Sedative Hypnotics (Part 03 Final) = Classification & Pharmacological Action of Barbiturate (HINDI)

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Hypnotics are the drugs which make a person calm but also induce sleep. This is an extension of a sedative dose of any drugs. Sedative in large dose act as hypnotics. The target of Benzodiazepine is on GABA receptor because GABA is a major inhibitory neurotransmitter in CNS. GABA is consisting of five- alpha, beta, gamma subunits that span the postsynaptic membrane. The influx of chloride Ions cause hyperpolarization of the neuron and decrease neurotransmitter by inhibiting the formation of action potentials.
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Sir All these points Discussed in this videos are effect of Barbiturates ??? Or All Sedative Hypnotic . I mean BZ + barbiturates ???

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Sir, barbiturates have gaba mimetic effect means ?

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Acting like gaba

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Sir, centrally acting muscle relaxant ra topic is not available????

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As barbiturate and benzodiazepines have same mechanism of action ?

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Sir how are dosing of barbiturates is given in tablets as eg sleeping pills , as the half life of barbiturates are to high ??

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Concentration

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Agr barbiturates hyperalgesia cause karta h mean pain induce then neeed kese aayegi pain hoga toh neeed toh aayegi hi nahi sir please tell me

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Ye subhypnotic or no. Hypnotic dose me algesia cause karta hai

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Sir can u plz give me the answer of this question with explanation Probably acts by binding to a component of GABA-receptor coupled chloride channel, prolonging the duration of channel open state, when the receptor is exposed to GABA: a) chlordiazepoxide b) pentobarbital C) fentanyl D) imipramine E) doxepin

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A

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A because chlordiazepoxide is a long acting Benzodiazepine

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@@kaleemullahshoaib1341 but benzodiazepine don't increase the duration of channel opening they increase the frequency of channel opening of chloride channel

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What is IPSP?

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Inhibitory post synaptic potential

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For this you need to watch the basic introduction about anaethetic. It can give anaesthetic action along with main anaesthetic by potentiating that action.

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