Treatment approaches for BRAF V600E mutant metastatic colorectal cancer

Chiara Cremolini, MD, PhD, University of Pisa, Pisa, Italy, highlights current treatment strategies for metastatic colorectal cancer. For patients with BRAF V600E mutations, treatment varies by mismatch repair (MMR) status. For proficient MMR (pMMR) tumors, the BEACON CRC trial (NCT02928224) supports using encorafenib plus cetuximab, with other ongoing trials evaluating nivolumab. For deficient MMR (dMMR) tumors, the SEAMARK trial (NCT05217446) shows promising results for pembrolizumab combined with encorafenib and cetuximab. This interview took place at 2024 European Society for Medical Oncology (ESMO) Gastrointestinal Cancer Annual Congress in Munich, Germany.
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