The basal ganglia - The direct pathway | Nervous system diseases | NCLEX-RN | Khan Academy

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[@anitas8833]

She speaks so eloquently. Wish my prof speaks like her. Very clear, not too fast, not too slow. Love it!

[@seoyooncha1512]

My mom just had an ischemic stroke three weeks ago which led me to watch this video. The doctor is prescribing my mom dopamine, and I wanted to see how it works. Im an accounting major and has absolutely no background about this subject, but this makes so much sense. Thank you for a simple and clear explanation!

[@quianawatson8159]

I have damage here. Anyone have any treatments or medications that has helped this situation?

[@BibekTimilsina007]

10 mins gone in a blink, so good and simple; thank you!!!!!

[@lbpmrb]

took my professor 90 mins to explain this, and i was still confused came here watched once it now it all makes sense Eureka forrrealll

[@giuliacirrincione6979]

I honestly could have not done it without you! Thank you!! My professor took an hour explaining this and I got nothing from it, you took 10 minutes and completely opened my mind.

[@khamikos1]

the best presentation i have ever seen concerning the basal ganglia. congratulations and thanks. YOU ARE THE BEST

[@mandyads]

4:29 for pathway (for those who just need the visual/audio)

[@NS-lt9cf]

I’m wondering how all khanacademy members have flawless handwriting!!

[@Iceshocker]

🤣🤣🤣

[@Mayank-rl5qn]

Hiring critera

[@turquoisecraft]

SubhanAllahh!! Thank you for sharing such a good lecture 💕

[@madsm8337]

The greatest explanation I've seen so far on this pathway. This is like the 5th video I'm watching and I finally understood. Thank you so much!

[@nystagmus]

We can memorize this all day But Who are geniuses who figured this pathway out?

[@nghiapham1756]

hard work and ten of thousands of experiments.

[@vinestreet7]

Love your voice. So pleasant to listen to. Thank you.

[@edwardj.kenway8998]

You're voice is so clear and nice way of teaching you got

[@cre8ived0c]

Unbelievably simple and crisp.. God bless you people..

[@davidndiulor8428]

Wow, I love medicine.

[@tizjoanne]

Learned this in neuroanatomy this week so great timing to revise :-)

[@kongnyuyfrida9831]

This is Just amazing thank you 🤗

[@zoenoel7431]

Not an RN but a DPT Student in neuro semester, thank you for this video!!!

[@BTSARMY-cu3tu]

3 hours class in 10 mins......Thank you

[@lmto9496]

2 hours lecture down to 10 mins. thank you

[@vajeehasajid9823]

This was amazing. I finally understand😭😭 Came here after watching a quick two min video on the topic which completely shattered my concepts. But this was❣️🙌🏽

[@chloroplast8611]

THE BEST VIDEO ON KZbinEEEE

[@mahnoorkhan5863]

Just so so so thankful to you for this video i got it all in 10 minutes.. God bless you

[@lwazim8754]

this is absolutely brilliant. How i wish my lectures were this good at explaining and simplifying

[@ToewaiAung-ue8po]

Crystal clear concept for me.Thanks.

[@Onyi18]

That was fricking amazing! Med student here!

[@vikasjadhav9573]

One of the best video I ever seen..... Thank you so much for understanding basal ganglion 👍

[@fns6990]

You guys are the best!! Makes it so much easier!!!

[@erwinabbeloos7018]

You're a lifesaver! Many thanks!

[@mahnoorkhan5863]

Explained everything.. Made very very easy.. Thank you

[@abdulrahmanalashkar5059]

Honestly bless your soul

[@bamshadt7118]

Great explanation. Thank you!

[@kimberleymontague8588]

Your videos are incredible - so simply explained!

[@sebastiaanpriem1994]

Great explanation!!

[@janakotherova5904]

Because I always forget this, I come here every year before my exams and THANK YOU SO MUCH for this video.

[@Chimzurum_]

Very neat lecture. I enjoyed this

[@joharimasika5730]

Very nice, clear and well understood

[@nithinr3617]

Thank you for making this complex mechanism easy

[@leenaghaeb4747]

YOU. ARE. AMAZING........

[@dr.jameswilson8648]

Such a nice speaker🥰 thanks

[@viviancici3936]

one of the best video!!! Thank you for making the awesome one💖💖❣

[@TanTan-ch3vq]

Best explanation!

[@王海-w6x]

incredible that we know so much about how ourselves work

[@ayeshabibi2460]

Teacher! you are a blessing

[@lokamathas4270]

Best explanation ever..Thank you

[@vivianyin4285]

Excellent! I learned a lot in just 10 mins

[@trianahardianti]

thank you so much for this concise explanation! but could you please tell me, who order the subthalamic nuclei to excite at the 1st place? thanks!

[@thatprettydoctor]

Love it.! Soo perfectly explained.! 👌🏻

[@SasiKumar-dc5lp]

You nailed it

[@Jacop-b5g]

agreat video , many thanks

[@engyeymesh2450]

Thank you !! Amazing work💗

[@ripaibanda5900]

Well explained thanks

[@MelissaJewell-n2v]

Brilliant explanation! Wish I had found this weeks ago! :)

[@jeffwillis3590]

Superb explanation!

[@shrutishah1102]

Hey stop exciting me, I've had enough excitement!!! hahah!!! Loved this video!! Was glued to it till the end!

[@juanherrera7282]

You are the best

[@تقيالجراح]

Nice. Thank you.

[@songheartzou7423]

英语听着舒服，讲得也清楚

[@rupamthelegend]

Substansia Nigra to Subthalamic nucleus:- "Stop it! Get some help!"🤣🤣

[@joshf1rstwizard]

short but clear. thanks!

[@zas881]

thank you so much. very clear.

[@vaishnavikarpe8251]

Wow you made it so simple to understand!! Thank-you!!😊

[@kasraakbari229]

Thank you very much, it was great

[@gokulreddy7640]

Amazing ....I got the concept😍

[@genesebelius4466]

Helps me understand 😅

[@annbehanan8871]

this is amazing!

[@dharanisudha7]

Clear and simple..tnq😊

[@Ardka]

Great, thank you so much from Mongolia💕💗

[@eddyallenby]

You just blowed up my brains!

[@Ramana05z]

Eddy Allenby r u alive then

[@LP-fz5xm]

It's time you knowed, the word is blew instead of blowed😜

[@ak27170]

thankss ! soo helpful

[@asmaamohamed8384]

thanks alot.

[@พิมพ์ภัทรโชติการ]

Could you please tell me what is the program used in this clip? I have to make a clip for my senior project. Any recommended programs ? Thank you:)

[@أوسكارأجدعفيلم-ي5ج]

you made it easy, thank you

[@margo_1993]

Great, simple, very informative. Only one question: what stimulates Subthalamic Nucleus to send an excitatory signal to Substantia Nigra?)

[@alexgraham3788]

nothing its constitutively active, like how the thalamus is constitutively inhibited

[@alexgraham3788]

or at least you can think of it that way for this pathway watch the video on the indirect pathway might clear it up

[@christopheidherr523]

very well and evenly understandable explained. thank you! :)

[@RocksTimmy]

Awesome video!

[@RomajaneAbrenio]

Thank you 😊

[@doctormsigwa8578]

Thank you!

[@haziqzulkifili4708]

So how do you explain tremors(which I presume is an increase in involuntary movement), in loss of Dopamine in Substantial nigra?

[@Hudamk99]

So nice 🥰👌🏻😍

[@katymostefaoui3567]

I love you, thank you!!!!

[@BALWANTPATLE]

Make video on endocanabinoid system

[@khalidalshammari6778]

great explanation

[@johnny4799]

I wonder if Tourette’s stems from dysfunction in the globus paliidus or if their is some over sensitivity/over drive in the striatum. I wonder where the community is leaning…very good video

[@trulylogical3476]

thank you very much

[@CallMeWarg]

Why is it so that the motor cortex cant communicate directly with the muscles? What is the purpose of requiring conformation from the thalamus in order to move?

[@LLL3x]

Great video

[@mrnomnom1729]

Awesome.

[@mjd8139]

and they call it direct pathway...WoW ...it looks like when a woman go to the market to buy something

[@Gymnasticslve]

lol

[@n_92alharbi71]

Lol 😂

[@DrMd172]

😂

[@vineshmanohar9978]

Thank you. Really helpful :)

[@ABC-fv7ow]

Good

[@aimhighsmile1]

What is the name of the excitatory neurotransmitter that goes from the subthalamic nucleus to the substantia nigra? Is it Glu or Dop or something different? Also coming back is it gaba? It would be very helpful if you included all neurotransmitters in the future. : ) LOVE your work! I don't know if you work in connectomics much regarding the 3 types of learning in real time....(physical structure of content, history of content and real time experience of content) I think your mother type voice regulates students making it easy to learn...lol....I know it sounds crazy but I think there is some truth to this. I found it much easier to learn from your videos....I believe I already have circuits in place that recognize the soft tone of your voice....from -9 months to 8 years old my mom had a very gentle tone as I imagine most moms do. Anyway, the point is when we are regulated it is much easier to learn. : )

[@mayureshutpat7312]

The neurotransmitter that goes from subthalamic nucleus to substantia nigra is glutamate. Not GABA, it is inhibitory neurotransmitter. Actually, as far as I have read, substantia nigra has two parts- substantia nigra pars compacta and substantia nigra pars reticulata. The one talking to striatum (sending dopamine to striatum) is pars compacta. Pars reticulata, along with globus pallidus (internal) (shown at 1:40), also works to inhibit the thalamus. The glutamate from subthalamic nucleus falls on, and excites, this pars reticulata part of substantia nigra (and on globus pallidus- internal), to increase the inhibition of thalamus, so that thalamus can't excite the motor cortex. This is, in fact, a part of indirect pathway which decreases the muscle movement when it is not needed. They have made another video on indirect pathway, where you might get more details on this.

[@shouqmohamed944]

this was faaaaaantastic

[@maxwell3578]

So basal ganglia is essential for dancing?

[@lucasprust1]

I thought that striatum inhibits globus pallidus (ext), that inhibits globus pallidus (int), therefore the striatum activate the global pallidus (int). Can someone explain this to me? I'm very confused now.

[@neilparikh8041]

+Lucas Prust Sorry if this is too late, but you appear to have slightly mixed up the indirect and direct pathways of the basal ganglia. The direct pathway was outlined correctly in the video; the indirect pathway DOES involve the striatum inhibiting GPe, but GPe inhibits the subthalamic nucleus (NOT GPi) which normally activates GPi indirect inhibition of GPi). This consecutive inhibition acts as an activator, and upregulates GPi inhibition of the thalamus. The overall effect of this pathway is inhibition of movement. However, D2 (dopamine 2) input to the striatum actually inhibits this pathway, leading to decreased inhibition of the thalamus (usually translating to increased movement).

[@Elixir01.k]

That u show there in coronal section Gp externus on right side is not that one....but rather is internal capsule....I think the marking is incorrect wrt gp externus

[@bahdoncali3811]

thank you very much :)

[@rolex4602]

Made easy

[@basmasalem5989]

What are the chemicals produced by the Subthalamic Nucleas that excite the Substansia Nigra, please?

[@Cairn_August]

it's said the striatum sends inhibitory signals to the globus pallidus but the globus pallidus is a part of the striatum, should be a little more specific there

[@aprilneha]

globus pallidus is not part of the striatum. the striatum is the putamen and caudate

[@jwilcox4726]

Please turn up the volume I can hardly hear this. Thank you.