Taurine - Fountain of Life | Aging and Mitochondria

Mitochondria and Aging
In this amazing study the researchers provide the evidence that mitochondrial membrane permeability plays an important role in cell senescence and death. We will use these concepts for the next series about Taurine. Let's review at a high level the study about mitochondria and aging.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Jan. 19 2024 14:13 PM
Aging? Blame your mitochondria - Science in the News
sitn.hms.harvard.edu/flash/20...
Apoptotic stress causes mtDNA release during senescence and drives the SASP | Nature
www.nature.com/articles/s4158...
Mitochondrial dysfunction in cell senescence and aging - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
Mitochondrial and metabolic dysfunction in ageing and age-related diseases | Nature Reviews Endocrinology
www.nature.com/articles/s4157...
Pleiotropic effects of mitochondria in aging | Nature Aging
www.nature.com/articles/s4358...
Bax, Bak and beyond - mitochondrial performance in apoptosis - PubMed
pubmed.ncbi.nlm.nih.gov/28755...
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression - PMC
www.ncbi.nlm.nih.gov/pmc/arti...

[@danelleoliver5441]

You speak at a slow pace. It gives the listener time to digest and then better understanding. Thanks for being such a great teacher and sharing your gift.

[@1961Lara]

I Never get tired of your lectures. Thank you!!

[@BD-3x3]

Leaving comment just to encourage the algorithm to favor more discussions of mechanisms (of any topic, not just aging-related).

[@xylongevity]

That is why we focus on Mitochondrial Health Optimization :-)

[@jeanoliveira9435]

Groundbreaking study! Fascinating! Thank you for presenting it. 🙏

[@ianstephenson9471]

You want cells to renew. The key to youth is the reduction of inflamation. To achieve this, you need to avoid activities that cause inflamation. Turmeric is a great spice to add to your daily diet (Organic) to maintain a constant low inflammatory state. Needs to be taken with black pepper to improve bio availability.

[@ianstephenson9471]

Senesent describes the cell reproduction limit, which is thought to be 50 x in a lifetime. At the end of the cell life, it no longer reproduces and stays with you in a constantly degrading state. If so, the key to longevity is to maintain your cells. Mitochondria can be increased through autophage and resistance training. The trick is to minimise introduced toxins and to provide the cell with the nutrients it requires. If this is true, then the introduction of mRNA will affect longevity. A test that its manufacturers have not performed. If all this is correct, then mRNA WILL excasserbate pre condition and aging. If we can establish this as fact, it could be the reason for excess deaths.

[@pjcdm]

Love that video. Please turn on the auto-translate caption for all languages feature please. There are many billions of people who cannot read or understand English. Thank you. PS: If you do not know how, leave a message and I will show you a video that explains the very simple process. It is a 3 minor steps process that takes maybe at a maximum 1 minute.

[@debpratt52]

You can turn it on in your settings.

[@pjcdm]

@@debpratt52 Thanks. I know. But, originally, it was not turned on by the creator here.

[@geraldkaupp5380]

Your lessons reveal the great mysteries. From this widespread platform you provide the growing medium for Knowledge. I pray for your health and thank you for the enlightenment you provide. Cheers from Sunny 😎 Alberta! I am on the wrong spot with my comment but I trust you will check replies.

[@waynemattera8552]

I wonder if COVID increases number of cells in this state. Taurine makes me feel better!

[@paulwolf3302]

I've read other papers about senescent cells but have never heard of this before, that the mechanism involves holes in the mitochondria and the mtRNA then causing SASP production. It sounds like really groundbreaking research. I wasn't totally clear on whether the molecules they are testing repair the holes in the mitochondria, or would only prevent them from forming? If they only prevent them from forming, you'd have to take this in advance of the stress on your cells? But I think it also said something about clearing or curing the senescent cells. The other approach to this problem has been to try to kill senescent cells (see James Kirkland's work at Mayo Clinic) by blocking their survival pathways for a period of about 48 hours. This research on mitochondria leakage, and a minority or majority of mitochondria being affected, makes me wonder if there could be a way to just clear the bad mitochondria, instead of clearing the whole cells ...

[@darkhorseman8263]

Study the impact of excessive oxidised mtdna on sasp expression. When damaged mitochondria release mtdna and other signalling molecules into the blood. If the body responds and mops it up quickly, there isn't a problem. If they become oxidised, that's when problems set in. Oxidised signalling molecules still plug into all the receptors they normally could, but the signals they send become garbled and lead to all sorts of chaos.

[@odette8905]

Love your illustrations! What a talent! Such a wonderful way to teach complex ideas. Thank you Dr Been. ❤

[@kaye9171]

This is an excellent teaching session. Thanks you for progressing with the mitochondria mechanisms. I need to go back and review mitochondrial electron chain session. Much appreciation for so beautifully covering this essential subject. Obachan Farmer

[@dhandoreson240]

Please discuss whether vitamin D3 role.

[@janetlong6295]

Taurine is an amino acid that is in depleted supply in dog foods also. And has been implicated in the poor health and early deaths of many canines.

[@SheenaRea]

Very true. Helps my dog fight seizures as well.

[@dsandman272]

Dr bean talk about the muscle fasciculation’s and what could be causing tons of people are suffering from it

[@Kitskacat]

I can't believe we could get through that description together and actually make some sense of it! Lots of new concepts and acronyms for me!

[@jmc8076]

Fun of learning and challenging ourselves. ; )

[@baylissfxbees2056]

Would explain why after my last Covid Infection my perimenopause feels like gone crazy as for inflammation and hormone decline. 👍🏼 This makes finally sense…

[@damnyankeesdaughter5427]

I found parabiosis, the fountain of youth (injecting “young blood”) The other things I found that were related weren’t very pleasing either.

[@ms_amanda2714]

Thanks! looking forward to this series!

[@Southerngrl]

First. Luv u Dr. B! Tysm for the education and sharing ur knowledge with us. The manner in which u teach is very relatable and easy to learn.

[@kayemoore]

I’m very thankful that you ensure I’m understanding you - I could learn anything from you!

[@pjcdm]

Love: "it's a mice study, but sometimes MY mouse stops working!" Feed your mouse more taurine, Dr.! Jesus!

[@jmc8076]

😂

[@sandy-qw4np]

😂😂

[@grochef]

Dr. Been, I am looking forward to your lecture on Taurine. Since 14 tablets of eltrombopag (Promacta) costs around $6500.00, I am hoping that my daily supplementation with Taurine and Creatine are proving some benefits to reduce BAX and BAK.

[@mauricependers3869]

Dr Bean how do you see this in relation to mitochondrial damage by spikeprotein and longcovid symptoms. Vitamine C may be important as beiing an antioxidant in preventing endothelial neighbour cell death in this process as well

[@ellenchan2357]

Love your drawing

[@zbyszeks3657]

I love the way you present information! It's mastery in pedagogy. But, saying that, I don't understand some things: 1. General concept that (apoptotic) stress concerns a cell, than the cell produces proteins, that in effect causes mitochondria to become permeable and release their mtDNA seems to me vague. The opposite might be true. It's that mitochondria are under stress and they initiate the whole process. 2. It seems not to be enough to make outer membrane of mitochondria permeable, because mtDNA are behind second - inner membrane. But these BAX proteins "make holes" only in outer membrane. 3. The mechanism of apoptosis and senesense seem to be the same, than preventing that mechanism from action will prevent pathway leading to apoptosis, which can have a serious negative effects. 4. If mtDNA is released to cytosol of the cell it means that inner membrane of mitochondrium is damaged or destroyed and that mitochondrium do not produce energy from obvious reason. Such mitochondrium probably will die. So again, the apoptotic stress seems to be result of mitochondria damage not the other way around. I'm not a professional, just ordinary man, looking at the youTube video, so I can be wrong :) I will watch more of your valuable lessons

[@JAACS74]

Wow😮 Dr. Your Amazing. Thank you for sharing ❤

[@TheNamami]

Absolutely brilliant explanation... Thank you, Doc

[@pjcdm]

How about fasting to turbocharge clearance, as in not overwhelming the system like by giving it ALSO thousands of spike proteins and cells to clear or not ingesting toxic chemicals (or all of the above).

[@user-vb3lu3lm1c]

Like setting up Autophagy; then maybe adding Nattokinase and/or Serrapeptase to assist in the clearance?😊

[@sncnutrition7118]

​@@user-vb3lu3lm1cSpermidine induces autophagy

[@blutamis7697]

Of course fasting is good but he covered that I believe. Fasting gets rid damaged of dead cells but once the cell goes into the stasis mode it isn't recognised as sick or damaged.

[@pjcdm]

​@@blutamis7697thanks for clarifying

[@babokumar]

Great Dr. Been. Thanks from Brazil

[@dustyarcher]

Thank you Dr Been, 💕💕💕 it!

[@9111logic]

What a wonderful study dr. Mobeen, 🙏thanks for sharing it with us and plese do expand on it in future lectures. A quick search for Eltrombopag seems to indicate that it also encourages platelets formation by the bone marrow. Makes us wonder if the BAI1 will also have some side effects 🤔

[@dorasneddon774]

The cellular stress which sets off the mitochondrial damage can come from various sources, I know. What practical lifestyle implications does this have, which people could try out to improve cellular energy production and reduce senescence?

[@drironmom6815]

Another outstanding presentation, thank you Dr. Been! You gave me new insight into the mechanism of senescence.!

[@cherryb6105]

Very interesting

[@blutamis7697]

Thanks so much for all the resources. It's hard to find the studies.

[@babblingalong7689]

It's a mice study so the cats go crazy in the background 😁07:03

[@Jimdandy1958]

If the spilled miDNA can cause the SASP it makes me wonder if foreign mRNA that is not supposed to be there can do the same.

[@Kurkuma10]

Dear Doctor Thank you for presenting !!!

[@cathygauronski5354]

Fascinating

[@eduardogutierrez5614]

Thanks a lot from Brazil

[@threeofeight197]

I wonder if this is the body’s “cancer prevention” mechanism run amok? I can see this being a good thing if there was a rogue cell replicating incessantly. This mechanism would remove potential cancerous cells in an entire area.

[@Fun4JC]

I always enjoy your lectures. The topics are well chosen examples of advancements in understanding biological processes. I liked the part of increasing healthfulness, but not life span. This is a real breakthrough. Thank you, doctor, for telling us about this. I'm looking forward to more.

[@biodivers5294]

Nice lecture 🙏

[@sparrowt4082]

Dr. Been, does the "stress" in this vidro also mean psychological stress/fear, or just physiological stress?

[@bobleclair5665]

In other videos, they talk about the vagus nerve ,it’s importance to health and how stress could have negative effects . I believe the placebo effect works in many ways other than a pill, the stress that the world is going through, has to have some effect all the way down to the DNA ,

[@bevgranz6926]

Thank you again for this revealing information!

[@ulaus4629]

Thank you Drbeen. Always enjoy your lectures❤.

[@valerielmd3275]

Thank you Sir.

[@tanu5628]

Awesome sir

[@db2660]

Very interesting, thanks for presenting it!

[@ohtoah]

Very Good

[@fenzda]

Thank you doc. Been following you since 2020. What happened that year? Learned so much.

[@Je-Lia]

It will be interesting to learn how this process differs from autophagy, and to learn what natural substances (minerals, foods, etc) mimic the effect of this new drug. I was a little surprised when you read in the study that the aging symptoms in the mice were reduced, yet the lifespan remained the same. How/Why might this be??

[@HarryJensen-kr4qz]

So, take Fisetin to flush senescent cells?

[@joemarion2284]

Have you looked at the role of Plasmalogens in the body homeostasis? There is new research on the role of Plasmalogens.

[@funeats8201]

I thought the American hospital system was the fountain of death…

[@JJ-hg5ho]

Fantastic doc where can you find Mitochondria pathways serum test been searching unable to find one help kindly

[@DrDanMD]

I need this drug!

[@ToddBadger-vp2nr]

There is relevance to cancer therapy here. Surgery and radiation therapy have taken the approach of cutting and burning out the cancer, only in many cases to have it return or metastasize. The very process of doing so damages surrounding tissue, which may go into senescience and secrete growth factors to compensate for the cell injury and death. It is better to pinpoint and target the cancer as closely as possible to avoid damaging surrounding tissue as much as possible, as well as rescueing non-cancerous cells.

[@VeganHorseman]

My question is what determines the number of mitochondria that become permeable in a cell, ie a large majority or just a few? Is it the quality and/or the quantity of stressful items that attack the cell? So if the cell is under a small amount of stress then the cell becomes senescent whereas if the cell is under a large amount of stress then the cell becomes apoptotic. Senescent cells would be like a pile of garbage that starts stinking and making the environment around the cell inhospitable. Whereas the apoptotic cells disassemble and the pieces get cleared away.

[@jmc8076]

20:03 “…here’s a curiosity…”Great teacher Dr M.

[@ground752]

the spike from vax stays in cell and makes cell sick but if cell is destroyed the amaloid just moves to the next cell

[@kathleenbarnett8126]

❤

[@fairwind8676]

What if mitophagy clears the damaged mitochondria?

[@mai_8j888]

🙏🙏🙏

[@fangliang5044]

👍

[@rbc812]

Meat and fish contain Taurine and most people eat them. Yet I am not seeing those who have meat and fish everyday looks younger by the day.

[@maralfniqle5092]

Well those on keto and carnivore diets swear by that

[@MarmaladeINFP]

Data shows that Americans eat less animal foods today than in the past. The average American gets 70% of their diet from plant foods. And most of those plant foods (carbs, seed oils, etc) are highly damaging. But what we know is back when Americans ate more animal foods they were healthier.