Targeted Protein Degradation Using PROTACs and Glues

There is growing interest in understanding how proteolysis-targeting chimeric molecules (PROTACs) and molecular glues can effectively degrade proteins that are important targets for drug discovery and therapeutic intervention. This Bench Tips webinar brings together scientists to share their expertise using various biochemical, cell-based and computational techniques to find the right degraders for the drug targets to enable their targeted degradation. In this webinar, you will hear about: 1) how to rationally design PROTAC degraders and molecular glues, 2) how to pick the right techniques for structural and mechanistic studies, 3) which biochemical and cell-based assays to use for measuring degradation, and 4) what are some of the common challenges-from sample prep to data analysis.
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