Can We Slow Down Aging? Venki Ramakrishnan on DNA Damage & Protein Synthesis for Extended Healthspan

[@Sunnysue31]

This MUST be the very best , almost 2 hrs spent....... Just LOVED these, two, genuine, truth speakers, truth seekers, who are clearly fine, with putting their Ego's aside.... Massive thanks, & massive respect .... Just LOVED this..... Thank You both xx

[@moneyinahurry]

@@Sunnysue31 mop

[@Viva-Longevity]

You could have had so many more views by hosting someone like Peter Attia, but instead you sacrificed views by bringing us an actual scientist, actually doing science, Nobel laureate, president of the Royal Society, and sacrificed the views. Bless you. 👏 Awesome interview.

[@VFNVFNVFN]

Bringing Venki Ramakrishnan is NOT a "sacrifice" of views or otherwise, INSTEAD it is an honour and privilege.

[@chewiewins]

Same thought occured to me!

[@AngieMeadKing]

🎉🎉🎉

[@WFPB_4_Life]

💯

[@mrdarryl2row]

Even Fauci claimed to be "science". Anyone can be bought. Attia is about as good as it gets... except for his statin push.

[@scienceislove2014]

1:41:02 i just want more time with my family.. i just wanna make it to my late 90s and still be active and then go peacefully in my sleep..

[@dominikh9526]

Excellent, this is what I say with having experts on the podcast and not shill contrarians. Thank you for this episode Simon!

[@musicmonsterman8395]

When he says "characters with vested interest" I always just think of Sinclair 🤣

[@lighthealerastrid1465]

@@musicmonsterman8395 the first person who came to my mind as well 😊

[@ScribblerDeStebbing]

I thought of Sinclair immediately. I suspect that's who he was talking about.

[@chewiewins]

He does have vested interest but I am still glad he does share freely what he does with everyone. No one ever forced to (& I certainly never felt inclined to) buy his supplements

[@AngieMeadKing]

@@musicmonsterman8395 same

[@milanpintar]

I’m so glad Venki came on!!! i’ve bought his book and audio book.

[@rombohnallavan1861]

Venki is very well spoken

[@lighthealerastrid1465]

I started listening to this a short while before bed, with the idea of staying up a little later.. Big mistake. The doctor has the most beautiful, calming voice and I started falling off. I hasten to say not from boredom. So I will have to wait until tomorrow to hear the rest of what this fascinating man has to say.

[@karenthornhill1508]

@@lighthealerastrid1465 that’s just what I was thinking he has a very calming voice.

[@niviensaleh9688]

This is one of the most interesting interviews I have heard in quite a while. Dr. Ramakrishnan is not only unusually insightful, but he has a very agreeable voice, too.

[@kostaspapazoglou2851]

One of your best because of the unpretentious and genuine knowledge of your guest, delivered in a humble, self-applied circumspection without the usual hyperbole and sensationalism on this topic! Cheers from Melbourne.

[@wallyrbc]

Enjoyed the talk! My biggest take-away was to enjoy my life - not be so fixated on avoiding death by being too strict with my diet and avoiding alcohol. Yes, I’m well aware of the health risks associated with alcohol, but it’s also one of life’s pleasures (in moderation) and can be part of a healthy social life. I know someone will probably be quick to tell me you don’t need to drink to have fun.

[@davidtapia4811]

@@wallyrbc didn't finish reading your comment but you don't need to drink to have fun :)

[@AlwaysSeekingTruth13]

@@wallyrbc, I'm waiting until we're past Longevity Escape Velocity to drink. 🙂

[@wallyrbc]

@@davidtapia4811 Thank you! Would’ve been disappointed if someone hadn’t mentioned it.❤️

[@chewiewins]

Since social grouping and happiness as important, key is balance of using alcohol if it helps those circumstances.

[@wallyrbc]

@@chewiewins Yes, for sure. Alcohol is obviously not “necessary” in every social situation. It’s really being demonized these days, though, and I’m attempting to point out it can be enjoyed once in a while. Some of us are guilty of being too incredibly obsessive with living a healthy lifestyle.

[@Sorrydidyouspeak]

Wow, I can't believe he's 72!

[@StephenMarkTurner]

Just leaving a generic comment to help feed the YT algorithm. Great guest.

[@TheProofWithSimonHill]

Ty

[@andynater1885]

Fellow Australian here Simon - You deserve more subs, they will come, god speed.

[@jonbarlow3542]

A fascinating & delightful conversation, full of un-rushed deep wisdom. Thank you.

[@sethboviper]

I listened to this via the pod, not youtube, the guest's voice was unbelievably soothing. science interesting, too ;)

[@karenthornhill1508]

The Proof is one of my favourite you tube channels. Thanks for this awesome guest speaker 😊

[@TheProofWithSimonHill]

Thanks for listening

[@peterz53]

On the blood exchange issue, the Conboy lab has shown (2020 and 2022 papers) that removing old plasma has many of the same positive effects as parabiosis. Although some of their work was in humans they have yet to show how long the effects last and how much old plasma needs to be taken out and at what age to start. Nevertheless, there is potentially a huge untapped dataset in that plasma donation has been around for a long time. Same for the medical treatment version (TPE). This doesn't stop unscrupulous MDs from charging thousands for this even though we can go to our local blood bank (in the US) and donate (free) about 25% of our plasma 1x/4 weeks. Some plasma-only centers allow 2x/week donation. Anyone doing this should use some of the markers noted the Conboy's 2022 paper as well as tracking normal blood markers. Another study showed that long term plasma donation will also reduce the load of persistent chemicals, like fire retardants (PEFAS).

[@bartstienen4161]

@@peterz53 well, that is a bonus, just last week i went for my second plasma donation and plan to go every other week.. knowing it maybe has benefits for my own health makes it even more worth while doing 👍

[@sebastianhoracioforondagon8813]

Nice interview as a scientist I started with some controversies about your content, but now I am understanding you are a good guy, scientific and accurate.

[@chbbbbgygvvggvvvvvbbhgg]

Please make video on statins and its risk with diabetes

[@scienceislove2014]

Gosh..this was a gem.. I'm instantly downloading this video.. This also inspires me to pursue a career in the field of medicine.

[@LaurenKomishane]

If you are interested in aging research, this podcast is extremely enjoyable. The discussion was honest and insightful, particularly how it cut through the hyperbole surrounding anti-aging interventions. I appreciated the honest segment on animal studies with caloric restriction, emphasizing the need to compare it against a healthy diet rather than a Western diet. Thank you Simon, for introducing us to Venki Ramakrishnan, the scientist involved in this research.

[@cinuk]

Super interesting interview. One of the best. Thank you

[@AGBRADFORD]

7am here in California, great way to wake up. Our research quarter has started at my UC school and talk of improving quality of life dominates all we do. Deeply wished your show could travel here one day and we can watch your live interviews with more insightful people like Venki. Even as we eat well and exercise, our biology still leaves so much to discover. The fog clearing over the ocean view this morning is a great metaphor for the moment. Your inquiries are refreshing and sincere. Thx Simon. ☺

[@c.d.c.s.]

Thanks for this. The philosophical question and answer at the end…spot on.

[@AP-ei4jt]

Bravo! This is what I have been leaning toward as well regarding the fundamental thesis of life extension. Protein is the lowest level structural component of life that requires continuous maintenance of form for function, from production to maintenance to degradation. Maintaining a healthy lifecycle is key to life and longevity. The professor nailed it.

[@BubblesBath]

Genes play huge role.My father is 87 yrs old.Both his parents lived until 93yrs in italy.He has no chronic illness or heart disease.

[@clukcluk]

Thank you very much for a most fascinating conversation

[@plants_and_wellness1574]

Loved him! Could you possibly ask your brilliant guest, just for fun, what a day of eating looks like for them. I think that would be intriguing for the listeners and fun 😊. Whatever he’s doing is definitely working! I can’t believe he is 72! Amazing ❤

[@TraceyValleroy-gj9kz]

Excellent!

[@susymay7831]

What are his big tips for increasing health and longevity? This is a well spoken talk on problems and philosophies surrounding aging.

[@123ChrisG]

@@susymay7831 the big main things is exercise, eat healthy majority plant based, don’t overeat and try to live a stress free lifestyle.

[@jeffj318]

Great interview and informative. Just a nice casual talk with two intelligent men. 👏💪

[@TheProofWithSimonHill]

Glad you enjoyed it!

[@ritacastanhito2223]

Pure gold!!!!

[@hopetn]

Very interesting, thank you.

[@Dieblauesau]

Very interesting, Thanks! It is good to get real information. There are many sensationalists out there.

[@tomedwards1879]

Nice interview Simon. I wonder what Venki thinks of the work on longevity of Valter Longo?

[@dystopian-future]

Hi Simon. After hearing all the miraculous stories of people healing depression, anxiety and PTSD after going carnivore, I decided to try it for myself for 3 months.... Well it didn't help at all lol. Anxiety and PTSD, obsessive overthinking etc, did not change in intensity. So now I'm wondering if going Vegan in a healthy manner (not vegan junk) might help? I'm willing to give this a go. Therapy never worked for me so I feel I have less options. Do you have any resources or podcasts that shed any light or evidence on Vegan improving mental health in the case of trauma and depression? Thank you ❤

[@TheProofWithSimonHill]

Ahh this sounds very tough. I’m so sorry that you’re going through this. There’s not a lot of strong clinical trial data looking at how nutrition directly affects depression. Strongly recommend seeking out help from a different psychiatrist or psychologist if you can and/or a qualified dietitian. It’s easy to get very confused on social media with so many non experts acting like they have answers to all ailments (including depression/anxiety) - often putting the horse before the cart. If you were to look someone up online, that is a true expert in diet and mental health, I would recommend Dr Felice Jacka. Her research on the Mediterranean diet stands out as the most robust research investigating diet and mental health today. It’s a greatly underfunded and understudied area of nutrition science. Hopefully that changes soon.

[@Dreamopticsredlightglasses]

That was amazing thank you 👍

[@TheProofWithSimonHill]

Glad you enjoyed it

[@wholefoodplantbasedmama5398]

Plant chompers, Dr Michael Greger and PCRM.

[@bartstienen4161]

Thanks, what an amazing guest 👍 the last statement he made was a bit of i feel because there is much enjoymend to be found in upgrading and refining the things that bring us excellent health, as if joy can only be found in things that are harmful to it ..

[@carinaekstrom1]

Some of that possible stagnation would of course be offset by people keeping their cognitive health longer than before. So the 60´s may become the new 30`s. I think it's also important to appreciate the immense intellektual and practical knowledge, as well as wisdom that older people have and that is now lost much too fast. When older people are healthier they will be better able to share all that.

[@33Crazydude]

I agree. If science can unlock methods to keep us biologically younger for longer, it could significantly extend the period in which we retain our fluid intelligence, creativity, and problem-solving abilities. This would allow individuals to remain productive and innovative well into older age, benefiting both themselves and society. The idea that increased longevity would cause societal stagnation seems unfounded to me. On the contrary, a longer, healthier life could provide more opportunities for continuous learning, exploration, and innovation, leading to progress rather than stagnation. A population that remains mentally sharp for longer could contribute to new advancements and ideas, driving society forward in ways we can’t yet fully imagine.

[@carinaekstrom1]

@@33Crazydude Yes. We often complain about generation after generation making the same mistakes over and over, never learning. Maybe with more healthy people around that actually remember the past mistakes, we can get better awareness and smarter at how to proceed.

[@33Crazydude]

@@carinaekstrom1 Agreed! By the way, if you're truly interested in anti-aging, I highly recommend looking into the work of American biologist Michael Levin. He's making remarkable strides in research that challenge traditional views, especially in areas like cellular regeneration and bioelectricity. His work could potentially revolutionise how we understand aging and regeneration, offering exciting new possibilities for extending healthy lifespans.

[@nolanwardy7409]

Great talk. But, i think it’s common sense that eating a seasonal ancestral diet is going to be beneficial for heath and life span. Diet, light, water and magnetism should be everyone’s health priority.

[@33Crazydude]

I suggest inviting American biologist Michael Levin to be a guest on your show. His innovative approach to addressing ageing could provide a fresh and insightful perspective on the topic. Levin’s work, particularly his research on bioelectricity and cellular regeneration, offers unique ideas that could enrich the discussion on how to slow or even reverse the ageing process. Having him on your show would not only introduce a novel angle but also engage your audience with cutting-edge scientific concepts that could redefine how we think about ageing.

[@sebastianhoracioforondagon8813]

Agree with you

[@jimparker2646]

Humans seem to not only have kids, but also help take care of grandkids. Might this select for living longer than mating age?

[@HakuCell]

9:00

[@wholefoodplantbasedmama5398]

Is Simon hill an Aussie?

[@andrewnorris5415]

I personally see new generations being less healthy. Certainly here in Europe where we got obese and fruit and veg taste bland compared to all the processed convenience foods. And this is having affects on my middle-aged friends. Even my parents seem to be less healthy than their parents were at the same age. For those who look after themselves of course it is a different matter. What's sad is the general public info - most do not know the harms they are doing and the effects on energy and mood these have.

[@bodyimagept4398]

👏🏼👏🏼

[@srki80]

kzbin.info/www/bejne/fpWpcp5_aLF9pKc I just want to point out that a papers published by John D Abramson in 2013 show that statins are not without side effects and effective preventives, yet they are generally accepted. Efforts were made to retract the paper; however, the independent review panel of BMJ do found that two published papers did not meet any of the criteria for retraction.

[@oonaghcleary3645]

Yes an older couple of ages 40 can have children but a couple aged 25 will pass on better genes as older sperm carries more mutations than younger sperm and older eggs loose their quality too this is from professor John Aitken professor of biological and reproductive science the message is that where possible it's best to have children before the age of 35 the younger the better genetics will be passed on

[@netto682]

👏👏👏🇧🇷

[@hidaven]

Whoa!!! Knowledgeable thinkers of our time! You’re both talking about longevity and that damn candle is pumping out sooty cancer causing chemicals in the air. Lol. Trim that wick my man! Otherwise great interview Pal. xo

[@melb.4626]

Assuming doesnt do you any favors, while paraffin wax candles are toxic; soy wax, beeswax, coconut and a few other alternative waxes for making candles are non toxic :) And they are increasingly popular, not hard to find. They probably know this, we don't know for sure those candles are cancer-causing paraffin.

[@hidaven]

@@melb.4626 oh wake up Junior! That black smoke is all the proof you need! NO black smoke is healthy! A properly lit and burning candle makes NO black smoke! And it’s NOT the wax Einstein, it’s the “too long” wick which may also have a thin wire within further adding to the toxicity. Learn from me Otis.

[@KatoKato-mx1gf]

I'd be more concerned with what is being sprayed in our atmosphere

[@hidaven]

@@KatoKato-mx1gfthat too…..

[@VFNVFNVFN]

@@melb.4626 It's the SMOKE. Period. All smoke is BAD for health, despite what is creating it.

[@marcusantonyledulx]

The problem with extending life are the mental & emotional aspects associated with this. In Western Culture people stop developing emotionally in older age. They become bored & cease to embrace novelty.

[@christinajohnstonperez9361]

All very good except his projections about how the world is going to be for a population that live 200 years. Very shortsighted projection as if we were going to be going down the same pub, still have to go to work, going to school and still eating burgers. He totally dismissed interplanetary travel and population, artificial intelligence in symbiosis with human beings as one new specie with quantum computing at full disposal finding cures in days for existing illness and the ones to come. Bio- nanotechnology fixing at cellular levels. The end of work and the beginning of studying for life, cellular cultured food 3d printed, abunce. But above all an explosion of knowledge.

[@jonathonmills3563]

Nice conversation, he’s clearly not very knowledgeable about rapamycin research, which is ok. I’m more interested in topics that are more directly in his wheelhouse

[@gregzaks6649]

Not a very informative podcast, I have not learned anything that I didn't know before. 😢

[@TheProofWithSimonHill]

Would you rather learn new things that are hype and likely inaccurate or reinforce things that work?

[@OsorioT]

@@TheProofWithSimonHillbrilliant answer! Thank you for this amazing episode

[@Combinationlock]

⁠​⁠​⁠​⁠​⁠Human evolution cares about survival first and foremost, seeking and consuming the highest quality food source followed by the mechanism of natural selection, survival of the fittest where individuals most adapt to their environment survive. These adaptations are a requirement prior to the mechanism of procreation, and to procreate for as long as possible. Seeking and consuming high quality nutrition enabled humans to live longer enabling more time to teach, learn, innervate, share knowledge and wisdom, make tools, etc. Ev

[@wholefoodplantbasedmama5398]

Is Simon hill an Aussie?