Nucleophilic Aromatic Substitution - Benzyne Intermediate and Meisenheimer Complex

[@Doc_McStuffins]

You're my favorite chem guy. Thanks for all you do!!! You're consistently amazing.

[@PunmasterSTP]

Meisenheimer? More like my, so much higher...in educational value than almost every other video on KZbin. Thanks again so much for making and sharing these!

[@scoobydoo02]

Never quit. I love this!!!!

[@ItisMe-n2u]

Thank you very much for this clear explanation

[@tom_winguill]

9:40 3️⃣50 C

[@Spogeboii]

Will NAS occur if there is an activating group and a good leaving group? Or is this process restricted to a deactivated ring and a nucleophilic reagent?

[@ansingh1338]

Same doubt...

[@PunmasterSTP]

Doesn't the reaction starting at 14:56 have an activating group (methyl) and a good leaving group (bromo)?

[@raiyanrahman79]

In Chlorobenzene there should slight negative charges in Ortho and para position due to resonance. Then why does a Neucleophile attack the H in the ortho position? Wouldn't it make more sense if it attacked the H in meta position where the electron density is relatively lesser?

[@deepamishal4683]

17:30 which one is major and minor

[@tom_winguill]

fuck you

[@tom_winguill]

F;U;C;K||||||Y;O;U

[@husseinfedilla6814]

Beautiful

[@1BigMan.Tshepo]

W video man, big up.

[@alexfrostbound4401]

You are a breathing miracle

[@gerstensaft2936]

In the last reaction. How's the ratio of meta to ortho and para? 1:2:1 (orto:meta:para) Or is para more likely to happen than ortho because of steric hindrance of the CH3 group?

[@janrenehaak]

I think that the methyl-group isn´t so bulky, so their is no hindrance. Because of that I suggest, that the ratio ist 1:2:1 as you said. I hope this didn´t come too late :D

[@musicmeister1313]

ok, but what are the other reagents that can go through the benzyne intermediate 😠😠?

[@dathuyadav8822]

Nice

[@VikasVerma-pn4rq]

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[@ramillucas2117]

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[@PunmasterSTP]

From your asking that question, I take it you two have chemistry together?

[@crenapun57]

tw