The Importance of the Imprintome with Dr. Randy Jirtle

[@kotone4516]

Just watched a bunch of these, they are so interesting as an undergraduate genetics student !! Please keep uploading :D

[@everythingepigenetics]

Thank you!! Season 2, episode 1 will be launched in about a week. You can always check out my page on Instagram if you want to learn more, @everythingepigenetics

[@lifeexplorer3247]

Biotech undergrad here. Same. Cool podcast

[@bipindeshpande2043]

Excellent podcast. Dr. Randy Jirtle was very eloquent and simple in his explanation of such a difficult topic. I appreciate it. Dr. Bipin Deshpande, Dermatologist, India.

[@everythingepigenetics]

THank you, Dr. Deshpande! Nice to meet you :)

[@juha7830]

Facinating. Should we consider ssupplementing with methyl donors, like b12.. I dont know but doing it.. Thank you both.

[@everythingepigenetics]

Thank you! The answer depends on a lot of other factors such as your genetics, however, studies have shown that supplementation of methyl donors during early life is essential for normal brain growth and development and has long-lasting effects on mental health.

[@juha7830]

@@everythingepigeneticsAs 58 yo male I have high protein intake and still think I need B12 while absorption reduces during aging. Also my glycine supplementation is another reason for needing methyl donor.. Helicobacteria infection may induce cancerous merhylation issues in DNA and many times infection is silent without symptoms. So my strategy is eradicate bacteria with artemisia herb and take methyl b12. Chris Masterjohn had nice presentation about aminoacid metabolism and methyl groups role in it. Maybe you could interview him someday.

[@monnoo8221]

its getting ridiculous calling everything an -ome.... why not calling the body an ome-ome???? Much like the talking about "anti-oxidants" i is a maker that someone does not understand anything about biology

[@everythingepigenetics]

I get what you're saying! The "ome" terminology does seem to be everywhere these days-from genome to proteome and beyond. It can definitely feel overwhelming, but the idea behind using "-ome" is to capture a comprehensive view of a specific biological system (e.g., all genes = genome, all proteins = proteome). It’s just a way scientists classify and analyze complex biological networks. While it might seem like overkill, these terms help researchers break down and study specific areas in detail. And you're right-sometimes the overuse can make it feel a bit like the "antioxidant" buzz, but in many cases, these "-omes" provide useful frameworks for understanding complex systems! And yes, "ome-ome" would certainly be taking it to the extreme! 😄