Stress Immune Brain (Part 2)

[@timmyschannel5]

Would love to have you as my doctor. 2 years long covid. Neurological problems, not Pots. Focal seizures in my sleep. Living in europe

[@sebek12345]

🎯 Key Takeaways for quick navigation: 00:00 *📜 Observation of Traditional Chinese Medicine* - Traditional Chinese Medicine (TCM) utilizes non-contemporary methods like pulse and tongue diagnosis. - Practitioners aim to uncover subtle signs and patterns of information in patients. - Training in TCM involves developing sensory capacities to gather relevant information subjectively. 02:08 *🧬 Integrated Physiology and Conventional Medicine* - Conventional medicine compartmentalizes the body into discrete systems for treatment. - Integrated physiology views the body as a system of systems, recognizing patterns that dictate health and illness. - Advancements in measurement tools and data analytics allow for more comprehensive understanding of physiological patterns. 03:47 *🔄 Stress Response and Allostasis* - Allostasis refers to stability through change, crucial for survival. - The stress response involves various physiological processes beyond the HPA axis, affecting cardiovascular, metabolic, and immune systems. - Treatment strategies aim to restore allostasis, emphasizing overall function and balance rather than just treating specific diseases. 05:06 *🔍 Understanding Stress Response Mechanisms* - Stress triggers metabolic responses geared towards survival, enhancing physical capabilities. - Prolonged stress leads to dysregulation of various bodily systems, resulting in diminished resilience. - Impaired stress response manifests through psychological, behavioral, and physiological changes. 12:05 *🧠 Stress-Immune-Brain Interaction* - The brain's response to stress involves a complex interplay with cortisol, affecting immune and brain function. - High cortisol levels, induced by stress, can lead to neurodegeneration, particularly impacting areas like the hippocampus. - Chronic stress may result in a shift from hormonally driven responses to immune system dominance, increasing inflammation. 17:44 *🌀 Stress Impact on Gut-Immune-Brain Axis* - Stress influences the gut-immune-brain axis, leading to neuroinflammation, immune suppression, and hormonal shifts. - Cortisol's role in stress modulation affects immune balance, potentially exacerbating inflammation. - Chronic stress can disrupt the body's adaptive responses, contributing to neurodegeneration and immune dysregulation. 20:18 *🧠 Impact of Stress on the Hippocampus* - Prolonged stress can damage the hippocampus, affecting its ability to regulate the stress response. - Cortisol elevation due to stress damages the hippocampus, leading to a cascade of effects such as increased cortisol levels, brain damage, and a shift towards a pro-inflammatory state. - Structural and functional alterations in the hippocampus, including volume loss, reduction of excitability, and memory alterations, occur due to long-term stress. 23:05 *🔥 Effects of Stress on Brain Health* - Chronic stress accelerates neurodegeneration and inhibits the brain's ability to heal and repair itself. - Stress-induced hippocampal atrophy and dysfunction contribute to cognitive deficits and dysregulation of the stress response. - Microglial cell activation, dendritic retraction, and glutamate pathway triggering exacerbate brain injury under prolonged stress conditions. 24:26 *🤯 Interplay Between Cortisol and the Immune System* - Cortisol and the immune system have a complex relationship, with cortisol affecting immune cell function directly. - Stress-induced cortisol elevation shifts T helper cell balance towards TH1 or TH2 pathways, influencing allergic or autoimmune responses. - Cortisol, along with the sympathetic nervous system, modulates immune cell activity, impacting inflammatory responses. 26:32 *💡 Brain and Gut Interaction under Stress* - Stress affects the gut-brain axis, leading to alterations in gut permeability and immune responses. - Immune-mediated alterations in the gut, such as histamine release and mucosal barrier dysfunction, exacerbate gut symptoms under stress. - Dysbiosis and stress-induced serotonin degradation in the gut can contribute to neuroinflammation and neurodegeneration. 31:49 *🔄 Adaptive Responses to Prolonged Stress* - Prolonged or repeated exposure to stress stimuli can lead to hypocortisolism as an adaptive mechanism to free bodily defenses against immune threats. - Hypocortisolism may protect against the harmful effects of a high allostatic load index, indicating the body's adaptive response to chronic stress. - Flattening of the cortisol curve is associated with worse outcomes across various health conditions, indicating the importance of cortisol regulation for overall health. 39:40 *🧠 Impact of stress on health outcomes* - Flattened cortisol patterns are associated with worsened health outcomes in cancer, cardiovascular issues, and diabetes. - Stress and sleep disruption can hinder neurogenesis, the production of new neurons in the adult brain. - Ongoing stress interferes with neuronal renewal and survival, affecting brain repair processes. 40:20 *🧬 Mediators of stress impact on brain function* - Stress and sleep disruption inhibit both proliferation and survival of adult progenitor cells, essential for neurogenesis. - Neuroinflammation and excitation stall neuronal progression, impacting brain repair mechanisms. - Lasting inhibition of adult neurogenesis can occur despite cortisol normalization after initial stressors. 42:14 *🌱 Strategies to mitigate stress effects* - Botanicals like philodendron and magnolia help normalize high cortisol levels, reducing stress and anxiety. - Theanine, extracted from green tea, acts as a natural anti-anxiolytic, promoting calmness and focus without sedation. - Plant sterolins modulate and balance immune responses, targeting TH1, TH2, TH17, and T reg cells to restore immunologic balance. 45:40 *🧪 Advanced approaches for brain protection* - Rg3, derived from Chinese ginseng, exhibits potent anti-inflammatory properties, protecting the brain from microglial cell activation and oxidative stress. - Nicotinamide riboside, a vitamin B3 derivative, serves as an NAD precursor, safeguarding the nervous system against degradation and degeneration. - Case study illustrates a comprehensive treatment approach targeting infections, immune balance, and stress support to restore cortisol levels and alleviate symptoms. 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[@handpanfusion]

Where can we buy NR2 spray ?

[@mv8908]

How are you doing dear

[@Lucidity__]

The best teacher. I love watching these, have been learning so much from them. Thank you thank you 🙏🏼