T cell development in the Thymus

This video gives a quick overview about the development process of T cell inside the thumus

[@tarunkant95]

I listen to your video more than I watch it. Great content but just a friendly suggestion, some words because of the accent are very hard to grasp in one go, try to minimize it and keep up the good work.

[@animatedbiologywitharpan]

Tarun Parihar thanks for the feedback ....it would help me to improve in future

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Animated biology With arpan I appreciate your willingness to teach. Oddly, I appreciate the accent because it encourages me to truly pay attention rather than multitasking as I do with other videos.

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Medical student at germany. This video made it so easy for me to learn this topic. thank you.

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This makes learning biochemistry so much easier, I wish this was available when I was a student, many years ago. Thank you

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[@animatedbiologywitharpan]

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[@animatedbiologywitharpan]

Watch the entire playlist on immunology for quick revision

[@olinko2849]

Thank you so much!! I was stuck so long on this because I couldn't visualize it right. Keep up the good work :)

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Don't forget to check out my entire immunology playlist. Please share my youtube channel link with your friends

[@gladysudoka193]

This is good , very simplied and enhances the understanding of difficult subjects as this. well done

[@animatedbiologywitharpan]

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[@RayyannAlqadry]

According to a research paper in the Journal of Experimental Medicine, T Cell training takes only 4 days. Just a sharing. Everything else is amazing, exactly what I was looking for

[@animatedbiologywitharpan]

Rayyann Alqadry thanks for your detailed feed back it would help me to improve my content..... also I am a learner and the audiance like you would help me to learn

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[@RayyannAlqadry]

@@animatedbiologywitharpan Oh, I wanted to know, where did you find the information that only 10% of the T Cells pass through Positive Selection? Thank you in advance

[@sanroopramesh7620]

Very useful. I like the comparison at the beginning

[@animatedbiologywitharpan]

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Your explanation is very beautiful. Keep on posting more videos. Love from Kathmandu

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Your video is well structured and very easy to understand. GREAT JOB!!! You should create more content.

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[@gurunathvenugopal4642]

Very well explained. Thank you for teaching

[@animatedbiologywitharpan]

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[@lurker7522]

@@animatedbiologywitharpan Hi, I have a question. Do regulatory T cells go through the same training process as other T cells?

[@abhibittu16]

Very simple and easy explanation. Thanks👍

[@animatedbiologywitharpan]

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Arpan da! Just another masterpiece. ❤️

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[@iot3136]

❤❤❤🙏 Excellent work. Could you please playlist for immunology. You are very talented in teaching immunology mate.

[@animatedbiologywitharpan]

immunology complete playlist kzbin.info/aero/PLKtiwIJ8Q7rq77W7r4cXPrbhi_VpLWw8c&si=Bh-eDMPn7QHw8Z-i

[@animatedbiologywitharpan]

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[@awestphal9602]

The regeneration of the Thymus is a current topic. Particularly, the use of Russian bioregulators such as Vladonix (A-6) and Thymic Protein A. Teach us how we can regenerate the Thymus and overcome future illnesses. Apparently, there are scientific studies and experts supporting the regeneration of the Thymus.

[@phoenixkepo2743]

Special forces selection training @ the cellular level. Amazing!

[@shakir1325]

This is osm ❤❤ I understood very well Thank you

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[@iambliscanna1592]

Brilliantly explained! Thank You! SUBSCRIBED! 😀

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[@zainabjummah7383]

Thanks you help me to understand this complicated process... go on

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[@hxdcm]

Such an interesting video, thanks for making it

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Recent one!.. liked it bro. Animation is good and description as well. Really nice and helpful

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@@animatedbiologywitharpan Of course. 😇

[@GauravKumar-fc7sr]

Awesome sir,,,, all basic concepts clear 😘😘😘

[@animatedbiologywitharpan]

Share among your friends

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[@animatedbiologywitharpan]

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[@012-p6t]

Beautiful and easy explanation! thank you

[@animatedbiologywitharpan]

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[@nedunchezhian9914]

Nicely demonstrated

[@customking8467]

Some much better than my lecturer

[@animatedbiologywitharpan]

here is immunology playlist for complete revision kzbin.info/aero/PLKtiwIJ8Q7rq77W7r4cXPrbhi_VpLWw8c&si=eafq-0lBBzfGLrAt

[@hope.pk1028]

Infornative ! good job

[@animatedbiologywitharpan]

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[@HarryPotter-vl3pc]

Woww... this really is awesome

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[@africkinamerican]

Fascinating. How do the T cells know when /how to enter the bloodstream to travel to "school"?

[@aaquib608]

Thymic epithelial releases certain chemokines which attracts immature T cells towards Thymus.

[@youhani9459]

amazing video! Very well explained :D

[@animatedbiologywitharpan]

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Insightful video.

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[@partibhapanchal7030]

@@animatedbiologywitharpan I'm on to it. Content might be available on sites but the way u delivered it making ur videos superb 👌.

[@animatedbiologywitharpan]

Thanks for the kind words

[@mindspaceinvaderskibinhhon4465]

Sorry but can someone please explain me more about the positve and negative selection when T cells are trained by the thymic epithelial cells? what is "MHC restriction" like? I need it for the coming test at school. If you know, guide me as soon as possible. Thank you so much

[@hibakaleed387]

Amazing video thank you so much

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[@biologylover1565]

Hematopoietic multipotent stem cell found in bone marrow. So it is multipotent stem cell able to give all cell of same linage of blood cell.

[@millbankowusuemmanuel4572]

Yes, it's the basic pluripotent cell that differentiates depending on the chemical signal received from the body for specific demands

[@Mchc167]

This was very helpful thank you

[@animatedbiologywitharpan]

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[@zzzsss00]

Can u please make a video what happens if u remove thymus gland and how would effect people after?

[@animatedbiologywitharpan]

Adaptive 8mmune response would be compromised in short...i will make a video on that

[@zzzsss00]

@@animatedbiologywitharpan thank you very much! Waiting for your video👍

[@amandaczymbor281]

Was a video made on this?

[@pranav6143]

@Animated biology With arpan sir as it says the thymus will be inactive on adulthood,then how is the t lymphocytes matures in the adulthood time? Bcz the TCR(t cell receptors)forming on the T cell membrane are said to be specific to the pathogenic antigen(by the response of related specific genes like TAG 1 or TAG 2 genes).Isnt this process of new pathogen encounter to be happened in furthur phase of ones life,so then isnt the thymus need to be active for those specific kind of functioning related to T Lymphocyte development? So again,my qstn is is thymus active in adulthood,if not ,how the t cells are developed in adults?

[@pranav6143]

I got the answer sir, Bcz on t cell production itself diff types of TCR having diff t cells are produced.So during an infection ,the t cells having the tcr, ie compactable to those pathogen will get activated and do their function Isn't it sir?

[@lunam7249]

HIV attacts the thymus....the thymus is "said" to contract and shrink normally with age, however this is not as significant as the common medical knowedge believes

[@sherbetstraw8605]

sensational thank you

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[@avantikachauhan1837]

Thanku for explaining this well

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[@triggerednj2709]

Superb presentation

[@animatedbiologywitharpan]

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[@s.papadatos6711]

Well explained, however the β chain is the one that has D genes, not the α.

[@akshitanarsinghani8383]

Yes!!

[@gaurishah9086]

Easy explanation, thank you

[@animatedbiologywitharpan]

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Thank u and may god bless u

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Azka Arshad please share among your friends

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[@animatedbiologywitharpan]

@@azkaarshad4773 You also stay safe my brother . Love from India

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[@animatedbiologywitharpan]

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good job, thanks!

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[@biotechstudent8658]

First of all thank you for this video, but I should ask for one concept, the hematopoietic stem cells are multipotent stem cells as I read from the other articles and from my stem cell lessons, Can I ask that where is it available the information of the HSC cells are pluripotent stem cells ?

[@animatedbiologywitharpan]

Kuby immunology 7th ed (not 6th ) chapter 2 or you can refer to revire article. Pdf of the book is there in pdfdrive

[@backbenchersbio3688]

Thank u sr My immuno is not so strong but after watching this vdo t cell maturation is totally cleared Sr make vdos on b cell maturation also

[@animatedbiologywitharpan]

I suggest you to go to my immunology playlist and watch each video.... everything is there

[@animatedbiologywitharpan]

B cell development link kzbin.info/www/bejne/oZy0f3mQhZeBm5o

[@animatedbiologywitharpan]

If you finish the playlist I assure you would have better understanding about immunology at least it would develop the basics

[@animatedbiologywitharpan]

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[@backbenchersbio3688]

Sure sr

[@sobis6670]

Thank you very helpful 👍

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[@HatiKeseorangan]

Like ... Wow !!! What happen on this earth... WBC not the one who stop the symbiosis, but thymus....

[@bio366geethasankar7]

🙏🏻🙏💖

[@animatedbiologywitharpan]

please share in your college group

[@roselinkitherik6972]

Superb bro

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[@biancaelena6675]

Nice explanation

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[@getitdone0010]

Hi Sir, I think at 6:00 you indicated the alpha vs. Beta chain captions wrong to their respective pictures... wont B-chain will have VDJ-C and alpha chain will have VJ-C recombination pattern for genes. Please correct me if I am wrong.

[@studyonline-kz1gf]

Thymic epithelial cells teacher of T Lymphocytes

[@animatedbiologywitharpan]

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

[@ToniDJohns]

wow ! Thank you !

[@muntakaalhassan959]

Thank you very much

[@animatedbiologywitharpan]

Subscribe to my other channel kzbin.info/door/4IpyopsGWSjaPACNTZLuqg

[@MUCOM2]

From where lid you learned that

[@animatedbiologywitharpan]

kuby immunology 7th ed

[@madhurabanerjee1965]

Owo u aktually made my doubt clear

[@animatedbiologywitharpan]

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[@joesteinwold5782]

Can the t-cells from the bone marrow grow the thymus?

[@animatedbiologywitharpan]

The mature in the thymus but are born in bone marrow. They can't be born in the thymus because thymus don't have the stem cells that produce t cells

[@somid7777]

I loved this video! However i thought VDJ was for B chain and VJ was alpha chain

[@animatedbiologywitharpan]

Vdj recombination happens for t cell receptor as well.

[@animatedbiologywitharpan]

Watch this video to know more kzbin.info/www/bejne/npmnpYhmgpuea6s

[@mdshahjahan618]

How to easily improve our body T- cell,plz suggested me.?

[@animatedbiologywitharpan]

By getting infected

[@gilbertgrejp]

Sorry, my Histology book says no HEV in the thymus. Only in lymph nodes and MALT/GALT/BALT

[@RaviKumar-sb4bp]

Helpfull

[@missesCarmenB]

The living cell, the True God's creation in my opinion. So wonderfully intelligent in ALL living beings. The rest is all about Evolution.

[@animatedbiologywitharpan]

I agree with your point

[@missesCarmenB]

@@animatedbiologywitharpan I was 19 in my first year studying biochemistry, this has been my "religion" ever since as it is the only thing that makes sense to me. I've never cared if anyone agrees with me or not, I avoided talking about it realizing that most friends or relatives will not understand. Thank you so much for agreeing with me.

[@halima2953]

For one Tcell and after TCR genes rearrangement will there be MANY types of TCRs or a single type of it which could be ( Alpha, Beta )or (gamma, Delta)

[@animatedbiologywitharpan]

One tcr type should be found in a particular T cell.. because after tcr vdj recombination one particular type is formed. But in a population of T cell we can find diversity of TCR

[@halima2953]

@@animatedbiologywitharpan ok I got it now thanks for replying

[@arindampaul5256]

Best understood this topic

[@paulchang8743]

whether negative selection happens in the thymic medullary region? by interacting with medullary thymic epithelial cell (mTEC)

[@johnnielee5618]

Please see wiki "thymus". Positive in cortex; negative in medulla. Knowledge should be shared. Good luck.

[@snowy2875]

I think you should tell us, how to increase the amount of t cell in my body that would be more practical.

[@animatedbiologywitharpan]

Diet is the most important thing for that. You can watch the following video to get an idea kzbin.info/www/bejne/rZeVYXqrZt5kldE

[@snowy2875]

@@animatedbiologywitharpan Thanks buddy!!!!!

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great exp sir

[@animatedbiologywitharpan]

Good.... glad to hear that you guys are liking it... please share among your friends and help me to reach big audience

[@animatedbiologywitharpan]

And I am not sir .... I am one of you guys

[@chtatarrachid2443]

Thanks

[@animatedbiologywitharpan]

je vous en prie

[@knowledgejunction1643]

Dear brother arpan yr content r amazing and also teaching but if u want more and more subc , share and populality then pls make video in also hindi language; next as u wish

[@animatedbiologywitharpan]

I can try but my hindi is not at al good.....cause i learned hindi by watching movies only...eventually i would think in that direction

[@animatedbiologywitharpan]

anyway share among your friends and help them as well...happy learning

[@knowledgejunction1643]

@@animatedbiologywitharpan ohk in which univ u compt ug

[@animatedbiologywitharpan]

Presidency university Kolkata

[@DarshiniMB-dc4hi]

Can it be possibly to get the slides

[@animatedbiologywitharpan]

@@DarshiniMB-dc4hi you can buy it @250₹ or 3$, if interested email us at [e-mail]

[@ritahtezra1386]

At what point are the RAG genes involved

[@animatedbiologywitharpan]

kzbin.info/www/bejne/r5SWpopsp9dsoq8 rag Gene's are essential for tcr receptor vdj recombination. Watch this video to know more

[@immadisarojini2775]

Nice

[@studyonline-kz1gf]

Myeloid progenitor and lymphoid progenitor

[@studyonline-kz1gf]

Innate immune systems and adaptive immune system

[@animatedbiologywitharpan]

do you want video on this topic ?

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Pretty slides

[@animatedbiologywitharpan]

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❤❤

[@animatedbiologywitharpan]

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​@@animatedbiologywitharpansure

[@kvnkvn9191]

I can see you learnd this from kuby

[@animatedbiologywitharpan]

Yes it is ...kuby is a good text book for immunology

[@studyonline-kz1gf]

Hematopoietic pluripotent stem cell

[@MehediHasan-gy8uz]

Book reference??????

[@animatedbiologywitharpan]

Kuby immunology 7th ed

[@studyonline-kz1gf]

T cells - bone marrow

[@animatedbiologywitharpan]

i am not understanding the point of these comments, could you please explain ?

[@kunalgaurav5181]

U r teaching is 👍!! But why u are faking your accent?🙄

[@animatedbiologywitharpan]

As I have spent a long time abroad I have developed this accent ..... cant help it ...any way thanks for the feed back ..please share among friends

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[@meeraislam7531]

❤

[@youtubeyoutube5887]

Why you are using fake accent otherwise it is good

[@animatedbiologywitharpan]

It's my inborn bengali accent

[@studyonline-kz1gf]

T cell