THE MOST BEAUTIFUL EXPERIMENT IN BIOLOGY: Meselson & Stahl, The Semi-Conservative Replication of DNA

yourekascience.org/portfolio/t...
In 1958, Matthew Meselson and Frank Stahl published the "most beautiful experiment", where they demonstrated that DNA undergoes semi-conservative replication. In this video, we describe the experiments that lead to this discovery and why understanding how DNA replicates is so important. This video is a complement to Matthew Meselson's iBiology Discovery talk, where Meselson recalls the events that led him to meet Frank Stahl and to plan and execute these experiments.
This video was produced in collaboration with iBiology.
iBiology (www.ibiology.org) is a growing collection of free open-access online videos by scientists about research and discoveries in fields including cell biology, neuroscience, molecular biology, microbiology, ecology, development, and biophysics, and also features short talks on topics such as professional development, careers, policy, and education. iBiology is funded by NSF, NIGMS, and HHMI, and is supported by the ASCB and UCSF.

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As a biology student I found this really helpful. Thank you for posting it!

[@marinaromanova3475]

The only Meselson and Stahl video on KZbin that actually helped me. Two thumbs up!

[@dreamstar18]

Wow I'm German and hadn't unterstand the Meselson and Stahl experiment til yet. I watched 10 german videos about Meselson and Stahl, but only THIS video has show me how it works! I thank you so much!! :)

[@barracudacsgovideos9056]

Indeed... :D

[@Antonia-pj1jf]

Salmmor haha Same 😂

[@mohammedsaqhibbilal1203]

How is being German related to better understanding of a molecular biology topic? Science is universal..nationality should hardly matter!

[@susukiii4836]

Omg ja einmal auf Englisch angeschaut und alles verstanden

[@Skittlezs710]

Actually, everyone gives Watson and Crick all the credit for discoverying DNA Structure buuuuuutttt, Rosalind Franklin was the one to discover this, for she spent so much time using X-Rays in order to figure out the DNA structure, which caused her Cancer. While she was sick battling cancer, two other students researching DNA Structure in the same University( WATSON AND CRICK) sneaked into her Dorm room and stole all her notes AND Published them taking all credit and A Nobel Prize for it But Rosalind Franklin died of cancer before she could take back all recognition of her Research.

[@DanielLieu]

+Adlin Hernandez I like how you talked about Rosalind Franklin! She was actually a huge part in the discovery of DNA because of the X-Ray diffraction she was able to obtain. It was critical in understanding that DNA spiraled in a double helix. Unfortunately, due to the reputation of women in science, her work wasn't really respected and neither was herself as a scientist in general. Unfortunate that her death occurred before the Nobel Prize because I believe she would have made a huge impact in the stigma that women scientists aren't as great as men -- which even exists today as women get paid less :) Hopefully that can change!

[@rohanshetty5103]

is it true ..? i mean i never heard of it before !

[@DarwiiNs]

yea she basically told them everything they wrote about

[@teresataylor-whiteley823]

This is not strictly true. Yes Rosalind Franklin was an X-Ray Crystallographer at Kings College London were work was undertaken to determine the crystal structure of DNA (along with the scientist Maurice Wilkins) , the data of which Watson and Crick used to describe the structure of DNA in their publication 'The Double Helix'. However, Watson and Crick were working at a laboratory at Cambridge, not Kings College London and neither of them were students, they were all research scientists working in different laboratory groups. In 1956, three years after Watson and Crick had published their model, Franklin was diagnosed with ovarian cancer, which exposure to x-rays has been suggested to be a possible factor in her illness although other members of her family had previously died of cancer.Nonetheless, Franklin's work was crucial to the development of Watson and Crick's model and she definitely should have received recognition.

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TRUTH she died because of her research and work

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This was amazing because you gave it so much context. My Biology teacher wasn‘t able to explain it in a logical way. 🙆🏻‍♀️ Now I‘m feeling well-prepared for my pre-exams. 👍🏼

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Ibrahim Aldhoon inshallah

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Brilliant! Was having a hard time understanding my Biology paper but this makes everything so clear! Thank you very much!

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This is the best video on the internet for learning this. Thank you guys for the amazing video :)

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OMG I finally understand what my teachers were talking about! Thank U so much ☺

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I have never studied anything bio related before my first bio class in college. I was crazy nervous but these videos have helped me understand much better! Thank you so much !! :)

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[@danicading1362]

This literally gonna help me on the bio test tomorrow. Thanks

[@gabriellewilliams1048]

this video is super good! definitely helped me understand this experiment A LOT more than i had before.

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Beautifully done, really helped!

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Thanks for this amazing video!! It makes it much more easy to understand

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Yours is one of the most beautiful videos on this topic .

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Just the video I was looking for!!!! Awesome!

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Great explanation!! LOVED IT

[@orangesandlemons40]

Thank you so much! It was hard to understand in class and in my textbook, but you explained it very well and now I understand it!

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Your voice makes the video more understandable ❤️

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this video is sooo good thank you!!

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OMGG!!!! THANK YOU SO MUCH!!! This was so helpful!!

[@SteadfastWorshipper577]

Thank you for this thorough and clear explanation of Meselson's and Stahl's experiment.

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Thank u for d video.. It was so simple and clear.

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thank you so much this was so easy to understand!! 😭😭👍👍

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Thank you So much. It is Simple,Intresting to understand the concept.

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This lesson is quite amazing, am glad that I finally understand DNA replication

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Easy to understand and fun to watch too

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I loved it even for the international student was so easy to understand

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Thanks now the concept is crystal clear😊😊😊

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Beautiful .

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This is the most beautiful way to explain,the most beautiful experiment in the history of biology.

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It is indeed a very elegant experiment

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Thank you... I understand!!

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English Rose me too

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Even if english isn't my first languaje you managed to explain it better than other videos in spanish (first languaje) congrats

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wow i have a bio final for college tommorrrow and you helped so muc

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You're very welcome!

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You explaind it soo well that I can unterstand it even if I am german

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why does the 1st to 2nd replication support semi conservative? i know you said it doesn't support conservative but it does support semi and dispersive, but why?

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Thanks a lot 😊

[@afifaamjed2294]

AMAZING EXPLANATION!!! I finally understand this yayayaya :D one question though: what if the bacteria were allowed to replicate a third time in N-14?

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Afifa Amjed it would depend on which strand was getting replicated i think. So if it was the light strand it would just come out as 2 light strands. But if it was the hald half strand it would come up with 1 strand that is light and 1 strand that is half half

[@afifaamjed2294]

www.thestudentroom.co.uk/attachment.php?attachmentid=698336&stc=1&d=1508899096 This is the picture in my textbook. I don't get the results of the 3rd generation with N-14 (test tube 4).

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