This Anti-Aging Supplement Might Actually Work

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If you've wandered down a supplement aisle recently, you may have come across a bottle for sale that has "anti-aging" ingredients to help your body make a molecule called NAD+, better known as nicotinamide adenine dinucleotide. Your body definitely does need NAD+ to keep ticking, but what does the research actually say about taking supplements to make more of it?
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[@SciShow]

Visit brilliant.org/scishow/ to get started learning STEM for free. The first 200 people will get 20% off their annual premium subscription and a 30-day free trial.

[@pishpishposh3541]

Hey SciShow! How do, an independent American, submit a patent or go about quickly but safely protect my new idea!? Any advice would help not just I but so many out there! We can’t all be on shark tank, but I feel so many of us are ready to be starting on new tools and potentially conceptualizing grandiose new age ideas!!

[@Jason608]

And surprise surprise, exercise increases the amount of NAD+ in your body. Not saying a supplement is a bad idea, just that you can get more NAD+ by exercising, and not just NAD+ but a TON of other beneficial adaptations that increase both healthspan AND lifespan.

[@HavaDay5979]

❤

[@KokoHekmatyarr]

The point is we want a higher quality of life. My life doesn't feel high quality while I'm exercising, or for a long while after. Lucky you if you enjoy it

[@Omar-ld9gy]

@@KokoHekmatyarr exercising is boring and monotonous for me too. But you don't need to do an entire routine an hour long 6 times a week, you just need 30 mins of high intensity exercise per week for all of the health benefits (according to some research)

[@KokoHekmatyarr]

@@Omar-ld9gy I've heard 30 mins per day, not per week. Are you sure about that?

[@Omar-ld9gy]

@@KokoHekmatyarr ok it says 30-60 mins per week, but yes, lifting weights/building strength though, not running and stuff

[@TomsBackyardWorkshop]

I dont want to live longer I just want to be healthy while im alive.

[@LimitedWard]

Idk those worms seemed fairly healthy. But may have had to do with the free healthcare.

[@gleipnirrr]

let me spell it out slower so you understand: you get sick because you get old. stop aging and you will be healthy. not smarter though

[@lakrids-pibe]

I want more good years.

[@AlexAlex10703]

i'd prefer both

[@steve00alt70]

You cant have your cake and eat it too

[@Kleineganz]

I was taking NMN supplements before the FDA pulled it from the market because someone was trying to get it approved as a prescription drug (huh?). I was primarily taking it for the promise of increased energy (I'm autistic and also suffer from chronic fatigue, which may or may not be related to my autism). I saw a significant increase in both my general energy and my ability to be more productive while I was taking it. Ever since the whole FDA thing, any NMN supplements I have been able to find online don't do anything (meaning they don't contain any actual NMN). I don't care if it's a prescription or over-the-counter thing, I really want it back on the market just to help me boost my energy again.

[@thomasferris3750]

Reduculous that these company’s can just claim a chemical that already exists cause they looked at it first, like calling dibs on a species of tree, I see a future for black market NADs

[@pierrecurie]

also possible there was another ingredient that clicked for you, and that's no longer present

[@Kleineganz]

@pierrecurie well, of that's true, I wish I knew what it was.

[@Jakalope_Circles]

@@Kleineganz a lot of these supplements contain tons of caffeine, so I would look into if what you were taking had caffeine

[@Kleineganz]

@Jakalope_Circles no, the one I was taking didn't have caffeine. Plus, I already drink 4-5 cups/day and it doesn't help my energy levels.

[@whittenaw]

Imagine having the energy of youth and the wisdom that comes from age and experience

[@Master_Therion]

Someday we will have breakthroughs that add decades to your life-expectancy. But if you are looking for advice that will add a few minutes to your life, I wouldn't hold your breath.

[@TrueWolves]

I don't know, I think not holding my breath has helped me live longer than just minutes!

[@existenceisillusion6528]

Haven't seen a comment from you for a few years. Welcome back, especially if you never left.

[@larka.sonder]

@@existenceisillusion6528 Haven't seen a comment from you since I haven't seen you before. Welcome to my ever gaining knowledge of individuals who i know exist.

[@PBTophie]

Well, of course not. Holding one's breath would have the opposite effect!

[@CH-fc8dm]

zing!

[@spiritbond8]

"If I could get back my youth, I'd do anything in the world EXCEPT get up early, take exercise or be respectable." - Lord Henry Wotton

[@TheLyricalWrdsmth]

I would very happily stick around for a few centuries. I want to experience history and witness the land change.

[@unevenelephant469]

One should not wish to live in Interesting Times.

[@Mr.Patrick_Hung]

Are you sure? Imagine someone from two hundred years ago being alive today.

[@RCynic75]

Watching civilizations rise would be cool, but remember that you'd have the opportunity to watch them fall as well.

[@Mr.Patrick_Hung]

@RCynic75 The rise and fall of civilizations tends to involve bloodshed. The first emperor of every dynasty comes to the dragon throne with blood soaked hands.

[@Flint-g4h]

But I say, if humans can live significantly long, I worry that there would be a suppression of the youth by the elderly majority. It is for the youth to inherit the world, the elderly should have no authority in dictating that. It is through the youth how society changes, it has never been done by middle aged or the elderly.

[@albedougnut]

A lot of people saying they do not want this, which is fine, but the point of this is, it should be available and accessible to everyone who does want it.

[@dh8203]

And I suspect that if we had the medical means to routinely have lifespans in the hundreds of years, most of those same people wouldn't look at it and go "Nah, 70 years is all I want."

[@vixxcelacea2778]

@@dh8203 This. I think it's a defense that or people feel they've had a pretty decent life and are okay with it ending in a short amount of time. Me, hell no. I'm sticking around as long as I can unless I actually hit a point where I'm truly okay with not being around. I see age as kind of a zombie disease. Everyone has it and every culture tried to make peace with it and many medical/scientific people tried to stop it.

[@gorgha3988]

I do very much agree with one thing in this video. Until they can prevent most if not all the potential horrible side effects of aging, modern medicine should be focused less on increasing life span and more on increasing "healthspan" as bro put it. Why would I want to live to 80, 90, 120, or any other number you can pick if chances are higher and higher that I could be a senile old invalid wearing diapers that someone else has to change for me? No thanks.

[@Ivegotyoursix911]

If it can help slow "aging" of the body, I feel that would include age-related mental issues as well. Hopefully that's the case!

[@fullmetal929]

Yeah, exactly. As long as I'm wearing diapers that I can change myself, I'm good to go.

[@rubylilamoore6322]

"delays certain age-related declines" 4:27

[@consciouscode8150]

Almost certainly any medicine which extends the lifespan also expands the healthspan. Once you've reached the end of your healthspan, you're living on borrowed time and will die sooner rather than later.

[@MiIIiIIion]

Those health issues are frequently what kills old people. So if you're working on extending life, you're at least indirectly working on extending health.

[@fatalimmortality801]

Cycstic fibrosis was still a death sentence for children in the UK/Europe until the late 1960s!! We didn't get a treatment that wasn't tipping people upside down or hotboxing them until the 90s!! We've made so much progress in treatment of so many things that improve child mortality rates!! Look at us go!!

[@Dingosilver57]

And just lately we've made strides that have led to some kinds of cycstic fibrosis patients living well into their 60s, long enough that even more improvements will be made to lengthen that time further.

[@Meskarune]

I learned about how life changing the new drugs are on the frey life. ❤

[@pynn1000]

Food sources of NAD+: whole grains, mushrooms, vegetables, fruit, cow milk and products. For omnivores: fish, meat, poultry. Good food - tastier than pills.

[@brandonhughes645]

thats almost everything lol

[@wavion2]

@@brandonhughes645 The solution to longer life is... eating.

[@FearsomeMedic]

@@brandonhughes645 Most Americans lack whole grains and vegetables. And whole meats are much better than processed and ground meats.

[@UHFStation1]

The concentration in food is way too low.

[@EffigyOfficial]

Concentration of NAD+ is meaningless, he said that in the video. We need the precursors

[@FelixFelicis117]

I want to be healthy, but instead, I just ate like 30 potstickers for lunch.

[@Tormekia]

But they were tasssty!

[@drbettyschueler3235]

I have been taking NMN since 2020 despite having stage 4 breast cancer. It is a slow-growing, estrogen-positive cancer that was diagnosed over 30 years ago. So far, it has been found in 7 different sites, throughout the years, so I've had to take a lot of toxic medications during that time. I don't know if the NMN is affecting the cancer in any way, but I rarely have to take any OTC pain medication, and when I do, it is for a spinal injury from an auto accident.

[@jenniferesein4813]

What brand of NMN do you use?

[@beccafranklin6683]

That’s really interesting. Hope you’re doing ok. I have an autoimmune disease. Perhaps I should give it a try too.

[@DariaM00re]

Keto diets might be worth researching, supposedly it can starve some cancers of the carb type fuel they need while the body lives of the ketone fuel At the very least, might provide an interesting read

[@robotninjashark1684]

My wife had a massive leap in recovery from me/cfs because of NAD. It's expensive, and it's a shame that insurance doesn't cover it, but it's a literal life saver.

[@DJ1573]

How much are you paying?

[@aqua_coloring]

What form did she take? I tried NMN for months (I think 1 gram/day), and it only gave me a very, very tiny bit more energy. And was very expensive.

[@larryc1616]

​@@aqua_coloringtry less expensive and possibly better than NMN are flush niacin and NR. all 3 have different pathways for NAD production.

[@brianlewis5692]

NAD precursors do not make you younger, they increase NAD+ which gives you more energy, but they can be detrimental as they allow for the build-up of Nicotinamide within the cells, which is why they should be taken with TMG. The root issue is the steady increase in CD38, which eats into our endogenous supply of NAD as we age. Keeping CD38 in check is what is really needed, not more NR/NMN=>NAD.

[@erinmac4750]

Interesting information. Do you have a source? I was going to add this to my list of things to look up on the NIH website, as they publish research on all sorts of relevant and interesting health topics. --hopefully they'll keep their funding and overall mission during the current administration. Them, NOAA, NASA and the USGS are some of my favorites for nerdy deep dives. 🍀

[@pjaworek6793]

Selling nuchido time?

[@pjaworek6793]

More nad with nmn and lower cd38 at the same time with dried parsley

[@eklectiktoni]

@@erinmac4750 Same. I love NIH, NPS, NOAA, and the USDA (specifically the PLANTS database). I too hope things don't go south over the next four years. 🤞🏾

[@H4CK41D]

keeping what? your comment is cut off with no "read more" button

[@charliesgotaguitar]

i don't care about human trials TEST IF THIS WORKS FOR CATS

[@omegahaxors9-11]

A realer statement has never been made.

[@cameroneridan4558]

Probably but there's a far cooler recent development in cat longevity. Cats usually die far sooner than their DNA would suggest they should live, because their kidneys give out. Recently we've developed a potential solution to the most common causes of cat kidney failure, which could potentially make cats live twice as long on average and reach 30 years old regularly!

[@migueljardim8177]

​@cameroneridan4558 What is it? I have a fountain that stimulates my cat to drink all the time, which helps combat a major risk with kidney failure, which is dehydration.

[@KokoHekmatyarr]

@@cameroneridan4558 And that solution is?...

[@KokoHekmatyarr]

@@cameroneridan4558 So what is that solution?

[@SilverFan21k]

Ty Sci Show for the great video ❤ Longevity & Life Extension are my future favorite technologies

[@CBSonPc]

My mom is 65 and takes it, she’s a Pilates instructor. She’s aged so slowly in the last 10 years, you wouldn’t guess she’s 66.

[@4gegtyreeyuyeddffvyt]

I would guess he’s 65

[@dupersuper1938]

@@4gegtyreeyuyeddffvyt I would guess he's a she...

[@1chumley1]

Sounds like she got a year older in one sentence.

[@IoannisNousias]

As a son of a 67 year old, I can tell you that my mom being 68 comes as a surprise to everyone. How can a 69 year old look so young? Are 70 year olds now the new 30? Will my 71 year old mom look that good 10 years down the line when she is 82?

[@Richard_Nickerson]

Yeah, because you said she's 65

[@JonoSSD]

My broken back wishes this thing was around some 5 years ago.

[@erikarussell1142]

You and me both my friend. Mine happened 25 years ago (in 4 days). I have two Herrington rods. But that doesn’t mean I can’t benefit from these supplements now. Especially with all the inflammation that comes from broken bodies. Even once they’ve healed.

[@TojiFushigoroWasTaken]

How did that happen? Was it because of an accident or a gym injury?

[@edwardfarinas]

It did exist 5 years ago. The research around nad+ isn’t new at all.

[@erikarussell1142]

@ right. It’s a form of B3

[@erikarussell1142]

@ 😂😂😂

[@militantpacifist4087]

We just got trolled 2:56 😂

[@DCGreenZone]

D3 receptor polymorphisms might be addressed with Liposomal D3/K2, loss of melatonin, near zero by age 70, loss of CoQ10 with statins and age, loss of Glutathione, near zero by age 70, Mg deficiendy, D3 deficiency. Taurine has been shown to extend healthspan by 23%.

[@HHHGeorge]

Thank you for an honest and informative video which was succinct in it presentation. I might just look at Brilliant and see if I can get my hands on some NR and NMN capsules.

[@TWX1138]

Who guessed that NADs would be the source of longevity?

[@josemv25]

You can have these nads

[@pennehoesje]

Go nads!

[@1chumley1]

But not maturity 😂😂😂!

[@TWX1138]

@ youth may wane, but immaturity can last a lifetime.

[@thagingerninjer5391]

@@TWX1138I hope so. It’s way more fun. 😂

[@TheRABIDdude]

The mention of healthspan was poorly timed. You implied that NAD+ supplements would extend your lifespan, while classic methods like exercise would increase your health span. This is a common misconception around anti-aging therapies. In reality, an all anti-aging techniques specifically aim to increase healthspan, and lifespan increases as a result of that.

[@katarh]

Exercise is CRUCIAL though because it is the only thing that can keep you out of a wheelchair in your later years. My 80 year old mother in law is still independent, mobile, and looks closer to 60. This is partially because she starts off her morning with body weight calisthenics. She can still pull off a six mile hike without complaint. The moment she stops trying to move is the moment she'll keel over and die, I suspect.

[@Sobergamer61]

Dr Rhonda Patrick talked about NAD like 6 years ago. This isn’t new. In fact I have it, I just forgot I had it until this video so thanks lol 😂

[@Fome]

I think you're my favorite presenter in SciShow. Clear, concise, and accurate, while being entertaining.

[@bentationfunkiloglio]

I don’t know if these supplements will keep me young forever, but they definitely have one very concrete benefit. They make my hair significantly thicker, something I didn’t expect. The change was noticeable enough that my barber noticed. After a couple months taking NR, she asked what I was doing because she noticed my hair was getting thicker. The downside, the effects don’t last if I stop taking the supplement. Given this, I switched to the much cheaper NMN. I’m 55yo, have perfect cholesterol levels and zero heart disease. Not sure if supplements are contributors or not. I eat a plant based diet and regularly exercise. Still, I’m about 10 to 15 pounds over my ideal weight, soooo … maybe. In terms of looking younger or having more energy, did not notice any relevant changes other than thicker hair. Truthfully, light therapy helps much, much better when it comes to looking younger. Just bought one of those light masks and, damn. They really do work … and work fast!

[@twiggyvlogs6441]

I thought the picture was a spaghetti and I'm like, yes, anti age me mr delicious spaghet.

[@kuntamdc]

Then all of our speghts will have names.

[@shadebug]

What we’re saying is that you know you’re old when your nads have dropped

[@MyrmidonsProductions]

there's a compound being sold as a supplement currently that i want to see more studies from its Turkesterone and ecdysterone because the current research is. very interesting

[@stoner4311]

Nad+ is a power molecule that helps makes ATP in the mitochondria, going from NADH goes to NAD+ and is the biggest contributer to atp production, fats create huge amounts of NADH. The citric acid cycle and the ATP production in the mitochondria especially the f protein, the smallest molecule machine is so awesome

[@KaosRunes]

Strength training can help fend off some affects of old age, doesnt even need to be hypertrophy. Exercising in general helps.

[@billpatterson1371]

I consumed NR TruNiagen daily for 2 years with no other supplements. It did make me feel alright, however, over time it caused Peripheral neuropathy numbness in multiple finger tips. As I have stopped for a few years the numbness only remains slightly in one finger tip and hopefully will recover over time. It also caused knee pain after exercise. I no longer suffer from this knee pain issue after I stopped consuming the product. I’m a male in my mid 30’s. Buyer BEWARE !!!

[@pattheplanter]

I didn't get neuropathy with NR but I did get vertigo and nausea - so I only had about ten or twelve pills. There are so many drinks and foods that have added niacinamide/nicotinamide like "Vitamin Water" that it is quite easy for people to take too much and get nerve damage. Especially if they take supplements as well. It is well known that overdoses are dangerous. It is usually mentioned in the tiny small print on bottles and packaging that nobody would think they need to read because - vitamins are healthy, right?

[@jmseipp]

A vitamin B12 deficiency can cause those same symptoms as well as other deficiencies.

[@joelharris4399]

I guess some of us aspire to be like naked mole rats: old, wrinkled and immune to that plague, cancer

[@exosproudmamabear558]

Thats exactly they try to do that tho. If your mitochondria and immune system works properly you can avoid getting cancer and antiinflamatory mechanisms really important in that.

[@TojiFushigoroWasTaken]

You should aspire to be that jellyfish that can revert back to its young form when times are tough or that sea grass that lives on for centuries.....Imagine being sea grass, dancing as the ocean waves passby and have fish and crustatians nibble at you and you literally have nothing to do but exist

[@chaoticatmos1461]

​@@TojiFushigoroWasTaken sounds amazing.

[@pdxmusl1510]

Better old and wrinkled than a crude person who over values youth ;)

[@larryc1616]

👽

[@PastaAivo]

I remember many, many years back, there was a biologist kind of guy who was already marketing the stuff and taking it himself. He did look great for fifty-something. Interesting to see something more on the topic pop up.

[@elizabetha8565]

My memory and energy levels really took a nose dive in my early 40's and heard about nmn tried it, and I had a ton of energy my memory/recall is way better and I have way better reactions. I know people that tried it and said nothing seemed to happen so maybe my body didn't make enough? Idk but it has been a miracle for me, and at a pretty low dose.

[@Viertelfranzose]

The next Video should be about C60. Thank you very much for this video and greetings from Andreas in Alsace/France

[@thaddeuszukowski4633]

One good subject for si-show would be "what is a healthy diet?". Many of us know to much of anything might be bad but what is better ??

[@BillyTWildi]

NR and NMN are typically expensive and the market is full of fakes. For some reason, people don't seem to realise that NMN and NR are just different forms of vitamin b3 - and you can therefore get a NAD booster by just buying niacin (b3) supplements, which are way cheaper. Note: the slow release version of niacin is associated with liver toxicity. The immediate release one is safer, but it does cause quite intense flushing.

[@sci1905]

I do not fear death, but I would love to live as long as possible. The reason for this is to experience as many incredible achievements in science as possible. I am curious what AI will be like in the future, how advanced medicine will be, and how far humanity will travel into the cosmos. When I do pass away, I would love to donate my body to science because I would die peacefully knowing that I am making a contribution in science even during death.

[@pattheplanter]

I never thought I would see a close-up of Pluto in my lifetime. Now I really want to see a good picture of an extra-solar planet.

[@Leto2ndAtreides]

I use NR, but ... NAD+ going down may be more a design feature rather than a bug. Seems to be related to inflammation and senescent cells... You don't want to rev up the engine when the car is starting to get rickety.

[@lekiscool]

I keep saying I only want anti-aging so I don’t fall a part before I’m 50. 😂

[@selgeaus]

Being Asian, non-drinker, non-smoker, and never done harmful substances have certain helped me looking younger than my chronological age

[@burchified]

you're gonna hit that yoda wall one day though 😂

[@katarh]

For me (not Asian) it's wearing sunblock consistently that has protected my face from the signs of aging. There's no such thing as a healthy tan, no matter what skin tone you're starting with.

[@larryc1616]

You gotta live life especially when you're a young adult.

[@StrangeChickandPuppo]

I really like your voice Reid

[@TheSirfa11111]

Just had this intravenously last two weeks

[@Mix1mum]

Not aging sounds great. Not dying would be torture.

[@consciouscode8150]

Longevity isn't magic; it isn't some genie's curse where you'd be unable to die for the rest of eternity. It's giving you the agency to choose whether you're ok with dying now or if you want to keep on living for tomorrow.

[@DoozyyTV]

why

[@Wakeupgrandowl]

@@DoozyyTVbecause of bodily decay. If your body continues to age and decay but you don’t die, there will become a moment where you’re so broken down you will wish for death. Not aging means you feel young and healthy for as long as you can

[@米空軍パイロット]

You can always die by any other mean.

[@mqb3gofjzkko7nzx38]

If you live a happy life, living for a very long time actually sounds pretty good.

[@zombiedad]

Interesting. Thanks

[@BR.]

Exercise, propper diet and sleep are the things that work

[@adamwishneusky]

again, thanks for adding a transition to the sponsored segment. it was so jarring before!

[@hasmond6808]

What effect would it have if you start taking it in your mid twenties? Would you stay young and healthy longer?

[@jeremycrossland3779]

No. Your body produces enough of the stuff when you are young. A deficit only occurs as you speed past 60. 😂

[@jehorigby8778]

Yes and no, mostly no. If you want to preserve youthful appearance, do each step as I tell you, some is easy, some is harder *but you should do all* - Quality skin care routine (cleanser, toner, chemical exfoliant, serum/active, moisturiser) done daily, with a different routine in the AM and PM, followed by a sunscreen designed for the face (non comedogenic) ALWAYS FOLLOWING AM ROUTINE [Side note: consult a dermatologist for your personal compatibility but alternating aha and bha in the AM /PM with a QUALITY formulation will do wonders] - From age 23 onwards begin exploring a prescription for retinoic acid from a dermatologist - following this you must *never* forget to apply sunscreen - no smoking, vaping. Edibles are okay however - minimal drinking - exercise (4 hours of high quality intense exercise every WEEK) - high quality balanced diet ---------------- In the event you decide to take nad+, understand that nad isn't the silver bullet it's been made out to be, *the key issue is cd38 regulation* and while you'll hear you can eat various herbs, like dried parsley. It's long-term wear on kidneys isn't worth the extremely weak and broadly unreliable results. A better way to think about this problem isn't ageing = bad, instead think, youth = a set of behaviours and tendencies. For example, youth do not drink, nor do they smoke, they exercise regularly, engage in meaningful social connection and have a strong self care drive - *start here* and then add the skincare and drugs

[@TheQueenOfStupidity]

Sounds very interesting for a spoonie with inflammation problems and who has had only a speck of the life experiences others my age has because of my illnesses. Living longer and combatting symptoms sounds like dreeeaaam 💭

[@voidwalkersystem]

We started taking that like half a year ago, at a doctor's suggestion, to help with our long covid. it seemed to help! Still does. Could it just be the placebo effect? Yeah, I guess. But we're really happy we found it!

[@Anthony_Gutierrez]

I would pay any price to live to see humanity become a multi-planetary species

[@trancendedmindpalace]

I wouldn't mind living forever in a healthy state so long as my loved ones also wanted to. Without my wife and kids, my brothers and friends it would be an empty world to me.

[@Terigena]

The problem with anti-aging drugs is that they take such a long time to properly test. Maybe try them on those kids who age too quickly.

[@nathan518]

This doesn't make any sense. Anti-aging drugs prevent cell and genetic breakdown, which has nothing to do with normal growth from childhood to adulthood. These drugs only do something when you're done growing and your body starts breaking down (that's what they mean by "aging").

[@Jobobn1998]

If you're talking about kids with progeria, that would probably not really translate into results for "baseline" humans, even if it did help the kids with it. Progeria specifically is the result of a genetic mutation that disrupts nuclear integrity, which has a lot of (apparently) downstream effects that appear very similar to aging. But this should not be confused with the actual aging process. Since actual aging seems to be a combination of telomere shortening, build up of oxidative stress, accumulated mitochondiral dysfunction, genomic damage, epigenetic changes, and cellular senescence (likely in response to much of the above), anything that might be a silver bullet for progeria would probably have little-to-no positive effect on people without progeria.

[@dyscotopia]

I was taking NMN for chronic fatigue. I definirely felt like working out more and had better muscle tone and had a bit more energy. I djd feel a little more anxious too, bur unlike many supplemebts I didn't feel like it was an effect I couldn't chalk up to placebo

[@markmuller7962]

Yes please, I've lost 40 years of my life as undiagnosed ADHD

[@altiarissuralis8535]

1. The largest killers of humans(not to mention a large portion of suffering) is by far heart disease, Cancers, diabetes, dementia, all accompanied by frailty. An all too small percentage of the federal budget is allocated towards it. This needs to change. 2. My genuine question is how many people who turn 80, but in perfect health(body of a 25 year old) would be OK with simply saying "that was enough life."? How many would choose to continue living and exploring and learning.

[@brindlekintales]

Fear of death would keep 'em going.

[@selgeaus]

I don't mean to sound like Thanos but the longer people live = more resources needed to maintain. It may mess up the balance...

[@brindlekintales]

@@selgeaus The plan is to only allow the rich to live longer, and there ain't many of them, they're an exclusive club. So put your worry to rest about this so-called "balance."

[@Abby-ug4xc]

Seems like a lot of people get high & mighty and talk big about the virtues of death because wanting more time is seen as narcissistic for some reason. But I'm certain that if given the chance they would choose life

[@altiarissuralis8535]

I understand your concern; it's a common one, but: 1. Birth rates are falling 2. Birthrates that are kept afloat by immigrants, are temporary; Mexico is at ~1.7, similar the US, according to the PRB, as an example.

[@FuzzyHuggs]

I suffer from a disease that causes chronic inflammation and take some prescription meds for it, as well as some doctor-recommended supplements. I also strictly adhere to a low histamine diet. If anything that seems scientifically promising can help with this awful disease, I'll try it and monitor the results closely. Hopefully, these NAD+ supplements are made in a high-quality control facility, with proper dosing, and are truthful about actually using the supplements they say they are using.

[@pattheplanter]

Polyunsaturated vegetable oils can be helpful for inflammation. Though the wrong ones may inflame more. Hempseed oil seems to have the precursors for the prostaglandins that reduce inflammation. Not the high CBD type oils, just the vegetable oil for salads and mashed potatoes. Also tastes good.

[@333rpd]

Time takes it's toll. Please have exact change.

[@victoria256r]

The fact that nobody talks about book called Health Secrets Industry Hides really gets to me. Always loved doctors that opens our eyes.

[@omegahaxors9-11]

Everyone has their reasons for wanting to live longer, but for me I want to watch all the animals of the world evolve into people.

[@freddiesimmons1394]

Which means you really don't understand evolution or evolutionary niches too well

[@omegahaxors9-11]

@@freddiesimmons1394 It didn't help that I worded it like every animal was going to go through a human-like evolution, and not the ones that are currently on that trajectory.

[@freddiesimmons1394]

@omegahaxors9-11 even saying "trajectory" exposes a misunderstanding. Or perhaps it is just another misuse of language. From over here, I cannot tell.

[@omegahaxors9-11]

@@freddiesimmons1394 OK so you're just being a debate pervert, got it.

[@darteaga1785]

I will also follow my other comment suggesting we worry about the quality of our life instead on how long we are around. A more balanced diet with mostly whole foods, being active (physically and mentally) staying in the present and planning for the future. Just a my two cents

[@jarterburn116]

@scishow please ask Reid where he got shirt! I neeeeed it

[@marcusroizen7424]

Probiotics are a superior source of NAD+, especially ones with antidiabetic and anticancer properties, because that reduces the risk of long term side effects from increased NAD+

[@explorerofmind]

The question of whether id want to live forever depends mostly on who else would be living and how healthy my body and mind would be. Because if my memory remains as bad as it currently is, then thousands of years won’t do me any favours.

[@gregmattson2238]

yeah they really didn't talk about my favorite NAD+ precursor, namely niacin (and not the long-release kind). Yes it makes you beet red, and yes. you itch a bit, but taking 500mg one time per week really does work well with apigenin and TMG.

[@gimmeagig]

I do Intermittent fasting and that is supposed to reduce inflammation as well. And you are actually saving money LOL

[@kkkk-wg6je]

Where can I get my hands on some NADS?

[@triviszla1536]

Being immortal would be nice, but I would like to have the guarantee of never getting ill too

[@ARKY-v3x]

Glad to hear this is available in supplement form, and foods. Always good to have a few options of keeping quality of life up & the reaper at bay. I f*cking hate aging, even if you try to do right , its like your body is programmed to just destruct on itself for no legitimate reason.

[@differentone_p]

Oh yeah, the "magical pill" we all wanted. I hope people will start exercising daily and make it something as important as brush your teeth daily.

[@MyFirstHandle]

Glad anti-aging is addressed as part of sci-fi fantasy other than robots taking care of you when you get old when you can imagine that you can stay alive for longer if you believe in immortality.

[@kittyhooch1]

I've experimented with the precursors. It's also true that calorie restriction can extend life and health. As I contracted diabetes type 2 I went on Keto. A lot of good things started happening. It turns out the constant glucose metabolism most people have is not in our evolutionary adaptations. Neither is a high carbohydrate diet. A ketogenic fat metabolism has intriguing advantages. One is that oxidative phosphorylation creates more NAD+ instead of converting it to NADH. It's also anti inflammatory. To fully benefit from autophogy you need exercise and several 3 day fasting sessions a year. Just taking a NAD precursor is ignoring most of the metabolic puzzle.

[@meowmeow-op7lp]

Totally agree. I used to take nmn, but stopped when I started trying the 168 plus keto diet. It took me 18 months to lose around 20 pounds. Worked very well on my prediabetes as well as age reverse (20 years younger). No one will believe I am 59. People think I'm in my late thirties at most 😂

[@ArrowofDarkness]

That swinger's shirt looks like it fits him perfectly

[@johnnyfog8134]

This video pairs wonderfully with the video of dark science on inflammation that came out the same day :)

[@alisondale979]

I'd love about 2000 healthy years, think I'd get everything done in that time; could spend a lifetime as a scientist, a lifetime as an artist, a lifetime as an athlete, so much to experience.

[@dh8203]

Experience caps at level 20.

[@SokarEntertainment]

Just make me biologically immortal already. I'll checkout myself once I get bored.

[@beginnereasy]

I support people who live forever for free and like it. I think being able to choose when you go, if you want to go, is better than rotting alive. They should replace youth with a more superior final form.

[@billyma6]

in all my career in biochem i've never heard anyone call it 'næd before, we always spell it out with the letters lmfao

[@OzzieBenzC300]

I have access to it but never thought about using it.

[@ReasonableGuy-l7o]

Dude, where did you get that shirt? I want one too.

[@Ronsonpeters]

If we are making people live longer, we need social services to care for these people past their working or able age. People deserve dignity more than they need more time.

[@brockobama257]

Lmao this title is the type that tricks old people on news websites

[@pyrogotz5076]

Probably could put it in salt, like we do with iodine?

[@A-Duck]

I just want to live as long as I choose to, go out when I feel it's time. Whether that means age 70 or 2,000, I want to last as long as the desire to hang around remains.

[@SirCharles12357]

I tried NMN for a few months and didn't notice any effect, good or bad. I stopped taking them. I'm a one case example, but I wasn't impressed. I'm just going to cut sugar, eat whole foods, and exercise.

[@SunSheepOfLight]

Oh… I wish my grandma 👵 knew about this.

[@ThereBeDargons]

If you want to maximize NAD+ production, it seems to be more or less just as simple as "eat well and exercise" 😂 Obviously this includes whole foods with a tendency toward green vegetables, with a full spectrum of fatty acids from fish, red meat, nuts and seeds.

[@AutocraticAardvark]

I just need more energy, dude. Tired of waking up tired.

[@ALucas73]

I take Aeon which contains 11 supplements for anti-aging: NMN & NR, EGCG (from Green Tea), Trans-Resveratrol, Quercetin, Fisetin, L-Theanine, Astragalus, TMG (as Betaine Anhyrous), Piperine (from Pepper), & Spermidine. As new research comes in they change the ingredients, this is the 3rd "recipe" they've had.

[@Mkoivuka]

There's no shortage of medications out there. The challenge is finding ones that do not come with adverse drawbacks.

[@alanarmstrong3186]

content is getting a lot more common interest clickbaity these last few weeks...

[@larka.sonder]

Hi Alan, you must be new around here. Welcome! SciShow is a strong mix of current topics, and long researched standalone episodes. If you'd like more concrete science check out SciShow News episodes. Have a great day!

[@H4CK41D]

my question is could this help cats and dogs live longer?

[@Arunnn241]

This might be the only type of study where the animals get to live for as long as they can during and after the trial.

[@jaredkennedy6576]

I took an NMN supplement for a while, but there was some research that indicated it helped cancer survive treatment. Being that I had cancer, and again do, I'd rather avoid helping it

[@gianpaulgraziosi6171]

Do Metformin and Berberine.

[@KarlaEmmerson]

Mitochondria is the powerhouse of the cell

[@TojiFushigoroWasTaken]

Bungee gum has the properties of both rubber and gum

[@JohnVance]

Mitochondria is the powerhouse of the cell

[@lbanepa]

Probably related to thermo dynamics

[@ToneyCrimson]

oOOH this is exciting, i want this for my parents!