The Link Between Clotting and Viral Reactivation in Long Covid & ME/CFS | With Dr Bhupesh Prusty

In this final video in the three part series with Dr Bhupesh Prusty, Dr Asad Khan and I ask about how clotting abnormalities fit in with the reactivated latent viruses theory, and the various ways treatment might fit in.
Supporting resources:
Film 1 with Dr Bhupesh Prusty:
• Reactivated Latent Vir...
Film 2 with Dr Bhupesh Prusty:
• How Viral Reactivation...
Latest pre-print:
www.medrxiv.org/content/10.11...
Herpesviruses, Messed Up Mitochondria and a Biomarker for ME/CFS and Long COVID:
www.healthrising.org/blog/202...
Tissue specific signature of HHV-6 in ME/CFS
www.researchgate.net/publicat...
Chronic viral infections in ME/CFS:
translational-medicine.biomed...
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Interested in my second channel?
Here are some links!
Why Strange New Worlds is the Best Trek in a Generation:
• Why Strange New Worlds...
5 Reasons Why Top Gun Maverick Crushes the Original | Film Director Breaks it Down:
• 5 Reasons Why Top Gun ...
Why Succession Shouldn't Work at All, But is Somehow the Best Show on TV:
• Succession Shouldn't W...
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The Long Covid Handbook (Feb 2023) by Gez Medinger & Professor Danny Altmann (and published by Penguin Books) is now available in paperback, ebook and audiobook. A singular resource that brings together everything patients, clinicians and academics have learnt about the condition to date, as well as lessons from sufferers and researchers of ME/CFS and other chronic conditions. It offers world leading expert advice on understanding, managing and treating Long Covid. It is available from the following links.
US: a.co/d/0gvkJCU
UK: amzn.eu/d/9KjurGb

[@deathveteranxd6650]

Theres random moments when my body\brain goes back to what it used to feel like when healthy. Without doing anything, almost like the inflamation goes away for a couple of minutes than comes back. Anybody else feel this?

[@RUNDMC1]

Yes, once in a blue moon!

[@itsjudystube7439]

Yes I do. With good food and a balance of rest and exercise

[@deathveteranxd6650]

So weird.2.5 years into LC, this is one of the indactors that tells me that my body still isnt 100%.

[@ash0787]

this happens sometimes in me/cfs, I have experienced it a few times myself, we have no idea why it happens though, but it does feel like a sudden 'mode switch' in the immune system, usually doesn't last more than 5, 10 minutes for me, at most 30 mins, some claim to have experienced lasting remissions. One issue with these diseases is its hard to verify who actually has the disease or just something that presents in a similar way ( thats why PEM is considered gold standard ).

[@jenniferj3663]

YES! its like it turns on and off!

[@hikingisnotwalking]

Thanks again Jez. What I find so immensely frustrating about this is where it fits on the medical funding priority list. Great work and the alleviation of suffering for millions is possible but it's such a struggle. I likened LC to a friend recently as like having cancer but no doctor has heard of cancer. Thank you again.

[@RUNDMC1]

Yep - exactly. Recent study showing QoL impact equal or worse to advanced cancers too

[@Feirin332]

Wow, this makes me sad. My mom died of cancer in 2021 and frankly I'm experiencing so many of the symptoms she used to complain about.

[@Jablicek]

We suspected early on - mid-2020(?) - when covid sequelae weren't resolving and some of them felt like ME/CFS that there might be a link. Is there research into both conditions being similar or having a similar base or trigger? What good news for those of us who've been ill for possibly decades, that there might be actual research now - but how terrible for everyone who'd developed it in the last couple of years. As a long-term ME endurer and long covid - oh, too tired to think of another synonym for "combatant" here but the Merrian Webster's got my back - possibly guerilla, as in a long and sustained campaign against this bloody thing that tries to steal my life, but I've got my ways of outsmarting it, generally by allowing it to lay me out completely a couple of times a month - maybe this is a war I'm not winning quite so much as maintaining a sort of uneasy stalemate through - my heart goes out to you all, knowing what some of you will be facing in coming years, and some of you will have it worse than me. Try to stay positive: remember the things you have to be grateful for and not focus too much on what you're losing or have lost, and find things that can replace what you had in the past within your energy budget - and be well. (Sorry for the rambliness - it's been stupidly busy with my project recently and the brain is protesting against ill-usage, hence stream of conciousness word salad above. Nobody's obliged to read it and frequently KZbin comments feel like shouting into the void, so hear my words, O Void!) Time for a cuppa.

[@RUNDMC1]

Enjoy that cuppa - and I enjoyed the ramble :)

[@Jablicek]

@@RUNDMC1 There's more of it but so many hours later it makes even less sense. :) Hope you're keeping well - you were a tremendous source of hope in those dark days of early research and recovery.

[@malaika2940]

@@Jablicek Let’s hope that all the research which is being conducted will help those suffering from ME/CFS as well. Having FMS I see and feel many similarities between FMS and LC so that would be an added bonus. After neigh on 30 years of pain (24/7) all over my body it will be surreal to no longer have that pain or the Fibro-Fog etc….. I won’t know what’s happening or what to do! lol You’re absolutely right - we’re in a daily guerrilla war where we can’t see our enemy. Wishing you all the best with your fight!

[@hckkerri3827]

His hypothesis is EXACTLY that LC and MECFS are the same. It's not C19, it's the latent viruses such as herpes that's the root cause. So hang in there!

[@SweetiePieTweety]

I love that you bring in different theories and theorist and different researchers who study based on their own background and paint a much broader picture of potentially everything that’s going on… there is A LOT going on… instead of making it fit into one funnel hypothesis. Thank you!😊

[@RUNDMC1]

Yes it’s an extraordinarily complex picture and I think we have to come at it from multiple angles!

[@Feirin332]

True. Though starting with treating the blood clots (with nattokinase and serrapeptase) and then focusing on healing up my endothelium was a great place to start. Secondly, a low histamine diet helps to keep symptoms under control. Thirdly, focusing on helping my mitochondria to produce energy has helped immensely. Lastly, I'm now also focusing on stopping leaky gut of the small intestine as that will keep driving the mast cell activation. However, all of the above do feel like just a (very expensive) plaster instead of the true treatment that is needed.

[@noname-mt6hz]

@@Feirin332 ⁠So would you please tell us how do you restore your mitochondria function? Coz I feel that it’s so hard to get back my strength although I am doing way better in everything else. I just lost my strength and stamina.

[@louisejackson1968]

My daughter, 15, 4 months into a medium level case of long covid/post viral fatigue syndrome, has just stsrted a targeted protocol (ultra detailed special immune blood test first) of Micro Immunotherapy with her childrens nutritionist 3 wks ago. It seems to make sense as a therapy (reading a lot about it) and is bringing slightly quicker improvement in my daughter's symptoms than what was the case with time, rest, pacing, breathing training, certain supplements to e.g. impair viral replication and break down histamine, and a reduced histamine diet. Google Micro immunotherapy. Also look up uk dr Sarah Myhill who i.a. uses this too for info.

[@louisejackson1968]

​@@Feirin332pls look up micro immunotherapy (I made an esrlier comment too) which my teen daughter has recently started witv a children's nutritionist. Seems to make sense and to be speeding up her gradual recovery.

[@maxblaha1143]

Those Interviews are pure gold for every LC-sufferer who is interested in the science behind their desease.

[@user-rl2er8uu6j]

I got a mild case of covid 1.5 years ago at 16, got slowly more tired, until 10 months ago had to leave school. My symptoms are really just fatigue and brain fog that worsens with exertion. I understand every case of long covid is different pathologically and was wondering because my only symptoms are fatigue and brain fog what mechanisms you think are worth focusing on.

[@lamartineine]

Vitamin B helped me a lot, especially methyl folate and b12. Two years later, only now starting to feel like myself, still not at 100%.

[@Gusski84]

So, micro blood clotting a symptom not the cause. The rest .... whoosh way over my head. 🙃

[@elsvandeginste4056]

Thank you for these videos! After not being taken serious and being pushed to do graded exercise at the hospital, I went to a kinesiologist. After running some tests he told me there was no more covidvirus to be found in my body but a strong reactivation of EBV! And shortly after that you posted these videos. 🥰

[@RUNDMC1]

Rest up!!

[@danielbrowning7965]

@@RUNDMC1 rest up? What about nutrition and plenty of sunshine

[@ninja2388]

Thank you again Gez - you continue to deliver hope

[@MicrobiomePrescription]

This issue was raised by David Berg DECADES ago and effectively ignored or discounted (i.e. "aspirin failed to cure ME/CFS so its not a coagulation issue") Berg D, Berg LH, Couvaras J, Harrison H. Chronic Fatigue Syndrome (CFS) &/or Fibromyalgia (FM) as a variation of Antiphospholipid Antibody Syndrome (APS): an explanatory model and approach to laboratory diagnosis. Blood Coagul Fibrinolysis. October 1999;10(7):435-438.

[@janieruby2lips]

Too technical for me . The best thing I heard was from Dr Khan "it gives us hope as you are making progress".

[@CLove-mo7cc]

Amazing video Gez. I was so excited when I saw you were interviewing Dr Prusty because I was doing some research into his work too. Interesting conclusion here about Immunoglobulins being a target treatment, my nutritionist wants me to start taking one called mega mucosa and funny enough herpesvirus have been shown to infect the mucosa barriers in humans. Lot of stuff making sense

[@Turtledove2009]

My first listen and I'm really paying attention. Will listen more tomorrow morning to get a better understanding. Thank you Gez.

[@sadnagoso-yn6iz]

Thank you gez other ones for giving hope coz I have given up. Thank you again god bless you 🙏🏾

[@carolenmarch7445]

Thank you Gez et al for helping us to undetstand whats going on ...one day we will and a sucessful treatment to regain your lives will follow .😊

[@malaika2940]

Positivity is always a good start. I know some days in particular it’s not easy, but definitely a better outlook to try to overcome this and believe you me, it’s certainly affected me, so I’m not saying this lightly or being trite (for those who might think I know nothing about it).

[@noname-mt6hz]

Found several missing puzzle in place. Thanks for your work. It is a treasure. Your interview is always helping me. And I’m also following you on Twitter.

[@deethompson3592]

Thank you Gez - i feel as though I've stumbled into the Doctors staff room at a research centre - I'm just grateful that you and your researchers are so driven 👏👏🏻👏🏻👏🏻👏🏻 Thank you 🙏

[@RUNDMC1]

Thanks Dee!

[@deethompson3592]

@@RUNDMC1 Any time. I've been watching 'Succession ' due to your flip the script chl. It's compelling viewing and like you say - It shouldn't work but it does 👏👏👏👏👏Thanks for the tip.

[@RUNDMC1]

@@deethompson3592 awesome - thank you! I’m glad you’re enjoying it :)

[@deethompson3592]

@@RUNDMC1 I'm riveted 👏👏👏 Imagine being the therapist to any of these characters - Oh what a tangled Web we weave when first we practise to deceive👏👏👏👏👏

[@ZeroGravitas]

Meaty last video.🙂Although hard not to see these findings like cresting a mountain, only to see there's another higher peak still to climb, beyond it. 🙄

[@RUNDMC1]

Yes, exactly 😫

[@wzupppp]

How can we restore igm naturally?

[@szaw4452]

Not much solid confirmed research on that as far as I can see. Some research on IVIgM, but again in mice and hard to know how long it lasts.

[@ParanoidBishop]

Cursory search suggested Ginseng (and two meds).

[@paulineroberts1815]

Vitamin C www.ncbi.nlm.nih.gov/pmc/articles/PMC8779769/#:~:text=In%20a%20clinical%20study%20involving,levels%20in%20blood%20%5B79%5D.

[@baileystruss7319]

Possibly reishi spores and maintain high levels of bifidobacteria

[@Asteroid_Editz]

Brilliant series, Gez!! I really appreciate your effort to bring to the public such important and relevant research. It helps me to keep my hopes high, as a 1.5 year long covid/ME-CFS patient. We seem every day closer to understanding the physio pathology of these chronic conditions, & hopefully successful treatments will follow.

[@RUNDMC1]

Thanks Isabel!

[@pja8901]

I don't really understand Dr Bhupesh Prusty. There is a lot of jargon. I prefer illustrations much like Dr Robert Phair does when explaining complex ideas.

[@macey74]

I’m taking an Asprin every morning. It makes me feel less sluggish for a few hours and takes away the aches in my legs and arms. By evening, the aches are back again.

[@MamaRestInPeace1424]

In recent studies patients were given 3 different Anti Platelet and Anti Coagulant medications. Unfortunately to keep the Micro Clotting in check, it is taking both medications, and even with three in the trials the effectiveness was only about 48-53-% reduction in Micro Clotting. Degrading the Spike is absolutely necessary, Nattokinase, NAC, Bromelain, Glycine together have shown good results degrading the Spike. Looking closely at any areas with edema is suspect of Micro Clots especially in the lower Limbs. VWF needs to be checked, and imaging with Contrast is needed, however many of the Micro Clots are so small even imaging sometimes does not show them. Inflammation must be kept down, and the Spike which in persistent causes alot of inflammation. Degrade the Spike, maybe stop the inflammation and Micro Clotting.

[@theancientsancients1769]

Have you looked into Ginkgo Biloba? It improves circulation

[@MamaRestInPeace1424]

If you are clotting you dont want to push blood circulation. The added pressures before the clots are dissolved could be a problem such as a clot breaking free causing an Embolism. The most important thing for patients right now is to stop the clots, and dissolve the clots. The Micro Clots are very evasive even on advanced imaging. Von Willebrand Factor and D-Dimer are good for showing the patients Doctors if there is Clotting. It is also very important if you have EVER been bitten even as a young child by a Tick, doctors check you for Lyme Disease. A large number of Long Covid patients, nearing 65% are testing Positive for Lyme, and Auto Immune like Lupus, ALS, MS etc are skyrocketing in post Covid patients, and vav injured patients. All Doctors need to be looking for Latent Viral Reactivation, such as EBV, CMG, Varicella and many more. It is a fact the Spike is reactivating sleeping viruses that then wreak misery on patients. One patient last week tested Positive for EBV he had 24 years ago, his numbers were above 650 I believe Sars Cov 2 is an Auto Immune Disease, the Virus and Vax deliver the nasty payload, the Spike, and long after the infection, Viral Persistence still prevails.

[@deadairconversion]

Take Nattokinase

[@ayianaarthur2551]

Nattokinase is said to be really good. I'm on aspirin too but am going to buy nattokinase next time I order something at iherb!

[@carolenmarch7445]

To date : 2 prong attack needed ...anti-virals and a way of boosting IgM. But will we further uncover other mechanisms that then cause the IgM to crash , and then this will be the Eureka moment to smash LC symptoms ? The beat goes on ...

[@danielbrowning7965]

Don't take any vaccines flu shots. Detox

[@krisklontzaris3329]

Maybe take the anticoagulants (eliquis and aspirin) along with an antiviral (maraviroc) to keep at bay the reactivation. I'm so happy to hear others are looking into this besides Patterson and Vaughn.

[@flagmichael]

Be aware Eliquis, at least in the USA, is spectacularly expensive - around $561 USD per month now.

[@marky5493]

​@@flagmichaeljeepers in south Africa it's the equivent of $50. I would also consider it expensive in my terms as well!

[@MaryinOmshanti]

Why not go to the root of the problem. At the risk of sounding like a stuck record ~ both the virus and the injection both contain gain of function research and spike protein. Look at the patents taken out on the non novel coronavirus and the injection.

[@edithnell227]

I'm new to this channel, and would like to see those patents. Is it possible to direct me to them without posting the actual links ? Many thanks.

[@MaryinOmshanti]

​@@edithnell227 please look for a video where Dr David Martin is speaking to Reiner Fuellmich about the patents. I have a full transcript of this conversation but I'm too sick to find them right now. I hope this helps you. If spike protein is in continual proliferation and is circulating then it will be necessary to find a method to rid the body of spike protein just to halt the damage it's doing. Not sure how they're going to heal irreversible damage done to the endothelium throughout our systems. My apologies for not replying sooner. I'm going to rest now.

[@charlottemacdonald4167]

After experiencing Long Covid since March 2029' I think the virus is still in my system. Then you have it constantly producing debris and on top of that you have the autoimmune response. The best treatment would be to kill the virus throughout the system because that eliminates the other two. I treat myself through a homeopath with CoQ10 and Magnesium for any heart issues, and adrenal support. I also take vitamin D, Vitamin C and high levels of Vitamin B complex daily.. I find any occurrences that takes place that uses alot of energy in a short span of time causes a flare up. It can be intense intellectual study, stressful emotions or physical exertion. I think this must be because these activities require alot of energy (and must be replenished) so it is harder for the immune system to cope. I think my body is fine except to the unwelcome guest of the virus. If it stopped causing problems, the rest would right itself. Thank you for all your efforts. I have not looked into this for many months. I am glad you are seeking answers. ❤❤❤❤

[@MrKelso85]

So Gez my friend and for future… why are we all improving on the whole each day and even now at 2 1/2 years in I am suddenly getting big improvements (Nattokinase has been added) but still even then we are improving incrementally….

[@CBEACH]

ArtemiC Rescue and Support combo treatment for Longcovid - it works😅

[@Lagos3sgte]

He mentioned that IgM antibodies are depleted in long Covid patients and need to be replaced. Could this be done by potentially drinking breast milk from someone who recovered from covid? I found a study online that claims that doctors gave breast milk to an immune compromised patient and they were able to fully recover. Could this be a potential treatment?

[@RUNDMC1]

Bit of a long shot 🤣

[@jamiesmith4141]

Good luck with that 😋

[@Lagos3sgte]

@@RUNDMC1 there is a peer reviewed study about it. I tried to post up a link but for some reason its not posting the reply. Yes i know it sounds silly, but a group of doctors did just this with a patient.

[@RUNDMC1]

@@Lagos3sgte KZbin doesn’t let you post links in comments as it’s a spam filter. What were the names of the authors?

[@marky5493]

I'm going down to the pub on Friday and that's gonna be my excuse lol. right now nothings too far out of the wild side!:)

[@baileystruss7319]

My IgM is very low. In the US IVIG lack IgM. Would boosting IgG? Help somehow? I wish there were more discussion on boosting IgM.

[@andreasrylander]

Yeah how do we boost it?

[@baileystruss7319]

Ive read that reisi can boost immune cells. Also having adequate bifidobacteria in microbiome can boost IgM.

[@vegamusician]

I just got word that we may have a similar issue as a tethered cord due to inflammation. Tethered cord symptoms are super similar to long haul covid, especially PEM and POTS. Any chance the inflammation is trapping and stretching our spinal cord????

[@Feirin332]

Gez has already made a video about this :-)

[@SuperSheena1967]

Would this have any relevance with the nictine patch theory and acetylcholine ? which has worled well with me. Just saying Gez

[@RUNDMC1]

They’re all different parts of the same puzzle!

[@ParanoidBishop]

Natto/Serra caused me brain fog (a sign it is working?), and I am allergic to penicillin, so aspirin out of the question. Hoping the forgetfulness and brain fog goes away now that I have ceased taking Natto (4000iu_ Serra (1-2 capsules at night).

[@Fuertisimodos]

When I started taking Nattokinase and Serrapeptase initially I felt worse, but within a few weeks my brain fog had essentially disappeared. I know this isn't true for everyone but for me it worked wonders.

[@theancientsancients1769]

Ginkgo Biloba may be a better alternative

[@ParanoidBishop]

@@Fuertisimodos thank you for sharing this. I think I may have upped the dose too much. May try one Natto (2000iu) and 1 capsule of Serra (night/day) every other day. I was told to go slow and low, which I did do. Was on it for about six weeks. Suddenly forgetting words, people, or why I have gone to the kitchen etc., is quite disconcerting. Having said that, with my ADHD, my memory has never been that great unless I am interested in something.

[@JuGren]

Hey, I've been suffering from forgetfulness this winter, even though I would rather call it dementia. It was horrible and changed only when my doctor recommended a keto diet. My memory went back to normal pretty fast, so perhaps it could be worth a try. Brainfog ist still there but at least now I remember why I went to the kitchen ;) (PS : Lion's mane mushroom helped me to focus in general and does no harm)

[@deadairconversion]

@@ParanoidBishop I would stop the Serra, and just use Natto. Drink lots of water! Make sure you’re not taking other blood thinners. I felt worse before I ended up feeling better with the Nattokinase. With the high dose of Nattokinase and Serra, it was probably an overload. I would stop both for a week or two, then start the Nattokinase at 1,000 ius a day for 2 weeks (they make smaller dose capsules), go to 2,000 till you start feeling better, then go to 4,000 until you feel consistently good. It took 3 months for me to really feel like I was ‘cured’. At that point I had been suffering from debilitating LC for over a year. I’m sorry I didn’t find Nattokinase sooner. Good luck.

[@eddylex4921]

Started taking Nattokinase 2,000 now on 6th day not having the flare ups as much but it seems to have increased my fatigue and brain fog. Also in addition to long covid I have interstitial cystitis and for some reason it seems to be increasing those symptoms as well?

[@theancientsancients1769]

I don't do great on natto unfortunately, it works not for everybody. Ginkgo Biloba improves circulation

[@deadairconversion]

Give it a couple weeks. You will feel worse before you feel better. As the clots get broken up you have to give your body some time to clear things out. I took 2,000 ius a day, felt good first few days, then felt like I was sick for a couple weeks- but knew this was part of the process. Drink LOTS of water, as it helps the Nattokinase work better, and flush things out. Try to rest through the first couple weeks. By week 3 and 4 I had a major turn around. By 3rd month, I tapered off it completely and have had no relapse. Very important: Nattokinase must reach the digestive track, but it’s very sensitive to stomach acid. To increase the chance it will reach the digestive track mostly intact, be sure to use a good brand with enteric coated capsule, take with a full glass of water and on an empty stomach, 3hrs before or after a meal. Most people don’t realize this, and it reduces the effectiveness. Good luck.

[@eddylex4921]

@@deadairconversion Thanks I needed to hear this right now I'm on my 9th day and starting to feel sick (flu like symptoms, brain fog ect.) It's really good to hear that there is a light at the end of the tunnel. I have the Dr. Best one that's slow releasing and I do take it on an empty stomach in the morning and haven't been eating breakfast to make sure my stomachs empty. I'll try to stick with it for a while despite not feeling well.

[@deadairconversion]

@@eddylex4921 I'd say give it 2 to 3 weeks (from the day you started). If you still feel bad, or get worse, I would stop altogether. Natto is pretty potent, and depending on your condition, not everyone tolerates it. Hang in there, hope you improve. Remember, drink lots of water and don't do too much activity until you feel better. Best of luck.

[@melissaevans1461]

Try taking 1 at night and 1 in the morning. I do that and it makes things more tolerable.

[@markdufour7792]

I had my blood pressure go up and started talking garlic and it went back down. It says that garlic is just as good as medications.

[@IVFRegulation]

Why in particular IgM not other natural IgG or IgA?

[@baileystruss7319]

I was wondering that too but seems that IgM has a special role in cleanup. Im IgM selective immunudefient and have no idea how to correct it.

[@IVFRegulation]

​@@baileystruss7319 After the natural infection, my natural IgG, IgA, and IgM are usually below normal and in rare cases close to it but no one gave me a proper diagnosis. The problem is with the frequent infections. Is it covid or another antigen? I wasn't like this before. Do you take any supplements or IVs to treat that?

[@samanthapurcell3125]

It would be nice to know who is fighting the vaccine, who is fighting covid , and who has been given the poisonous vacination?

[@MaryinOmshanti]

They both contain gain of function research and spike protein ~ I'm #Infectednotinjected

[@samanthapurcell3125]

@@MaryinOmshanti apparently the top doctor who was killed recently working with a team of doctors had found something that could kill the spike protein, that’s why he was killed

[@MaryinOmshanti]

Not sure why people see this as helpful. He truly has no answers and stops off to say he is not an autoimmune expert when the autoimmune system is being compromised. (Revisiting videos here in order to glean any insights).

[@samanthapurcell3125]

Take another aspirin then

[@itsjudystube7439]

I am unable to take aspirin

[@heyoka9012]

Lol. Get another booster, genius.