure how green tea fits into all that fasting. EGCG has been shown to increase senescence. Not what something one should aim for if one is over 60 .

[@shambhaveemishra9842]

@@DrBradStanfield sir whats your take on green tea? Does that increases senasense or is it good for anti-ageing?

[@r.guerreiro140]

@@shambhaveemishra9842 The concept of a natural substance increase senescence is per si mind-blowing A whole new field of research may come from this

[@negvey]

this has officially became my fav youtube channel, pure logic, str8 to the point, great job dude!!!!

[@Rafi2002M]

Brad, thank you for a thorough and thoughtful interview. This helped shed some light on the state of the research today and what we might want to try now as opposed to wait for more data. Excellent!

[@Zsaqwes8]

Didn't Sinclair demonstrate epigenetic reprogramming in the mouse retina study

[@tomshoham3548]

wow what a great interview. shows how far we are from significant results w all the hype behind expensive supplements

[@joeh212]

This was one of the most valuable videos I've ever seen.

[@calebweintraub1]

Informative. One of the best and most down-to-earth conversations on this topic. Thank you.

[@DavidMM255]

Amazing interview Dr Brad!! Keep the good work in 2022. Congratulations and long live

[@kiosunightstep6640]

Love how straightforward this guy is.

[@johnny7808]

awesome job with the timestamping Brad. Thanks!

[@LeslieAlysonLawrence]

Great interview, Brad!! Absolutely wonderful discussion. 💖

[@jnsmeets]

Thanks Brad. Great interview, great guest and thank you for broadening the spectrum of the discussion.

[@TheSheekeyScienceShow]

Great interview Brad!

[@toom2141]

Wow, that was uttmost helpful. So glad to see real experts talking (nonjournalists) so that the general public gets a true image of what is really going on inbetween the shiny finy marketing predictions made by companies (and sadly also scientsits for getting publicity) Thank you Brad, your is one of the best and trustful channels here on youtube.

[@rebg3789]

Wow! A true Scientist that is unbiased! This is the best interviews ever by a scientist that gives facts instead of hype!

[@MichaelMerritt]

What a fantastic guest and interview, thank you for sharing this.

[@fastingfeastingbeasting]

Fantastic content Doc ! Keep em coming ! Thank you !!

[@rseed42]

Watched the full interview in full, was really informative. Please, keep it up, we really need an objective view on aging research as you provide!

[@kiwihame]

Fascinating interview. Well done! I'm impressed that you're chasing the 'truth' not following the herd or chasing the $$$. I'm a 53yr old active male taking NR and Hardys Daily Essentials Micronutrients. I'm NZ based so would be interested in your Rapamycin trial if you're doing it locally Brad.

[@jesseenriquez1097]

Do you also take Resveratrol? When your personal take on Resveratrol?

[@mimilili99]

Thank you for the great interview and iniciative and relevant questions. It is so helpful.

[@innov_8263]

Great discussion! Thank you do much💖

[@arielmalanga9303]

What an impressive presentation. Thank you Dr. Stanfield. 👍

[@altar1102]

Great interview! Love it 🙌

[@scc8728]

I've just discovered your channel and love it. I'm binge watching because your content is excellent.

[@Hail2MasterChief]

Finally, a definitive interview about resveratrol. For me, its time to close the chapter on it. Also, there was always something wrong about Dr Sinclair's impish smile, like he knew something that we don't, so now, we know it too.

[@shelchicago8997]

I’ve been following Professor Matt Kaeberlein for a while.

[@justinrogers4435]

I love these conversations! Keep it up.

[@ConflictedYouth]

I started losing muscle and lost 60% strength in the gym, was wondering why, then I read about resveratrol impacting exercise.

[@stepananokhin693]

Great interview! Thanks a lot!

[@ricdenic]

I really appreciate your willingness to host knowledgeable people who provide their understanding of the literature even when it might contradict “ conventional dogma”. Thanks for the pursuit of truth and for the effort that you put into educating those like me who are fascinated and interested in this new field of science.

[@Kelt.]

Super interesting interview, thank you !

[@rogehnimunoz4327]

Love this podcast. Thanks

[@jbarron4596]

Interesting data based perspectives. Very informative, clear and concise interview. Thanks for the presentation.

[@KoltonLukes]

Very professional! Thank you!!!

[@jackpaillard156]

Wow wow wow!!!......... Thank you Dr. Brad for sharing this "bomb" with us, you deserve a huge applaud for that.

[@robo265]

One of your best ever videos Dr thank you

[@jaimemarun2841]

Hello Dr Brad: Are you going to change your supplement stack?

[@TheBiffsterLife]

Great episode! Subheading could be”Tell me Dr Sinclair is a hypeman, without telling me he’s a hypeman.”

[@LeslieAlysonLawrence]

🤣

[@shambhaveemishra9842]

😬🙄

[@shambhaveemishra9842]

@@LeslieAlysonLawrence Sinclair talks and talks and is not giving any thing new i mean any good research for the last few years 😬

[@LeslieAlysonLawrence]

@@shambhaveemishra9842 true. At this point, it looks like he’s just a PR guy.

[@theancientsancients1769]

I warned of Sinclair over a decade ago! He was written off back then , but he appears to have a revival by new people interested in this field

[@vindrock8176]

Great diskussion!

[@tomyoung2674]

Really appreciate the effort

[@kellietowner3268]

Loving this content. X

[@scottk1525]

Seriously excited to read the paper he mentioned discussing the effects of different dietary strategies on dog longevity. Being the swell fella that you are, when it gets published in a couple weeks, would you post a quick video either summarizing it and/or just announcing its release and posting a link? Cheers.

[@KoltonLukes]

When the dog data publishes it would be great if you could review it for us and share your opinion!

[@DrBradStanfield]

Definitely

[@danno1800]

Excellent! Thanks very much…

[@DonaGeek]

Wow amazing information! Thank you

[@DrBradStanfield]

Glad you enjoyed it

[@shakyabhattacharjee9100]

Such channels always got a lot of vested interest. People who share similar views are interviewed. A truly impartial channel must interview all contrasting views

[@olyav5819]

Good interview!

[@Am5634]

Great talk thanks

[@Spartan21blue]

Thank you very much for the time stamps Brad . So apart from D3 and a.one time use of rapamycin which worked for him, he does not take any other supplements ☺️

[@maximiliancrunchyroll131]

Cool guy who makes a lot of sense. Cheers Brad

[@JacobAFarmer]

This was super interesting. The best was the last minute. I love it when a scientist gets excited about anecdotal evidence. Makes me want to try rapamycin.

[@tygrysbee9718]

Fantastic !!

[@vonettagrant4879]

I'm looking forward to the findings of the paper on feeding frequency.

[@ivanandreevich8568]

Whether you agree or disagree with him, this is one sharp dude.

[@NickWestgate]

Great interview with a top tier researcher. My only disappointment is that I haven't seen anyone ask Matt about his opinion on young blood research compared to all the things you discussed.

[@nka3129]

Thanks Brad, great interview! Really curious about the results of the mentioned dog paper, although I have a feeling it'll lean towards time restricted feeding being beneficial

[@invincible-frame]

This guy may not agree with David Sinclair in many ways. But being over 50 years old, he shares one uncommon trait with David Sinclair, which everyone can tell. This is the most telling message I get from the long video.

[@gamblinguru33]

what is the trait?

[@bobbybrown1258]

@@gamblinguru33 I think he's saying they both look very good for their age

[@leighnash6140]

Great interview and great information! I would love to know the results of the dog feeding experiment when it comes out.

[@susymay7831]

Good timestamps.

[@Boycott_for_Occupied_Palestine]

Good video.

[@kamanashisroy]

Loved the oral improvement part. I got huge oral improvement from akg.

[@shawna7813]

Both NAD and resveratrol has a caffeine like effect on me. They're impact on me is exactly the same way.

[@deborahbehr3910]

I am crushed about the comments on Resveratrol and NAD. I need Rapamycin!!!!

[@rosevanderreijden3216]

See, this is great. We need more videos like this. I think that my presence is not appreciated on several KZbin channels because I question David Sinclair's veracity and contributions to the field of anti-ageing. I know he likes attention and publicity, and that he is making A LOT of money at something. (Lab experimentation doesn't pay that well.) I have read through hundreds of papers (I am a chemist, but involved in art restoration) and do not find evidence for the life extending protocols that Sinclair promotes.

[@Pluvo2for1]

After seeing Sinclair using a youth enhancing filter, I'm not such a huge fan either. Anyway, with your research what do you think is the best way forward regarding longevity?

[@rosevanderreijden3216]

​@@Pluvo2for1 Right now I usually refer people to the work of Valter Longo. He's a solid and sincere researcher who doesn't make outrageous claims. Periodic fasts or employing fast mimicking (Prolon or water fasting) for 5 days about 3x a year looks promising. A plant-based Mediterranean-type diet comes out at the top for good health, limiting protein intake and employing moderate IF (12-14 hours daily) to reduce mTOR, moderate alcohol consumption (1-2 glasses of red wine,) and moderate daily exercise - these are your best bets right now and dovetails with rapamycin research which looks promising. Also, do not look to purchase rapamycin - this needs to be researched more. Taking rapamycin unregulated can be dangerous. Make sure you get enough vitamin D + K and try to de-stress. Dr. Brad is doing some good work here. I'm impressed (and that's saying a lot. I've never been impressed with David Sinclair.) Feel free to ask any questions, Pluvo2for1. 🌹

[@rosevanderreijden3216]

@@Pluvo2for1 Right now I usually refer people to the work of Valter Longo. He's a solid and sincere researcher who doesn't make outrageous claims. Periodic fasts or employing fast mimicking (Prolon or water fasting) for 5 days about 3x a year looks promising. A plant-based Mediterranean-type diet comes out at the top for good health, limiting protein intake and employing moderate IF (12-14 hours daily) to reduce mTOR, moderate alcohol consumption (1-2 glasses of red wine,) and moderate daily exercise - these are your best bets right now and dovetails with rapamycin research which looks promising. Also, do not look to purchase rapamycin - this needs to be researched more. Taking rapamycin unregulated can be dangerous. Make sure you get enough vitamin D + K and try to de-stress. Dr. Brad is doing some good work here. I'm impressed (and that's saying a lot. I've never been impressed with David Sinclair.) Feel free to ask any questions, Pluvo2for1. 🌹

[@arielmalanga9303]

@@rosevanderreijden3216 Great advice. 👍🌟 We get to save some serious ＄＄ too.

[@Pluvo2for1]

@@rosevanderreijden3216 so no NAD precursors for you?

[@Letsplay222]

57:04 "Nobody has shown yet that you can do partial reprogramming in an old mouse and actually restore youthful function...", except David Sinclair's lab did a year ago.....the study was titled "Reprogramming to recover youthful epigenetic information and restore vision" and it was published in Nature. The lead author was Yuancheng Lu. How could he have missed that? "...or increase lifespan" - In order to do this you would have to deliver the gene therapy to an old mouse's failing internal organs. The concept is pretty sound, however, the required biological engineering to accomplish it remains to be worked out. That is why Sinclair's lab started with the eye, because it is a complex organ that can be accessed without cutting open the animal. I have to wonder, for a guy whose next big study is the effect of intermittent fasting on canines, why he feels the need to throw so much shade at people's work.

[@msnewmind328]

Exactly my thoughts as well… He was throwing in a shade without saying David Sinclair’s name. I listen to this video to get more insight on the updated findings on rapamycin supplementation; to add with David Sinclair’s research findings.

[@danbuckles2745]

@@msnewmind328 He said his name in the beginning.

[@msnewmind328]

@@danbuckles2745 thank you 😊

[@pavelchorda8425]

I agree

[@davidderidder2667]

Puzzling why Sinclair’s studies can not be replicated!!!!!!!!

[@ew2886]

Thanks Dr Brad and Dr Matt. I also learn that we have to honestly find out what works and what doesn't, when it works and when it doesn't. Be happy to know when there's a good finding that disproves our beliefs. Our beliefs are not the reality. The map is not the territory. It's very important to do reality check consistently in any discipline, and advices.

[@Pluvo2for1]

Totally love the individuality point raised around fasting and diet. One size does not fit all.

[@kavemanbites]

outstanding vid :)

[@LivingisGiving]

Another amazing and informative video. Dr. Brad, Is it benefecial to be on metformin and rapamycin silmultaenously? Is there a overlap in benefits since the both inbihit Mtor? Or would you suggest cycle them in instead?

[@dougcane4059]

Being too sceptical is as useless as not being sceptical at all. He spent most of the interview negating pretty much everything, and the little research information he did have, he decided to withhold anyway. Don't forget about the power of placebo Mr Kaeberlein.

[@SebastianNiemann]

Thanks for the great video! It would also be interesting to learn what people can do now. Especially when you are 70 or 80 years old and don't have so much time to wait for well-founded study results and established therapies... of course every year that you gain can decide if you reach age escape velocity … The question for me is always: what is applicable without major risks and of course no "snakeoil"

[@Nilamoire]

Fascinating and exciting interview! I was very surprised to hear that some people don’t or might not respond well to caloric restriction based on their genetics. I haven’t found any discussions about this online yet…I thought caloric restriction was nearly universal for most/all organisms for either extending lifespan or improving health. Can you or anyone in the comments section here clarify?

[@lucieclemons5463]

I'm concerned about this as well. I was under the impression that that was universally beneficial

[@anthonylawrence5842]

I have an anecdotal feeling that my very low biological age is mainly due to High Intensity Resistance Training 3-4 times a week over 45 years. I think it ultimately protects the immune system, stimulates hypertrophy (age 70 at 70kg and bench 100kg) and improves lactic acid utilisation through the cori cycle...

[@mrpmac]

55:46 "Rapamycin is the most effective, non-genetic (other than Caloric Restriction) way to increase lifespan & healthspan in mice... by far."

[@TheSaassaf]

And there is no place we can get it :(

[@mrpmac]

@@TheSaassaf No place? Says who? At the VERY least, you can go to another country, like Mexico.

[@manuelojeda9144]

Thank u Dr. Brad a valuable interview. Where can you buy Rapamycin and the mg needed..?

[@christopherellis2663]

Uau! One of your best!♨️⚡☄

[@Maveric78]

Great interview… I’ve been taking 1g NMN per day for 6 months with 30g olive oil. No discernible difference in resting HR; HR variability; sleep quality; body weight or FTP (cycling)… Still taking it though because I’m a sucker for an expensive placaebo

[@Fearzero]

3 years of 1g of NMN for me. My memory is definitely better, that I know for sure.

[@theancientsancients1769]

For me Niacin Or Nicotinic acid works best for me with the palpitations I get and energy which boost NAD also

[@welanduzfullo8496]

18:01 1. feeling mentally sharp is very different from actually being mentally sharp. you feel sharp on lower carb, bc of increased stress hormone concentrations (impaired mental ability across the board compared to moderate to high carb) 2. feeling physically sharp is very different from actually being physically sharp (low carb decreases work capacity, relative perceived intensity for the same intensity increase on low carb, motor unit recruitment decrease on low/lower carb ,which in turn lowers the potency of any working set done in the gym for a given movement) ......

[@SteveHazel]

finally someone is doing a study on rapamycin, eh? it's about tiiiiiime. thank goodness. and thank you! Cuz no one else seems to care I guess? Peter Attia and others have been talkin about rapalogs for years now I think. And he and Matt have said - few side effects, safe, and very good early results. gotta keep this video on my to watch later list so I can find it again. (I did watch the whole thing but I don't wanna lose this.)

[@Boycott_for_Occupied_Palestine]

Are you afraid of death?

[@paulwolf3302]

I hope Dr. Kaeberlein can help you find a sponsor to get your rapamycin clinical trial going. In the meantime, I think the weekly dosing of rapamycin he suggests could be substituted with berberine, which is sold over the counter.

[@theancientsancients1769]

Finally a refreshing view rather than the overly sold Sinclair narrative which I warned about over a decade ago

[@bobwhite4748]

There is several key points to this presentation however I will narrow it down to this question 2017 NIH paper, Towards natural mimetics of metformin and rapamycin. Does metformin, berberine still fall in the mtor agonist category?

[@gegan5986]

this guy is so unbiased towards everything else that he is biased on rapamycine

[@shambhaveemishra9842]

Sir whats your thoughts on fisetin and quercetin on ageing? And also whats ur take on green tea on ageing?

[@JonathanOvnat]

Great interview! Can having an undiagnosed autoimmune condition help getting a prescription for Rapamycin?

[@sportsdude2828]

Do you have any followup on the section around 40m about data on the optimal dog diet? Have the results been published yet?

[@davidegariboldi9596]

Low carbs or keto is the way to go for improving lifespan…. Well done MATT!!!!

[@stephanehuard9275]

DR Brad, Thank you for this interview. From this, do you still reccommend NAD precursor for the 50+ croud?

[@DrBradStanfield]

I personally still plan on using them

[@betzib8021]

Ok..so what is something this guy WOULD take to impact health and longevity...and I volunteer for the rapamycin trial.

[@KenOtwell]

He didn't specifically address fasting as a way to block mTOR aside from just calorie restriction. Do we have any data showing that fasting blocks MTOR as well as rapamycin? I'm thinking that his once a week rapamycin dose could be mimicked by weekend fasting? Any thoughts?

[@Nilamoire]

I had the same question

[@jemhuckabee4222]

Resveratrol stopped my back pain a ton! I'm on it for the 3rd day and I have no pain. No pain killer ever did this!

[@jansloniewski9789]

what would be the once a week dose of Rapamycin tho? I love this talk btw.

[@willyouwright]

Does rapamycin restore mtor sensitivity similar to keto for insulin resistance ? We always assume more is better but i feel the right amount at the right time and sufficient sensitivity would be wiser? Insulin is great but clearly we overuse it. Perhaps same for mtor?

[@Adel3625]

This is not my first time that I write comments which are only thanks to Dr Brad for his efforts to help us understand science or questions relating to scientific publications, nothing else, to my surprise they all disappear completely. Weird. Anyway Thank You

[@theatheistpaladin]

I do shift work, so I am very interested NAD.

[@waynegrant9524]

1:15:37 An interesting comparison would be Rapamycin verses Metforman vs. 1-3 days of fasting. It could be that fasting provides the most benefit with AMPK activation (and with no side affects).

[@lifeisforlivinghereandnow877]

Can you talk about the subject of hormone replacement and if its good or bad to do when get older and if the synthetic hormones are as good as the natural.hormones or if there are side effects and reasons why taking them comes with riscs of side effects?

[@Brandoni65]

Does nmn have to be kept cold or it breaks down and is no longer affective?