Ubiquitination of Proteins and Protein Degradation

[@saniyapamnani8494]

I am at beginner level in research and this video helps me understand the process in the best way possible. Thank you so much and keep up the good work.

[@hussainbiology]

Thanks Saniya for appreciation... Glat it helps...

[@kvl_001]

I am a doctorate microbiology student, and this helped a lot to understand protein degradation. Thank you, please keep on making these videos!

[@hussainbiology]

thanks Abagail for appreciation..Glad it helps

[@mustafamohammed1850]

Big Thanks for you from the ground of Hussein (Iraq🇮🇶) ❤️💚

[@hussainbiology]

Thanks Doc for appreciation..✌️✌️✌️

[@DrHazi]

❤سلام یا حسین

[@anshulgohel7283]

this video was a blessing, explained my complicated lecture and hit every single point of the lecture in less than 5 min. aapko bahot dua!

[@bhags815]

Explained better than my uni lecturer! Well done, Keep it up.

[@hussainbiology]

thanks for appreciation..Glad to know that it helps ✌️

[@inder970]

@@hussainbiology \kk hu

[@abeedashaik4730]

Watching this video just 2 hrs before the exam and it's really helpful. Thank you soooo much ❤

[@hussainbiology]

thanks Abeeda for appreciation....Glad to know that it helps ✌️

[@bellamuerte4953]

Thanks so much from a second year biochem student in Ireland! This is so helpful

[@hussainbiology]

thanks Bella for appreciation.. Glad it helps

[@nuhk9001]

Your videos are better then my uni teacher's lectures. thank you so much

[@BiologyRoots]

One of the best channels on YT ❤

[@hussainbiology]

thanks buddy

[@maryambeirami9435]

This concept was explained beautifully, in a clear way. Thank you so much!

[@hussainbiology]

thanks Mariam for appreciation.. Glad it helps ✌️

[@pranavkankal5604]

Even after reading the whole concept twice I understand it but couldn't feel it . Your video helped to feel it thank you very much big brother 🙏🏻

[@alizayfatimah6787]

The explanation we all wanted 😍

[@hussainbiology]

thanks for appreciation. Glad it helps

[@wardgoetschalckx1072]

Thank you for this video, my professor did not quite explain it in a propper way. Great video!

[@microalexis6788]

So simple yet so consistent. Thank you so much!

[@hussainbiology]

thanks for appreciation..Glad it helps

[@sanughosh6540]

Your videos are such a lifesaver

[@hussainbiology]

thanks for appreciation..Glad it helps..

[@rajeshkothandaraman6008]

Hi, Explained beautifully, people who are not technically related to biology can understand very clearly. Thanks much.

[@sakhawatshah2046]

Brilliant and amazing... excellent work

[@gg025]

you are very talented at teaching. thank you for this.

[@hussainbiology]

You are very welcome

[@nadimshaikh9854]

Very informative and brief. Please keep it up.

[@marytragessertina9721]

This was fantastic. Thank you so much for the diagrams and step instruction on both processes

[@hussainbiology]

Thanks Mary for appreciation... Glad it helps

[@andershayes8498]

sorry to be so off topic but does any of you know of a tool to get back into an instagram account..? I was stupid lost the password. I would love any tricks you can give me

[@marvinnova1553]

@Anders Hayes instablaster :)

[@andershayes8498]

@Marvin Nova i really appreciate your reply. I got to the site through google and im trying it out atm. Looks like it's gonna take quite some time so I will get back to you later when my account password hopefully is recovered.

[@andershayes8498]

@Marvin Nova it did the trick and I now got access to my account again. I'm so happy:D Thanks so much, you saved my account :D

[@siyarkhan3364]

Keep it up Son May you prosper and go hike. Ameen

[@dikshyapanthi7681]

I also found this video very helpful for ubiquitination of proteins kzbin.info/www/bejne/hIiQnHR6e61-isU

[@alibaldiwala1604]

Thank you so much for this!

[@noorulain7302]

This is very informative video bro....... Very well explained. Respect and love from Pakistan.

[@hussainbiology]

thanks for appreciation.... Glad to know that it helps......Keep sharing and supporting

[@noorulain7302]

@@hussainbiology yeah, thanks alot, i will watch many of the videos from ur channel. Thumbs up for you.

[@violettedelforge5103]

very well explained, the drawings help a lot ! Thanks for this video

[@hussainbiology]

thanks for appreciation..Glad it helps....✌️

[@aimanawan463]

Very well explained. It helps me a lot

[@hussainbiology]

thanks Aiman for appreciation..Glad to know that it helps ✌️

[@kaleemullahmohmand8096]

Tomorrow is my presentation on topic thank you help me alot

[@hussainbiology]

thanks.. All the best.. do well

[@kaleemullahmohmand8096]

@@hussainbiology 🙏

[@mahamshahid1519]

Understandable .. good job

[@gagandalal5233]

Excellent!! Thank you so much !

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@navaneeth_us]

Conceptually enlightened video. Thank you so much.

[@ruqayayousuf53]

Stay blessed and happy always ❤️ jazakala,our great teacher.and make more vedios for csir net,and also make one vedio for csir net aspirants

[@hussainbiology]

Thanks Ruqaya for appreciation...Glad to know that it helps ✌️ keep sharing and supporting

[@marielrivamargaja6992]

Thank you so much this was so easy to undeestand

[@fianoanthonio]

Thanks from Bali, Indonesia!

[@vishwasn5424]

Very nice explanation. Thank you.

[@hussainbiology]

thanks for appreciation.. Glad to know that it helps

[@doctorofmedicine1113]

Well explained my dear brother...

[@hussainbiology]

Shukriya boi...

[@johnbates2709]

Excellent and very clear

[@hussainbiology]

thanks John

[@screamingperson8188]

Buddy this was a lot of help! Thank you brother!

[@hussainbiology]

thanks for appreciation

[@-k9517]

MashAllah good work!

[@jayamaheshwari3660]

Thank you so much, amazing video!

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@AlkaSingla-v7w]

Its so nicely explained

[@seaguardian4409]

Thank you from Canada : )

[@hussainbiology]

Lots of love... ✌️✌️

[@bakhtawarfayyaz2067]

! this 4 minute video is blasttttttttttttttt. perfection.....................

[@hussainbiology]

thanks Fayaz for appreciation Glad it helped

[@nastarannazari5062]

Thank you, sir. It was so helpful as usual. I have a question. Are all misfolded proteins destined for degradation or are there some helpers that protect misfolded proteins until they are ready to get folded properly?

[@saimaahad7238]

There are first helper proteins called chaperones ( Hsp 70 , Hsp 60 ) which help misfolded proteins to fold correctly , still if misfolded proteins are not capable of folding properly or their functions are lost then they are directed to degradation.

[@caseybertina507]

Hi! This really helped me understand. Thanks! But what does "SH" in "E1-SH" and "E2-SH" mean?

[@alishanamakula]

I'm an a level biology student thank you so much

[@AnNa-pb6gi]

Well explained. ❤️

[@hussainbiology]

thanks for appreciation

[@ayeshatariq1041]

Thank you Soo much brother it's very helpful ❤❤

[@nehafathima9431]

very good explaination , thank u

[@hussainbiology]

thanks for appreciation..Glad to know that it helps ✌️

[@ImranMalik78]

God bless #Thanks for the effort dear

[@hussainbiology]

Thanks brother.... Always keep me in your prayers, 😊😊

[@JustSalva15]

Gracias por el video!

[@pawandeepkaur8820]

gud efforts...keep it up

[@hussainbiology]

Thanks for appreciation

[@suhana5352]

Thank you so much❤❤ It was really helpful :)

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@rockycycle2682]

Awesome video thanks

[@_beautyyofislam]

This was so helpful 😭🫶🏽

[@hussainbiology]

thanks for appreciation..Glad it helps

[@anandruban8348]

Why you did not mentioned about the parts of proteosome like Ubiquitin receptors - Rpn-13 and Rpn-10, DUB- De-ubiquitination enzyme, and Rpt-1 to Rpt-6 (ATPase subunit). Examples of Ubiquitin ligase enzyme like SCF- (Skp 1, cullin, and F-box protein) and APC/C - Anaphase Promoting Complex or Cyclosome which degrades cyclins in cell cycle.

[@rubaiyaruba7931]

Nice explanation ❤ Thank you.

[@nicole708]

Thanks you ! iAn excellent explanation. :)

[@hussainbiology]

Glad it was helpful!

[@learneverythingowaisbhat2348]

u r the best in the world

[@ramchandrasuthar2848]

Very nice analysis bhai ji

[@hussainbiology]

Thanks Bhai..

[@siddhantdhingra6422]

Can ubiquitination be done at cysteine residues in a protein backbone?

[@evaciampo8269]

This is perfect. Thank you!

[@edu-bsc]

Thank you so much....It is really helpful 😊☺️

[@hussainbiology]

Most welcome 😊

[@mdirfanqureshi4637]

So informAtive thank you brother

[@dikshyapanthi7681]

I also found this video very helpful for ubiquitination of proteins kzbin.info/www/bejne/hIiQnHR6e61-isU

[@ilkiiny]

Thank you so much!

[@alexandrerebmann203]

thanks from switzerland!

[@dikshyapanthi7681]

I also found this video very helpful for ubiquitination of proteins kzbin.info/www/bejne/hIiQnHR6e61-isU

[@venuskataria5230]

Omg ...this is superb..

[@hussainbiology]

thanks for appreciation.. Glad to know that it helps ✌️

[@abinashbeherabiology9578]

I have a doubt how many types of proteasom are there in human cells?

[@wardtaylore]

Ub4 is the shortest chain that binds to the cap of the proteasome. Not Ub3.

[@hussainbiology]

Yes for 26 Protesome to work , it needs at least 4 Ubiquitins to degrade the Protein effectively. In diagram i have shown only 3 Ubiquitins which is a mistake.

[@zarlishattique4167]

Hi, Thankyou sir, but can you please tell how upregulation and downregulation of UBC cause tumor or cancer or its progression.

[@aishabhat2358]

Thank you.This is too good

[@hussainbiology]

Thanks for appreciation.....

[@dikshyapanthi7681]

I also found this video very helpful for ubiquitination of proteins kzbin.info/www/bejne/hIiQnHR6e61-isU

[@rukminidubey320]

What is the mechanism of keratin degredation

[@fathmanawaz5025]

Excellent👍

[@hussainbiology]

Thanks for appreciation.....Glad to know that it helps...

[@tanu6464]

Thanku Thanku Thanku Thanku Thanku Thanku Thanku Thanku

[@hussainbiology]

first u laughed... I thought i have made a mistake....

[@hussainbiology]

Most welcome 👍

[@tanu6464]

@@hussainbiology no 😂 I am just happy so that's why I send you these smily 😊😊

[@hussainbiology]

@@tanu6464 okayy great

[@dipalibokde7864]

Protein degradation control and protein degradation is same? ?

[@elizap5532]

Thanks!

[@Barnoxon_11]

Thank you 🙏🇺🇿

[@trixiamaeelizan]

thank you!

[@hussainbiology]

My pleasure..Keep sharing and supporting

[@shubhagupta99]

Really useful..thanks

[@hussainbiology]

thanks for appreciation....Glad to know that it helps

[@ekaterinashul3194]

Great! Many thanks!

[@hussainbiology]

Thanks for appreciation....Glad to know that it helps

[@shishirbain3615]

Superb amezing 😊.. i watched it in 2022 😂😂😂

[@hussainbiology]

thanks for appreciation..Glad it helps....✌️

[@gulbano4292]

plz also make a video on neddylation., NEDD8.

[@prastutidebi8034]

thank youuu sooo muchhhhh😇😇😇😇😇

[@hussainbiology]

most welcome...Keep sharing

[@pianobun6305]

Who is this guy? So knowledgeable and good teacher, give me ur bio pls I wanna stalk you

[@hussainbiology]

U can stalk me @ Instagram.... BTW thanks for appreciation...✌️✌️

[@shirse9331]

Thank you so much...

[@hussainbiology]

Thanks buddy.....Keep supporting

[@mehwishnawaz9369]

It helps a lot Thank you

[@hussainbiology]

Thanks for appreciation.....😊

[@dikshyapanthi7681]

I also found this video very helpful for ubiquitination of proteins kzbin.info/www/bejne/hIiQnHR6e61-isU

[@arjunanil3213]

Can Ubiquitin tag on prions ?

[@BioAxis]

Nice .

[@sakshin7324]

how to control its degradation of casien???

[@cheshtaagarwal3945]

sir 26 proteasome consist only one cap of 19s RP with two cap it becomes 30s proteasomes

[@hussainbiology]

kzbin.info/www/bejne/bnaTc2ikitqtrc0 Plz watch this video first

[@gulbano4292]

thanks alot

[@azzmangal8722]

Soooo nice

[@hussainbiology]

Thanks for appreciation

[@Tony-xl2ob]

excuse me , i want to ask a question. the numbers of ub need three or four? cuz i remember it need at least four ub.

[@hussainbiology]

Yes for 26 Protesome to work , it needs at least 4 Ubiquitins to degrade the Protein effectively.

[@dooach]

Is this important for usmle

[@hussainbiology]

If u think it is

[@ASHTUTORIAL]

Best

[@hussainbiology]

Thanks Ash for appreciation

[@Muzee123]

Are u from kashmir

[@hussainbiology]

Yes dear...✌️

[@l.4055]

you basically saved my life! hahah

[@hussainbiology]

thanks for appreciation 😊

[@akhil.nitrkl.22]

wow

[@sakiaakbar791]

Sir i guess u r from kashmir?

[@hussainbiology]

Yes Sakia i am from Kashmir ✌️

[@sakiaakbar791]

@@hussainbiology That's great sir.. Keep going u are doing a fab job..

[@leonblickshyd]

그냥 솖묹자로 쓹지 왜 댊묹잛로 쓻닧가 오탋내곪 덮어쓻냐...

[@KennethHarris-g2q]

King Greens

[@tanu6464]

😀😀