The Nuts and Bolts of Parkinson’s Disease - Dr. J. Eric Ahlskog, M.D. Ph.D

[@TheOriginalKilamanjaro]

The more i hear about Parkinson's disease that i been diagnosed with, the more I'm getting depressed. I don't even know what to think anymore

[@jdanderson915]

My father has this disease. PD is brutal and relentless. He is 85 years old. He has had PD since his early 60s. He fought it all these years. He was pretty active up until 5-6 years ago. He started losing his balance and started falling. I cant remember how many ER visits we had over the past 5 years. He is now confined to bed and a wheelchair. The PD Dementia was especially advanced in the past few years. Listening to this doctor, my father's brain and entire nervous system has been destroyed over the past 20-25 years by the slow progression of PD. Just a terrible disease. My father is in a memory care/hospice care facility. He needs 24/7 care. He does not know where he is or whats happening to him. 2 months ago he was still shuffling around and living on his own. Well PD has been patiently waiting over the past 25 years to take a little piece of my Dad's brain and nervous system every week, month and year. When he did go down hill, (early Dec 2022), He went down hill super fast. Like a nuclear meltdown. Hey 85 years old. I get it. But still not a very nice way to go out. Drooling. Mumbling. Delusional. Anxiety. Unable to feed or go to the bathoom by himself. Just tucked away in a hospice/palliative care facility. And we are not even close to a cure or even able arrest this horrific disease!

[@wingchunindia1026]

See doc vs. Parkinson Also check B1 therapy

[@louthomas4524]

I would recommend this doctor's book (and this video) to anyone currently facing Parkinson's. However, in my opinion, the part of the presentation (and book) that deals with drugs that can slow progression needs to be updated to cover the *reduced* form of CoQ10, Ubiquinol. Every CoQ10 trial listed on Dr. Ahlskog's chart is of the unreduced form of CoQ10, Ubiquinone, and as he correctly notes, this substance has been established by each such trial to be unsuccessful in slowing PD. However, in 2015 a double blind placebo-controlled study of Ubiquinol (the reduced form of CoQ10, linked below) showed clear benefit. The likely reason for this difference is that older people are very inefficient at converting Ubiquinone to the active form, Ubiquinol. By taking Ubiquinol directly, that conversion step becomes unnecessary, and the Ubiquinol can get to work bolstering mitochondrial complex I, thus increasing the energy available to neurons for defending themselves against immune system attacks, and improving the functioning of a PD patient's remaining dopamine neurons. "Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson's disease" www.ncbi.nlm.nih.gov/pubmed/26054881

[@bettyotis5785]

Lou Thomas Parkinson’s

[@katywu8127]

L😅

[@wendyneill6689]

Fantastic.

[@aileenklassen2085]

What about dystonia