Histamine (Part 04) Second Generation Antihistamine Drugs | Classification of Antihistaminic Agents

Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. ... Antihistamines that target the histamine H1-receptor are used to treat allergic reactions in the nose (e.g., itching, runny nose, and sneezing).
Antihistaminic drugs or histamine blockers are the drugs which block the action of histamine or its release. Histamine is responsible for local action like- itching and other allergic response. Antihistaminic drugs ar are useful in following categories-
1- Anti Allergic Rhinitis by Antihistaminic Drugs
2- Anti Conjunctivitis by Antihistaminic Drugs
3- Anti Hay Fever- by Antihistaminic Drugs
4- Anti Pollinosis by Antihistaminic Drugs
5- Dermographism by Antihistaminic Drugs
6- All other kinds of an allergic reaction
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@@solutionpharmacy sir you wrote that the 2nd generation of antihistamines is used for parkinsonism. So I have a question the 2nd generation has no anticholinergic effect, not crosses the BBB. SO HOW IT IS USED FOR PARKINSONISM?

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@@immojani3185 this effect is possible effect not mainly used a primary option and that effect may be due to their non specific activity

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Sedation in common cold also helps in the symptomatic action as written in KDT . It does not decrease sedative action.

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Sir vertigo ke liye apne bola ki 2nd gen antihistamines use krte hai ...example promethazine to ye to 1st gen antihistamine hai na ?

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[@prettyvibes1477]

But promethazine is 1generation anti histaminic drug why is this mentioned here???

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[@keerthanagopal6220]

Sir i have a doubt.. in this topic u specify about second generation antihistamines right.. but u give promethacine as an eg. for motion sickness.

[@solutionpharmacy]

Keerthana Gopal Its not necessry that one drug will produce only 01 action. It gives many effects

[@HarshitArts]

sir is there any drug mechanish who increase DOA (diamino oxidase) level so that histamine can be metabolise much better without showing or doing allergy reaction

[@solutionpharmacy]

Sorry not sure at the moment

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[@amritashukla182]

Sir as first generation antihistamine side effect is tremors or shaking then how antihistamine drugs used as anti Parkinson drugs and reduse tremors

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They will not affect on tremors, they affect the cause of itb

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[@ruchikagarg9735]

Sir Q Histamine is autocoid and autocoids not circulate in body they show their action locally so why antihistaminic drug H1 blocker 1st geneartion go in corculation and in brain also and cross blood brain barrier Kindly give me answer please🙏

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It is its property. Antihistamine is not autacoid

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Why should we not take them in common cold?

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sir allegy is the side effect of histamine. am i right?

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Allergy is response of allergen which start release of histamine

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