SCLERODERMA (Systemic sclerosis) Pathogenesis Diagnostic criteria Classification EULAR Treatment

[@palanisamyhariharan7026]

I am glad that atleast I found this channel now ,with such a pinpoint accurate details and diagnostic criteria ,THANK YOU SIR

[@Foxterrier]

Thank you )

[@chaeyunera]

I'm starting my Rheumatology round next week. Everybody told me to just memorize the clinical knowledge as there isn't much room for understanding but thanks to you I'm having fun learning and understanding WHY everything happens that way. Thank you so much for teaching me Rheumatology 💞💞💞

[@Foxterrier]

Thank you very much, it is a pleasure for me to hear ) 💙

[@shyampatel999]

This is the 1st time 1 buy subscription for any youtube channel. Because your videos teach me better concepts than any other channel. Thank you 🙌

[@Foxterrier]

Thank you, man. Appreciate it very much. 💙

[@AravindhanS-d8f]

Underrated channel

[@IhtishamMD]

Great 👍👍👍👍 thanks for such a clear Crystal way for making students understand the topic

[@Foxterrier]

Thank you, appreciate it very much)

[@erikvanwyk1297]

Brilliant video, Thanks a lot

[@chaitramurthy6635]

Great ❤ I understood everything 🎉❤ Thank u sir

[@Foxterrier]

Thank you for the feedback. Appreciate it very much )

[@AravindhanS-d8f]

Awesome videos and explanation ❤

[@Foxterrier]

Thank you very much )

[@medlinafarah3226]

Thank you very mush sir for this beautiful explanation

[@Foxterrier]

Thanks for watching )

[@akankshasandhu581]

Thanks Make it very easily topic to understand

[@Foxterrier]

Thanks)

[@hamzamahmoud8816]

Is the antibody able to destruct healthy cell which the nuclear is intact in it ?

[@Foxterrier]

Hi, yes it can

[@hamzamahmoud8816]

@@Foxterrier Great as always man ,hope you are good

[@salsabilferhat7780]

Hi in the pathogenesis u didn't mention endothelin 1 produced by endothelium cells but from what i learned it is the main cause of vasoconstriction (not the myofibroblast) and HTAP too also the endothelium cells can produce TGF BETA and activate fibroblast by itself so what can u say about this correct me if i am wrong and thank you

[@Foxterrier]

Hi, endothelin-1 indeed plays crucial role in initial vasoconstrictor (reversible), which is the central factor contributing to development of pulmonary arterial hypertension. (we have drug Bosentan which blocks ET-1 receptor - for PAH) But in terms of tissue remodeling and fibrosis myofibroblasts is the major factor. Fibrosis cause irreversible vasoconstriction. Do endothelial cells produce TGF-beta - yes. But are they the major producers of TGF-beta - no. So in terms of ET-1 and pathogenesis of early stages of vasoconstriction - you are correct. In this video i made an accent on fibrosis and sclerosis (cause it's scleroderma) and the role of immune cells ( cause in treatment we use MTX and other immunosuppressive agents), but when i will remake this video at some point, adding new features, i will definitely add the role of ET-1.

[@thunderfeel]

Some questions: 1. Can will be used Penicillin for treatment scleroderma? 2. Is the level of hydroxyproline determined for the diagnosis of scleroderma?

[@Foxterrier]

Penicillin is not commonly used in the treatment of scleroderma, as the disease is primarily managed through immunosuppressive medications. The level of hydroxyproline in scleroderma is elevated, cause it's a breakdown product of collagen. In scleroderma increased collagen turnover - leads to increase in hydroxyproline level. However, hydroxyproline is not used as a primary diagnostic test for this disease.

[@thunderfeel]

@@Foxterrier I was wrong. I did not mean Penicillin, but Penicillamine. Thanks!

[@Foxterrier]

@@thunderfeel Penicillamine is not commonly used anymore due to the high risk of side effects (esp Renal side effects as nephrotic/nephritic syndromes etc.). Also nowadays we have more effective agents as MTX for example.

[@thunderfeel]

@@Foxterrier I understand. Thank you very much!

[@ydhdhev2490]

You are incredible

[@Foxterrier]

hah, thanks for watching )

[@bluesky7704]

Methylene Blue seems to be healing my scleraderma

[@joudyhaider6296]

❤❤❤❤

[@Foxterrier]

Thanks ) 💙

[@thunderfeel]

It is the brilliant work. I get great pleasure

[@Foxterrier]

Thank you very much )))