The Physiological Basis of Comparative Pharmacokinetics

, Utrecht University’s Dr. Ronette Gehring, will talk about the Physiological Basis of Comparative Pharmacokinetics. Veterinary pharmacology has a long history of conducting studies to empirically describe the pharmacokinetics of drugs in a wide range of different animal species. More recently, physiologically-based pharmacokinetic (PBPK) models have been applied to describe and extrapolate pharmacokinetics between species. PBPK models are complex, resource intensive and have many parameters of which the values are not always known a priori. Another approach is to use more minimalistic, semi-mechanistic models to explore how changes in anatomy and physiology might explain differences in the pharmacokinetics of a drug. In this webinar, we will explore how this can be done in Phoenix NLME®.
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