Transformation, Conjugation, and Transduction: 200 Highest Yield Topic Countdown- USMLE Step 1

In this video I discuss and explain the concepts surrounding horizontal gene transfer mechanisms.
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Disclaimer #1: All of the highest yield facts described in this video are those that I perceive to be most important. This is subjective and based on my experiences teaching and studying for this examination. Please note that others may have differing opinions as to which sentences are the most relevant. Thank you for watching and please enjoy the video.

[@Knstar5566]

Thank you so much for this topic, I had much problem with this topic but not any more.

[@aishwaryaramesh6395]

This is amazing! The number of times i've tried reading this topic in FA or some other material and ended up with anxiety because i could never completely understand the difference between lytic and lysogenic transduction. Could not have explained it in a better way. Just awesome. Gosh! Thank you so much for doing this wonderful series!

[@rupacharya6601]

Thank you sir! Understand a lot. You explain way better than Mnemonic guy, Dirty. You should have more views than him.

[@MedManiac1]

excellent. quality similar to dirty usmle. way to go!

[@tobyme1]

Sir, you are amazing. For sure you explained it a gazillion times better than the brand named! prep resources. Thank you so much.

[@mahwashfarooq7225]

detailed and informative! literally helped me prepare this topic of bacterial genetics :)

[@LunarColony]

Beautifully explained! Thanks!

[@monzilachowdhury6590]

Thank you so much . It was so helpful.

[@imjustlivinglife1747]

Great video! That question and explanation was very informative. I didn't pay attention to that syndrome's classic features before. Thank you!

[@nataliamullins6919]

Excellent explanation! Great lifesaver! Also, really liked the question at the end, really helped reinforce some concepts. Please keep making videos!

[@rosstaylor7743]

thanku man! this was so good

[@Olguis005]

you saved my day

[@Zeefatima123]

So well explained! Thank you

[@AdamTaghavi1]

💯💯💯🔥🔥

[@KinzaHussain]

Thank you so much for this video! UWorld likes to ask a lot about whether these bacteria are then able to produce progeny. I have step in a few days..Do you mind replying to this comment with whether these modes of genetic transfer would be able to produce progeny, please? Transformation: Conjugation: Transduction

[@DrRoviso]

Hey Kinza, (love your YT channel btw), I think you are referring to vertical gene transfer, where genes are given to progeny of the parent organism? Horizontal gene transfer (such as transformation, conjugation, and transduction) is usually referring to the transfer of genetic material between two cells of the same generation. Good luck on your exam! If you need anything shoot me a message or email. Wishing you all the best!!

[@KinzaHussain]

@@DrRoviso OMG thank you!!! I love your channel too. I can't wait to recommend it in my next video after this awful exam is over. Ohhh! that may be why I'm so confused...Is "progeny virion" also through vertical transmission?

[@DrRoviso]

For sure, hang in there a little bit longer. Life is a lot better after Step 1. 💪 To try and answer your question, progeny virion is probably referring to bacteriophages that originated in a bacteria that was infected. For example, in generalized transduction, a donor phage injects genetic material into the donor bacterium. Then the phage carrying donor genes are replicated in the bacteria and eventually the bacteria lyses and all of the progeny virions are released to infect new recipient bacteria. Most of the progeny are exact duplicates of the original infected phage, however a small fraction can sometimes carry fragments of the host bacterial DNA. In vertical gene transfer, genetic information from one bacteria is transferred from parent to offspring and bacteria typically reproduce via binary fission where one cell divides into two identical daughter cells with the same DNA copy as the parent.

[@KinzaHussain]

@@DrRoviso Thank you SO much!!!! I'll try to find all the uworld questions that tripped me up on this for context! I appreciate all the videos you have put out!