Retrosynthesis with Aldols

[@samzlotnikov8311]

Love your videos! Explanations are always perfect. Please continue, it makes my day when I see you've posted another one :)

[@CasualChemistry]

Thanks 🙂 I’ve worked out what my next few will be and more on the way

[@jozefkristek505]

Hi! Keep working on these educational videos, they are great! The explanation of strategy is excellent and very useful for me (for us all). Amazing. Greetings from Olomouc - Czech Republic :)

[@CasualChemistry]

Thanks for the feedback 🙂 More on the way - hoping to record another retrosynthesis one tomorrow, and then try a couple with a slightly different type of emphasis.

[@PorcusCrassus]

Excellent video as always!

[@CasualChemistry]

Thanks 🙂

[@theonearney205]

Awesome video as usual!

[@CasualChemistry]

Thanks 🙂

[@romo1099]

amazing! really enjoy your videos and concise explanations. some suggestions for future topics: hammett analysis and physical organic chemistry, and carbene chemistry

[@CasualChemistry]

Thanks for the feedback :) I'll have a think on those suggestions as I haven't used those topics yet

[@mytoasterwentflying]

Amazing content as usual!

[@CasualChemistry]

Thanks 🙂

[@FladEriclp]

Nice Video, especially the TCA part was nice. Never heard about this before. Is there any reference about the usage of it?

[@CasualChemistry]

Thanks 🙂 I was doing some awareness raising for the method as the TCA reagents are pretty easy to use. You’ll see them about in big polyketide total syntheses. There’s a few links here to eg bryostatin www.sigmaaldrich.com/GB/en/technical-documents/technical-article/chemistry-and-synthesis/reaction-design-and-optimization/trichloroacetimidate

[@dlvivlviv]

Excellent

[@CasualChemistry]

Thanks 🙂

[@DamnBoiya]

Just a casual chemist you know how it is

[@CasualChemistry]

😎

[@petevenuti7355]

How to make Trichloroacetal nitrile?

[@CasualChemistry]

I probably would buy it in as it’s very cheap. If forced you could probably make it using enolate type chemistry by deprotonating MeCN and reacting with an electrophilic chlorine source. Or the same thing on the anode MeC(O)NH2 followed by a dehydration to the triple bond

[@ПавлоЯсман]

pKa of EA is not 20

[@CasualChemistry]

Agreed but the point I’m trying to make is it’s a good rough average value for alpha to a general carbonyl for the purposes of mechanisms.

[@DamnBoiya]

Hydrogen substitution brother.. I hope I'm right.. please me right haha..

[@DamnBoiya]

Be

[@CasualChemistry]

🙂