The Weirdest Things We've Done to Fruit Flies | Compilation

[@SciShow]

Visit brilliant.org/scishow/ to get started learning STEM for free, and the first 200 people will get 20% off their annual premium subscription.

[@bobsterclause342]

THAT'S NURGLES FLY alright. Yep. FOR THE GRANDFATHER!!!!!

[@richy4368]

14:04 Maybe the fruit fly immune responses to an increase in gravity is the same response to a increase in moisture in the air(denser atmosphere). High humidity could lead to more fungal infections. Like it might be a “dense atmosphere” response not a high gravity response. 🤷🏾‍♂️

[@catebrooks6779]

I DO miss this version of Hank (as his child says, BI - Before Injury) but very much adore the new version, with many more years, we all hope, to come! Hank... keep the goatee? If the wife likes it and you do, too, oc... just: it's cool to let my mind wander into not really evil but still close lol hee hee hee to you taking over the world.... Which, if we look closely... might not be a poor choice! Ok, everyone with me now: HANK FOR... UM... WORLD LEADER OR SOMETHING!!!!😂😂😂🎉🎉🎉🎉🎉🎉🎉

[@aleccandib5312]

9:48 I’m a fruit fly researcher in a lab that studies aging and neural stressors, our wild-type (ie “normal”) flies typically have an average lifespan of 30-50 days, which is a lot longer than most people expect. But the gestation period (from egg through larvae, pupa, and to adulthood) is only 10ish days, so its still easy to study multiple generations very quickly. Of course genetics, nutrition, temperature, humidity, and a bunch of other stuff can drastically increase or decrease lifespan and gestation time. The longest lifespan we’ve recorded in an individual fly was over 100 days- that fly had a mutation that increased autophagy, which is a process the cell uses to dispose of protein aggregates and old mitochondria

[@CL-go2ji]

Increased autophagy. Huh. Sounds energy-intensive, but otherwise okay?

[@unnamellie]

@@CL-go2ji well there's a cash back of sorts iirc, you can reuse proteins you got while destroying bad parts

[@mrmagoo.3678]

so you tortred and imprisoned whole civilizations of innocent Fruit Flies, so You could study them? Cool. :) I've never been s fan of the little b@stardos..used to infect my moms kitchen every year like clockwork.. clean and disinfect..and they'll be back in 2 days..lol.. I hope You made them sufer!

[@supernerd1999]

Same here, we actually have 2 different wildtype, one for a collaborator’s experiment and the lifespan are 25-35 days and 35 to 45 days

[@ShyDigi]

That’s awesome! I’m so happy my children (all flies on earth) get to live so long

[@aleccandib5312]

Fly people are also very creative when it comes to gene names! Some of my favorites are: sonic hedgehog swiss cheese (knockout causes holes in the brain) I’m not dead yet (indy) fear of intimacy sex lethal skeletor smaug tinman (knockout causes heart defects) kenny (as in Kenny from South Park, knockout causes death in the first few days of life) cheap date (knockout causes susceptibility to alcohol)

[@rebekahdavis5935]

Thanks for sharing. I read your other comment on your research with fruit flies. Very interesting. I had no idea we were learning so much from them..

[@jaymeselliot8181]

these are amazing

[@BubbleyB99]

“Deadbeat” (as in deadbeat dad) is one of my favorite funny fly gene names (involved in sperm maturation)

[@fartnutte1724]

these read like fallout perks

[@peterkallese6967]

I remember reading how a doctor was feeling horrible as he/she had to tell would-be parents that their baby died in the very early stages of development due to a mutation in its sonic hedgehog protein (or at least thats how I remember it) - now said parents could go out and remember this horrible experience every time the cartoon character would pop up

[@MichaelEnsly]

Time flies like an arrow, fruit flies like a banana

[@papalosopher]

Classic!

[@lolam4209]

i see what you did there

[@novi_key]

amazin

[@micheal49]

Thank you, Groucho!

[@demonatemu]

i remember we learned about genetics in my high school biology class and each group had a different mutation i.e. "white eyes instead of red", "no wings", "glow in the dark" etc. I was glad I wasn't the group that had "legs instead of antennae"

[@Munchkin.Of.Pern09]

Just finished my last genetics lab of the semester last Thursday. We have the white eye, yellow body, and mini wings mutations. FlyNap smells AWFUL. My poor father who got an entire genetics degree only to go “Nope! I’m not dealing with this crap!” And then proceeded to do an entire new degree to avoid ever having to breed Drosophila again.

[@camdenlove3348]

@@Munchkin.Of.Pern09any advice for that class? i have to take genetics for my major and im unbearably anxious about it

[@Sarafan92]

That fruitfly ejaculation experiment was the most hilariously absurd yet interesting experiment I've ever seen.

[@Max-js1mx]

I immediately looked it up and damn we really are just like fruit flies lol

[@mylaughinghog]

It was a hard nut to crack.

[@_GLXC]

Flashes the light Fly: AMBATUKAM OMAYGOTT

[@ishechad5960]

😂😂😂 and they would drink less alcohol afterwards!!

[@MarcColten73]

Did they check to see if they smoked cigarettes?

[@3756hans]

I remember reading a white paper that detailed aggression in fruit flys in response to being swatted at. Where they'd harass the swatter. In my experience that strategy doesn't end well for them.

[@cadensauerbrey9005]

In undergrad school, my genetics class did a study on carcinogenic genes in fruitflies and traced them back to the same gene in humans. It was super cool and helped us learn more about tumors and how to treat them.

[@90sMillenial]

"Activating the ejaculation neuron of a fruit fly..." is a totally new phrase that I learned.

[@wumplepuff]

One of my favourite things people have ever done with fruit flies is that one time they gave them a ton of oxygen and they got slightly bigger lmao

[@semaj_5022]

Thank goodness it was only *slightly*

[@wumplepuff]

@@semaj_5022 nah dude I want a parrot sized fruit fly to sit on my shoulder so I can be a fly pirate for a little while

[@semaj_5022]

@@wumplepuff Damn why that pirate lookin so fly

[@peachymunmagenta]

They’re not genetically able to get much bigger than slightly anymore I bet

[@karezaalonso7110]

Tropical areas are well known for bigger insects

[@mrbismarck]

I worked in IT for a year at a place that experimented on fruit flies. Someone there showed me how to look at a batch of fruit flies and pick out the virgins. I didn't ask him why he needed to know that.

[@czcbearsrule1]

This is a pretty normal technique for genetic breeding. In order to know the exact father of the brood you need to segregate the females as virgins.

[@mrbismarck]

@@czcbearsrule1 I thought he was just lonely. Your explanation makes much more sense.

[@therealjammit]

How did you know? Was the fly doing the Naruto run everywhere? Was it wearing a Linux t-shirt? Little Fedora?

[@czcbearsrule1]

@@therealjammit the honest answer is that flies have their pupal poop for the first 6 hours of life during which they can’t have sex, so if you see the poop still in them they are virgins.

[@DrachenGothik666]

@@therealjammit Hey, don't sell Linux short. Not all who use it are virgins. Some people program in it. Like my wife.😉

[@jamesmccollom7246]

Sleep isn't something we need, it's something so valuable that we don't want to miss it. Take it from someone that is in chronic pain. There's countless days of little to no sleep

[@jamesmccollom7246]

@Heather Petersen I wonder sometimes. Because there's stories of monks that never sleep. Some famous people are also recorded as sleeping 2hrs or less a night. With my chronic pain, there's some days I run 3-4 days without sleeping. Usually only sleep 2-4hrs. I've got severe sleep apnea aswell, so I never really slept when I do. Some doctors have wondered how I functioned with low testosterone aswell. I'd laugh at them because I used to be a amateur athlete aswell as working full time, partying, school, and pavement/backyard sports.

[@nyx4506]

"Red light district." I absolutely snorted.

[@gerrimilner9448]

loved experimenting on these little guys, loved this vid. at uni some students delibratly released there experimental ones, so that around the uni there were many variations, the staff confiscated our flys and euthenised them themselves by the time we were there so we couldent free them into the local population

[@duyanhng8430]

yo that's biological warfare lmao

[@EmilyJelassi]

It’s very weird knowing that we share that many genes with a fruit fly..

[@DrMonty-ng5fo]

I'm pretty sure we share 50% of our genes with a banana xD But really, the 60% figure isn't that weird. Humans and flies both share a common ancestor, and even though humans and flies are vastly different, we share a LOT in common. We both have organs like hearts, eyes, eat food, have dna, have limbs, etc.

[@RaGiAn87]

Its not that weird. You probably thought we share "that many" genes with monkeys so fruitflies would be less, but thats not how it works. We are 98.8% close to monkeys. Once you understand that, being 60% close to fruitflys is not surprising at all. Humans are not unique animals.

[@grum5776]

@@RaGiAn87 not to mention evolution plays by the rules, many times arriving at similar if not identical solutions

[@Philemaphobia]

Mew is made of the same code as Pikachu Creeper is from the same code as Steve. Synth is from the same Code as Ghoul.

[@perkyraid9089]

@@RaGiAn87Also something to consider as well, we all “evolved” from a single tree of organisms. Hell even the viruses we have are the same. Like technically about 99% of dogs i believe share a common ancestor, and better yet that common aancestor isnt actually “dead” but is still alive and reproducing. Its a virus… A dog that lived thousands of years ago had a virus that replicated some living cells of the said dog and made them rogue. Those cells in a dormant state transfered to another dog via sex. The virus is then in the kids, the kids mate, have kids, they matec have kids etc etc etc. I forgot what its called but the virus was dormant for many generations but the original dog was still “alive” in the living dogs.

[@joshyoung1440]

6:44 "Normally, this would be a hard nut to crack." NO. YOU STOP THAT RIGHT NOW, HANKSTOPHER GROBIN.

[@J.A.huscher]

A few days ago I saw you in a video used in my psychology class. I didn't know you did other stuff other than what's on SciShow so that is cool. I think it was on the CrashCourse channel thing where you talked about the scientific method in psychology

[@jamesmurray438]

Yep. Hank also presents on CC. That's how I initially discovered him. Thanks to Hank and CC, I passed various modules in college like anatomy and physiology and psychology

[@kathyjohnson2043]

All of Crash Course is great but my favorite will always be World History, the original, with. ..wait for it, The Mongols.

[@MuscarV2]

You mean "I didn't know you did other stuff than SciShow"? (The scientific method is obvious science...) Hank does MANY other things, multiple youtube channels like both the other SciShow spinoff channels, other unrelated ones and stuff outside of KZbin. Surprising anyone doesn't know that.

[@J.A.huscher]

​@@MuscarV2 Yes I meant SciShow, I'm sorry. It's been a long day. And this is kind of the only KZbin channel I actively watch. I knew there were spinoffs but I never really watched them. I know he's written books and stuff and doesn't major in just science, I just never really thought of the other KZbin channels he's been in. I'm sorry for wording it weirdly. And the video we watched in psychology was about the scientific method.

[@semaj_5022]

@H.U.S.K. Project Hank presented Crash Course Psychology, Philosophy, and History of Science, as well as Chemistry and Biology. All of them are worth a watch, but the first 3 I listed especially. The scientific method video could have been any of those 3, too, honestly. I think he touches on it in all of them. You should absolutely try to check them out whenever you have the time. They're really educational, of course, but also very entertaining in that classic "Hank Green" sort of way.

[@MiniMii550]

Could you imagine having a whole box full of those flies that can nut on command you're about to initiate an experiment with these guys and your new intern accidentally turns on the red light?

[@thaddeuszukowski4633]

The "red light district" really, thank you for the laughter! Oh did I need that!

[@Natalia-09]

These guys are so fun! We used these guys to study some different things about genetics in my genetics lab last semester.

[@mud1905]

This will be the first and last time I EVER thank a fruit fly……………… Thank you.

[@nothanks9503]

Excuse me LGBTQIA+ flys

[@lottieew135]

I love how they, the scientists, called the Notch gene after notches in the wings! I've had a bit of a scary time, wondering if my Notch3 gene test came back as normal, because if it didn't, it was likely that I had Cerebral Autosomal Dominant Artereopathy with Subcortical Infarct Leucoencephalopathy (aka CADASIL), and my mum & deadbeat father would have to have a test to see who passed on the faulty gene. Thank god I'm not that broken, my immune system just likes to royally attack the myelin sheaths on my neurons. I have come to terms with the diagnosis I got of MS, and I am happy my husband-to-be is just as cool with helping me with every new symptom or relapse 🤷‍♀️💓

[@jrmckim]

My comment disappeared

[@joshchotiner]

"That's a hard but to crack" - come on, Hank! 😂😂😂

[@paulbennett7021]

I wanted to see the bit about exploding ants.

[@jbbrutal6714]

Like ×10

[@aftersexhighfives]

Baking soda

[@Symphing12]

It's videos like this one that remind me why I love SciShow. DFTBA!!

[@PlutosAsleep]

i love scishow, y’all are why i’m passing science, you make it fun! ❤

[@bjdefilippo447]

I had a SURF (fellowship) in a biology lab at Caltech that was really fascinating, so I considered switching my major from ChemE to Bio. Then we got to the fruit fly genetics part of Bio lab, and I watched one of the flies I'd just dosed giving birth while dying. That was it for me, I'm afraid. That research is better done by folks made of sterner stuff than I.

[@aftersexhighfives]

This is wonderfully wholesome. Never change. ❤

[@injunsun]

@SciShow @ about 13:30, I have a hypothesis: On Earth, the fruitflies exposed to higher winds or who need to fly more experience more centripetal forces in their lives, and may also be more likely exposed to airborne fungal spores. Those living in areas with little or no winds, and who didn't need to fly as much, exposed to less centripetal forces, also happened to be less exposed to fungal spores. It's possible this is a natural thing, and spaceflight is simply exposing it. That would be cool, and if it ends up being real, I called it.

[@637dan]

Controversial take: the space fly research also need to make a giant flightless variant. So I can raise my little space puppy from a maggot when I get to space.

[@FeedEgg]

I would love to see how a flea behaves in micro gravity!

[@holeshothunter5544]

Confused.

[@kayleighlehrman9566]

The cadence with which Hank exclaimed "Space! People would spend a lot of money to go to space!" just really reminded me of John Mulaney

[@mandarinD]

The drosophila melanogaster. I had the latin name drilled into my memory over 10 years ago. Thanks Ms Dunn!

[@Ratciclefan]

Fruit flies: [exist] Scientists: and I took that personally

[@vailstales3639]

I love the attention to detail when talking about sex and not confusing it with gender. “People with XY” rather than just hearing men made my queer heart happy :)

[@AriJeru]

Dude! My favorite are all the completely insane body patterning experiments.

[@Fabala827]

Sci show re: wasps: “You’d think “parents would want to protect their offspring from viruses” Me, having spaced out for a second: “Oh damn, are we talking about vaccines now? What’d I miss?!”

[@vaszgul736]

"We also have traits controlled by our genes on our sex chromosomes. One example is red-green color blindness which is passed down on the X chromosome. That's why people who are XY and only have one copy of this chromosome are more likely to be colorblind; usually men. People with two X chromosomes would need to have the gene for color blindness on both [chromosomes], which is less likely." Holy schnitzel I just wanna say I love how fluid and flawless the execution of this sentence is. Informative, accurate and ever so perfectly inclusive.

[@vaszgul736]

Usually in videos like these, (not by scishow, but you know the ones) the narrator will just slap together a quick quotable quip like "only men can be colorblind" which is just wildly inaccurate, doesn't take into account the strange way chromosomes can be/break/or rearrange themselves not only in cis and intersex people but also in trans people as well. Or the fact that yes, cis women with two XX chromosomes can be colorblind and even completely colorblind, it just requires two copies of the same gene which is rarer, but not impossible. And yknow, not all men are colorblind, but some people have taken and run with the idea after hearing sentences like that. So while it's so much easier to say "only men can be colorblind," easier said doesn't mean correct, informative, or inclusive of statistical outliers.

[@snowgoon]

Time flies like an arrow, fruit flies like a banana.

[@SilentRacer911]

I wonder if the gravity effecting the fly’s immune for fungus has anything to do with how hyphae grow?

[@karezaalonso7110]

For regular folks who need to get rid of them you can put small container with couple drops of liquid soap and also few drops of apple cider vinegar and the rest with warm water, mix and leave it in the infested area. It will kill lots of them.

[@alleny2971]

i just kept imagining the male fruit flies looking at dirtly fruit fly magazines

[@theoneandonlyguyallikian1190]

"Crack the nut" 🤣 LMAO

[@archionblu]

The exasperation in that ending was *chefs kiss*

[@3756hans]

I put one on the nosecone of a fan and turned it on high . It flew around in circles for a minute before it could fly straight again .

[@ac9206]

Sci show, the compilation king, the repost monarch, the reteller of stories already told!!

[@DrachenGothik666]

Not everyone obsessively follows every Sci-Show post. Compilations are great for those who may have missed older episodes, or who might be new subscribers. You can't always see 'em all. Themed episodes are also neat and having a single topic all in one place is cool.

[@ac9206]

@@DrachenGothik666 playlist were designed for exactly this purpose

[@HeliotropeElephant]

Had to check the calendar to see if the red light / fruit fly experiment video was posted in April

[@johnnyregs2378]

My brothers a research biophysicist and he used fruit flies to study prostate cancer which directly led to new treatments.

[@tolic14ever]

Just started...recently heard about some of these living more than several years hope to hear..😬

[@FloozieOne]

When I looked at those jars of fruit flies I had a vision of someone dropping one and letting a zillion fruit flies loose in the space station. Does microgravity make it easier to swat things or harder? In any case it would be a disaster.

[@Jaredeva01]

Do the flies that go to space have to pass the same astronaut training program and evaluation in order to make the flight off planet?

[@jimparsons6803]

And they don't jump in the middle of a newspaper that you're reading because they want to be petted. And they don't walk around on your keyboard, purring, and destroying fifteen pages of copy that you failed to back up. But pets are cute and cuddly, in spite of their angora hair that gets into everything. Unlike fruit flies, that don't have the SPCA or other organizations that might put you in jail for doing to those flies, if you were doing the same to horses, cows, or pooches.

[@jigilub]

I have one phrase running through my head as I watch this, "Fly TMI!"

[@nicksamek12]

@21:53 when he added in flies I was like oh yeah sure, then when he added that it's in mice as well? That's pretty promising

[@StardogTheRed]

"Not *just* out of spite" - suggesting that it is done out of spite, as well as for other reasons

[@frankied.roosevelt6232]

Drosphila-lalalalalala- you likely will outlive the roaches and the ripen fruit will be no compare... DROSPHILA! (sung to the Mail time songs from blue clues)

[@justinweatherford8129]

Cells not only know how to multiply, they know how to divide too. Wait, cells divide in order to multiply.

[@MarcColten73]

Somewhere, in a higher dimension, "Why,you may ask, do we torment these fragile humans and what hsve we learned from them?"

[@nunyobidness9055]

Nothing gets me going like a nice grapefruit 😂

[@MadCat-75]

Hi, shown were two different families of flies, that's the problem with trival names... the last video shows Tephritidae, the others were about Drosophilidae.

[@skybluskyblueify]

Remember when a politician seemed to be outraged at how much science that the government funds is on fruit flies? Today that's actually cute compared to some outrages produced by politicians and associated people.

[@Bloodshotistic]

I cannot believe for one instance our top leading, apparently thirsty, research scientists, tried to start fruit fly hands free orgies for a solid reason why.

[@_andrewvia]

Ok, I don't know where else to submit an idea, so I'll put it here, hoping that one of you will see it. "Are pupae aware while they are changing from caterpillar to butterfly? Can they respond to stimuli as they are able before or after the pupa stage? Might they get bored? Et cetera?"

[@Wootzel]

Having handled pupae of moths and beetles, I can answer part of that: they DO respond to stimuli. Lots of pupating insects can wiggle when handled, which I suppose is a defense that makes them slightly harder to keep a grip on. I couldn't tell you anything about what's going on in their brains, though I have heard about studies showing that some moths basically liquefy themselves during metamorphosis, yet retain memories in adulthood. Bugs are weird!

[@bet3240]

​ look no further than jumping beans. Their entire thing is being extremelly awake the entire time

[@AlixL96]

That thing about anesthesia bursting the lipid rafts makes me kinda worried about whether anesthesia has any long term affects we don't know about.

[@shutupsprinkles]

…i could have gone my entire life without knowing so much about fruit fly ejaculation but here we are

[@djentlemanb]

"How are we going to stop these cancer-causing x-rays?" -"I got it; we'll use a cancer-causing heavy metal apron!"

[@rostkowianka]

there's a fruit fly on the monitor as i watch this

[@ThatSkyThing]

I love these intelligent little flies.

[@sarah.s.flanagan]

Would be so wild if the gravity/fungal connection wound up being time-based. I'd watch a movie with that premise regardless

[@leonestello]

We know now why we need to sleep. It's a cool down period for our brain can unswell and circulate it's coolant. 🧠 It's literally a way to deactivate the brain so it can cool off♨️

[@amydixon9982]

It seems that the sestrin researchers should talk to the space life researchers? Might be the answer to muscle weakness in space.

[@ABetterWeapon]

Hmmm, going with a jacket now? A bold move.

[@monk607]

I really wish y'all would list the title of the video in each compalation

[@MattsInTheBelfry]

Catch them with fruit or wine in a glass, cover with plastic wrap poked with tiny holes

[@karezaalonso7110]

9:40 So Space is limited in...Space🌌

[@Essman614]

Time Flies like an arrow, Fruit Flies like a banana -Zilean

[@marcus_cole_2]

7 minutes in and I said to myself red light district for flies 7 minutes 30 seconds later rad this district for fly shows up...lmaf

[@matthewcalifana488]

A wasp must of had some fear when it came thru a window & I smacked it with 1000 volts , it shook it,s head and kept trying to go back outside .

[@Swanke]

So, what you're saying is, I need some red lights around my house. Not for the flies. Got it.

[@EmanuelGaldr]

I love how you said people with one x chromosome / two x chromosomes... instead of men and women. That was neat.

[@Rachel-fi4sc]

Exactly. Chromosomes aren't actually as cut and dried as we're taught in middle school. I can't remember the details, but there was one university where the first "project" in the bio undergrad was to take a DNA swab and look at your own sex chromosomes (those being the easiest to differentiate), but they had to stop doing it because they accidentally gave so many students an existential crisis when the results came back with the "wrong" chromosomes.

[@williehasenbos4899]

I know where you'r intro is from ...... and its oooooold .....

[@Nazuiko]

Sestrin treatments sound useful in space, preventing some of the atrophy and decayof muscles in microgravity

[@AnthonyHernandez-tr4sl]

I wonder if any flies have got free and reproduced and that's why they seem to be getting worse.

[@paurushbhatnagar8100]

So fruit flies aren't so bad as we think. They are pests but they are also pollinator.

[@LockandLoad79]

Any one other than me when hearing no-exercise-needed-buff protein thinking "oh hey, hello Super Soldier Serum" ? Also, combine that with that "fear trigger" research.

[@geoffreymartin6363]

This episode is... pretty fly

[@mike1983mn]

… for a white eye(d fruit fly).

[@januszbogumil]

Absolutely entertained by how scientists gave fruit flies a red light fetish

[@sarah.s.flanagan]

5:51 starts the compilation, after the broader introductory biz

[@jws1948ja]

Sleep is needed, and if you do not get it, you die.

[@elimcfly350]

Thanks, flies. Thlies.

[@Amocles]

Maybe if I dress up as a fruit fly I can participate in that experiment?

[@karezaalonso7110]

Just curious if the fruit flies went blind from the *Excessive * red light,.... if you know what I mean.

[@ChrisWard64658]

Interesting thanks for sharing

[@MrDDiRusso]

TIME FLIES LIKE AN ARROW. FRUIT FLIES LIKE A BANANA!

[@aurorafauna4195]

6:45 You know what you said. :P 8:35 Uh-huh

[@christinefedruk5161]

Love my induction stove.

[@iratami]

I'm still surprised that we havent started building a space ring to implement artificial gravity. We have the technology

[@katiebarber407]

mainly because it's very expensive with very little reward

[@iratami]

@@katiebarber407 having astronauts come back with less physical degradation is a very minor benefit

[@ripwig6682]

Great video.

[@exiledtobronze8694]

i just imagine someone shining a red light at people and egmmmhhh...ahhh

[@undying3132]

21:25 I was expecting the return of Buff Hank. I was disappointed.

[@mikeg2306]

So the conclusion is that humans drink because they can’t get any. Sounds about right.

[@katiebarber407]

and if you don't drink and also don't get any, you turn into an incel