This New Chemical is Fascinating But How Does it React? “Diazo-Ylide Hybrid”

[@totalsynthesis]

Did you learn something new? Let me know how you liked it - thanks again for supporting the channel and watching! www.patreon.com/totalsynthesis | instagram.com/totalsynthesis_official/

[@MultiAXEeffect]

when he said homologation, I felt that...

[@atescoshorse8399]

I think this video proves that chemistry never seizes to amaze, what a both crazy and useful reagent!

[@totalsynthesis]

Facts

[@davonitos]

Another banger video best chemistry youtuber for sure

[@totalsynthesis]

Thanks - folks like you are why I keep going!!!

[@mimortal1000]

Bro you are a legend ! Keep up the good work, already impatient to see the next video. Have a great day !

[@totalsynthesis]

🔥🔥🔥 thanks brother!

[@mattilindstrom]

Seeing the "Ph" in the thumbnail, I tried to recall what element that is, of course drawing a blank. Well, now I know what it is for, thank you.

[@totalsynthesis]

Phluorine

[@therealguy403]

You never fail to amaze me! Great video as always.

[@totalsynthesis]

Thanks! Right in the feels

[@OmegaPaladin144]

"N2 has left the chat" - LOL, that's great. I'm really surprised a diazo compound is that stable. Diazomethane is legendary for how dangerous it is, and most diazoalkanes are similarly ready to ragequit existence.

[@totalsynthesis]

😂😂 yep it really is hella surprising

[@chemdelic]

Keep it up bro

[@totalsynthesis]

Thanks mate!

[@swastikbiswas8293]

Loved the straightforward explanation of this video!!

[@totalsynthesis]

Thank you!

[@swastikbiswas8293]

@@totalsynthesis I binged watched all of your videos instead of writing my thesis😭😂

[@totalsynthesis]

@@swastikbiswas8293 Respect haha

[@Chemicator]

What a beautiful chemistry! 👍

[@ewwserr]

not the carbon making the sickest chemistry possible again

[@totalsynthesis]

😂

[@OrganometallicPsychonaut]

Amazing video. Please keep uploading

[@totalsynthesis]

Will do! (Trying to keep monthly but barely holding on 😂)

[@kevinburgess1183]

Excellent contribution again. I think more people watch your videos about papers than actually read them, because you distill them down to the essentials so clearly.

[@totalsynthesis]

Thanks so much!

[@user-pb4dz6mc6n]

beautiful thank you

[@keithkeiser9678]

Absolutely fascinating!

[@totalsynthesis]

Thanks!!

[@abs0lute-zer061]

I love your high quality videos

[@totalsynthesis]

Thank you so much!

[@-r-495]

Wow, this is really cool!

[@totalsynthesis]

Thanks for the comment!

[@Oxyten]

Very interesting! I didnt come across with this reagent before

[@samueldeschwanden3065]

Let's gooo another one ❤🎉

[@ChemicaLove]

there's also been some other new highly oxidized carbon chemistry recently, good stuff

[@totalsynthesis]

Which one?

[@ChemicaLove]

@@totalsynthesis a crystaline doubly oxidized carbene Nature 2023 623 p66

[@dominikfendre3305]

Absolutely amazing quality of the video as always and great chemistry behind it :D One question tho. How did you make the thumbnail structure with the colored outline? I don't think it's possible like that with ChemDraw :/

[@totalsynthesis]

Thank you! Just paste as picture into powerpoint, then add "Glow" format

[@dominikfendre3305]

@@totalsynthesis Wow, thank you!!! Would have never figure it out like that :D

[@dominikfendre3305]

@@totalsynthesis One more thing. Is there a way you can outline parts of a molecule with different colors in PowerPoint or is that like a Photoshop thing?

[@totalsynthesis]

@@dominikfendre3305 That I don't know, sorry!

[@jakuborvos1575]

Thanks!

[@totalsynthesis]

Wow thank YOU! 🔥💕

[@jakuborvos1575]

@@totalsynthesis That is my way to thank you for your effort and immense knowledge you put into these videos. Despite I am PhD organic chemist, I learn something new with every video you release. Very refreshing and educational, everytime. KZbin deserve more chads like you, not another "viral bros" :)

[@tentast8916]

extremely interesting ngl

[@mmmhorsesteaks]

It kind of reminds me a little bit of TOSMIC, one of those interesting one-carbon synthons (kind of).

[@totalsynthesis]

True

[@WielkiKaleson]

Insane.

[@AlligatorKrokodil]

7:54 is this even considered a mesomeric structure? i mean its also a constitutional isomer because the carbon makes a new bond to the terminal nitrogen which it didnt have previously.

[@totalsynthesis]

Not sure what the strict definition os (does it truly have to have the same connectovitied), but the authors called it canonical structure as well in the SI (which is a synonym unless I forgot something). In any case, it's just the "extreme" human representation which does not exist but contributes/ can help rationalize the properties/ computations

[@emmanuelmartinez9726]

Wow, how do you made that models of molecules?

[@totalsynthesis]

Complicated but basically Blender

[@Flesh_Wizard]

"carbon atom transfer" I'm not a chemistry expert but does that mean that this can add carbon atoms to most things?

[@totalsynthesis]

Not to most things, it depends on the specific molecule!

[@firstmkb]

I think the explanations were going to be clear, but this isn’t going to stick without more time on the basics.

[@totalsynthesis]

I still need to find the balance of basic vs advanced content as the background of my viewers is quite heterogeneous

[@AlligatorKrokodil]

10:35 i cant see a proton leaving like you drew under the reaction arrow.

[@totalsynthesis]

I typoed that it seems, maybe thinking about the next step already 🧐

[@venkatibethi98]

👏

[@williambouthillier8611]

I really like your video, but I have to admit it pains me to look at those di-ylids drawing. 2 consecutive double-bonds should be drawn as linear, just like the diazo moiety. If you wanna draw the angle in the di-ylid molecule, I would suggest you leave at least 1 pair of opposite charges so that the hybridization of the central carbon is appropriately correlated to the geometry pictured in the video.

[@totalsynthesis]

Thanks! I think its completely fine drawing like this, similar to how you draw cyclic allenes bent as well

[@KrashFries]

what does the organic chemist eat for dinner? a carbon-ara

[@totalsynthesis]

😂

[@PunmasterSTP]

I feel like we're just exploiting glitches in the simulation at this point...

[@kevinburgess1183]

I am wondering how I might get in touch with you without posting my email or other contact info. I am a chemistry professor. Do you happen to know who I am?

[@totalsynthesis]

My email is in my channel contact info!

[@kevinburgess1183]

@@totalsynthesis Thanks I sent you an email yesterday .... did you receive it?

[@kevinburgess1183]

No I did not. Thanks for following up. I just sent you another email (actually two).

[@helldad4689]

lmao at that 5 membered ring with FOUR different atoms. extremely blursed shit.

[@totalsynthesis]

😂😂😂